AR075249A1 - DERIVATIVES OF 6- (6-O-SUBSTITUTED-TRIAZOLOPIRIDAZINA-SULFANIL) BENZOTIAZOLES AND BENCIMIDAZOLES, METHOD OF PREPARATION OF THE SAME AND INTERMEDIARIES OF SUCH SYNTHESIS, MEDICINES CONTAINING THEM AND USE OF THE MYSTS AND ALERTS IN THE TRACKS, ALERTS OTHER DISEASES. - Google Patents

DERIVATIVES OF 6- (6-O-SUBSTITUTED-TRIAZOLOPIRIDAZINA-SULFANIL) BENZOTIAZOLES AND BENCIMIDAZOLES, METHOD OF PREPARATION OF THE SAME AND INTERMEDIARIES OF SUCH SYNTHESIS, MEDICINES CONTAINING THEM AND USE OF THE MYSTS AND ALERTS IN THE TRACKS, ALERTS OTHER DISEASES.

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AR075249A1
AR075249A1 ARP100100317A ARP100100317A AR075249A1 AR 075249 A1 AR075249 A1 AR 075249A1 AR P100100317 A ARP100100317 A AR P100100317A AR P100100317 A ARP100100317 A AR P100100317A AR 075249 A1 AR075249 A1 AR 075249A1
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radical
optionally substituted
heterocycloalkyl
phenyl
cycloalkyl
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ARP100100317A
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Spanish (es)
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Sylvie Wentzler
Antonio Ugolini
Conception Nemecek
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Sanofi Aventis
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Publication of AR075249A1 publication Critical patent/AR075249A1/en

