AR087754A1 - 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina - Google Patents
6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepinaInfo
- Publication number
- AR087754A1 AR087754A1 ARP120103224A ARP120103224A AR087754A1 AR 087754 A1 AR087754 A1 AR 087754A1 AR P120103224 A ARP120103224 A AR P120103224A AR P120103224 A ARP120103224 A AR P120103224A AR 087754 A1 AR087754 A1 AR 087754A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- alkoxy
- compounds
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Agentes farmacéuticos y su uso en la terapia, en especial para la prevención y terapia de enfermedades tumorales. Reivindicación 1: Compuestos de la fórmula (1) en donde X representa un enlace e Y representa un átomo de nitrógeno o X representa el grupo -NH- e Y representa el grupo -CH-, y R¹ y R² representan, de modo independiente entre sí, hidrógeno o un grupo alquilo C₁₋₆, y m es 0 ó 1, y n es 0 ó 1, y o es 0 ó 1, y p es 0 ó 1, en donde la suma de m, n, o y p es de al menos 2, cuando Rᵇ¹ y Rᵇ² forman un puente, tal como se define para los compuestos de la fórmula (1), y RS¹ y RS² representan, de modo independiente entre sí, hidrógeno o un grupo alquilo C₁₋₆, o RS² junto con RS¹ forman un grupo ceto -C(O)-, o RS² junto con RS¹ y el átomo de carbono al que están unidos RS¹ y RS², forma un carbo- o heterociclo saturado de 3 a 8 miembros, que eventualmente (i) puede estar mono- o polisustituido con halógeno, hidroxi, ciano, nitro y/o con un radical alquilo C₁₋₃, halógeno-alquilo C₁₋₆, alcoxi C₁₋₆, halógeno-alcoxi C₁₋₆, alcoxi C₁₋₆-alquilo C₁₋₆ y/o alquil C₁₋₆-carbonilo, igual o distinto, y/o (ii) puede contener un grupo ceto -C(O)-, y Rᵇ¹ y Rᵇ² representan hidrógeno, o Rᵇ¹ y Rᵇ² forman un puente compuesto por uno de los grupos -O-, -C(O)-, -NR³-, -NR⁴-CHR⁵- o -CHR⁶-CHR⁷- en donde R³, R⁴, R⁵, R⁶ y/o R⁷ representan, de modo independiente entre sí, hidrógeno, un grupo alquilo C₁₋₆ o alcoxi C₁₋₆ o el grupo -C(O)-R⁸ con R⁸ que representa un grupo alquilo C₁₋₆ o alcoxi C₁₋₆ siempre que Rᵇ¹ y Rᵇ² formen un puente, tal como se define para los compuestos de la fórmula (1), o RS² junto con RS¹ y el átomo de carbono al que RS¹ y RS², forme un carbo- o heterociclo saturado de 3 a 8 miembros, o Rᵇ¹ y Rᵇ² formen un puente, tal como se define para los compuestos de la fórmula (1), y RS² junto con RS¹ y el átomo de carbono al que están unidos RS¹ y RS², forma un carbo- o heterociclo saturado de 3 a 8 miembros, así como sus diastereómeros, racematos y sales fisiológicamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011082013A DE102011082013A1 (de) | 2011-09-01 | 2011-09-01 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
Publications (1)
Publication Number | Publication Date |
---|---|
AR087754A1 true AR087754A1 (es) | 2014-04-16 |
Family
ID=46939692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103224A Pending AR087754A1 (es) | 2011-09-01 | 2012-08-31 | 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina |
Country Status (10)
Country | Link |
---|---|
US (1) | US20140213575A1 (es) |
EP (1) | EP2751114A1 (es) |
JP (1) | JP2014525421A (es) |
CN (1) | CN103827120A (es) |
AR (1) | AR087754A1 (es) |
CA (1) | CA2846692A1 (es) |
DE (1) | DE102011082013A1 (es) |
TW (1) | TW201313725A (es) |
UY (1) | UY34308A (es) |
WO (1) | WO2013030150A1 (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
