AR065728A1 - Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergico - Google Patents
Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergicoInfo
- Publication number
- AR065728A1 AR065728A1 ARP080101040A ARP080101040A AR065728A1 AR 065728 A1 AR065728 A1 AR 065728A1 AR P080101040 A ARP080101040 A AR P080101040A AR P080101040 A ARP080101040 A AR P080101040A AR 065728 A1 AR065728 A1 AR 065728A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- disorder
- pain
- deuterium
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/64—Quaternary ammonium compounds having quaternised nitrogen atoms bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe la síntesis química y usos médicos de inhibidores novedosos de absorcion de neurotransmisores de monoamina y sus sales y prodrogas farmacéuticamente aceptables, para el tratamiento y/o manejo de trastornos psicotropicos, trastornos deansiedad, trastornos generalizados de ansiedad, depresion, trastornos post-traumáticos de estrés, trastorno obsesivo-compulsivo, trastornos por pánico, despedir calor, demencia senil, migrana, síndrome hepatopulmonar, dolor cronico, dolornociceptivo, dolor neuropático, retinopatía diabética dolorosa, depresion bipolar, apnea obstructiva del sueno, trastornos psiquiátricos, trastorno disforica premenstrual, fobia social, trastorno de ansiedad social, incontinencia urinaria, anorexia,bulimia nervosa, obesidad, isquemia, herida en la cabeza, sobrecarga de calcio en células cerebrales, dependencia de la droga, trastorno hiperactivo de déficit de atencion, fibromialgia, síndrome de colon irritable, y/o eyaculacion precoz. Reivindicacion 1: Un compuesto con formula (1) estructural o su sal, solvato o prodroga farmacéuticamente aceptable, en donde: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26,y R27 se seleccionan independientemente del grupo que consiste en hidrogeno y deuterio; y al menos uno de R11, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, y R27 es deuterio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89504907P | 2007-03-15 | 2007-03-15 | |
US94439907P | 2007-06-15 | 2007-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065728A1 true AR065728A1 (es) | 2009-06-24 |
Family
ID=39595792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101040A AR065728A1 (es) | 2007-03-15 | 2008-03-13 | Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergico |
Country Status (16)
Country | Link |
---|---|
US (4) | US20080234257A1 (es) |
EP (5) | EP3269706A1 (es) |
AR (1) | AR065728A1 (es) |
AU (1) | AU2008251773A1 (es) |
CA (1) | CA2680912C (es) |
CY (1) | CY1118174T1 (es) |
DK (1) | DK2125698T3 (es) |
ES (3) | ES2716048T3 (es) |
HR (1) | HRP20161581T1 (es) |
HU (1) | HUE031070T2 (es) |
LT (1) | LT2125698T (es) |
PL (1) | PL2125698T3 (es) |
PT (1) | PT2125698T (es) |
SI (1) | SI2125698T1 (es) |
TW (1) | TW200846305A (es) |
WO (1) | WO2008140859A1 (es) |
Families Citing this family (19)
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US20100076087A1 (en) * | 2005-10-06 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Methods of reduction of interpatient variability |
HUE027865T2 (en) | 2005-12-01 | 2016-11-28 | Auspex Pharmaceuticals Inc | Substituted phenyl ethylamines with serotonergic and / or norepinephrine activity |
TW200846305A (en) | 2007-03-15 | 2008-12-01 | Auspex Pharmaceuticals Inc | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity |
WO2010028130A2 (en) * | 2008-09-03 | 2010-03-11 | Concert Pharmaceuticals, Inc. | Antidepressant compounds |
ES2343050B1 (es) * | 2008-12-16 | 2011-06-14 | Chemo Iberica, S.A. | Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables. |
US8637577B2 (en) | 2009-01-22 | 2014-01-28 | Absorption Pharmaceuticals, LLC | Desensitizing drug product |
JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
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US8987327B1 (en) * | 2013-10-11 | 2015-03-24 | Eugene Lipov | Kits and methods for treating post traumatic stress disorder (PTSD) and hot flashes |
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US20170071975A1 (en) * | 2014-05-12 | 2017-03-16 | Steerwasher, Llc | Compositions and methods for treating depressive disorders |
US9592239B2 (en) | 2014-09-12 | 2017-03-14 | Demerx, Inc. | Methods and compositions for ibogaine treatment of impulse control disorder, anxiety-related disorders, violence and/or anger, or regulating food intake |
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CN110218157B (zh) * | 2018-03-01 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 一种r-***及其可药用盐的制备方法 |
CN108440315A (zh) * | 2018-03-12 | 2018-08-24 | 钦州学院 | 氘代o-去甲基文拉法辛及其制备方法和用途 |
CN115667217A (zh) | 2020-05-19 | 2023-01-31 | 赛本爱尔兰有限公司 | 氘化的色胺衍生物和使用方法 |
CN116500172B (zh) * | 2023-06-29 | 2023-09-05 | 成都普康唯新生物科技有限公司 | 一种酸性底物中胺类溶剂的检测方法 |
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-
2008
- 2008-03-13 TW TW097108816A patent/TW200846305A/zh unknown
- 2008-03-13 US US12/048,012 patent/US20080234257A1/en not_active Abandoned
- 2008-03-13 EP EP17169980.4A patent/EP3269706A1/en not_active Withdrawn
- 2008-03-13 EP EP16183223.3A patent/EP3130580A1/en not_active Withdrawn
- 2008-03-13 AR ARP080101040A patent/AR065728A1/es not_active Application Discontinuation
- 2008-03-13 ES ES12176584T patent/ES2716048T3/es active Active
- 2008-03-13 CA CA2680912A patent/CA2680912C/en active Active
- 2008-03-13 AU AU2008251773A patent/AU2008251773A1/en not_active Abandoned
- 2008-03-13 HU HUE08732084A patent/HUE031070T2/en unknown
- 2008-03-13 SI SI200831714A patent/SI2125698T1/sl unknown
- 2008-03-13 ES ES08732084.2T patent/ES2605371T3/es active Active
- 2008-03-13 ES ES16179352.6T patent/ES2693948T3/es active Active
- 2008-03-13 EP EP08732084.2A patent/EP2125698B1/en not_active Not-in-force
- 2008-03-13 EP EP12176584.6A patent/EP2514740B1/en not_active Not-in-force
- 2008-03-13 PL PL08732084T patent/PL2125698T3/pl unknown
- 2008-03-13 WO PCT/US2008/056780 patent/WO2008140859A1/en active Application Filing
- 2008-03-13 LT LTEP08732084.2T patent/LT2125698T/lt unknown
- 2008-03-13 DK DK08732084.2T patent/DK2125698T3/en active
- 2008-03-13 PT PT87320842T patent/PT2125698T/pt unknown
- 2008-03-13 EP EP16179352.6A patent/EP3103790B1/en not_active Not-in-force
-
2014
- 2014-12-03 US US14/559,520 patent/US10421710B2/en active Active
-
2016
- 2016-10-31 CY CY20161101104T patent/CY1118174T1/el unknown
- 2016-11-28 HR HRP20161581TT patent/HRP20161581T1/hr unknown
-
2019
- 2019-09-10 US US16/566,197 patent/US20200172469A1/en not_active Abandoned
-
2020
- 2020-08-21 US US16/999,367 patent/US20210101863A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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AU2008251773A1 (en) | 2008-11-20 |
WO2008140859A1 (en) | 2008-11-20 |
US20210101863A1 (en) | 2021-04-08 |
PL2125698T3 (pl) | 2017-03-31 |
US20200172469A1 (en) | 2020-06-04 |
SI2125698T1 (sl) | 2016-12-30 |
HUE031070T2 (en) | 2017-06-28 |
EP2125698A1 (en) | 2009-12-02 |
TW200846305A (en) | 2008-12-01 |
ES2716048T3 (es) | 2019-06-07 |
EP2514740B1 (en) | 2018-12-19 |
CA2680912C (en) | 2017-11-14 |
EP3103790A1 (en) | 2016-12-14 |
US20150152042A1 (en) | 2015-06-04 |
US10421710B2 (en) | 2019-09-24 |
CA2680912A1 (en) | 2008-11-20 |
US20080234257A1 (en) | 2008-09-25 |
EP2125698B1 (en) | 2016-08-31 |
PT2125698T (pt) | 2016-12-12 |
EP3130580A1 (en) | 2017-02-15 |
CY1118174T1 (el) | 2017-06-28 |
LT2125698T (lt) | 2016-10-10 |
EP3103790B1 (en) | 2018-05-09 |
ES2693948T3 (es) | 2018-12-14 |
ES2605371T3 (es) | 2017-03-14 |
EP2514740A1 (en) | 2012-10-24 |
DK2125698T3 (en) | 2016-11-07 |
EP3269706A1 (en) | 2018-01-17 |
HRP20161581T1 (hr) | 2016-12-30 |
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