AT315842B - Verfahren zur Herstellung von neuen 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-aminoäthyl)-pyridinen und von deren Säureadditionssalzen - Google Patents

Verfahren zur Herstellung von neuen 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-aminoäthyl)-pyridinen und von deren Säureadditionssalzen

Info

Publication number
AT315842B
AT315842B AT63972A AT63972A AT315842B AT 315842 B AT315842 B AT 315842B AT 63972 A AT63972 A AT 63972A AT 63972 A AT63972 A AT 63972A AT 315842 B AT315842 B AT 315842B
Authority
AT
Austria
Prior art keywords
hydroxy
pyridines
aminoethyl
hydroxymethyl
preparation
Prior art date
Application number
AT63972A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AT315842B publication Critical patent/AT315842B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT63972A 1971-02-16 1972-01-27 Verfahren zur Herstellung von neuen 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-aminoäthyl)-pyridinen und von deren Säureadditionssalzen AT315842B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11587871A 1971-02-16 1971-02-16
US25664172A 1972-05-25 1972-05-25

Publications (1)

Publication Number Publication Date
AT315842B true AT315842B (de) 1974-06-10

Family

ID=26813670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT63972A AT315842B (de) 1971-02-16 1972-01-27 Verfahren zur Herstellung von neuen 2-Hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-aminoäthyl)-pyridinen und von deren Säureadditionssalzen

Country Status (9)

Country Link
US (2) US3700681A (de)
AT (1) AT315842B (de)
BE (1) BE778771A (de)
CA (1) CA978962A (de)
CH (1) CH541560A (de)
DE (2) DE2265581C2 (de)
FR (1) FR2125309B1 (de)
GB (2) GB1367669A (de)
NL (1) NL174349C (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207639A1 (es) * 1973-12-26 1976-10-22 Pfizer Un procedimiento para preparar pirido (3,2-d)1,3-dioxin-6-epoxietanos y compuestos intermediarios desprovistos de actividad terapeutica
US3952101A (en) * 1975-04-14 1976-04-20 Smithkline Corporation α-Amino methyl-5-hydroxy-2-pyridinemethanols
US4011231A (en) * 1975-10-03 1977-03-08 Pfizer Inc. 2-Phenyl-6-(1-hydroxy-2-t-butylaminoethyl)-4H-pyrido[3,2-d]-1,3-dioxin maleate and its use as an intermediate
SE7708307L (sv) * 1976-08-26 1978-02-27 Pfizer Forfarande for framstellning av farmaceutiska kompositioner anvendbara sasom bronkodilatorer
US4175128A (en) * 1979-01-03 1979-11-20 Pfizer Inc. Method for treating congestive heart failure
SU1194273A3 (ru) * 1981-02-09 1985-11-23 Пфайзер Инк (Фирма) Способ получени пирбутерола или его аналогов
US4632992A (en) * 1981-02-09 1986-12-30 Pfizer Inc. Intermediates for preparing pirbuterol and analogs
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
EP0220054A3 (de) * 1985-10-16 1987-12-02 Glaxo Group Limited Ethanolaminderivate
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
WO1993000090A1 (en) * 1991-06-26 1993-01-07 Sepracor, Inc. Methods and compositions for treating pulmonary and cardiac disorders using optically pure (+) pirbuterol
WO1993000091A1 (en) * 1991-06-26 1993-01-07 Sepracor, Inc. Methods and compositions for treating pulmonary and cardiac disorders using optically pure (-)pirbuterol
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
NZ545748A (en) * 2003-08-29 2010-03-26 Ranbaxy Lab Ltd Isoxazoline derivatives as inhibitors of phosphodiesterase type-IV
WO2005051931A2 (en) * 2003-11-26 2005-06-09 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
WO2005092860A1 (en) * 2004-03-23 2005-10-06 Pfizer Limited Compounds for the treatment of diseases
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
WO2007045980A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
ME00594B (me) 2006-08-22 2011-12-20 Ranbaxy Laboratories Ltd Inhibitori matriksne metaloproteinaze
MX2009003100A (es) * 2006-09-22 2009-05-11 Ranbaxy Lab Ltd Inhibidores de fosfodiesterasa tipo iv.
US20100029728A1 (en) * 2006-09-22 2010-02-04 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
EP1958947A1 (de) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitoren für Phosphodiesterase Typ 4
EP2124943A1 (de) * 2007-03-14 2009-12-02 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridinderivate als phosphodiesterasehemmer
MX2009009793A (es) 2007-03-14 2009-10-16 Ranbaxy Lab Ltd Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa.
EP2111861A1 (de) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Zusammensetzungen von Phosphodiesterase-IV-Hemmern
BR112013002370A2 (pt) 2010-07-30 2017-06-20 Ranbaxy Laboratories Ltd composto, composição farmacêutica e processo de preparação de um composto
CN103228634A (zh) 2010-09-24 2013-07-31 兰贝克赛实验室有限公司 基质金属蛋白酶抑制剂
CN103848781B (zh) * 2012-11-30 2017-06-30 重庆华邦制药有限公司 高选择性氧化二羟甲基吡啶中一个羟甲基的方法
PE20151158A1 (es) 2012-12-03 2015-08-14 Pfizer Moduladores selectivos del receptor de androgenos novedosos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1089189A (en) * 1964-09-23 1967-11-01 Koninklijke Pharma Fab Nv Ethers of -(2-pyridyl)benzyl alcohols

Also Published As

Publication number Publication date
NL174349B (nl) 1984-01-02
DE2265581C2 (de) 1982-07-01
GB1367668A (en) 1974-09-18
BE778771A (fr) 1972-08-01
DE2204195C2 (de) 1981-11-19
NL174349C (nl) 1984-06-01
FR2125309A1 (de) 1972-09-29
CA978962A (en) 1975-12-02
FR2125309B1 (de) 1976-05-14
DE2204195A1 (de) 1972-08-17
US3700681A (en) 1972-10-24
CH541560A (fr) 1973-10-31
GB1367669A (en) 1974-09-18
NL7201471A (de) 1972-08-18
US3763173A (en) 1973-10-02

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