AR113758A1 - Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo - Google Patents

Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo

Info

Publication number
AR113758A1
AR113758A1 ARP180102928A ARP180102928A AR113758A1 AR 113758 A1 AR113758 A1 AR 113758A1 AR P180102928 A ARP180102928 A AR P180102928A AR P180102928 A ARP180102928 A AR P180102928A AR 113758 A1 AR113758 A1 AR 113758A1
Authority
AR
Argentina
Prior art keywords
metoxypiridin
methylpropoxy
heptan
pyrazolo
carbonitrile
Prior art date
Application number
ARP180102928A
Other languages
English (en)
Inventor
Mike Welch
Sylvie Asselin
Katelyn Chando
Zack Crane
Stacey Spencer
Charles Todd Eary
Tony P Tang
Gabrielle R Kolakowski
Weidong Liu
Andrew T Metcalf
Adam Cook
David A Moreno
Original Assignee
Array Biopharma Inc
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Loxo Oncology Inc filed Critical Array Biopharma Inc
Publication of AR113758A1 publication Critical patent/AR113758A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, dicho proceso caracterizado porque comprende tratar un compuesto de fórmula (2) o una sal del mismo con 6-metoxinicotinaldehído y un agente reductor para formar el compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo.
ARP180102928A 2017-10-10 2018-10-10 Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo AR113758A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762570565P 2017-10-10 2017-10-10

Publications (1)

Publication Number Publication Date
AR113758A1 true AR113758A1 (es) 2020-06-10

Family

ID=64051741

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102928A AR113758A1 (es) 2017-10-10 2018-10-10 Proceso para la preparación de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo

Country Status (10)

Country Link
US (3) US10745419B2 (es)
EP (1) EP3694853B1 (es)
JP (1) JP6926329B2 (es)
CN (1) CN111263760B (es)
AR (1) AR113758A1 (es)
CA (1) CA3079019C (es)
ES (1) ES2949265T3 (es)
TW (1) TWI783057B (es)
UY (1) UY37927A (es)
WO (1) WO2019075092A1 (es)

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TWI791053B (zh) * 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI783057B (zh) * 2017-10-10 2022-11-11 美商絡速藥業公司 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法
CN112771043B (zh) * 2018-09-30 2023-04-28 北京志健金瑞生物医药科技有限公司 取代吡唑稠环类衍生物及其制备方法和应用
WO2020248972A1 (en) * 2019-06-10 2020-12-17 Js Innopharm (Shanghai) Ltd Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
CN112939967A (zh) * 2019-12-11 2021-06-11 深圳晶泰科技有限公司 吡唑并[1,5-a]吡啶类化合物及其制备方法和应用
CN111057075B (zh) * 2019-12-24 2021-04-27 武汉九州钰民医药科技有限公司 Ret抑制剂及其制备方法
CN111004257B (zh) * 2019-12-24 2021-06-29 武汉九州钰民医药科技有限公司 制备RET抑制剂Selpercatinib的方法
CN113121524B (zh) 2019-12-31 2023-04-25 南京创济生物医药有限公司 杂环亚砜亚胺化合物及其中间体、制备方法和应用
NL2024731B1 (en) 2020-01-22 2021-09-09 Sonova Ag Acoustic device with deformable shape as valve
NL2024842B1 (en) 2020-02-05 2021-09-13 Sonova Ag Acoustic device with sma microspring switch
CN111302945B (zh) * 2020-02-21 2023-06-13 上海再启生物技术有限公司 3-羟基-4-甲氧基-2-硝基苯甲酸的制备方法
CN111410662B (zh) * 2020-03-27 2020-12-29 苏州信诺维医药科技有限公司 一种酪氨酸激酶抑制剂
TW202202501A (zh) * 2020-04-17 2022-01-16 美商絡速藥業公司 結晶ret抑制劑
CN113880865A (zh) * 2020-07-01 2022-01-04 上海艾力斯医药科技股份有限公司 吡唑[1,5-a]吡啶类化合物及其制备方法与应用
WO2022020279A1 (en) 2020-07-21 2022-01-27 Teva Pharmaceuticals International Gmbh Solid state forms of selpercatinib and process for preparation thereof
CN114621256A (zh) * 2020-12-11 2022-06-14 深圳众格生物科技有限公司 吡唑并[1,5-a]吡啶类化合物及其制备方法和应用
CN112679494B (zh) * 2020-12-24 2023-05-16 贵州民族大学 一种吡唑并[1,5-a]吡啶衍生物的制备方法
WO2022168122A1 (en) * 2021-02-06 2022-08-11 Msn Laboratories Private Limited, R&D Center Processes for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CN113321668A (zh) * 2021-06-21 2021-08-31 江苏慧聚药业有限公司 塞尔帕替尼的合成
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节***受体合成活性的吡唑并吡啶衍生物
AU2022416156A1 (en) * 2021-12-13 2024-05-30 Loxo Oncology, Inc. Processes for the preparation of the crystalline form a of selpercatinib. a ret inhibitor
CN117229292A (zh) * 2022-10-18 2023-12-15 药雅科技(上海)有限公司 Ret抑制剂的制备及其应用

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CN102827073A (zh) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
EP3322706B1 (en) 2015-07-16 2020-11-11 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
TWI704148B (zh) * 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
TWI783057B (zh) * 2017-10-10 2022-11-11 美商絡速藥業公司 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法

Also Published As

Publication number Publication date
ES2949265T3 (es) 2023-09-27
JP6926329B2 (ja) 2021-08-25
UY37927A (es) 2019-04-30
EP3694853A1 (en) 2020-08-19
US20200308194A1 (en) 2020-10-01
JP2020536084A (ja) 2020-12-10
US20190106438A1 (en) 2019-04-11
US20210380609A1 (en) 2021-12-09
CN111263760A (zh) 2020-06-09
TWI783057B (zh) 2022-11-11
WO2019075092A1 (en) 2019-04-18
TW201922757A (zh) 2019-06-16
EP3694853B1 (en) 2023-05-17
US11098064B2 (en) 2021-08-24
US10745419B2 (en) 2020-08-18
CA3079019C (en) 2022-07-19
US11807651B2 (en) 2023-11-07
CN111263760B (zh) 2023-06-23
CA3079019A1 (en) 2019-04-18

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