AR241452A1 - Un compuesto peptido que comprende por lo menos un grupo de proteccion un procedimiento para obtener dicho compuesto y un procedimiento de aplicacion. - Google Patents
Un compuesto peptido que comprende por lo menos un grupo de proteccion un procedimiento para obtener dicho compuesto y un procedimiento de aplicacion.Info
- Publication number
- AR241452A1 AR241452A1 AR84295336A AR29533684A AR241452A1 AR 241452 A1 AR241452 A1 AR 241452A1 AR 84295336 A AR84295336 A AR 84295336A AR 29533684 A AR29533684 A AR 29533684A AR 241452 A1 AR241452 A1 AR 241452A1
- Authority
- AR
- Argentina
- Prior art keywords
- arg
- tyr
- asn
- phe
- protector
- Prior art date
Links
- 230000001012 protector Effects 0.000 abstract 4
- -1 GLU CARBOXYL Chemical class 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN COMPUESTO PEPTIDO QUE COMPRENDE POR LO MENOS UN GRUPO DE PROTECCION O UN ANCLAJE AL SOPORTE DE RESINA, DE FORMULA (II), O SUS FRAGMENTOS DE LOS PRIMEROS 27, A 43 AMINOACIDOS, EN LA CUAL R1 ESTYR, MET, D-TYR, PHE, D-PHE, LEU, D-HIS O HIS; R8 ES SER O ASN; R10 ES TYR, PHE O D-TYR; R12 ES ARG O LYS; R13 ES ILE O VAL; R15 ES GLY O D-ALA; R18 ES TYR O SER; R24 ES HIS O GLN; R25 ES GLU O ASP; R27 ES D O L ALA, NLE, ILE, LEU, MET Y VAL; R28 ES SER, ASN O D-ALA; R34 ES ARG O SER; R38 ES GLN O ARG; R39ES ARG O GLY; R40 ES SER O ALA; R42 ES PHE O ALA; R43 ES ASN O ARG; Y R44 ES VAL OLEU; A CONDICION DE QUE CUANDO R1 ES TYR, SE CUMPLE POR LO MENOS UNA DE LAS CONDICIONES SIGUIENTES: R27 ES DIFERENTE QUE MET; R8 ES SER; R12 ES ARG; R13 ES ILE; R18 ES TYR; R24 ES HIS; R25 ES GLU; R28 ES ASN; R34 ES ARG; R38 ES GLN; R39 ES ARG; R40 ES SER; R42 ES PHE; O R43 ES ASN; EN DONDE ADEMAS X1 ES H O UN PROTECTOR DE ALFA-AMINO, X ES H O TOS; X2 ES H O UN PROTECTOR PARA LA HIDROXILO FENOLICO, X3 ES H OÑ UN PROTECTOR PARA EL CARBOXILO DE ASP O GLU, X4 ES H O UN PROTECTOR PARA EL HIDROXILO DE THR O SER, X5 ES H O XAN; X6 ES H O UN PROTECTOR PARA EL GUANIDINO DE ARG, X7 ES H OUN PROTECTOR PARA EL AMIDO X8 ES H O UN PROTECTOR DE CADENA LATERAL Y UN SOPORTE DE RESINA NH; X9 ES ELEGIDO DE X3 Y UN ENLACE DE ANCLAJE USADO EN LA SINTESIS EN FASE SOLIDA O ES DES-X9, EN CUYOCASO EL AMINOACIDO EN EL C TERMINAL TIENE UN -COOR O CON(R) (R'), REPRESENTANDO R Y R' UN H O UN ALQUILO QUE PUEDE SER SUBSTITUIDO POR F.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/457,862 US4529595A (en) | 1983-01-13 | 1983-01-13 | GRF Analogs |
| US06/488,748 US4595676A (en) | 1983-04-26 | 1983-04-26 | Rat hypothalamic GRF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR241452A1 true AR241452A1 (es) | 1992-07-31 |
Family
ID=27038761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR84295336A AR241452A1 (es) | 1983-01-13 | 1984-01-04 | Un compuesto peptido que comprende por lo menos un grupo de proteccion un procedimiento para obtener dicho compuesto y un procedimiento de aplicacion. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0117034B1 (es) |
| JP (1) | JPH0689033B2 (es) |
| KR (1) | KR900006713B1 (es) |
| AR (1) | AR241452A1 (es) |
| AU (1) | AU557046B2 (es) |
