AR067896A1 - Procedimiento para sintetizar compuestos utiles para tratar hepatitis c - Google Patents

Procedimiento para sintetizar compuestos utiles para tratar hepatitis c

Info

Publication number
AR067896A1
AR067896A1 ARP080103487A ARP080103487A AR067896A1 AR 067896 A1 AR067896 A1 AR 067896A1 AR P080103487 A ARP080103487 A AR P080103487A AR P080103487 A ARP080103487 A AR P080103487A AR 067896 A1 AR067896 A1 AR 067896A1
Authority
AR
Argentina
Prior art keywords
ammonium
formula
alkyl
compound
independently selected
Prior art date
Application number
ARP080103487A
Other languages
English (en)
Inventor
Shawn K Pack
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067896(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR067896A1 publication Critical patent/AR067896A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Los compuestos obtenidos por el procedimiento descrito resultan utiles en el tratamiento de la hepatitis C. Reivindicacion 1: Un procedimiento caracterizado porque es para preparar un compuesto de formula (1) o una de sus sales farmacéuticamente aceptable; en la que n es 0, 1 o 2; s es 0, 1, 2, 3 o 4; u y v se selecciona cada uno independientemente de 0, 1. 2 o 3; X se selecciona de O, S, S(O), SO2, CH2, CHR5 y C(R5)2, con la condicion de que cuando n es o, X se selecciona de CH2, CHR5 y C(R5)2; R1 y R2 se selecciona cada uno independientemente de alcoxi, alquilo y halo; y cuando s es 2, 3 o 4, cada R5 en el anillo se selecciona independientemente de alcoxi, alquilo y arilo, donde el alquilo puede formar opcionalmente un anillo condensado de tres a seis miembros con un átomo de carbono adyacente, estando el anillo de tres a seis miembros opcionalmente sustituido con uno o dos grupos alquilo; con la condicion de que los dos anillos heterocíclicos que sustituyen los anillos imidazol son idénticos; comprendiendo el procedimiento: (a) hacer reaccionar un compuesto de formula (2) en la que u, v, R1 y R2 son como se describen para la formula (1); y LG es un grupo saliente; con un compuesto de formula (3) en la que PG es un grupo protector de nitrogeno; (b) tratar el producto de la etapa (a) con un reactivo seleccionado de acetato amonico, formiato amonico, sulfamato amonico, fosfato amonico, citrato amonico, carbamato amonico y amoníaco; y (c) tratar el producto de la etapa (b) con un agente de desproteccion.
ARP080103487A 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c AR067896A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
AR067896A1 true AR067896A1 (es) 2009-10-28

Family

ID=39865546

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP080103487A AR067896A1 (es) 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c
ARP160103748A AR106929A2 (es) 2007-08-08 2016-12-06 Procedimiento para sintetizar compuestos útiles para tratar hepatitis c

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP160103748A AR106929A2 (es) 2007-08-08 2016-12-06 Procedimiento para sintetizar compuestos útiles para tratar hepatitis c

Country Status (25)

Country Link
US (1) US7728027B2 (es)
EP (1) EP2178863B1 (es)
JP (2) JP5324574B2 (es)
KR (1) KR101528542B1 (es)
CN (1) CN101778841B (es)
AR (2) AR067896A1 (es)
AU (1) AU2008284097B2 (es)
BR (1) BRPI0815611B1 (es)
CA (1) CA2695711C (es)
CL (1) CL2008002355A1 (es)
CO (1) CO6251317A2 (es)
CY (1) CY1113547T1 (es)
DK (1) DK2178863T3 (es)
EA (1) EA017173B1 (es)
ES (1) ES2396267T3 (es)
HK (1) HK1137454A1 (es)
HR (1) HRP20120990T1 (es)
IL (1) IL203685A (es)
MX (1) MX2010001415A (es)
PE (1) PE20090611A1 (es)
PL (1) PL2178863T3 (es)
PT (1) PT2178863E (es)
SI (1) SI2178863T1 (es)
TW (1) TWI423963B (es)
WO (1) WO2009020825A1 (es)

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