WO2014015175A1 (en) * | 2012-07-18 | 2014-01-23 | Massachusetts Institute Of Technology | Compositions and methods for modulating brd4 bioactivity |
US9266891B2 (en) * | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
EP2970312B1 (en) | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
KR102216288B1 (ko) | 2013-03-15 | 2021-02-18 | 인사이트 홀딩스 코포레이션 | Bet 단백질 저해제로서의 삼환식 복소환 |
AR096837A1 (es) | 2013-07-08 | 2016-02-03 | Incyte Corp | Heterociclos tricíclicos como inhibidores de proteínas bet |
US9676790B2 (en) | 2013-08-30 | 2017-06-13 | Concert Pharmaceuticals, Inc. | Substituted thienotriazolodiazapines |
EP3066101B1 (en) | 2013-11-08 | 2020-07-29 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
EP3074018A1 (en) * | 2013-11-27 | 2016-10-05 | Oncoethix GmbH | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
KR20160079822A (ko) | 2013-11-27 | 2016-07-06 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 비소세포성 폐암을 치료하는 방법 |
US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
US10150756B2 (en) | 2014-01-31 | 2018-12-11 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
JP6526060B2 (ja) * | 2014-02-10 | 2019-06-05 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換トリアゾロベンゾジアゼピン |
SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
AU2015222887B2 (en) | 2014-02-28 | 2019-06-27 | The Regents Of The University Of Michigan | 9H-pyrimido[4,5-b]indoles and related analogs as BET bromodomain inhibitors |
US9540368B2 (en) | 2014-04-23 | 2017-01-10 | Incyte Corporation | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins |
CA2947601A1 (en) * | 2014-05-02 | 2015-11-05 | Oncoethix Gmbh | Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds |
BR112016029012A2 (pt) | 2014-06-13 | 2017-08-22 | Oncoethix Gmbh | método de tratamento de câncer de pulmão de células não pequenas e/ou câncer de pulmão de células pequenas usando compostos de tienotriazolodiazepina |
TR201906788T4 (tr) | 2014-06-20 | 2019-05-21 | Constellation Pharmaceuticals Inc | 2-((4s)-6-(4-klorofenil)-1-metil-4h-benzo[c]izoksazolo[4,5-e]azepın-4-il)asetamidin kristal formları. |
KR20170044172A (ko) * | 2014-08-28 | 2017-04-24 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 함유하는 약학적 조성물을 사용하여 급성 골수성 백혈병 또는 급성 림프구성 백혈병을 치료하는 방법 |
TWI712603B (zh) | 2014-09-15 | 2020-12-11 | 美商英塞特公司 | 作為bet蛋白抑制劑之三環雜環 |
JP6715243B2 (ja) | 2014-10-27 | 2020-07-01 | テンシャ セラピューティクス,インコーポレイテッド | ブロモドメイン阻害剤 |
US10307407B2 (en) | 2015-02-27 | 2019-06-04 | The Regents Of The University Of Michigan | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors |
GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
WO2016196065A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Methods and compositions for assessing responsiveness of cancers to bet inhibitors |
CA2996974A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
CR20180199A (es) | 2015-09-11 | 2018-05-25 | Dana Farber Cancer Inst Inc | Acetamida tienotriazolodiazepinas y usos de las mismas |
AR106520A1 (es) | 2015-10-29 | 2018-01-24 | Incyte Corp | Forma sólida amorfa de un inhibidor de proteína bet |
CR20180336A (es) | 2015-11-25 | 2018-08-06 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
WO2017142881A1 (en) | 2016-02-15 | 2017-08-24 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors |
WO2017176958A1 (en) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
JP7037500B2 (ja) | 2016-04-06 | 2022-03-16 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Mdm2タンパク質分解剤 |
KR20180132861A (ko) | 2016-04-12 | 2018-12-12 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bet 단백질 분해제 |
HUE062234T2 (hu) | 2016-06-20 | 2023-10-28 | Incyte Corp | Egy BET inhibitor kristályos szilárd halmazállapotú formái |
ES2857743T3 (es) | 2016-09-13 | 2021-09-29 | Univ Michigan Regents | 1,4-diazepinas fusionadas como degradadores de proteína BET |
CN110062759B (zh) | 2016-09-13 | 2022-05-24 | 密执安大学评议会 | 作为bet蛋白降解剂的稠合的1,4-氧氮杂䓬 |
US11046709B2 (en) | 2017-02-03 | 2021-06-29 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as BET bromodomain inhibitors |
JP6494886B1 (ja) * | 2017-05-31 | 2019-04-03 | あゆみ製薬株式会社 | 6H−チエノ[2,3−e][1,2,4]トリアゾロ[3,4−c][1,2,4]トリアゼピン誘導体 |
WO2019055444A1 (en) | 2017-09-13 | 2019-03-21 | The Regents Of The University Of Michigan | DEGRADATION AGENTS OF BROMODOMAIN BET PROTEIN WITH CLEAR BINDERS |
CA3076759A1 (en) * | 2017-09-22 | 2019-03-28 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Thienodiazepine derivatives and application thereof |
CN107879989B (zh) * | 2017-11-29 | 2020-01-03 | 重庆市中药研究院 | 具有生物活性的3,4,5-取代苯并二氮卓2-酮类药物分子及其制备方法 |
CN107759607B (zh) * | 2017-11-29 | 2019-08-23 | 上海万巷制药有限公司 | 具有抗肿瘤活性的三氮唑并二氮卓化合物及其制备方法 |
JP2022536574A (ja) * | 2019-03-22 | 2022-08-18 | シーエスピーシー チョンチー ファーマシューティカル テクノロジー(シーチアチョアン)カンパニー,リミティド | 固体形態のbrd4阻害剤化合物およびその調製方法およびその使用 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3878833T2 (de) * | 1987-05-28 | 1993-06-09 | Yoshitomi Pharmaceutical | Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. |
CA2120939A1 (en) | 1991-10-11 | 1993-04-15 | Tetsuya Tahara | Therapeutic agent for osteoporosis and diazepine compound |
EP0661284A1 (en) | 1992-09-18 | 1995-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compound and medicinal use thereof |
CN1227555A (zh) * | 1996-06-12 | 1999-09-01 | 日本烟草产业株式会社 | 细胞因子生成抑制剂、三氮䓬化合物及其中间体 |
EP0989131B1 (en) | 1996-09-13 | 2002-11-13 | Mitsubishi Pharma Corporation | Thienotriazolodiazepine compounds and medicinal uses thereof |
EP1887008B1 (en) | 2005-05-30 | 2021-04-21 | Mitsubishi Tanabe Pharma Corporation | Thienotriazolodiazepine compound and a medicinal use thereof |
EP1963285A1 (en) * | 2005-12-07 | 2008-09-03 | Amgen Inc. | Bradykinin 1 receptor antagonists |
EP2239264A4 (en) | 2007-12-28 | 2012-01-11 | Mitsubishi Tanabe Pharma Corp | ANTITUMOR AGENT |
JP2012506883A (ja) * | 2008-10-29 | 2012-03-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換されたスピロアミン |
TW201035102A (en) * | 2009-03-04 | 2010-10-01 | Gruenethal Gmbh | Sulfonylated tetrahydroazolopyrazines and their use as medicinal products |
GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
BR112012010706A2 (pt) | 2009-11-05 | 2016-03-29 | Glaxosmithkline Llc | composto, composição farmacêutica, combinação do produto farmacêutico, uso de um composto, e, métodos para o tratamento de uma doença ou condição, e para inibir um bromodomínio |
DK2496582T3 (en) | 2009-11-05 | 2016-03-21 | Glaxosmithkline Llc | Benzodiazepine-BROMDOMAeNEINHIBITOR. |
GB0919426D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
-
2011
- 2011-09-01 DE DE102011082013A patent/DE102011082013A1/de not_active Withdrawn
-
2012
- 2012-08-27 CN CN201280041332.3A patent/CN103827120A/zh active Pending
- 2012-08-27 WO PCT/EP2012/066600 patent/WO2013030150A1/de active Application Filing
- 2012-08-27 JP JP2014527612A patent/JP2014525421A/ja active Pending
- 2012-08-27 US US14/342,519 patent/US20140213575A1/en not_active Abandoned
- 2012-08-27 CA CA2846692A patent/CA2846692A1/en not_active Abandoned
- 2012-08-27 EP EP12766291.4A patent/EP2751114A1/de not_active Withdrawn
- 2012-08-31 AR ARP120103224A patent/AR087754A1/es active Pending
- 2012-08-31 UY UY0001034308A patent/UY34308A/es not_active Application Discontinuation
- 2012-08-31 TW TW101131939A patent/TW201313725A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20140213575A1 (en) | 2014-07-31 |
UY34308A (es) | 2013-04-05 |
EP2751114A1 (de) | 2014-07-09 |
WO2013030150A1 (de) | 2013-03-07 |
CN103827120A (zh) | 2014-05-28 |
JP2014525421A (ja) | 2014-09-29 |
CA2846692A1 (en) | 2013-03-07 |
DE102011082013A1 (de) | 2013-03-07 |
TW201313725A (zh) | 2013-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR087754A1 (es) | 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina | |
CO2018003565A2 (es) | Compuestos de espiro[3h-indol-3,2´-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53 | |
CO6210729A2 (es) | Derivados de sulfonil-fenil-2h-[1,2,4]oxadiazol-5-ona procedimientos para su preparacion y su uso como agente farmaceutico | |
UY31730A (es) | Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica. | |
UY35377A (es) | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso | |
CR20140091A (es) | Nuevos derivados dihidroquinolina-2-ona | |
AR098912A1 (es) | Inhibidores de syk | |
AR098048A1 (es) | Inhibidores de fgfr4 | |
ECSP13012692A (es) | Compuestos tricíclicos inhibidores de la pi3k y métodos de uso | |
NI201300081A (es) | Uso de 3 - ( 5 - amino - 2 - metil - 4 - oxoquinazolin - 3(4h) - il) piperidin - 2 - 6 -diona en el tratamiento de enfermedades relacionadas con el sistema inmunitario e inflamatorias. | |
UY31950A (es) | Inhibidores de ciclopropil-polimerasa | |
GT201400009A (es) | 4-imidazopiridazin-1-il-benzamidas y 4-imidazotriazin-1-il-benzamidas como inhibidores de btk | |
DOP2018000065A (es) | Derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer | |
UY31728A (es) | Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica | |
CR20130580A (es) | Spiro-[1,3]-oxacinas y spiro-[1,4]-oxacepinas como inhibidores de bace1 y/o bace2 | |
PA8783501A1 (es) | Derivados de quinaxolina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus | |
ECSP11011461A (es) | Espironucleósidos uracílicos oxetánicos | |
UY31729A (es) | Derivados polisustituidos de 2-heteroaril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapeútica | |
SV2007002397A (es) | Aminopiridinas como inhibidores de b-secretasa ref. am101663 | |
CL2011002180A1 (es) | Compuestos derivados de benzimidazol, inhibidores de mpges-1; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades inflamatorias y dolor. | |
UY31727A (es) | Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica | |
NI201200191A (es) | Derivados de indolizina, su procedimiento de preparación y su aplicación en terapéutica | |
ECSP15035530A (es) | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
CL2017000432A1 (es) | Inhibidores espirocíclicos de catepsina c | |
UY33817A (es) | ?nuevas oxindolpirimidinas bencílicas?. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |