AR078734A1 - Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones - Google Patents
Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composicionesInfo
- Publication number
- AR078734A1 AR078734A1 ARP100103877A ARP100103877A AR078734A1 AR 078734 A1 AR078734 A1 AR 078734A1 AR P100103877 A ARP100103877 A AR P100103877A AR P100103877 A ARP100103877 A AR P100103877A AR 078734 A1 AR078734 A1 AR 078734A1
- Authority
- AR
- Argentina
- Prior art keywords
- ivig
- body fluid
- mammal
- treatment
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
Abstract
Reivindicacion 1: Un método de mejora, tratamiento o prevencion de una enfermedad o trastorno asociados con una presencia de uno o varios autoanticuerpos en una circulacion de un mamífero, que comprende, en secuencia: (a) eliminacion de uno o varios de dichos autoanticuerpos de la circulacion de dicho mamífero; y (b) administracion a dicho mamífero de una preparacion intravenosa de inmunoglobulina (IVIG) que comprende al menos el 20% de inmunoglobulina 1 2 en una cantidad suficiente para restaurar el sistema inmune de dicho mamífero hasta homeostasis, en donde la preparacion de IVIG no contiene organismos virales detectables. Reivindicacion 31: Un método de purificacion de una inmunoglobulina intravenosa humana (IVIG) de un fluido corporal, en donde la IVIG resultante es apropiada para uso terapéutico, que comprende las etapas de: (a) remover uno o varios componentes de la vía de coagulacion del fluido corporal; (b) adicion de uno o varios alcoholes a fluido corporal para remover las proteínas no deseadas; (c) concentracion del fluido corporal en condiciones que evitan la activacion de la vía complementaria en el fluido corporal; y (d) tratamiento del fluido corporal para eliminar uno o varios contaminantes activos virales y microbianos; y (e) ensayo de la actividad de la IVIG al menos después de (d) para obtener una IVIG purificada del concentrado proteico plasmático, en donde la lVlG purificada es una lVlG altamente eficaz para el tratamiento de una o varias enfermedades o trastornos en un mamífero. Reivindicacion 43: Composiciones para mejorar, tratar o prevenir enfermedades o trastornos asociados con la presencia de uno o varios autoanticuerpos en la circulacion de un mamífero, en donde las composiciones contienen una o varias inmunoglobulinas obtenidas por medio del método de acuerdo con las reivindicaciones 31 a 42.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25407209P | 2009-10-22 | 2009-10-22 | |
US30671810P | 2010-02-22 | 2010-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR078734A1 true AR078734A1 (es) | 2011-11-30 |
Family
ID=43898625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103877A AR078734A1 (es) | 2009-10-22 | 2010-10-22 | Composiciones, metodos para el tratamiento, y diagnostico de trastornos relacionados con la autoinmunidad y metodos para preparar tales composiciones |
Country Status (8)
Country | Link |
---|---|
US (2) | US20110097344A1 (es) |
EP (1) | EP2490721A4 (es) |
AR (1) | AR078734A1 (es) |
AU (1) | AU2010310562A1 (es) |
CA (1) | CA2778158A1 (es) |
RU (1) | RU2012120620A (es) |
TW (1) | TW201125582A (es) |
WO (1) | WO2011050259A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130068691A1 (en) * | 2011-08-05 | 2013-03-21 | Henry John Smith | Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders |
CN103257190B (zh) * | 2013-04-15 | 2015-02-25 | 南京艾德凯腾生物医药有限责任公司 | 一种测定布洛芬/法莫替丁复方制剂含量的方法 |
CN106290657B (zh) * | 2016-09-27 | 2018-07-06 | 海口南陆医药科技股份有限公司 | 一种用于检测地氯雷他定中杂质的方法 |
EP3431988B1 (en) * | 2017-07-18 | 2021-03-10 | CBmed GmbH Center for Biomarker Research in Medicine | Method to determine the state of the humoral immune system in a patient |
CA3115821A1 (en) * | 2018-10-11 | 2020-04-16 | Momenta Pharmaceuticals, Inc. | Treatment with highly silylated igg compositions |
CN111057153B (zh) * | 2019-12-06 | 2021-09-07 | 广州康盛生物科技股份有限公司 | 一种免疫球蛋白结合蛋白及其制备方法和应用 |
CN111929394B (zh) * | 2020-08-25 | 2022-11-08 | 北京和合医学诊断技术股份有限公司 | 华法林的检测方法 |
CN112763625B (zh) * | 2020-12-30 | 2022-07-15 | 江苏正济药业股份有限公司 | 一种法莫替丁及其有关物质的检测方法 |
WO2023235428A1 (en) | 2022-05-31 | 2023-12-07 | Lyfspn, Inc. | Compositions and methods for plasmapheresis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6911204B2 (en) * | 2000-08-11 | 2005-06-28 | Favrille, Inc. | Method and composition for altering a B cell mediated pathology |
AU2006292132A1 (en) * | 2005-09-19 | 2007-03-29 | Palingen, Inc. | Treatment of B cell diseases using anti-germline antibody binding agents |
GB0819720D0 (en) * | 2008-10-28 | 2008-12-03 | Univ Birmingham | Methods and products |
-
2010
- 2010-10-22 CA CA2778158A patent/CA2778158A1/en not_active Abandoned
- 2010-10-22 US US12/910,452 patent/US20110097344A1/en not_active Abandoned
- 2010-10-22 EP EP10825737.9A patent/EP2490721A4/en not_active Withdrawn
- 2010-10-22 WO PCT/US2010/053726 patent/WO2011050259A1/en active Application Filing
- 2010-10-22 AU AU2010310562A patent/AU2010310562A1/en not_active Abandoned
- 2010-10-22 AR ARP100103877A patent/AR078734A1/es unknown
- 2010-10-22 RU RU2012120620/15A patent/RU2012120620A/ru not_active Application Discontinuation
- 2010-10-22 TW TW099136139A patent/TW201125582A/zh unknown
-
2014
- 2014-10-10 US US14/512,106 patent/US20150153357A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2012120620A (ru) | 2013-11-27 |
AU2010310562A1 (en) | 2012-06-07 |
EP2490721A4 (en) | 2013-05-15 |
WO2011050259A1 (en) | 2011-04-28 |
US20110097344A1 (en) | 2011-04-28 |
CA2778158A1 (en) | 2011-04-28 |
US20150153357A1 (en) | 2015-06-04 |
TW201125582A (en) | 2011-08-01 |
EP2490721A1 (en) | 2012-08-29 |
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