AR060990A1 - Acidos carboxilicos sustituidos con fenilaminobenzoxazol y composiciones farmaceuticas que los contienen, utilizadas para el tratamiento de la diabetes - Google Patents
Acidos carboxilicos sustituidos con fenilaminobenzoxazol y composiciones farmaceuticas que los contienen, utilizadas para el tratamiento de la diabetesInfo
- Publication number
- AR060990A1 AR060990A1 ARP070102008A ARP070102008A AR060990A1 AR 060990 A1 AR060990 A1 AR 060990A1 AR P070102008 A ARP070102008 A AR P070102008A AR P070102008 A ARP070102008 A AR P070102008A AR 060990 A1 AR060990 A1 AR 060990A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- alkylene
- alkenylene
- diabetes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos son adecuados para el tratamiento de la diabetes. Reivindicacion 1: Un compuesto de la formula (1) en la que: R1 es H o alquilo C1-6; R6, R7, R8, R9, R10 son, independientemente unos de otros, H, F, Cl, Br, CN, CF3, OH, OCF3, OCHF2, SCH3, SCF3, fenilo, O-fenilo, COOH, COO-alquilo C1-6, CO-alquilo C1-6, alquilo C1-6, O-alquilo C1-6, OBn, SO3H, SO2NR3R4, NR3R4 o SO2-N-piperidinilo, donde alquilo y fenilo pueden estar sustituidos una o más veces con R2, y donde en cada caso dos de los radicales R6, R7, R8, R9, R10, en posicion adyacente en el anillo fenilo pueden formar juntos un radical -O-CH2-O-, -O-(CH2)2-O- o -CH=CH-CH=CH-; m es 0, 1, 2 o 3; enlace X es alquileno C2-10, cicloalquilo C3-12, alquilen C1-8-cicloalquil C3-12- alquileno C1-8, alquilen C1-8-cicloalquilo C3-12, cicloalquil C3-12-alquileno C1-8, alquenilen C2-8-cicloalquil C3-12-alquileno C1-8, alquilen C1-8-cicloalquil C3-12-alquenileno C2-8, alquenilen C2-8-cicloalquilo C3-12, cicloalquil C3-12-alquenileno C2-8, alquenileno C2-10 o alquinileno C2-10, en los que alquileno, cicloalquilo, alquenileno y alquinileno pueden estar sustituidos una o más veces con R5; R2 es OH, F, Cl, Br, CN, OCH3, OCF3, CH3, CF3, alquilo C1-6 o O-alquilo C1-6, en los que el alquilo puede estar sustituido una o más veces con OH, F, Cl, Br o CN; R3, R4 son, independientemente uno del otro, H o alquilo C1-6, donde el alquilo puede estar sustituido una o más veces con OH, F, Cl o Br; R5 es NH2, NH-alquilo C1-4, N[alquilo C1-4]2, F, Cl, Br, CN, OH, O-alquilo C1-6, alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; y sus sales fisiologicamente toleradas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006021878A DE102006021878A1 (de) | 2006-05-11 | 2006-05-11 | Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060990A1 true AR060990A1 (es) | 2008-07-30 |
Family
ID=38371048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102008A AR060990A1 (es) | 2006-05-11 | 2007-05-09 | Acidos carboxilicos sustituidos con fenilaminobenzoxazol y composiciones farmaceuticas que los contienen, utilizadas para el tratamiento de la diabetes |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20090149519A1 (es) |
| EP (1) | EP2024347B1 (es) |
| JP (1) | JP2009536629A (es) |
| KR (1) | KR20090006846A (es) |
| CN (1) | CN101437805B (es) |
| AR (1) | AR060990A1 (es) |
| AU (1) | AU2007250213B2 (es) |
| BR (1) | BRPI0711448A2 (es) |
| CA (1) | CA2651660A1 (es) |
| CO (1) | CO6241107A2 (es) |
| CY (1) | CY1113177T1 (es) |
| DE (1) | DE102006021878A1 (es) |
| DK (1) | DK2024347T3 (es) |
| ES (1) | ES2391203T3 (es) |
| HK (1) | HK1131978A1 (es) |
| HR (1) | HRP20120829T1 (es) |
| IL (1) | IL195179A0 (es) |
| MA (1) | MA30402B1 (es) |
| MX (1) | MX2008014102A (es) |
| MY (1) | MY148258A (es) |
| NO (1) | NO20085068L (es) |
| NZ (1) | NZ572692A (es) |
| PL (1) | PL2024347T3 (es) |
| PT (1) | PT2024347E (es) |
| RS (1) | RS52450B (es) |
| RU (1) | RU2434003C2 (es) |
| SI (1) | SI2024347T1 (es) |
| TW (1) | TW200812987A (es) |
| UY (1) | UY30338A1 (es) |
