AR071530A1 - Derivados de tienopiridonas como activadores de proteina quinasa activa-dos por amp (ampk) - Google Patents

Derivados de tienopiridonas como activadores de proteina quinasa activa-dos por amp (ampk)

Info

Publication number
AR071530A1
AR071530A1 ARP090101562A ARP090101562A AR071530A1 AR 071530 A1 AR071530 A1 AR 071530A1 AR P090101562 A ARP090101562 A AR P090101562A AR P090101562 A ARP090101562 A AR P090101562A AR 071530 A1 AR071530 A1 AR 071530A1
Authority
AR
Argentina
Prior art keywords
denotes
het
formula
hal
atoms
Prior art date
Application number
ARP090101562A
Other languages
English (en)
Inventor
Franck Lepifre
Sophie Hallakou-Bozec
Daniel Cravo
Christine Charon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40756916&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071530(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR071530A1 publication Critical patent/AR071530A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

La invencion se refiere a compuestos de la formula (1) en donde R1 denota H, A, OA, OH, Hal, NO2, COOA, COOH, CHO, COA, CONH2, CONHA, CONA2, CN, SO2A, SO2NH2, Ar o Het, R2 denota Ar o Het, B1 denota Ar-diílo o Het-diílo, B2 denota Ar o Het, Ar denota fenilo, naftilo, cada uno de los cuales no está sustituido o está mono-, di-, tri-, tetra- o pentasustituido con A, Hal, OA, OH, CHO, COA, NH2, NHA, NA2, NO2, COOA, COOH, CONH2, CONA, CONA2, SO2A, CN, C(=NH)NH2, C(=NH)NHOH y/o Het, Het denota un heterociclo insaturado o aromático mono- o bicíclico que tiene de 1 a 4 átomos de N, O y/o S, que puede estar mono-, di- o trisustituido con Hal, A, OA, OH, CHO, COA, COOH, COOA, CN, NO2, NH2, NHA, NA2, CONH2, CONHA y/o CONA2, A denota alquilo no ramificado o ramificado que tiene 1-10 átomos de C, en los que 1-7 átomos de H pueden estar reemplazados por OH, F, Cl y/o Br, o denota cicloalquilo que tiene 3-7 átomos de C, Hal denota F, Cl, Br o I, y sus derivados, sales, solvatos y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Incluyendo sus composiciones farmacéuticas y su uso en el tratamiento y/o la prevencion de enfermedades y trastornos modulados por agonistas de AMP. La invencion también se refiere a intermediarios y a un método de preparacion de compuestos de la formula (1). Reivindicacion 12: Un compuesto de la formula (2) para preparar un compuesto de la formula 1 en donde R1, R2, B1 tienen los significados indicados en la reivindicacion 1, y X es un átomo de halogeno, y sus sales. Reivindicacion 13: Un compuesto de la formula (3) para preparar un compuesto de la formula 2 en donde R1, R2, B1 tienen los significados indicados en la reivindicacion 1, X es un átomo de halogeno, y ALK denota alquilo C1-6 y sus sales.
ARP090101562A 2008-05-05 2009-04-30 Derivados de tienopiridonas como activadores de proteina quinasa activa-dos por amp (ampk) AR071530A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290423 2008-05-05

Publications (1)

Publication Number Publication Date
AR071530A1 true AR071530A1 (es) 2010-06-23

Family

ID=40756916

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101562A AR071530A1 (es) 2008-05-05 2009-04-30 Derivados de tienopiridonas como activadores de proteina quinasa activa-dos por amp (ampk)

Country Status (27)

Country Link
US (1) US8604202B2 (es)
EP (1) EP2280952B1 (es)
JP (1) JP5536757B2 (es)
KR (2) KR20160038065A (es)
CN (1) CN102015676B (es)
AR (1) AR071530A1 (es)
AU (1) AU2009243811B2 (es)
BR (1) BRPI0910832B8 (es)
CA (1) CA2723429C (es)
CO (1) CO6331304A2 (es)
CY (1) CY1113112T1 (es)
DK (1) DK2280952T3 (es)
EA (1) EA020773B1 (es)
EC (1) ECSP10010654A (es)
ES (1) ES2388485T3 (es)
HK (1) HK1156313A1 (es)
HR (1) HRP20120549T1 (es)
IL (1) IL208988A (es)
MX (1) MX2010011916A (es)
MY (1) MY160357A (es)
NZ (1) NZ589690A (es)
PL (1) PL2280952T3 (es)
PT (1) PT2280952E (es)
SI (1) SI2280952T1 (es)
UA (1) UA103617C2 (es)
WO (1) WO2009135580A1 (es)
ZA (1) ZA201008722B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US20130085169A1 (en) 2010-04-02 2013-04-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2611801B1 (de) * 2010-09-01 2016-05-04 Bayer Intellectual Property GmbH Herbizid wirksame ketosultame und diketopyridine
JP2014507452A (ja) * 2011-03-07 2014-03-27 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー キノリン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2015103480A1 (en) 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
WO2015114663A1 (en) 2014-01-30 2015-08-06 Council Of Scientific & Industrial Research Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties
EP3310355B1 (en) 2015-06-16 2020-11-11 University of Virginia Patent Foundation Ptp4a3 inhibitor for the treatment of cancer
KR102614872B1 (ko) 2015-06-25 2023-12-15 유니버시티 헬스 네트워크 Hpk1 억제제 및 이의 사용 방법
EP3355876A2 (en) 2015-09-30 2018-08-08 Instituto de Medicina Molecular Methods for attenuating parasite virulence
US11584755B2 (en) 2017-09-26 2023-02-21 Ideaya Biosciences, Inc. Dihydrothieno[3,2-b]pyridine compounds
WO2019106087A1 (en) * 2017-11-29 2019-06-06 Syddansk Universitet Ampk inhibitors
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
WO2022072397A1 (en) 2020-09-30 2022-04-07 Bioverativ Therapeutics Inc. Ampk activators and methods of use thereof
WO2022106892A1 (en) 2020-11-17 2022-05-27 Instituto De Medicina Molecular Anti-malarial compounds

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
DE4444815A1 (de) * 1994-12-15 1996-06-20 Merck Patent Gmbh Thienopyridone
AR040123A1 (es) * 2002-05-31 2005-03-16 Upjohn Co Compuestos tiofeno, antihelminticos e insecticidas
US7119205B2 (en) * 2003-05-16 2006-10-10 Abbott Laboratories Thienopyridones as AMPK activators for the treatment of diabetes and obesity
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
US7563813B2 (en) * 2005-05-13 2009-07-21 Wyeth Iminothiazolidinone derivatives as SFRP-1 antagonists
EP1754483A1 (en) 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
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WO2009124636A1 (en) * 2008-04-11 2009-10-15 Merck Patent Gmbh Thienopyridone derivatives as amp-activated protein kinase (ampk) activators

Also Published As

Publication number Publication date
BRPI0910832B1 (pt) 2020-09-15
CY1113112T1 (el) 2016-04-13
PT2280952E (pt) 2012-09-28
HK1156313A1 (en) 2012-06-08
CA2723429A1 (en) 2009-11-12
ES2388485T3 (es) 2012-10-15
EP2280952A1 (en) 2011-02-09
CO6331304A2 (es) 2011-10-20
HRP20120549T1 (hr) 2012-07-31
DK2280952T3 (da) 2012-07-23
MY160357A (en) 2017-02-28
JP5536757B2 (ja) 2014-07-02
WO2009135580A1 (en) 2009-11-12
ECSP10010654A (es) 2011-01-31
US20110060001A1 (en) 2011-03-10
EA020773B1 (ru) 2015-01-30
KR101648593B1 (ko) 2016-08-16
ZA201008722B (en) 2012-01-25
IL208988A (en) 2016-02-29
SI2280952T1 (sl) 2012-09-28
KR20110010757A (ko) 2011-02-07
BRPI0910832A2 (pt) 2015-08-11
BRPI0910832A8 (pt) 2016-07-12
PL2280952T3 (pl) 2012-10-31
JP2011519876A (ja) 2011-07-14
CA2723429C (en) 2016-10-11
NZ589690A (en) 2012-07-27
CN102015676B (zh) 2014-05-28
MX2010011916A (es) 2010-11-26
US8604202B2 (en) 2013-12-10
UA103617C2 (ru) 2013-11-11
AU2009243811B2 (en) 2014-04-10
EP2280952B1 (en) 2012-06-27
KR20160038065A (ko) 2016-04-06
IL208988A0 (en) 2011-01-31
EA201001733A1 (ru) 2011-06-30
AU2009243811A1 (en) 2009-11-12
BRPI0910832B8 (pt) 2021-05-25
CN102015676A (zh) 2011-04-13

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