AR073044A1 - Compuestos polisustituidos de azetidinas, su preparacion y su aplicacion en terapeutica - Google Patents

Compuestos polisustituidos de azetidinas, su preparacion y su aplicacion en terapeutica

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Publication number
AR073044A1
AR073044A1 ARP090103132A ARP090103132A AR073044A1 AR 073044 A1 AR073044 A1 AR 073044A1 AR P090103132 A ARP090103132 A AR P090103132A AR P090103132 A ARP090103132 A AR P090103132A AR 073044 A1 AR073044 A1 AR 073044A1
Authority
AR
Argentina
Prior art keywords
group
alkyl group
haloalkyl
cyano
halogen
Prior art date
Application number
ARP090103132A
Other languages
English (en)
Inventor
Corinne Terrier
Patrick Bernardelli
Jean-Francois Sabuco
Florian Auger
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR073044A1 publication Critical patent/AR073044A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Procedimiento de preparacion y aplicacion en terapéutica para tratar o prevenir trastornos psiquiátricos, metabolismo, dolor, gastrointestinales. Reivindicacion 1: Compuestos de formula (1) en la que R representa un grupo alquilo C1-6, un grupo haloalquilo C1-6; R1 representa un átomo de hidrogeno; R2 representa un grupo heterociclo unido por un átomo de carbono, un grupo heterocicloalquilo C1-4, estando estos grupos opcionalmente sustituidos con uno o varios átomos o grupos elegidos entre un halogeno, un hidroxi, oxo, ciano, NH2, C(O)NH2, un grupo alquilo C1-6, un grupo haloalquilo C1-6, un grupo alcoxi C1-6, un grupo haloalcoxi C1-6 o un grupo COO-alquilo C1-6; R3 y R4 representan independientemente uno del otro un grupo fenilo, opcionalmente sustituido con uno o varios átomos o grupos elegidos entre un halogeno, un ciano, un grupo alquilo C1-6, un grupo haloalquilo C1-6, un grupo alcoxi C1-6 o un grupo haloalcoxi C1-6; Y representa un átomo de hidrogeno, un halogeno, un ciano, un grupo alquilo C1-6, un grupo haloalquilo C1-6, un grupo alcoxi C1-6, un grupo haloalcoxi C1-6 o un grupo alquil C1-6-S(O)p; p está comprendido entre 0 y 2; en forma de base o de sal de adicion a un ácido.
ARP090103132A 2008-08-14 2009-08-13 Compuestos polisustituidos de azetidinas, su preparacion y su aplicacion en terapeutica AR073044A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804596A FR2934996B1 (fr) 2008-08-14 2008-08-14 Composes polysubstitues d'azetidines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR073044A1 true AR073044A1 (es) 2010-10-06

Family

ID=40352477

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103132A AR073044A1 (es) 2008-08-14 2009-08-13 Compuestos polisustituidos de azetidinas, su preparacion y su aplicacion en terapeutica

Country Status (16)

Country Link
US (1) US20110183961A1 (es)
EP (1) EP2313392A1 (es)
JP (1) JP2011530576A (es)
KR (1) KR20110042114A (es)
CN (1) CN102186838A (es)
AR (1) AR073044A1 (es)
AU (1) AU2009281058A1 (es)
BR (1) BRPI0917944A2 (es)
CA (1) CA2734082A1 (es)
FR (1) FR2934996B1 (es)
IL (1) IL211209A0 (es)
MX (1) MX2011001669A (es)
RU (1) RU2011109204A (es)
TW (1) TW201022248A (es)
UY (1) UY32050A (es)
WO (1) WO2010018329A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934995B1 (fr) * 2008-08-14 2010-08-27 Sanofi Aventis Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique
CN103524393B (zh) * 2013-10-29 2015-01-07 广东省中医院 氮杂环丁烷-3-磺胺类衍生物及其合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805817B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation

Also Published As

Publication number Publication date
BRPI0917944A2 (pt) 2015-11-17
WO2010018329A1 (fr) 2010-02-18
CN102186838A (zh) 2011-09-14
KR20110042114A (ko) 2011-04-22
FR2934996B1 (fr) 2010-08-27
IL211209A0 (en) 2011-04-28
EP2313392A1 (fr) 2011-04-27
MX2011001669A (es) 2011-03-24
AU2009281058A1 (en) 2010-02-18
RU2011109204A (ru) 2012-09-20
JP2011530576A (ja) 2011-12-22
CA2734082A1 (fr) 2010-02-18
FR2934996A1 (fr) 2010-02-19
US20110183961A1 (en) 2011-07-28
UY32050A (es) 2010-03-26
TW201022248A (en) 2010-06-16

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