AR119496A1 - Proteínas de unión a antígeno anti-il13 - Google Patents

Proteínas de unión a antígeno anti-il13

Info

Publication number
AR119496A1
AR119496A1 ARP200102098A ARP200102098A AR119496A1 AR 119496 A1 AR119496 A1 AR 119496A1 AR P200102098 A ARP200102098 A AR P200102098A AR P200102098 A ARP200102098 A AR P200102098A AR 119496 A1 AR119496 A1 AR 119496A1
Authority
AR
Argentina
Prior art keywords
antibodies
light chain
directed against
antigen
sequences
Prior art date
Application number
ARP200102098A
Other languages
English (en)
Inventor
Agnieszka Kielczewska
Ian Nevin Foltz
Palaniswami Rathanaswami
Maria Sheena Amador
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR119496A1 publication Critical patent/AR119496A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente se refiere a anticuerpos dirigidos contra la IL-13 y a los usos de dichos anticuerpos. Por ejemplo, de acuerdo con la presente, se proporcionan anticuerpos monoclonales humanos dirigidos contra la IL-13. Se proporcionan secuencias polinucleotídicas aisladas que codifican, y secuencias de aminoácidos que comprenden, moléculas de inmunoglobulina de cadena pesada y ligera, en particular secuencias correspondientes a secuencias de cadena pesada y ligera contiguas que abarcan las regiones marco conservadas (FR) y/o regiones determinantes de la complementariedad (CDR). Adicionalmente, también se proporcionan métodos de uso de estos anticuerpos para tratar pacientes.
ARP200102098A 2019-07-26 2020-07-27 Proteínas de unión a antígeno anti-il13 AR119496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962879335P 2019-07-26 2019-07-26

Publications (1)

Publication Number Publication Date
AR119496A1 true AR119496A1 (es) 2021-12-22

Family

ID=72139660

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102098A AR119496A1 (es) 2019-07-26 2020-07-27 Proteínas de unión a antígeno anti-il13

Country Status (10)

Country Link
US (1) US20220281966A1 (es)
EP (1) EP4004041A1 (es)
JP (1) JP2022542890A (es)
AR (1) AR119496A1 (es)
AU (1) AU2020323901A1 (es)
CA (1) CA3148591A1 (es)
MX (1) MX2022000988A (es)
TW (1) TW202118783A (es)
UY (1) UY38807A (es)
WO (1) WO2021021676A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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WO2024097104A1 (en) * 2022-10-31 2024-05-10 Amgen Inc. Methods of antibody characterization

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Also Published As

Publication number Publication date
CA3148591A1 (en) 2021-02-04
US20220281966A1 (en) 2022-09-08
MX2022000988A (es) 2022-05-03
TW202118783A (zh) 2021-05-16
EP4004041A1 (en) 2022-06-01
JP2022542890A (ja) 2022-10-07
UY38807A (es) 2021-02-26
AU2020323901A1 (en) 2022-02-24
WO2021021676A1 (en) 2021-02-04

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