AR119376A1 - Compuestos heterocíclicos - Google Patents
Compuestos heterocíclicosInfo
- Publication number
- AR119376A1 AR119376A1 ARP200101928A ARP200101928A AR119376A1 AR 119376 A1 AR119376 A1 AR 119376A1 AR P200101928 A ARP200101928 A AR P200101928A AR P200101928 A ARP200101928 A AR P200101928A AR 119376 A1 AR119376 A1 AR 119376A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- halo
- aryl
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Reivindicación 1: Compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que: X es -CH₂CR³R⁴- o -CH=CR³ -, Y es -O-, -S-, -SO-, o -SO₂-, R¹ es arilo C₆₋₁₄ o heteroarilo de 5 a 14 elementos, en el que dicho arilo C₆₋₁₄ o heteroarilo de 5 a 14 elementos se sustituye opcionalmente con 1 a 5 sustituyentes seleccionados independientemente de alquilo C₁₋₆, alcoxi C₁₋₆, halo-alquilo C₁₋₆, halo-alcoxi C₁₋₆, halógeno, ciano, hidroxi y un grupo de fórmula (2), R² es hidrógeno o alquilo C₁₋₆, R³ es un grupo de fórmula (3), R⁴ es hidrógeno, halógeno o hidroxi, R⁵ es hidrógeno, halógeno, hidroxi, amino, halo-alquilo C₁₋₆, alcoxi C₁₋₆, alquilo C₁₋₆, halo-alcoxi C₁₋₆, ciano o oxo, R⁶ es hidrógeno, halógeno, arilo C₆₋₁₄, heteroarilo de 5 a 14 elementos, haloalcoxi C₁₋₆, halo-alquilo C₁₋₆, oxo, alquilo C₁₋₆, alcoxi C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₁₄ o ciano, en el que dicho heteroarilo de 5 a 14 elementos o arilo C₆₋₁₄ se sustituye opcionalmente con 1 a 2 sustituyentes seleccionados de halógeno, ciano, amino, hidroxi, alquilo C₁₋₆ y alcoxi C₁₋₆, A y B son, cada uno independientemente, heteroarilo de 5 a 14 elementos, arilo C₆₋₁₄, heterociclilo de 3 a 14 elementos o cicloalquilo C₃₋₁₄, y n y p son, cada uno independientemente, 1, 2, 3, 4 ó 5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19185088 | 2019-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR119376A1 true AR119376A1 (es) | 2021-12-15 |
Family
ID=67220669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200101928A AR119376A1 (es) | 2019-07-09 | 2020-07-08 | Compuestos heterocíclicos |
Country Status (18)
Country | Link |
---|---|
US (1) | US20220242876A1 (es) |
EP (1) | EP3997096A1 (es) |
JP (1) | JP2022539604A (es) |
KR (1) | KR20220034104A (es) |
CN (1) | CN114096545A (es) |
AR (1) | AR119376A1 (es) |
AU (1) | AU2020311584A1 (es) |
BR (1) | BR112021026899A2 (es) |
CA (1) | CA3145338A1 (es) |
CL (1) | CL2022000019A1 (es) |
CO (1) | CO2022000186A2 (es) |
CR (1) | CR20220004A (es) |
IL (1) | IL288987A (es) |
MX (1) | MX2022000243A (es) |
PE (1) | PE20220515A1 (es) |
TW (1) | TW202116781A (es) |
WO (1) | WO2021005034A1 (es) |
ZA (1) | ZA202110352B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019134985A1 (en) | 2018-01-08 | 2019-07-11 | F. Hoffmann-La Roche Ag | Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors |
EP3837263A1 (en) | 2018-08-13 | 2021-06-23 | F. Hoffmann-La Roche AG | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
EP4028403B1 (en) | 2019-09-12 | 2023-11-22 | F. Hoffmann-La Roche AG | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2014110401A (ru) * | 2011-08-19 | 2015-09-27 | Мерк Шарп И Доум Корп. | Ингибиторы внешнего медуллярного калиевого канала почек |
EP2934533B1 (en) * | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US10323038B2 (en) * | 2015-11-20 | 2019-06-18 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
BR112019014099A2 (pt) * | 2017-01-23 | 2020-02-11 | Pfizer Inc. | Compostos espiro-heterocíclico como inibidores de magl |
JOP20190267A1 (ar) * | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
-
2020
- 2020-07-07 CA CA3145338A patent/CA3145338A1/en active Pending
- 2020-07-07 BR BR112021026899A patent/BR112021026899A2/pt unknown
- 2020-07-07 JP JP2022500908A patent/JP2022539604A/ja active Pending
- 2020-07-07 CN CN202080050165.3A patent/CN114096545A/zh active Pending
- 2020-07-07 AU AU2020311584A patent/AU2020311584A1/en active Pending
- 2020-07-07 KR KR1020227000611A patent/KR20220034104A/ko active Search and Examination
- 2020-07-07 MX MX2022000243A patent/MX2022000243A/es unknown
- 2020-07-07 EP EP20740259.5A patent/EP3997096A1/en active Pending
- 2020-07-07 CR CR20220004A patent/CR20220004A/es unknown
- 2020-07-07 PE PE2021002265A patent/PE20220515A1/es unknown
- 2020-07-07 WO PCT/EP2020/069074 patent/WO2021005034A1/en unknown
- 2020-07-08 AR ARP200101928A patent/AR119376A1/es unknown
- 2020-07-08 TW TW109123050A patent/TW202116781A/zh unknown
-
2021
- 2021-12-13 ZA ZA2021/10352A patent/ZA202110352B/en unknown
- 2021-12-14 IL IL288987A patent/IL288987A/en unknown
-
2022
- 2022-01-04 CL CL2022000019A patent/CL2022000019A1/es unknown
- 2022-01-06 US US17/569,749 patent/US20220242876A1/en active Pending
- 2022-01-13 CO CONC2022/0000186A patent/CO2022000186A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CR20220004A (es) | 2022-01-31 |
BR112021026899A2 (pt) | 2022-05-10 |
CN114096545A (zh) | 2022-02-25 |
JP2022539604A (ja) | 2022-09-12 |
AU2020311584A1 (en) | 2022-01-20 |
MX2022000243A (es) | 2022-02-03 |
EP3997096A1 (en) | 2022-05-18 |
KR20220034104A (ko) | 2022-03-17 |
PE20220515A1 (es) | 2022-04-07 |
IL288987A (en) | 2022-02-01 |
TW202116781A (zh) | 2021-05-01 |
CO2022000186A2 (es) | 2022-01-17 |
US20220242876A1 (en) | 2022-08-04 |
WO2021005034A1 (en) | 2021-01-14 |
ZA202110352B (en) | 2022-08-31 |
CL2022000019A1 (es) | 2022-10-21 |
CA3145338A1 (en) | 2021-01-14 |
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