AR101413A1 - INHIBITORS OF THE TUTOSINA CINASA DE BRUTON - Google Patents
INHIBITORS OF THE TUTOSINA CINASA DE BRUTONInfo
- Publication number
- AR101413A1 AR101413A1 ARP150102488A ARP150102488A AR101413A1 AR 101413 A1 AR101413 A1 AR 101413A1 AR P150102488 A ARP150102488 A AR P150102488A AR P150102488 A ARP150102488 A AR P150102488A AR 101413 A1 AR101413 A1 AR 101413A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- independently
- alkyl
- conditions
- Prior art date
Links
Abstract
En la presente descripción se describen compuestos amido que forman enlaces covalentes con la tirosina cinasa de Bruton (Btk). Se describen, además, inhibidores irreversibles de Btk. Se describen, además, composiciones farmacéuticas que incluyen los compuestos. Los métodos de uso de los inhibidores de Btk se describen, para usarse solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o afecciones autoinmunitarias, enfermedades o afecciones heteroinmunitarias, cáncer, que incluye linfoma, y enfermedades y afecciones inflamatorias. Reivindicación 1: Un inhibidor de cinasa caracterizado porque es un compuesto de acuerdo con la fórmula (1), en donde: A es un resto de fórmula (2) ó (3); Hy es 2-piridilo sustituido con 1 - 5 grupos independientemente seleccionados de R⁴, o Hy es imidazolilo ,tiazolilo, oxazolilo, pirazolilo, oxadiazolilo, tiadiazolilo, triazolilo, cada uno de ellos sustituido con 1 - 2 grupos independientemente seleccionados de R⁴; cada R¹ y R² es, independientemente, H, alquilo o CN; o R¹ y R² combinados forman un enlace; R³ es, independientemente, H, alquilo, CN o cicloalquilo; cada R⁴ es, independientemente, H, halo, hidroxilo, CN, alquilo sustituido o no sustituido, amino sustituido o no sustituido, alcoxi sustituido o no sustituido, amido sustituido o no sustituido, sulfonilo sustituido o no sustituido, carboxi sustituido o no sustituido, arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; o dos R⁴ conectados con Hy para formar una anillo bicíclico; y cada n es, independientemente, 0, 1 ó 2; y p es 0, 1 ó 2; o un metabolito, un solvato, una sal farmacéuticamente aceptable o un profármaco de estos.Amido compounds that form covalent bonds with Bruton tyrosine kinase (Btk) are described in the present description. In addition, irreversible Btk inhibitors are described. In addition, pharmaceutical compositions including the compounds are described. The methods of using Btk inhibitors are described, for use alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases and conditions. Claim 1: A kinase inhibitor characterized in that it is a compound according to formula (1), wherein: A is a residue of formula (2) or (3); Hy is 2-pyridyl substituted with 1-5 groups independently selected from R⁴, or Hy is imidazolyl, thiazolyl, oxazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, each substituted with 1-2 groups independently selected from R⁴; each R¹ and R² is, independently, H, alkyl or CN; or R¹ and R² combined form a bond; R³ is independently H, alkyl, CN or cycloalkyl; each R⁴ is, independently, H, halo, hydroxyl, CN, substituted or unsubstituted alkyl, substituted or unsubstituted amino, substituted or unsubstituted alkoxy, substituted or unsubstituted amido, substituted or unsubstituted sulfonyl, substituted or unsubstituted carboxy, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; or two R⁴ connected with Hy to form a bicyclic ring; and each n is, independently, 0, 1 or 2; and p is 0, 1 or 2; or a metabolite, a solvate, a pharmaceutically acceptable salt or a prodrug thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462032257P | 2014-08-01 | 2014-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR101413A1 true AR101413A1 (en) | 2016-12-14 |
Family
ID=56361135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150102488A AR101413A1 (en) | 2014-08-01 | 2015-08-03 | INHIBITORS OF THE TUTOSINA CINASA DE BRUTON |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR101413A1 (en) |
TW (1) | TW201613926A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111454268B (en) * | 2019-01-18 | 2023-09-08 | 明慧医药(上海)有限公司 | Cyclic molecules as inhibitors of bruton's tyrosine kinase |
-
2015
- 2015-07-31 TW TW104124894A patent/TW201613926A/en unknown
- 2015-08-03 AR ARP150102488A patent/AR101413A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201613926A (en) | 2016-04-16 |
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