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Abstract

Reivindicacion 1: Productos de formula (1) en la que - - - - representa un enlace sencillo o doble; Rb representa un átomo de hidrogeno o un átomo de fluor; Ra representa un radical -O-Z-Rc en el que Z representa un enlace sencillo o un radical alquileno lineal o ramificado que tiene de 1 a 6 átomos de carbono y que está opcionalmente sustituido con un grupo alquilo o un átomo de halogeno; Rc representa un radical cicloalquilo, heterocicloalquilo, arilo o heteroarilo opcionalmente sustituidos; X representa S, SO o SO2; A representa NH o S; W representa un átomo de hidrogeno; un radical alquilo o cicloalquilo opcionalmente sustituidos con alcoxi, heterocicloalquilo o NR3R4; o el radical COR en el que R representa un radical cicloalquilo, o un radical alquilo, opcionalmente sustituido con un radical NR3R4, alcoxi, -O-cicloalquilo, -O-CO-R5, hidroxi, fenilo, heteroarilo, o heterocicloalquilo, ellos mismos opcionalmente sustituidos; un radical alcoxi opcionalmente sustituido con NR3R4, alcoxi, hidroxi o con heterocicloalquilo; un radical O-fenilo o un radical O-(CH2)n-fenilo, con el fenilo opcionalmente sustituido y n representa un numero entero de 1 a 4; o el radical NR1R2 en el que R1 y R2 son tales que uno de R1 y R2 representa un átomo de hidrogeno, un radical cicloalquilo o un radical alquilo y el otro de R1 y R2 representa un átomo de hidrogeno, un radical cicloalquilo o un radical alquilo opcionalmente sustituido con uno o varios radicales idénticos o diferentes elegidos entre los radicales hidroxilo, alcoxi, heteroarilo, heterocicloalquilo, NR3R4, fenilo opcionalmente sustituido; o bien R1 y R2 forman con el átomo de nitrogeno al que están unidos, un radical cíclico que tiene de 3 a 10 eslabones y opcionalmente uno o varios heteroátomos distintos elegidos entre O, S, N y NH, pudiendo estar el eventual S opcionalmente en forma de SO o SO2; estando este radical, incluido el NH opcional que contiene, opcionalmente sustituido; con R3 y R4, idénticos o diferentes, representando un átomo de hidrogeno, un radical alquilo, un radical cicloalquilo, un radical heterocicloalquilo, un radical heteroarilo o un radical fenilo, todos opcionalmente sustituidos con uno o varios radicales idénticos o diferentes elegidos entre los radicales hidroxilo, alcoxi, heteroarilo, heterocicloalquilo, NH2, NHAlk, N(Alk)2, fenilo opcionalmente sustituido; o bien R3 y R4 forman con el átomo de nitrogeno al que están unidos, un radical cíclico que tiene de 3 a 10 eslabones y opcionalmente uno o varios heteroátomos distintos elegidos entre O, S, N y NH, pudiendo estar el eventual S opcionalmente en la forma de SO o SO2; estando este radical, incluido el NH opcional que contiene, opcionalmente sustituido; estando todos los radicales definidos anteriormente alquilo, alcoxi, -O-cicloalquilo, cicloalquilo, heterocicloalquilo, heteroarilo, arilo y fenilo así como los radicales cíclicos que pueden formar R1 y R2 o R3 y R4 con el átomo de nitrogeno al que están unidos, opcionalmente sustituidos con uno o varios radicales elegidos entre los átomos de halogeno, los radicales hidroxilo, oxo, alcoxi, -O-CO-R5, -OR5 -COOH, COOR5, -CONH2, CONHR5, NH2, NHR5, NR5R5', -NH-CO-R5, -NHCOOR5 y los radicales alquilo, heterocicloalquilalquilo, cicloalquilo, heterocicloalquilo, CH2- heterocicloalquilo, fenilo, CH2-fenilo, CO-fenilo, heteroarilo y S-heteroarilo, representa un arilo opcio en estos ultimos radicales, los radicales alquilo, alcoxi, heterocicloalquilo, fenilo y heteroarilo están ellos mismos opcionalmente sustituidos con uno o varios radicales elegidos entre los átomos de halogeno y los radicales hidroxilo, oxo, alquilo y alcoxi que tienen 1 a 4 átomos de carbono, NH2, NHalk y N(alk)2; estando además todos los radicales definidos anteriormente, cicloalquilo, heterocicloalquilo, heteroarilo y fenilo, opcionalmente sustituidos con un radical Si(alk)3; R5 y R5', idénticos o diferentes, representan un radical alquilo o cicloalquilo que tiene como máximo 6 átomos de carbono; alk representa un radical alquilo que tiene como máximo 4 átomos de carbono; entendiéndose que: 1) cuando Rb representa hidrogeno y Z representa un enlace sencillo, entonces Rc no representa un radical cicloalquilo; y 2) cuando Rb representa hidrogeno y Z representa un radical alquileno, entonces Rc no representa un radical heterocicloalquilo; estando dichos productos de la formula (1) en todas las formas posibles de isomeros, racémicos, enantiomeros y diastereoisomeros, así como las sales de adicion con los ácidos minerales y orgánicos o con las bases minerales y orgánicas de dichos productos de la formula (1).Claim 1: Products of formula (1) in which - - - - represents a single or double bond; Rb represents a hydrogen atom or a fluorine atom; Ra represents a radical -O-Z-Rc in which Z represents a single bond or a linear or branched alkylene radical having 1 to 6 carbon atoms and which is optionally substituted with an alkyl group or a halogen atom; Rc represents an optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl radical; X represents S, SO or SO2; A represents NH or S; W represents a hydrogen atom; an alkyl or cycloalkyl radical optionally substituted with alkoxy, heterocycloalkyl or NR3R4; or the COR radical in which R represents a cycloalkyl radical, or an alkyl radical, optionally substituted with an NR3R4 radical, alkoxy, -O-cycloalkyl, -O-CO-R5, hydroxy, phenyl, heteroaryl, or heterocycloalkyl, themselves optionally substituted; an alkoxy radical optionally substituted with NR3R4, alkoxy, hydroxy or with heterocycloalkyl; an O-phenyl radical or an O- (CH2) n-phenyl radical, with the optionally substituted phenyl and n represents an integer from 1 to 4; or the radical NR1R2 in which R1 and R2 are such that one of R1 and R2 represents a hydrogen atom, a cycloalkyl radical or an alkyl radical and the other of R1 and R2 represents a hydrogen atom, a cycloalkyl radical or a radical alkyl optionally substituted with one or several identical or different radicals chosen from among the hydroxyl, alkoxy, heteroaryl, heterocycloalkyl, NR3R4, optionally substituted phenyl radicals; or R1 and R2 form with the nitrogen atom to which they are attached, a cyclic radical having 3 to 10 links and optionally one or several different heteroatoms chosen from O, S, N and NH, the eventual optionally being optionally S form of SO or SO2; this radical being, including the optional NH it contains, optionally substituted; with R3 and R4, identical or different, representing a hydrogen atom, an alkyl radical, a cycloalkyl radical, a heterocycloalkyl radical, a heteroaryl radical or a phenyl radical, all optionally substituted with one or more identical or different radicals chosen from among the radicals hydroxyl, alkoxy, heteroaryl, heterocycloalkyl, NH2, NHAlk, N (Alk) 2, optionally substituted phenyl; or R3 and R4 form with the nitrogen atom to which they are attached, a cyclic radical having 3 to 10 links and optionally one or several different heteroatoms chosen from O, S, N and NH, the eventual optionally being optionally S the form of SO or SO2; this radical being, including the optional NH it contains, optionally substituted; all the radicals defined above being alkyl, alkoxy, -O-cycloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, aryl and phenyl as well as the cyclic radicals that can form R1 and R2 or R3 and R4 with the nitrogen atom to which they are optionally attached substituted with one or several radicals chosen from halogen atoms, hydroxyl, oxo, alkoxy, -O-CO-R5, -OR5 -COOH, COOR5, -CONH2, CONHR5, NH2, NHR5, NR5R5 ', -NH- CO-R5, -NHCOOR5 and the alkyl, heterocycloalkylalkyl, cycloalkyl, heterocycloalkyl, CH2-heterocycloalkyl, phenyl, CH2-phenyl, CO-phenyl, heteroaryl and S-heteroaryl radicals, represents an opium aryl in the latter radicals, the alkyl radicals, alkoxy, heterocycloalkyl, phenyl and heteroaryl are themselves optionally substituted with one or more radicals chosen from the halogen atoms and the hydroxyl, oxo, alkyl and alkoxy radicals having 1 to 4 carbon atoms, NH2, NHalk and N (alk) 2; in addition all the radicals defined above, cycloalkyl, heterocycloalkyl, heteroaryl and phenyl, optionally substituted with a Si (alk) 3 radical; R5 and R5 ', identical or different, represent an alkyl or cycloalkyl radical having a maximum of 6 carbon atoms; alk represents an alkyl radical having a maximum of 4 carbon atoms; it being understood that: 1) when Rb represents hydrogen and Z represents a single bond, then Rc does not represent a cycloalkyl radical; and 2) when Rb represents hydrogen and Z represents an alkylene radical, then Rc does not represent a heterocycloalkyl radical; said products of the formula (1) being in all possible forms of isomers, racemic, enantiomers and diastereoisomers, as well as the addition salts with the mineral and organic acids or with the mineral and organic bases of said products of the formula (1 ).

ARP100100317A 2009-02-06 2010-02-05 DERIVATIVES OF 6- (6-O-SUBSTITUTED-TRIAZOLOPIRIDAZINA-SULFANIL) BENZOTIAZOLES AND BENCIMIDAZOLES, METHOD OF PREPARATION OF THE SAME AND INTERMEDIARIES OF SUCH SYNTHESIS, MEDICINES CONTAINING THEM AND USE OF THE MYSTS AND ALERTS IN THE TRACKS, ALERTS OTHER DISEASES. AR075249A1 (en)

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JP (1) JP2012517408A (en)
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AU2012310168B2 (en) 2011-09-15 2015-07-16 Novartis Ag 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
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