AR061761A1 - Moduladores tiazolopirimidina de trpv1 - Google Patents
Moduladores tiazolopirimidina de trpv1Info
- Publication number
- AR061761A1 AR061761A1 ARP070102936A ARP070102936A AR061761A1 AR 061761 A1 AR061761 A1 AR 061761A1 AR P070102936 A ARP070102936 A AR P070102936A AR P070102936 A ARP070102936 A AR P070102936A AR 061761 A1 AR061761 A1 AR 061761A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- halo
- substituted
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen ciertos compuestos de tiazolopirimidina, los cuales son utiles como moduladores de TRPV1. Dichos compuestos se pueden usar en composiciones farmacéuticas y métodos para el tratamiento de estados patologicos, trastornos y afecciones mediadas por TRPV1, tales como dolor, artritis, prurito, tos asma o enfermedad de intestino inflamatoria. Reivindicacion 1: Una entidad química seleccionada de (a) compuestos de Formula (1): donde: R1 es -H; -NRaRb; un grupo -alquiloC1-6, - OalquiloC1-6, -S-alquiloC1-6 o -SO2-alquiloC1-6 no sustituido o sustituido con un sustituyente -OH, -OalquiloC1-4, -NReRf o halo; o un grupo cicloalquilo o fenilo monocíclico no sustituido o sustituido con un sustituyente -alquiloC1-6, -OH, - OalquiloC1-4, -NReRf o halo; donde Ra y Rb son cada uno independientemente -H; -alquiloC1-6; un grupo -alquiloC2-3 sustituido con un sustituyente -OH, -OalquiloC1-4, -NRcRd o halo; o un grupo cicloalquilo monocíclico saturado, -alquilC1- (cicloalquilo monocíclico saturado), heterocicloalquilo monocíclico saturado, -alquilC1-(heterocicloalquilo monocíclico saturado), fenilo o bencilo no sustituido o sustituido con uno, dos o tres restos seleccionados independientemente del grupo que consiste en sustituyentes -alquiloC1-6, -OH, -OalquiloC1-4, -NRpRq y halo; o Ra y Rb, tomados junto con el nitrogeno de union en -NRaRb, forman un grupo heterocicloalquilo monocíclico saturado no sustituido o sustituido con uno, dos o tres restos seleccionados independientemente del grupo que consiste en sustituyentes -alquiloC1-6, -OH, -OalquiloC1-4, -NRpRq, halo, -CO2H y bencilo; donde Rc y rd son cada uno independientemente -H o -alquiloC1-6; o Rc y Rd, tomados junto con el nitrogeno de union en -NRcRd, forman un heterocicloalquilo monocíclico saturado; donde Rp y Rq son cada uno independientemente -H o -alquiloC1-6; o Rp y Rq, tomados junto con el nitrogeno de union en -NRpRq, forman un heterocicloalquilo monocíclico saturado; donde Re y rf son cada uno independientemente -H o -alquiloC1-6; o Re y Rf, tomados junto con su nitrogeno de union en -NReRf, forman un heterocicloalquilo monocíclico saturado; R2 es -H o -alquiloC1-6; R3 es un grupo cicloalquilo monocíclico, fenilo, bencilo, fenetilo, indanilo, heteroarilo monocíclico de cinco miembros, heteroarilo monocíclico de seis miembros o -alquilC1-(heteroarilo monocíclico) no sustituido o sustituido con uno, dos o tres sustituyentes rg; donde cada sustituyente Rg es -alquiloC1-6, -OH, -OalquiloC1-6, fenoxi, -CN, -NO2, -N(Rh)Ri, -C(O)N(Rh)Ri, -N(Rh)C(O)Ri, -N(Rh)SO2alquiloC1-6, -C(O)alquiloC1-6, -S(O)0-2-alquiloC1-6, -SO2CF3, -SO2N(Rh)Ri, -SCF3, halo, -CF3, -OCF3, -CO2H, -CO2alquiloC1-6, -C(Rj)2-OH; o dos sustituyentes Rg adyacentes tomados juntos forman -OalquilC1-2O-, -alquilC2-6O- o -alquilC2-6N(Rh)-; donde Rh y Ri son cada uno independientemente -H o -alquiloC1-6; donde cada Rj es independientemente -H o alquiloC1-6; R4 es -H o -alquiloC1-6; y R5 es un grupo fenilo, heteroarilo monocíclico de cinco miembros o heteroarilo monocíclico de seis miembros no sustituido o sustituido con uno, dos o tres sustituyentes Rk; donde cada sustituyente Rk es independientemente -alquiloC1-6, -OH, -OalquiloC1- 6, fenilo, fenoxi, -CN, -NO2, -N(Rl)Rm, -C(O)N(Rl)Rm, -N(Rl)C(O)Rm, -N(Rl)SO2alquiloC1-6, -N(Rl)SO2CF3, -C(O)alquiloC1-6, -S(O)0-2-alquiloC1-6, -SO2CF3, -SO2N(Rl)Rm, -SCF3, halo, -CF3, -OCF3, -CO2H o -CO2alquiloC1-6; o dos sustituyentes Rk adyacentes tomados juntos forman -OalquilC1-2O-; donde Rl y Rm son cada uno independientemente -H o -alquiloC1-6; y (b) sales farmacéuticamente aceptables de los compuestos de Formula 1, profármacos farmacéuticamente aceptables de los compuestos de Formula 1 y metabolitos farmacéuticamente activos de los compuestos de Formula 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81815306P | 2006-06-30 | 2006-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061761A1 true AR061761A1 (es) | 2008-09-17 |
Family
ID=38740251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102936A AR061761A1 (es) | 2006-06-30 | 2007-06-29 | Moduladores tiazolopirimidina de trpv1 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080004253A1 (es) |
EP (1) | EP2044086A2 (es) |
AR (1) | AR061761A1 (es) |
CL (1) | CL2007001921A1 (es) |
PE (1) | PE20080348A1 (es) |
TW (1) | TW200821320A (es) |
UY (1) | UY30454A1 (es) |
WO (1) | WO2008005303A2 (es) |
Families Citing this family (46)
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EP3536687B8 (en) * | 2007-11-28 | 2021-09-08 | Dana-Farber Cancer Institute, Inc. | Small molecule myristate inhibitors of bcr-abl and methods of use |
WO2009079000A1 (en) * | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolopyrimidine modulators of trpv1 |
CL2008003749A1 (es) * | 2007-12-17 | 2010-01-15 | Janssen Pharmaceutica Nv | Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras. |
JP5749017B2 (ja) | 2008-01-22 | 2015-07-15 | ダウ アグロサイエンシィズ エルエルシー | 5−フルオロピリミジン誘導体 |
MX2011008450A (es) * | 2009-02-10 | 2011-09-01 | Abbott Lab | Agonistas y antagonistas del receptor s1p5, y metodos de uso de los mismos. |
EP2405973B1 (en) | 2009-03-13 | 2015-04-22 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Thiazolopyrimidine modulators as immunosuppressive agents |
PL2448938T3 (pl) | 2009-06-29 | 2014-11-28 | Incyte Holdings Corp | Pirymidynony jako inhibitory PI3K |
UA112284C2 (uk) * | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
KR101743791B1 (ko) | 2009-08-07 | 2017-06-05 | 다우 아그로사이언시즈 엘엘씨 | N1-술포닐-5-플루오로피리미디논 유도체 |
UA106889C2 (uk) * | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
UA107671C2 (en) * | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
CA2786250A1 (en) | 2010-01-07 | 2011-07-14 | Dow Agrosciences Llc | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals |
EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PT2775842T (pt) | 2011-08-17 | 2017-11-15 | Adama Makhteshim Ltd | Derivados 1-substituídos de 5-fluoro-3,6-dihidro-6-imino-2(1h)-pirimidinona como agentes fungicidas para utilização na proteção de plantas |
KR102131612B1 (ko) | 2011-09-02 | 2020-07-08 | 인사이트 홀딩스 코포레이션 | Pi3k 억제제로서 헤테로시클릴아민 |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
KR20150100869A (ko) | 2012-12-28 | 2015-09-02 | 다우 아그로사이언시즈 엘엘씨 | N-(치환된)-5-플루오로-4-이미노-3-메틸-2-옥소-3,4-디히드로피리미딘-1(2h)-카르복스아미드 유도체 |
WO2014105844A1 (en) | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxylate derivatives |
UA117123C2 (uk) | 2012-12-28 | 2018-06-25 | Адама Махтешім Лтд. | Похідні 1-(заміщений бензоїл)-5-фтор-4-іміно-3-метил-3,4-дигідропіримідин-2(1h)-ону |
WO2014105845A1 (en) | 2012-12-31 | 2014-07-03 | Dow Agrosciences Llc | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1h)-one derivatives as fungicides |
WO2015048281A1 (en) | 2013-09-27 | 2015-04-02 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
CN103694243B (zh) * | 2013-12-20 | 2015-09-09 | 中国农业大学 | 2-取代吡啶基-1,2,4-***并[1,2-a]哒嗪化合物 |
NZ722439A (en) | 2013-12-31 | 2018-01-26 | Adama Makhteshim Ltd | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1- (arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
CN106061262A (zh) | 2013-12-31 | 2016-10-26 | 阿达玛马克西姆股份有限公司 | 用防治谷类中真菌的协同杀真菌混合物 |
DK3119397T3 (da) | 2014-03-19 | 2022-03-28 | Infinity Pharmaceuticals Inc | Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser |
WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
MA41607B1 (fr) | 2015-02-27 | 2021-01-29 | Incyte Corp | Sels d'un inhibiteur de pi3k et procédés de préparation de ces sels |
WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
AU2016322552B2 (en) | 2015-09-14 | 2021-03-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
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CN111187181B (zh) * | 2019-11-22 | 2023-05-05 | 吉林大学 | 一种2-(4-氨基苯基)-2-甲基丙腈化合物的制备方法 |
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US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
ATE399766T1 (de) * | 2000-10-20 | 2008-07-15 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische heterozyklen |
MXPA05008309A (es) * | 2003-02-10 | 2005-09-20 | Amgen Inc | Ligandos de receptor vaniloide y su uso en tratamientos. |
AU2004263515A1 (en) * | 2003-08-05 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Condensed pyrimidine compounds as inhibitors of voltage-gated ion channels |
AU2004270740A1 (en) * | 2003-09-09 | 2005-03-17 | Neurogen Corporation | 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists |
AU2004278382B2 (en) * | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
AU2004278276B2 (en) * | 2003-10-07 | 2007-10-18 | Astrazeneca Ab | New 2-substituted, 4-amino-thiazolo(4,5-d) pyrimidines, useful as chemokine receptor antagonists, esp. CX3CR1 |
JP5305905B2 (ja) * | 2005-08-08 | 2013-10-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チアゾロピリミジンキナーゼ阻害剤 |
-
2007
- 2007-06-28 EP EP07810020A patent/EP2044086A2/en not_active Withdrawn
- 2007-06-28 WO PCT/US2007/015079 patent/WO2008005303A2/en active Application Filing
- 2007-06-28 US US11/824,202 patent/US20080004253A1/en not_active Abandoned
- 2007-06-29 CL CL200701921A patent/CL2007001921A1/es unknown
- 2007-06-29 AR ARP070102936A patent/AR061761A1/es unknown
- 2007-06-29 TW TW096123615A patent/TW200821320A/zh unknown
- 2007-07-02 UY UY30454A patent/UY30454A1/es unknown
- 2007-07-02 PE PE2007000838A patent/PE20080348A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20080004253A1 (en) | 2008-01-03 |
EP2044086A2 (en) | 2009-04-08 |
WO2008005303A2 (en) | 2008-01-10 |
PE20080348A1 (es) | 2008-04-25 |
TW200821320A (en) | 2008-05-16 |
CL2007001921A1 (es) | 2008-03-14 |
UY30454A1 (es) | 2008-01-31 |
WO2008005303A3 (en) | 2008-04-10 |
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