AR087754A1 - 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina - Google Patents

6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina

Info

Publication number
AR087754A1
AR087754A1 ARP120103224A ARP120103224A AR087754A1 AR 087754 A1 AR087754 A1 AR 087754A1 AR P120103224 A ARP120103224 A AR P120103224A AR P120103224 A ARP120103224 A AR P120103224A AR 087754 A1 AR087754 A1 AR 087754A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
alkoxy
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP120103224A
Other languages
English (en)
Inventor
Dr Schmees Norbert
Dr Kuhnke Joachim
Dr Haendler Bernard
Dr Lienau Philip
Ernesto Dr Fernandez-Montalvan Amaury
Dr Lejeune Pascale
Dr Siegel Stephan
Dr Scott William
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Bayer Intellectual Property GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Intellectual Property GmbH filed Critical Bayer Intellectual Property GmbH
Publication of AR087754A1 publication Critical patent/AR087754A1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Agentes farmacéuticos y su uso en la terapia, en especial para la prevención y terapia de enfermedades tumorales. Reivindicación 1: Compuestos de la fórmula (1) en donde X representa un enlace e Y representa un átomo de nitrógeno o X representa el grupo -NH- e Y representa el grupo -CH-, y R¹ y R² representan, de modo independiente entre sí, hidrógeno o un grupo alquilo C₁₋₆, y m es 0 ó 1, y n es 0 ó 1, y o es 0 ó 1, y p es 0 ó 1, en donde la suma de m, n, o y p es de al menos 2, cuando Rᵇ¹ y Rᵇ² forman un puente, tal como se define para los compuestos de la fórmula (1), y RS¹ y RS² representan, de modo independiente entre sí, hidrógeno o un grupo alquilo C₁₋₆, o RS² junto con RS¹ forman un grupo ceto -C(O)-, o RS² junto con RS¹ y el átomo de carbono al que están unidos RS¹ y RS², forma un carbo- o heterociclo saturado de 3 a 8 miembros, que eventualmente (i) puede estar mono- o polisustituido con halógeno, hidroxi, ciano, nitro y/o con un radical alquilo C₁₋₃, halógeno-alquilo C₁₋₆, alcoxi C₁₋₆, halógeno-alcoxi C₁₋₆, alcoxi C₁₋₆-alquilo C₁₋₆ y/o alquil C₁₋₆-carbonilo, igual o distinto, y/o (ii) puede contener un grupo ceto -C(O)-, y Rᵇ¹ y Rᵇ² representan hidrógeno, o Rᵇ¹ y Rᵇ² forman un puente compuesto por uno de los grupos -O-, -C(O)-, -NR³-, -NR⁴-CHR⁵- o -CHR⁶-CHR⁷- en donde R³, R⁴, R⁵, R⁶ y/o R⁷ representan, de modo independiente entre sí, hidrógeno, un grupo alquilo C₁₋₆ o alcoxi C₁₋₆ o el grupo -C(O)-R⁸ con R⁸ que representa un grupo alquilo C₁₋₆ o alcoxi C₁₋₆ siempre que Rᵇ¹ y Rᵇ² formen un puente, tal como se define para los compuestos de la fórmula (1), o RS² junto con RS¹ y el átomo de carbono al que RS¹ y RS², forme un carbo- o heterociclo saturado de 3 a 8 miembros, o Rᵇ¹ y Rᵇ² formen un puente, tal como se define para los compuestos de la fórmula (1), y RS² junto con RS¹ y el átomo de carbono al que están unidos RS¹ y RS², forma un carbo- o heterociclo saturado de 3 a 8 miembros, así como sus diastereómeros, racematos y sales fisiológicamente aceptables.
ARP120103224A 2011-09-01 2012-08-31 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina Pending AR087754A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102011082013A DE102011082013A1 (de) 2011-09-01 2011-09-01 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Publications (1)

Publication Number Publication Date
AR087754A1 true AR087754A1 (es) 2014-04-16

Family

ID=46939692

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103224A Pending AR087754A1 (es) 2011-09-01 2012-08-31 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina

Country Status (10)

