AR073431A1 - Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica - Google Patents

Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica

Info

Publication number
AR073431A1
AR073431A1 ARP090104599A ARP090104599A AR073431A1 AR 073431 A1 AR073431 A1 AR 073431A1 AR P090104599 A ARP090104599 A AR P090104599A AR P090104599 A ARP090104599 A AR P090104599A AR 073431 A1 AR073431 A1 AR 073431A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally mono
substituted
heterocycloalkyl
optionally
Prior art date
Application number
ARP090104599A
Other languages
English (en)
Inventor
Didier Babin
Thierry Gouyon
Serge Mignani
Olivier Bedel
David Papin
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0901368A external-priority patent/FR2943674B1/fr
Priority claimed from FR0956944A external-priority patent/FR2950891B1/fr
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR073431A1 publication Critical patent/AR073431A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Abstract

Aplicacion en terapéutica para el tratamiento del cáncer. Reivindicacion 1: Compuestos de la formula general (1) siguiente: en la que: Z2, Z3, Z4 idénticos o diferentes, representan CH, CRa, CRs o N; R3 se elige entre: H, halogeno (F, CI, Br, I), CF3, CHF2, OH, alcoxi cuya parte alquilo está opcionalmente mono, di o tri sustituida, NH2, NH(alquilo), N(alquilo)2, cuya parte alquilo está opcionalmente mono, di o tri sustituida, C(O)Oalquilo opcionalmente mono, di o tri sustituido, CONH(alquilo),CON(alquilo)2, cuya parte alquilo está opcionalmente mono, di o tri sustituida, alquilo C1-10 lineal, ramificado o cíclico que lleva opcionalmente un heteroátomo y que está opcionalmente mono, di o tri sustituido, arilo o heteroarilo opcionalmente mono, di o tri sustituido; siendo R6 un heteroarilo (de 5 o 6 miembros con 1 a 4 heteroátomos elegidos entre N, S u O) unido al motivo azacarbolina ya sea por un C o ya sea por un N que pertenece a R6, estando R6 opcionalmente mono o poli sustituido; siendo Ra obligatoriamente elegido entre: CONH2, CONHalquilo, CONHcicloalquilo opcionalmente mono, di o tri sustituido, CONHheterocicloalquilo opcionalmente mono, di o tri sustituido, CON(alquilo)2 opcionalmente mono, di o tri sustituido, CON(alquilo)(heterocicloalquilo) opcionalmente mono, di o tri sustituido, CONHN(alquilo)2 cuya parte alquilo está opcionalmente mono, di o tri sustituida, C(O)heterocicloalquilo, llevando el radical heterocicloalquilo al menos un átomo de nitrogeno unido al C(O); y estando opcionalmente mono, di o tri sustituido; siendo elegido Rs entre los grupos siguientes: H, F, CI, Br, I, OH, O-alquilo(C1-10) lineal o ramificado opcionalmente mono o poli sustituido, NH2, N(alquilo(C1-10) o cicloalquilo(C3-7))2, estando cada grupo opcionalmente mono o poli sustituido, NHC(O)R3a, N(alquilo(C1-10)C(O)R3a, NHS(O2)R3a, N(alquilo(C1-10)S(O2)R3a, CO2R3a, SR3a, S(O)R3a, S(O2)R3a, pudiendo Ra y Rs formar opcionalmente un ciclo sustituido con un radical oxo. que tiene de 4 a 7 miembros, que comprende al menos un átomo de nitrogeno y opcionalmente otro heteroátomo elegido entre N, O y S y que está opcionalmente sustituido con uno o varios radicales elegidos entre los radicales oxo, F, CI, Br, I, CF3, CHF2, alquilo, OH, Oalquilo, NO2, NH2, NHAlk o N(Alk)2; siendo R3a elegido entre: F, CI, Br, I, CF3, alquilo C1-10 lineal o ramificado, cicloalquilo C3-7, alquenilo C2-6, alquinilo C2-6, OH, O-alquilo(C1-10) lineal, ramificado o cíclico (C3-7), heterocicloalquilo (C3-7), NH2, NH-(alquilo(C1-10) o cicloalquilo(C3-7)), N(alquilo(C1-10) o cicloalquilo(C3-7))2, NH-(alquilo(C1-10) o heterocicloalquilo (C3-7)), N(alquilo(C1-10) o heterocicloalquilo (C3-7))2; estando dichos productos de la formula (1) en todas las formas posibles de isomeros, racémicos, enantiomeros y diastereoisomeros, así como las sales de adicion, con los ácidos minerales y orgánicos o con las bases minerales y orgánicas, de dichos productos de la formula (1).
ARP090104599A 2009-03-24 2009-11-30 Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica AR073431A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901368A FR2943674B1 (fr) 2009-03-24 2009-03-24 Derives d'azacarbolines,leur preparation et leur utilisation therapeutique
FR0956944A FR2950891B1 (fr) 2009-10-06 2009-10-06 Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
AR073431A1 true AR073431A1 (es) 2010-11-03

Family

ID=42101692

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104599A AR073431A1 (es) 2009-03-24 2009-11-30 Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica

Country Status (16)

Country Link
US (1) US20120208809A1 (es)
EP (1) EP2411389A2 (es)
JP (1) JP2012521394A (es)
KR (1) KR20110130504A (es)
CN (1) CN102365282A (es)
AR (1) AR073431A1 (es)
AU (1) AU2009342734A1 (es)
BR (1) BRPI0924844A2 (es)
CA (1) CA2756152A1 (es)
IL (1) IL215286A0 (es)
MX (1) MX2011010062A (es)
RU (1) RU2011142791A (es)
SG (1) SG174903A1 (es)
TW (1) TW201035097A (es)
UY (1) UY32275A (es)
WO (1) WO2010109084A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2725754C (en) 2008-06-11 2017-05-23 Hazel Joan Dyke Diazacarbazoles and methods of use
US20110183938A1 (en) 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
CN102432472A (zh) * 2011-11-03 2012-05-02 浙江工业大学 一种2，2-二氟丙烷-1，3-二胺的制备方法
KR101561330B1 (ko) 2012-09-19 2015-10-16 주식회사 두산 인돌로인돌계 유기 발광 화합물 및 이를 이용한 유기 전계 발광 소자
PE20150887A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
US11034649B2 (en) * 2016-04-25 2021-06-15 Duke University Benzoylglycine derivatives and methods of making and using same
BR112021002614A2 (pt) 2018-08-14 2021-05-04 Osteoqc Inc. compostos pirrol-dipiridina
CN113166058A (zh) 2018-08-14 2021-07-23 奥斯特克有限公司 氟β-咔啉化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1896472A1 (de) * 2005-06-09 2008-03-12 Boehringer Ingelheim International GmbH Alpha-carboline als cdk-1 inhibitoren
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2009531376A (ja) * 2006-03-28 2009-09-03 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ヒスタミンｈ３受容体活性を有するベンゾチアゾール
CA2725754C (en) * 2008-06-11 2017-05-23 Hazel Joan Dyke Diazacarbazoles and methods of use
AR072084A1 (es) * 2008-06-12 2010-08-04 Sanofi Aventis Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica como inhibidores de las quinasas pim

Also Published As

Publication number Publication date
AU2009342734A1 (en) 2011-10-13
CN102365282A (zh) 2012-02-29
JP2012521394A (ja) 2012-09-13
IL215286A0 (en) 2011-11-30
WO2010109084A2 (fr) 2010-09-30
RU2011142791A (ru) 2013-04-27
UY32275A (es) 2010-06-30
SG174903A1 (en) 2011-11-28
MX2011010062A (es) 2011-11-18
WO2010109084A3 (fr) 2011-01-06
KR20110130504A (ko) 2011-12-05
TW201035097A (en) 2010-10-01
EP2411389A2 (fr) 2012-02-01
US20120208809A1 (en) 2012-08-16
BRPI0924844A2 (pt) 2016-01-26
CA2756152A1 (fr) 2010-09-30

Similar Documents

Publication Publication Date Title
AR073431A1 (es) Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica
NI201900029A (es) COMPUESTOS DE BENZO[b]TIOFENO COMO AGONISTAS DE STING
AR082112A1 (es) Derivados de imidazopiridina, su procedimiento de preparacion y su aplicacion en terapeutica
CR20140548A (es) Derivados de aril-sultamo como moduladores de rorc
AR094964A1 (es) USO DE DERIVADOS DE PIRAZOLOPIRIMIDINA PARA EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON LA FOSFOINOSITIDA 3-CINASA d (PI3Kd)
UY36122A (es) ?derivados de pirrolidina-2,5-diona, composiciones farmacéuticas y métodos para usar como inhibidores ido1?
UY37900A (es) Nuevos derivados de rapamicina
SV2016005229A (es) Inhibidores de syk
UY32462A (es) Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
CR20150371A (es) Inhibidores de prmt5 y sus usos
AR085489A1 (es) Derivados de triazolopiridinas, composiciones farmaceuticas que los contienen, proceso para prepararlos, intermediarios de dicho proceso y uso de los mismos para el tratamiento de enfermedades autoinmunes e inflamatorias
DOP2014000036A (es) Compuestos de piridazinona y su uso como inhibidores daao
AR082768A1 (es) Derivados de indolizina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen
UY33961A (es) Compuestos de bis(fuoroalquil)-1,4-benziodiazepinona
UY32483A (es) Nuevos compuestos de bencimidazol para el tratamiento del virus sincicial respiratorio
UY31254A1 (es) Derivados sutituidos de n4-(5-metil-1h-pirazol-3-il)- 1,3,5-triazina-2,4-diamina, sus enantiómeros, sales farmacéuticamente aceptables de los mismos, composiciones, procesos de preparación y aplicaciones
ECSP15012804A (es) Alcoxipirazoles como activadores de guanilato ciclasa soluble
UY32916A (es) Nuevas pirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones
GT201600091A (es) Derivados de purina 2, 6-sustituidos y su uso en el tratamiento de trastornos proliferativos
MX2020004283A (es) Derivados de piridincarbonilo y usos terapéuticos de los mismos como inhibidores de trpc6.
UY35551A (es) Derivados heteroarilos como inhibidores de aldosterona sintasa
CR20170496A (es) Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas
AR077080A1 (es) Compuestos de 2,3-dihidro-1h-indeno
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
CL2021000844A1 (es) Compuestos de indolinona para uso como inhibidores de map4k1

Legal Events

Date Code Title Description
FB Suspension of granting procedure