AR109205A1 - Control de plagas de coleópteros utilizando moléculas de arn - Google Patents

Control de plagas de coleópteros utilizando moléculas de arn

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Publication number
AR109205A1
AR109205A1 ARP170102161A ARP170102161A AR109205A1 AR 109205 A1 AR109205 A1 AR 109205A1 AR P170102161 A ARP170102161 A AR P170102161A AR P170102161 A ARP170102161 A AR P170102161A AR 109205 A1 AR109205 A1 AR 109205A1
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AR
Argentina
Prior art keywords
seq
insecticidal protein
insecticidal
diabrotica
nucleic acid
Prior art date
Application number
ARP170102161A
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English (en)
Inventor
Isabelle Maillet
Lies Degrave
Pascale Feldmann
Yann Naudet
Kevin V Donohue
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Syngenta Participations Ag
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Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of AR109205A1 publication Critical patent/AR109205A1/es

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/42Lectins, e.g. concanavalin, phytohaemagglutinin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2434Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2442Chitinase (3.2.1.14)
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin
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    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01014Chitinase (3.2.1.14)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Botany (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Reivindicación 1: Una molécula de ácido ribonucleico interferente (ARN) donde el ARN comprende al menos un ARNbc, donde el ARNbc es una región de ARN bicatenario que comprende hebras complementarias hibridadas, donde una de las hebras comprende una secuencia de al menos 19 nucleótidos contiguos que es al menos parcialmente complementaria a una secuencia de nucleótidos diana dentro de un gen diana de Diabrotica spp, y (i) es idéntica en al menos un 85% a un fragmento de al menos 19 nucleótidos contiguos de las SEQ ID Nº 121 - 210, SEQ ID Nº 274 - 276, SEQ ID Nº 280 - 282, SEQ ID Nº 298 - 312, SEQ ID Nº 345 - 371, SEQ ID Nº 373, 374, 378, 380, 389 - 396, 399, 400, o una de sus complementarias; (ii) comprende al menos un fragmento de 19 nucleótidos contiguos de las SEQ ID Nº 121 - 210, SEQ ID Nº 274 - 276, SEQ ID Nº 280 - 282, SEQ ID Nº 298 - 312, SEQ ID Nº 345 - 371, SEQ ID Nº 373, 374, 378, 380, 389 - 396, 399, 400, o una de sus complementarias; (iii) comprende al menos un fragmento de 19 nucleótidos contiguos de una secuencia de nucleótidos que codifica una secuencia de aminoácidos codificada por las SEQ ID Nº 121 - 210, SEQ ID Nº 274 - 276, SEQ ID Nº 280 - 282, SEQ ID Nº 298 - 312, SEQ ID Nº 345 - 371, SEQ ID Nº 373, 374, 378, 380, 389 - 396, 399, 400, o sus complementarias, o (iv) se puede hibridar en condiciones rigurosas con un polinucleótido seleccionado a partir del grupo constituido por las SEQ ID Nº 121 - 210, SEQ ID Nº 274 - 276, SEQ ID Nº 280 - 282, SEQ ID Nº 298 - 312, SEQ ID Nº 345 - 371, SEQ ID Nº 373, 374, 378, 380, 389 - 396, 399, 400, y sus complementarias, donde la molécula de ARN interferente tiene actividad insecticida sobre una plaga de coleópteros que atacan plantas. Reivindicación 9: Un constructo de ácido nucleico que comprende la molécula de ARN interferente de cualquiera de las reivindicaciones 1 a 8. Reivindicación 14: Una composición que comprende dos o más de las moléculas de ARN interferente de cualquiera de las reivindicaciones 1 a 8. Reivindicación 24: Una composición insecticida de la reivindicación 22, donde el segundo agente insecticida es una proteína insecticida de Bacillus cereus, una proteína insecticida de Xenorhabdus spp., una proteína insecticida de Photorhabdus spp., una proteína insecticida de Brevibacillus laterosporous, una proteína insecticida de Lysinibacillus sphearicus, una proteína insecticida de Chromobacterium ssp., una proteína insecticida de Yersinia entomophaga, una proteína insecticida de Paenibacillus popiliae o una proteína insecticida de Clostridium spp o se deriva de estas. Reivindicación 25: Una planta transgénica, o parte de esta, que comprende la molécula de ARN interferente, la molécula de ácido nucleico, el constructo de ácido nucleico y/o la composición de cualquiera de las respectivas reivindicaciones anteriores, donde la planta transgénica presenta una mayor resistencia a un insecto de Diabrotica en comparación con una planta de control. Reivindicación 43: Un método para controlar un insecto de Diabrotica que comprende poner en contacto el insecto de Diabrotica con una molécula de ácido nucleico que es una molécula de ARN interferente de las reivindicaciones 1 - 8, o que es capaz de producirla, para inhibir la expresión de un gen diana en el insecto de Diabrotica y poner en contacto el insecto de Diabrotica con al menos un segundo agente insecticida para controlar el insecto de Diabrotica. Reivindicación 62: Un método para producir una planta transgénica con una mayor tolerancia al daño debido a la alimentación de insectos de Diabrotica que comprende introducir en una planta la molécula de ARN interferente, la molécula de ácido nucleico o el constructo de ácido nucleico de cualquiera de las respectivas reivindicaciones anteriores, con el fin de producir de este modo una planta transgénica con una mayor tolerancia al daño debido a la alimentación de insectos de Diabrotica en comparación con una planta de control.
ARP170102161A 2016-08-05 2017-07-31 Control de plagas de coleópteros utilizando moléculas de arn AR109205A1 (es)

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US201662371259P 2016-08-05 2016-08-05

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US (1) US11945843B2 (es)
EP (2) EP4079857A3 (es)
CN (1) CN109790544A (es)
AR (1) AR109205A1 (es)
BR (1) BR112019002186A2 (es)
CA (1) CA3031143A1 (es)
MX (2) MX2019001292A (es)
WO (1) WO2018026770A2 (es)

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Publication number Publication date
CA3031143A1 (en) 2018-02-08
US20190185526A1 (en) 2019-06-20
EP4079857A3 (en) 2023-01-18
RU2019105354A3 (es) 2020-12-11
EP3494222A4 (en) 2020-08-19
BR112019002186A2 (pt) 2019-07-09
CN109790544A (zh) 2019-05-21
MX2022000736A (es) 2022-02-14
EP3494222A2 (en) 2019-06-12
RU2022102484A (ru) 2022-03-16
EP4079857A2 (en) 2022-10-26
WO2018026770A2 (en) 2018-02-08
RU2019105354A (ru) 2020-09-07
MX2019001292A (es) 2019-07-04
US11945843B2 (en) 2024-04-02
WO2018026770A3 (en) 2019-04-25

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