AR073474A1 - PIRIDINIC DERIVATIVES OF PICOLINAMIDE INHIBITORS OF PIM QUINASES OF SERINA / TREONINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME AS ANTICANCER AGENTS. - Google Patents
PIRIDINIC DERIVATIVES OF PICOLINAMIDE INHIBITORS OF PIM QUINASES OF SERINA / TREONINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME AS ANTICANCER AGENTS.Info
- Publication number
- AR073474A1 AR073474A1 ARP090103346A AR073474A1 AR 073474 A1 AR073474 A1 AR 073474A1 AR P090103346 A ARP090103346 A AR P090103346A AR 073474 A1 AR073474 A1 AR 073474A1
- Authority
- AR
- Argentina
- Prior art keywords
- quinases
- piridinic
- treonina
- serina
- picolinamide
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1), o un estereoisomero, tautomero, o una sal farmacéuticamente aceptable del mismo, en donde: Y es ciclohexilo sustituido con uno a tres sustituyentes; R1 es hidrogeno, -NH2, o halogeno; R12, independientemente en cada presentacion, se selecciona a partir del grupo que consiste en hidrogeno y halogeno; y R5 se selecciona a partir de ciclohexilo, fenilo, y piridilo, en donde este ciclohexilo, este fenilo, y este piridilo están cada uno independientemente sustituidos con hasta tres sustituyentes seleccionados a partir de halogeno, hidroxilo, alquilo C1-4, y O-alquilo C1-4. Reivindicacion 18: Un compuesto de la formula (1), o un estereoisomero, tautomero, o una sal farmacéuticamente aceptable del mismo en donde Y es piperidinilo sustituido con metilo, hidroxilo, y amino; R1 se selecciona a partir del grupo que consiste en hidrogeno NR2, y F; R12, independientemente en cada presentacion, se selecciona a partir del grupo que consiste en H y halogeno; y R5 se selecciona a partir de piridilo, fluoro-piridilo, ciclohexilo, y fenilo, en donde el fenilo está sustituido con hasta tres sustituyentes seleccionados a partir de fluor, hidroxilo, y metilo.Claim 1: A compound of the formula (1), or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof, wherein: Y is cyclohexyl substituted with one to three substituents; R1 is hydrogen, -NH2, or halogen; R12, independently in each presentation, is selected from the group consisting of hydrogen and halogen; and R5 is selected from cyclohexyl, phenyl, and pyridyl, wherein this cyclohexyl, this phenyl, and this pyridyl are each independently substituted with up to three substituents selected from halogen, hydroxyl, C1-4alkyl, and O- C1-4 alkyl. Claim 18: A compound of the formula (1), or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof wherein Y is piperidinyl substituted with methyl, hydroxyl, and amino; R1 is selected from the group consisting of NR2 hydrogen, and F; R12, independently in each presentation, is selected from the group consisting of H and halogen; and R5 is selected from pyridyl, fluoro-pyridyl, cyclohexyl, and phenyl, wherein the phenyl is substituted with up to three substituents selected from fluorine, hydroxyl, and methyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9366608P | 2008-09-02 | 2008-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073474A1 true AR073474A1 (en) | 2010-11-10 |
Family
ID=43566735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103346 AR073474A1 (en) | 2008-09-02 | 2009-09-01 | PIRIDINIC DERIVATIVES OF PICOLINAMIDE INHIBITORS OF PIM QUINASES OF SERINA / TREONINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME AS ANTICANCER AGENTS. |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR073474A1 (en) |
| JO (1) | JO3055B1 (en) |
| UA (1) | UA103034C2 (en) |
-
2009
- 2009-08-31 UA UAA201101618A patent/UA103034C2/en unknown
- 2009-09-01 JO JOP/2009/0326A patent/JO3055B1/en active
- 2009-09-01 AR ARP090103346 patent/AR073474A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JO3055B1 (en) | 2017-03-15 |
| UA103034C2 (en) | 2013-09-10 |
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