| BG (1) | BG40815A3 (es) |
| DD (1) | DD218371A5 (es) |
| DE (1) | DE3473764D1 (es) |
| DK (1) | DK161096C (es) |
| EG (1) | EG16824A (es) |
| ES (1) | ES528821A0 (es) |
| FI (1) | FI87080C (es) |
| GR (1) | GR81733B (es) |
| IE (1) | IE56568B1 (es) |
| IL (1) | IL70530A (es) |
| IN (1) | IN160129B (es) |
| MX (1) | MX161186A (es) |
| NO (1) | NO168362C (es) |
| OA (1) | OA07631A (es) |
| PL (1) | PL143842B1 (es) |
| PT (1) | PT77934B (es) |
| RO (1) | RO88702A (es) |
| SG (1) | SG67591G (es) |
| YU (1) | YU45587B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| DE3482387D1 (en) * | 1983-03-07 | 1990-07-05 | Hoffmann La Roche | Polypeptide. |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
| US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| JPS61115098A (ja) * | 1984-11-09 | 1986-06-02 | Sumitomo Seiyaku Kk | ポリペプチド |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| EP0544706A4 (en) * | 1990-06-29 | 1993-10-13 | Hoffmann-La Roche Inc. | Histidine substituted growth hormone releasing factor analogs |
| ATE119916T1 (de) * | 1990-12-10 | 1995-04-15 | Hoffmann La Roche | Verfahren zur enzymatischen herstellung von grf(1-44)nh2. |
| CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
| JPH0578344U (ja) * | 1992-04-03 | 1993-10-26 | 合同製鐵株式会社 | 多ストランド連続鋳造装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3482387D1 (en) * | 1983-03-07 | 1990-07-05 | Hoffmann La Roche | Polypeptide. |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
-
1983
- 1983-12-23 IL IL70530A patent/IL70530A/xx not_active IP Right Cessation
-
1984
- 1984-01-04 AU AU23075/84A patent/AU557046B2/en not_active Expired
- 1984-01-04 AR AR84295336A patent/AR241452A1/es active
- 1984-01-09 PT PT77934A patent/PT77934B/pt unknown
- 1984-01-10 DE DE8484300150T patent/DE3473764D1/de not_active Expired
- 1984-01-10 EP EP84300150A patent/EP0117034B1/en not_active Expired
- 1984-01-11 GR GR73488A patent/GR81733B/el unknown
- 1984-01-11 NO NO840086A patent/NO168362C/no not_active IP Right Cessation
- 1984-01-12 MX MX200024A patent/MX161186A/es unknown
- 1984-01-12 IE IE62/84A patent/IE56568B1/en not_active IP Right Cessation
- 1984-01-12 DK DK012984A patent/DK161096C/da not_active IP Right Cessation
- 1984-01-12 KR KR1019840000097A patent/KR900006713B1/ko not_active IP Right Cessation
- 1984-01-12 JP JP59004235A patent/JPH0689033B2/ja not_active Expired - Lifetime
- 1984-01-12 PL PL1984245687A patent/PL143842B1/pl unknown
- 1984-01-12 ES ES528821A patent/ES528821A0/es active Granted
- 1984-01-12 DD DD84259373A patent/DD218371A5/de not_active IP Right Cessation
- 1984-01-12 FI FI840111A patent/FI87080C/fi not_active IP Right Cessation
- 1984-01-12 IN IN17/MAS/84A patent/IN160129B/en unknown
- 1984-01-13 BG BG8463874A patent/BG40815A3/xx unknown
- 1984-01-13 RO RO84113317A patent/RO88702A/ro unknown
- 1984-01-13 YU YU5284A patent/YU45587B/sh unknown
- 1984-01-14 EG EG27/84A patent/EG16824A/xx active
- 1984-02-12 OA OA58203A patent/OA07631A/xx unknown
-
1991
- 1991-08-19 SG SG675/91A patent/SG67591G/en unknown
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