Country Link
US (1) US20140213575A1 (es)
EP (1) EP2751114A1 (es)
JP (1) JP2014525421A (es)
CN (1) CN103827120A (es)
AR (1) AR087754A1 (es)
CA (1) CA2846692A1 (es)
DE (1) DE102011082013A1 (es)
TW (1) TW201313725A (es)
UY (1) UY34308A (es)
WO (1) WO2013030150A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2014015175A1 (en) * 2012-07-18 2014-01-23 Massachusetts Institute Of Technology Compositions and methods for modulating brd4 bioactivity
US9266891B2 (en) * 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
EP2970312B1 (en) 2013-03-11 2017-11-15 The Regents of The University of Michigan Bet bromodomain inhibitors and therapeutic methods using the same
KR102216288B1 (ko) 2013-03-15 2021-02-18 인사이트 홀딩스 코포레이션 Bet 단백질 저해제로서의 삼환식 복소환
AR096837A1 (es) 2013-07-08 2016-02-03 Incyte Corp Heterociclos tricíclicos como inhibidores de proteínas bet
US9676790B2 (en) 2013-08-30 2017-06-13 Concert Pharmaceuticals, Inc. Substituted thienotriazolodiazapines
EP3066101B1 (en) 2013-11-08 2020-07-29 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
EP3074018A1 (en) * 2013-11-27 2016-10-05 Oncoethix GmbH Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds
KR20160079822A (ko) 2013-11-27 2016-07-06 온코에틱스 게엠베하 티에노트리아졸로디아제핀 화합물을 함유하는 제약 제제를 사용하여 비소세포성 폐암을 치료하는 방법
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
US10150756B2 (en) 2014-01-31 2018-12-11 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
JP6526060B2 (ja) * 2014-02-10 2019-06-05 コンサート ファーマシューティカルズ インコーポレイテッド 置換トリアゾロベンゾジアゼピン
SG11201607108XA (en) 2014-02-28 2016-09-29 Tensha Therapeutics Inc Treatment of conditions associated with hyperinsulinaemia
AU2015222887B2 (en) 2014-02-28 2019-06-27 The Regents Of The University Of Michigan 9H-pyrimido[4,5-b]indoles and related analogs as BET bromodomain inhibitors
US9540368B2 (en) 2014-04-23 2017-01-10 Incyte Corporation 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
CA2947601A1 (en) * 2014-05-02 2015-11-05 Oncoethix Gmbh Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds
BR112016029012A2 (pt) 2014-06-13 2017-08-22 Oncoethix Gmbh método de tratamento de câncer de pulmão de células não pequenas e/ou câncer de pulmão de células pequenas usando compostos de tienotriazolodiazepina
TR201906788T4 (tr) 2014-06-20 2019-05-21 Constellation Pharmaceuticals Inc 2-((4s)-6-(4-klorofenil)-1-metil-4h-benzo[c]izoksazolo[4,5-e]azepın-4-il)asetamidin kristal formları.
KR20170044172A (ko) * 2014-08-28 2017-04-24 온코에틱스 게엠베하 티에노트리아졸로디아제핀 화합물을 함유하는 약학적 조성물을 사용하여 급성 골수성 백혈병 또는 급성 림프구성 백혈병을 치료하는 방법
TWI712603B (zh) 2014-09-15 2020-12-11 美商英塞特公司 作為ｂｅｔ蛋白抑制劑之三環雜環
JP6715243B2 (ja) 2014-10-27 2020-07-01 テンシャ セラピューティクス，インコーポレイテッド ブロモドメイン阻害剤
US10307407B2 (en) 2015-02-27 2019-06-04 The Regents Of The University Of Michigan 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors
GB201504694D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Covalent conjugates
WO2016196065A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Methods and compositions for assessing responsiveness of cancers to bet inhibitors
CA2996974A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
CR20180199A (es) 2015-09-11 2018-05-25 Dana Farber Cancer Inst Inc Acetamida tienotriazolodiazepinas y usos de las mismas
AR106520A1 (es) 2015-10-29 2018-01-24 Incyte Corp Forma sólida amorfa de un inhibidor de proteína bet
CR20180336A (es) 2015-11-25 2018-08-06 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos
WO2017142881A1 (en) 2016-02-15 2017-08-24 The Regents Of The University Of Michigan Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors
WO2017176958A1 (en) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
JP7037500B2 (ja) 2016-04-06 2022-03-16 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Ｍｄｍ２タンパク質分解剤
KR20180132861A (ko) 2016-04-12 2018-12-12 더 리젠츠 오브 더 유니버시티 오브 미시간 Bet 단백질 분해제
HUE062234T2 (hu) 2016-06-20 2023-10-28 Incyte Corp Egy BET inhibitor kristályos szilárd halmazállapotú formái
ES2857743T3 (es) 2016-09-13 2021-09-29 Univ Michigan Regents 1,4-diazepinas fusionadas como degradadores de proteína BET
CN110062759B (zh) 2016-09-13 2022-05-24 密执安大学评议会 作为bet蛋白降解剂的稠合的1,4-氧氮杂䓬
US11046709B2 (en) 2017-02-03 2021-06-29 The Regents Of The University Of Michigan Fused 1,4-diazepines as BET bromodomain inhibitors
JP6494886B1 (ja) * 2017-05-31 2019-04-03 あゆみ製薬株式会社 ６Ｈ−チエノ［２，３−ｅ］［１，２，４］トリアゾロ［３，４−ｃ］［１，２，４］トリアゼピン誘導体
WO2019055444A1 (en) 2017-09-13 2019-03-21 The Regents Of The University Of Michigan DEGRADATION AGENTS OF BROMODOMAIN BET PROTEIN WITH CLEAR BINDERS
CA3076759A1 (en) * 2017-09-22 2019-03-28 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Thienodiazepine derivatives and application thereof
CN107879989B (zh) * 2017-11-29 2020-01-03 重庆市中药研究院 具有生物活性的3,4,5-取代苯并二氮卓2-酮类药物分子及其制备方法
CN107759607B (zh) * 2017-11-29 2019-08-23 上海万巷制药有限公司 具有抗肿瘤活性的三氮唑并二氮卓化合物及其制备方法
JP2022536574A (ja) * 2019-03-22 2022-08-18 シーエスピーシー チョンチー ファーマシューティカル テクノロジー（シーチアチョアン）カンパニー，リミティド 固体形態のｂｒｄ４阻害剤化合物およびその調製方法およびその使用
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3878833T2 (de) * 1987-05-28 1993-06-09 Yoshitomi Pharmaceutical Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
CA2120939A1 (en) 1991-10-11 1993-04-15 Tetsuya Tahara Therapeutic agent for osteoporosis and diazepine compound
EP0661284A1 (en) 1992-09-18 1995-07-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
CN1227555A (zh) * 1996-06-12 1999-09-01 日本烟草产业株式会社 细胞因子生成抑制剂、三氮䓬化合物及其中间体
EP0989131B1 (en) 1996-09-13 2002-11-13 Mitsubishi Pharma Corporation Thienotriazolodiazepine compounds and medicinal uses thereof
EP1887008B1 (en) 2005-05-30 2021-04-21 Mitsubishi Tanabe Pharma Corporation Thienotriazolodiazepine compound and a medicinal use thereof
EP1963285A1 (en) * 2005-12-07 2008-09-03 Amgen Inc. Bradykinin 1 receptor antagonists
EP2239264A4 (en) 2007-12-28 2012-01-11 Mitsubishi Tanabe Pharma Corp ANTITUMOR AGENT
JP2012506883A (ja) * 2008-10-29 2012-03-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換されたスピロアミン
TW201035102A (en) * 2009-03-04 2010-10-01 Gruenethal Gmbh Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
BR112012010706A2 (pt) 2009-11-05 2016-03-29 Glaxosmithkline Llc composto, composição farmacêutica, combinação do produto farmacêutico, uso de um composto, e, métodos para o tratamento de uma doença ou condição, e para inibir um bromodomínio
DK2496582T3 (en) 2009-11-05 2016-03-21 Glaxosmithkline Llc Benzodiazepine-BROMDOMAeNEINHIBITOR.
GB0919426D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds

Also Published As

Publication number Publication date
US20140213575A1 (en) 2014-07-31
UY34308A (es) 2013-04-05
EP2751114A1 (de) 2014-07-09
WO2013030150A1 (de) 2013-03-07
CN103827120A (zh) 2014-05-28
JP2014525421A (ja) 2014-09-29
CA2846692A1 (en) 2013-03-07
DE102011082013A1 (de) 2013-03-07
TW201313725A (zh) 2013-04-01

Similar Documents

Publication Publication Date Title
AR087754A1 (es) 6h-tieno[3,2,-f][1,2,4]triazolo[4,3-a][1,4]diazepina
CO2018003565A2 (es) Compuestos de espiro[3h-indol-3,2´-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53
CO6210729A2 (es) Derivados de sulfonil-fenil-2h-[1,2,4]oxadiazol-5-ona procedimientos para su preparacion y su uso como agente farmaceutico
UY31730A (es) Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica.
UY35377A (es) Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso
CR20140091A (es) Nuevos derivados dihidroquinolina-2-ona
AR098912A1 (es) Inhibidores de syk
AR098048A1 (es) Inhibidores de fgfr4
ECSP13012692A (es) Compuestos tricíclicos inhibidores de la pi3k y métodos de uso
NI201300081A (es) Uso de 3 - ( 5 - amino - 2 - metil - 4 - oxoquinazolin - 3(4h) - il) piperidin - 2 - 6 -diona en el tratamiento de enfermedades relacionadas con el sistema inmunitario e inflamatorias.
UY31950A (es) Inhibidores de ciclopropil-polimerasa
GT201400009A (es) 4-imidazopiridazin-1-il-benzamidas y 4-imidazotriazin-1-il-benzamidas como inhibidores de btk
DOP2018000065A (es) Derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer
UY31728A (es) Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica
CR20130580A (es) Spiro-[1,3]-oxacinas y spiro-[1,4]-oxacepinas como inhibidores de bace1 y/o bace2
PA8783501A1 (es) Derivados de quinaxolina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus
ECSP11011461A (es) Espironucleósidos uracílicos oxetánicos
UY31729A (es) Derivados polisustituidos de 2-heteroaril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapeútica
SV2007002397A (es) Aminopiridinas como inhibidores de b-secretasa ref. am101663
CL2011002180A1 (es) Compuestos derivados de benzimidazol, inhibidores de mpges-1; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades inflamatorias y dolor.
UY31727A (es) Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica
NI201200191A (es) Derivados de indolizina, su procedimiento de preparación y su aplicación en terapéutica
ECSP15035530A (es) Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas
CL2017000432A1 (es) Inhibidores espirocíclicos de catepsina c
UY33817A (es) ?nuevas oxindolpirimidinas bencílicas?.

Legal Events

Date Code Title Description
FB Suspension of granting procedure