AT317211B - Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen - Google Patents

Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen

Info

Publication number
AT317211B
AT317211B AT272373A AT272373A AT317211B AT 317211 B AT317211 B AT 317211B AT 272373 A AT272373 A AT 272373A AT 272373 A AT272373 A AT 272373A AT 317211 B AT317211 B AT 317211B
Authority
AT
Austria
Prior art keywords
azapurin
derivatives
salts
preparation
new
Prior art date
Application number
AT272373A
Other languages
English (en)
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Application granted granted Critical
Publication of AT317211B publication Critical patent/AT317211B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT272373A 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen AT317211B (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5955270 1970-12-15
GB5955670 1970-12-15
GB4975671A GB1338235A (en) 1970-12-15 1971-10-26 Azapurinones
GB5345771 1971-11-17

Publications (1)

Publication Number Publication Date
AT317211B true AT317211B (de) 1974-08-26

Family

ID=27449009

Family Applications (4)

Application Number Title Priority Date Filing Date
AT272373A AT317211B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten und von deren Salzen
AT1075671A AT315838B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten
AT272473A AT315839B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von pharmazeutisch zulässigen Salzen von neuen 8-Azapurin-6-on-derivaten
AT272273A AT319235B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT1075671A AT315838B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten
AT272473A AT315839B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von pharmazeutisch zulässigen Salzen von neuen 8-Azapurin-6-on-derivaten
AT272273A AT319235B (de) 1970-12-15 1971-12-15 Verfahren zur Herstellung von neuen 8-Azapurin-6-on-derivaten

Country Status (25)

Country Link
US (1) US3987160A (de)
JP (1) JPS5310599B1 (de)
AR (4) AR192602A1 (de)
AT (4) AT317211B (de)
AU (1) AU458277B2 (de)
BE (1) BE776683A (de)
BG (3) BG20806A3 (de)
CH (5) CH552610A (de)
DD (1) DD95007A5 (de)
DE (1) DE2162096A1 (de)
DK (1) DK141249B (de)
FI (1) FI53457C (de)
FR (1) FR2118078B1 (de)
GB (1) GB1338235A (de)
HK (1) HK42177A (de)
HU (1) HU165079B (de)
IE (1) IE35897B1 (de)
IL (1) IL38364A (de)
IS (1) IS1099B6 (de)
LU (1) LU64457A1 (de)
NL (1) NL174943C (de)
NO (1) NO134257C (de)
OA (1) OA03930A (de)
SE (1) SE393381B (de)
ZM (1) ZM18971A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
FR2406638A1 (fr) * 1977-10-21 1979-05-18 May & Baker Ltd Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant
EP0007727B1 (de) * 1978-07-24 1983-11-30 Beecham Group Plc Benzopyranotriazole, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende pharmazeutische Zusammensetzung
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
CA1303037C (en) * 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Purinone derivatives as bronchodilators vasodilators and anti-allergic agents
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
DE3873812D1 (de) * 1987-04-07 1992-09-24 Ciba Geigy Ag 3h-1,2,3-triazolo(4,5-d)pyrimidine.
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
DE4211239C2 (de) * 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
US5734053A (en) * 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
DE19881732D2 (de) 1997-11-12 2000-08-24 Bayer Ag 2-Phenyl-substituierte Imidazotriazinone als Phoshodiesterase Inhibitoren
DE19838705A1 (de) * 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2328910B1 (de) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
EP2968439A2 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Zusammensetzungen zur behandlung von magen-darm-störungen
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
RU2019121646A (ru) 2016-12-14 2021-01-15 Респира Терапьютикс, Инк. Способы и композиции для лечения легочной гипертензии и других заболеваний легких
MA54825A (fr) 2019-01-24 2021-12-01 Prometheus Biosciences Inc Modulateurs de gpr35
EP3972599A1 (de) 2019-05-21 2022-03-30 Ardelyx, Inc. Kombination zur senkung des serum-phosphatspiegels bei einem patienten
WO2022020617A1 (en) * 2020-07-23 2022-01-27 Prometheus Biosciences, Inc. Therapeutic agents targeting gpr35

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407204A (en) * 1944-07-22 1946-09-03 American Cyanamid Co Triazolo (d) pyrimidines and methods of preparing the same
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars

Also Published As

Publication number Publication date
CH550814A (fr) 1974-06-28
IS2047A7 (is) 1972-06-16
IE35897L (en) 1972-06-15
FR2118078A1 (de) 1972-07-28
IE35897B1 (en) 1976-06-23
JPS5310599B1 (de) 1978-04-14
DK141249C (de) 1980-08-04
CH555351A (fr) 1974-10-31
DK141249B (da) 1980-02-11
AR199467A1 (es) 1974-09-09
OA03930A (fr) 1975-08-14
DE2162096A1 (de) 1972-07-06
AR192689A1 (es) 1973-02-28
DD95007A5 (de) 1973-01-12
NO134257B (de) 1976-05-31
NL7117142A (de) 1972-06-19
CH552610A (fr) 1974-08-15
HK42177A (en) 1977-08-19
BE776683A (fr) 1972-06-14
ZM18971A1 (en) 1972-08-21
SE393381B (sv) 1977-05-09
BG20806A3 (de) 1975-12-20
FI53457C (fi) 1978-05-10
LU64457A1 (de) 1972-08-23
IL38364A0 (en) 1972-02-29
FI53457B (de) 1978-01-31
AU3686771A (en) 1973-06-21
FR2118078B1 (de) 1975-08-01
DE2162096C2 (de) 1988-02-11
BG20807A3 (de) 1975-12-20
AR199468A1 (es) 1974-09-09
CH556860A (de) 1974-12-13
BG20805A3 (de) 1975-12-20
AT315838B (de) 1974-06-10
NL174943C (nl) 1984-09-03
NL174943B (nl) 1984-04-02
AT315839B (de) 1974-06-10
HU165079B (de) 1974-06-28
AU458277B2 (en) 1975-02-20
AR192602A1 (es) 1973-02-28
CH546779A (fr) 1974-03-15
IL38364A (en) 1975-08-31
NO134257C (de) 1976-09-08
US3987160A (en) 1976-10-19
AT319235B (de) 1974-12-10
GB1338235A (en) 1973-11-21
IS1099B6 (is) 1982-11-18

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee