AR084505A1 - Derivados de 5-metil-1-(naftalen-2-il)-1h-pirazol - Google Patents
Derivados de 5-metil-1-(naftalen-2-il)-1h-pirazolInfo
- Publication number
- AR084505A1 AR084505A1 ARP110104503A ARP110104503A AR084505A1 AR 084505 A1 AR084505 A1 AR 084505A1 AR P110104503 A ARP110104503 A AR P110104503A AR P110104503 A ARP110104503 A AR P110104503A AR 084505 A1 AR084505 A1 AR 084505A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- formula
- naftalen
- pirazol
- methyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a derivados de pirazol de fórmula (1) que tienen actividad farmacológica, procedimientos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden, y a su uso en la terapia y/o la profilaxis de dolor.Reivindicación 1: Compuesto de la fórmula (1) en la que R1 y R2 se seleccionan independientemente del grupo que consiste en alquilo C1-6 sustituido o no sustituido, halógeno, hidroxilo y alcoxilo C1-6; n y m se seleccionan independientemente de 0, 1 y 2; la línea discontinua (representada por - - - - -) representa un doble enlace opcional o un solvato, profármaco, isómero o sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382326A EP2460804A1 (en) | 2010-12-03 | 2010-12-03 | 5-methyl-1-(naphthalen-2-yl)-1h-pyrazole derivatives and their use in potentiating the effect of opioid analgesics |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084505A1 true AR084505A1 (es) | 2013-05-22 |
Family
ID=43500092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104503A AR084505A1 (es) | 2010-12-03 | 2011-12-02 | Derivados de 5-metil-1-(naftalen-2-il)-1h-pirazol |
Country Status (11)
Country | Link |
---|---|
US (1) | US8729073B2 (es) |
EP (2) | EP2460804A1 (es) |
JP (1) | JP5860895B2 (es) |
CN (1) | CN103261192B (es) |
AR (1) | AR084505A1 (es) |
CA (1) | CA2819389A1 (es) |
ES (1) | ES2573315T3 (es) |
HK (1) | HK1190145A1 (es) |
MX (1) | MX340585B (es) |
TW (1) | TW201305148A (es) |
WO (1) | WO2012072781A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
EP2818166A1 (en) * | 2013-06-26 | 2014-12-31 | Laboratorios del Dr. Esteve S.A. | Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS) |
MA39147B1 (fr) | 2013-12-17 | 2019-12-31 | Esteve Labor Dr | Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000020005A1 (en) * | 1998-10-01 | 2000-04-13 | EGIS Gyógyszergyár Rt. | Pharmaceutical compositions containing an opiate analgesic and a synergizing substance |
EP1634872A1 (en) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
EP2325174A1 (en) * | 2004-08-27 | 2011-05-25 | Laboratorios Del. Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP1994032A1 (en) | 2006-03-01 | 2008-11-26 | Laboratorios del Dr. Esteve S.A. | Pyrazole derivatives as sigma receptor inhibitors |
EP2113501A1 (en) * | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | 5-Methyl-1-(naphthalen-2-YL)-1H-Pyrazoles useful as sigma receptor inhibitors |
-
2010
- 2010-12-03 EP EP10382326A patent/EP2460804A1/en not_active Withdrawn
-
2011
- 2011-11-25 TW TW100143324A patent/TW201305148A/zh unknown
- 2011-12-02 MX MX2013006004A patent/MX340585B/es active IP Right Grant
- 2011-12-02 AR ARP110104503A patent/AR084505A1/es not_active Application Discontinuation
- 2011-12-02 EP EP11793736.7A patent/EP2646435B1/en not_active Not-in-force
- 2011-12-02 WO PCT/EP2011/071583 patent/WO2012072781A1/en active Application Filing
- 2011-12-02 JP JP2013541368A patent/JP5860895B2/ja not_active Expired - Fee Related
- 2011-12-02 US US13/991,267 patent/US8729073B2/en not_active Expired - Fee Related
- 2011-12-02 ES ES11793736.7T patent/ES2573315T3/es active Active
- 2011-12-02 CN CN201180058240.1A patent/CN103261192B/zh not_active Expired - Fee Related
- 2011-12-02 CA CA2819389A patent/CA2819389A1/en not_active Abandoned
-
2014
- 2014-04-02 HK HK14103153.1A patent/HK1190145A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5860895B2 (ja) | 2016-02-16 |
EP2646435A1 (en) | 2013-10-09 |
CN103261192A (zh) | 2013-08-21 |
HK1190145A1 (zh) | 2014-06-27 |
ES2573315T3 (es) | 2016-06-07 |
MX340585B (es) | 2016-07-15 |
CA2819389A1 (en) | 2012-06-07 |
CN103261192B (zh) | 2016-08-10 |
EP2646435B1 (en) | 2016-03-02 |
US20130303540A1 (en) | 2013-11-14 |
MX2013006004A (es) | 2013-07-15 |
JP2013544270A (ja) | 2013-12-12 |
TW201305148A (zh) | 2013-02-01 |
US8729073B2 (en) | 2014-05-20 |
EP2460804A1 (en) | 2012-06-06 |
WO2012072781A1 (en) | 2012-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR084505A1 (es) | Derivados de 5-metil-1-(naftalen-2-il)-1h-pirazol | |
CY1124117T1 (el) | Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων | |
UY38297A (es) | Compuestos derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-diona, composiciones, métodos y usos de los mismos | |
AR056873A1 (es) | Derivados de pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina, composiciones farmaceuticas | |
AR092269A1 (es) | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b | |
CY1118879T1 (el) | Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor | |
PE20181093A1 (es) | Compuestos heterociclicos y usos de los mismos | |
AR097079A1 (es) | SALES DE DERIVADOS DE 2-AMINO-1-HIDROXIETIL-8-HIDROXIQUINOLIN-2(1H)-ONA QUE TIENEN ACTIVIDAD ANTAGONISTA DE RECEPTORES MUSCARÍNICOS ASÍ COMO ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO | |
CU20110145A7 (es) | Derivados de sulfonamida | |
EA201592144A1 (ru) | Производное фенола, способ его получения и его применение в медицине | |
UY32490A (es) | Inhibidores de beta-secretasa | |
AR083879A1 (es) | Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos | |
BR112016016844A2 (pt) | Compostos heterocíclicos | |
AR081426A1 (es) | Derivados de pirazol inhibidores del receptor sigma | |
BR112016010080A8 (pt) | compostos de pirazolopirimidina, composição farmacêutica e seu uso | |
CO6690768A2 (es) | Derivados de triazina-oxadiazoles, útiles como inhibidores de los canales de sodio navi.7 | |
CL2015002520A1 (es) | Compuestos novedosos de pirimidina y piridina y su uso. | |
HRP20170873T1 (hr) | Monociklički derivat piridina | |
AR070299A1 (es) | Derivados de pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas, usos y composiciones farmaceuticas | |
EA201291217A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 1-(β-D-ГЛЮКОПИРАНОЗИЛ)-2-ТИЕНИЛМЕТИЛБЕНЗОЛА КАК ИНГИБИТОРЫ НЗПГ | |
AR073551A1 (es) | Pirimidinas macrociclicas como inhibidores de proteina cinasa | |
TR201802944T4 (tr) | İlaç olarak azai̇ndazol veya di̇azai̇ndazol türünün türevleri̇ | |
CL2008001669A1 (es) | Compuestos derivados de piperidina/piperazina inhibidora de dgat-1; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento de la obesidad, dislipidemia, fibrosis hepatica y diabetes tipo ii, entre otras. | |
BR112015023705A2 (pt) | composto da fórmula (ia) ou um sal, hidrato, solvato ou forma cristalina farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composto e método para síntese do composto da fórmula (ia) | |
MY196788A (en) | Fused tricyclic ?-amino acid derivative, preparation method therefor, and medical use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |