AR070949A1 - COMPOUNDS DERIVED FROM SULFAMATE FOR MEDICAL USE, MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, PROCEDURES TO PREPARE THESE COMPOUNDS AND THEIR USE - Google Patents

COMPOUNDS DERIVED FROM SULFAMATE FOR MEDICAL USE, MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, PROCEDURES TO PREPARE THESE COMPOUNDS AND THEIR USE

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Publication number
AR070949A1
AR070949A1 ARP080104465A ARP080104465A AR070949A1 AR 070949 A1 AR070949 A1 AR 070949A1 AR P080104465 A ARP080104465 A AR P080104465A AR P080104465 A ARP080104465 A AR P080104465A AR 070949 A1 AR070949 A1 AR 070949A1
Authority
AR
Argentina
Prior art keywords
bicyclo
hept
aryl
formula
group
Prior art date
Application number
ARP080104465A
Other languages
Spanish (es)
Inventor
Dania Reiche
Holger Sann
Jochen Antel
Peter-Colin Gregory
Harald Waldeck
Michael Wurl
Uwe Schon
Uwe Reinecker
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of AR070949A1 publication Critical patent/AR070949A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1), en la que R1 y R2 se seleccionan independientemente del grupo que consiste en: hidrogeno, alquilo, cicloalquilo y arilo, de los que alquilo y cicloalquilo están opcionalmente sustituidos con al menos un sustituyente Y, y de los que arilo está opcionalmente sustituido con al menos un sustituyente Z, o en donde R1 y R2 forman, juntos; un anillo de 5 o 6 miembros que puede contener, adicionalmente, 1 a 2 heteroátomos seleccionados independientemente del grupo consistente en: nitrogeno, oxígeno y azufre, y dicho anillo de 5 o 6 miembros está sustituido opcionalmente con al menos un sustituyente Y; R3 se selecciona del grupo consistente en: (1S,2S,5S)-6,6-dimetil-biciclo[3.1.1]hept-2-ilo; (1R,2R,5R)-6,6-dimetil-biciclo[3.1.1]hept-2-ilo; (1R,2S,5R)-6,6-dimetil-biciclo[3.1.1]hept-2-ilo; (1R,4S)-biciclo[2.2.1]hept-2-ilo; (1S,4R)-3-metil-biciclo[2.2.1]hept-2-ilo; biciclo[2.2.2]oct-5-en-2-ilo; (4S)-biciclo[2.2.1]hept-5-en-2-ilo; (1S,2R,4S)-1,7,7-trimetil-biciclo[2.2.1]hept-2-ilo; (1R,2S,4R)-1,7,7-trimetil-biciclo[2.2.1]hept-2-ilo; (1R,2R,4R)-1,7,7-trimetil-biciclo[2.2.1]hept-2-ilo y ciclohexilo; n es de 0 a 3; Y se selecciona del grupo consistente en: alquilo, alcoxi, tioalquilo, arilo, CO-arilo, heteroarilo, amino y carboxialquilo; Z se selecciona del grupo consistente en: alquilo, alcoxi, tioalquilo, halogeno, arilo, CO-arilo, CN, heteroarilo y carboxialquilo; y sus sales, hidratos y solvatos fisiologicamente aceptables. Reivindicacion 6: Un medicamento que comprende un compuesto segun una cualquiera de las reivindicaciones 1 a 5, o una sal, hidrato o solvato farmacéuticamente aceptable del mismo. Reivindicacion 7: Una composicion farmacéutica que comprende: A) una cantidad farmacologicamente eficaz de un compuesto de la formula (1), segun cualquiera de las reivindicaciones 1 a 5, o una sal, hidrato o solvato farmacéuticamente aceptable del mismo, como ingrediente activo; y B) opcionalmente, al menos un vehículo farmacéuticamente aceptable y/o al menos una sustancia auxiliar farmacéuticamente aceptable. Reivindicacion 10: Un procedimiento para preparar un compuesto de la formula (1) segun cualquiera de las reivindicaciones 1 a 5, caracterizado porque compuestos de la formula (2) en los que Hal significa un halogeno, seleccionado del grupo consistente en cloro, y bromo, preferiblemente cloro, se hacen reaccionar con un alcohol de la formula (3) para dar compuestos de la formula (1). Reivindicacion 13: El uso de un compuesto segun cualquiera de las reivindicaciones 1 a 5 o de sus sales, hidratos y solvatos fisiologicamente aceptables, como medicamento para mamíferos, preferiblemente humanos.Claim 1: A compound of formula (1), wherein R1 and R2 are independently selected from the group consisting of: hydrogen, alkyl, cycloalkyl and aryl, of which alkyl and cycloalkyl are optionally substituted with at least one substituent Y, and of which aryl is optionally substituted with at least one substituent Z, or where R1 and R2 form, together; a 5 or 6 member ring which may additionally contain 1 to 2 heteroatoms independently selected from the group consisting of: nitrogen, oxygen and sulfur, and said 5 or 6 member ring is optionally substituted with at least one Y substituent; R3 is selected from the group consisting of: (1S, 2S, 5S) -6,6-dimethyl-bicyclo [3.1.1] hept-2-yl; (1R, 2R, 5R) -6,6-dimethyl-bicyclo [3.1.1] hept-2-yl; (1R, 2S, 5R) -6,6-dimethyl-bicyclo [3.1.1] hept-2-yl; (1R, 4S) -bicyclo [2.2.1] hept-2-yl; (1S, 4R) -3-methyl-bicyclo [2.2.1] hept-2-yl; bicyclo [2.2.2] oct-5-en-2-yl; (4S) -bicyclo [2.2.1] hept-5-en-2-yl; (1S, 2R, 4S) -1,7,7-trimethyl-bicyclo [2.2.1] hept-2-yl; (1R, 2S, 4R) -1,7,7-trimethyl-bicyclo [2.2.1] hept-2-yl; (1R, 2R, 4R) -1,7,7-trimethyl-bicyclo [2.2.1] hept-2-yl and cyclohexyl; n is 0 to 3; And it is selected from the group consisting of: alkyl, alkoxy, thioalkyl, aryl, CO-aryl, heteroaryl, amino and carboxyalkyl; Z is selected from the group consisting of: alkyl, alkoxy, thioalkyl, halogen, aryl, CO-aryl, CN, heteroaryl and carboxyalkyl; and its physiologically acceptable salts, hydrates and solvates. Claim 6: A medicament comprising a compound according to any one of claims 1 to 5, or a pharmaceutically acceptable salt, hydrate or solvate thereof. Claim 7: A pharmaceutical composition comprising: A) a pharmacologically effective amount of a compound of the formula (1), according to any one of claims 1 to 5, or a pharmaceutically acceptable salt, hydrate or solvate thereof, as active ingredient; and B) optionally, at least one pharmaceutically acceptable carrier and / or at least one pharmaceutically acceptable auxiliary substance. Claim 10: A process for preparing a compound of the formula (1) according to any one of claims 1 to 5, characterized in that compounds of the formula (2) in which Hal means a halogen, selected from the group consisting of chlorine, and bromine , preferably chlorine, are reacted with an alcohol of the formula (3) to give compounds of the formula (1). Claim 13: The use of a compound according to any one of claims 1 to 5 or of its physiologically acceptable salts, hydrates and solvates, as a medicament for mammals, preferably humans.

ARP080104465A 2007-10-19 2008-10-14 COMPOUNDS DERIVED FROM SULFAMATE FOR MEDICAL USE, MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, PROCEDURES TO PREPARE THESE COMPOUNDS AND THEIR USE AR070949A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07118932 2007-10-19

Publications (1)

Publication Number Publication Date
AR070949A1 true AR070949A1 (en) 2010-05-19

Family

ID=39495891

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104465A AR070949A1 (en) 2007-10-19 2008-10-14 COMPOUNDS DERIVED FROM SULFAMATE FOR MEDICAL USE, MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, PROCEDURES TO PREPARE THESE COMPOUNDS AND THEIR USE

Country Status (10)

Country Link
EP (1) EP2207766A1 (en)
JP (1) JP2011500641A (en)
CN (1) CN101801921A (en)
AR (1) AR070949A1 (en)
AU (1) AU2008313663A1 (en)
CA (1) CA2700568A1 (en)
MX (1) MX2010002869A (en)
RU (1) RU2010119646A (en)
TW (1) TW200927090A (en)
WO (1) WO2009050252A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574782B (en) * 2009-10-21 2014-10-08 拜耳知识产权有限责任公司 Substituted halophenoxybenzamide derivatives
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
NZ702974A (en) * 2012-06-21 2016-03-31 Eisai R&D Man Co Ltd Novel indanesulfamide derivative
EP3769759B1 (en) 2018-03-20 2023-11-15 Eisai R&D Management Co., Ltd. Combination of an indanesulfamide derivative with perampanel for use in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives

Also Published As

Publication number Publication date
TW200927090A (en) 2009-07-01
CA2700568A1 (en) 2009-04-23
EP2207766A1 (en) 2010-07-21
AU2008313663A1 (en) 2009-04-23
CN101801921A (en) 2010-08-11
RU2010119646A (en) 2011-11-27
JP2011500641A (en) 2011-01-06
MX2010002869A (en) 2010-03-31
WO2009050252A1 (en) 2009-04-23

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