| WO (1) | WO2007131622A1 (es) |
| ZA (1) | ZA200808490B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| WO2007033002A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| WO2008030520A1 (en) | 2006-09-07 | 2008-03-13 | Amgen Inc. | Heterocyclic gpr40 modulators |
| US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009048527A1 (en) | 2007-10-10 | 2009-04-16 | Amgen Inc. | Substituted biphenyl gpr40 modulators |
| WO2009145829A1 (en) | 2008-04-01 | 2009-12-03 | University Of Massachusetts | Type iii secretion inhibitors, analogs and uses thereof |
| JP2011515341A (ja) | 2008-03-06 | 2011-05-19 | アムジエン・インコーポレーテツド | 代謝障害の治療に有用な立体配座的に制限されたカルボン酸誘導体 |
| AU2009303475B2 (en) | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| JP2013538215A (ja) | 2010-08-31 | 2013-10-10 | エスエヌユー アールアンドディービー ファウンデーション | ＰＰＡＲδアゴニストの胎児再プログラミング用途 |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| TW201317229A (zh) * | 2011-09-14 | 2013-05-01 | Daiichi Sankyo Co Ltd | 稠合雜環衍生物 |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| WO2015084692A1 (en) | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
| MX2020008404A (es) | 2018-02-13 | 2020-09-25 | Gilead Sciences Inc | Inhibidores de molecula de muerte programada 1 (pd-1)/ligando de molecula de muerte programada 1 (pd-l1). |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| AU2019301811B2 (en) | 2018-07-13 | 2022-05-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| EP3908278A4 (en) | 2019-01-11 | 2022-09-28 | Naegis Pharmaceuticals Inc. | LEUCOTRIENE SYNTHESIS INHIBITORS |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1491863A (en) * | 1973-10-23 | 1977-11-16 | Lilly Industries Ltd | 2,5-or 2,6-disubstituted benzoxazoles |
| US4025637A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
| US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| EP0664792B1 (en) * | 1992-10-14 | 2000-01-05 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
| ATE244717T1 (de) * | 1997-03-14 | 2003-07-15 | Vertex Pharma | Inhibitoren des impdh-enzyms |
| AU5052199A (en) * | 1998-07-23 | 2000-02-14 | Astrazeneca Ab | Chemical compounds |
| DK1153017T3 (da) * | 1999-02-16 | 2006-07-17 | Aventis Pharma Ltd | Bicykliske forbindelser og deres anvendelse som integrinreceptorligander |
| GB0001346D0 (en) * | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
| EP1330432A2 (en) * | 2000-11-04 | 2003-07-30 | Aventis Pharma Limited | Substituted alkanoic acids |
| ATE524441T1 (de) * | 2000-12-28 | 2011-09-15 | Daiichi Seiyaku Co | Vla-4-inhibitoren |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| GB0401334D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| JP2006056830A (ja) * | 2004-08-20 | 2006-03-02 | Dai Ichi Seiyaku Co Ltd | ２−アリールアミノベンゾオキサゾール誘導体 |
-
2006
- 2006-05-11 DE DE102006021878A patent/DE102006021878A1/de not_active Withdrawn
-
2007
- 2007-04-30 JP JP2009508193A patent/JP2009536629A/ja active Pending
- 2007-04-30 SI SI200731028T patent/SI2024347T1/sl unknown
- 2007-04-30 EP EP07724733A patent/EP2024347B1/de active Active
- 2007-04-30 CN CN2007800162659A patent/CN101437805B/zh not_active Expired - Fee Related
- 2007-04-30 CA CA002651660A patent/CA2651660A1/en not_active Abandoned
- 2007-04-30 MY MYPI20084472A patent/MY148258A/en unknown
- 2007-04-30 WO PCT/EP2007/003806 patent/WO2007131622A1/de active Application Filing
- 2007-04-30 NZ NZ572692A patent/NZ572692A/en not_active IP Right Cessation
- 2007-04-30 PT PT07724733T patent/PT2024347E/pt unknown
- 2007-04-30 RS RS20120395A patent/RS52450B/en unknown
- 2007-04-30 AU AU2007250213A patent/AU2007250213B2/en not_active Expired - Fee Related
- 2007-04-30 PL PL07724733T patent/PL2024347T3/pl unknown
- 2007-04-30 MX MX2008014102A patent/MX2008014102A/es active IP Right Grant
- 2007-04-30 DK DK07724733.6T patent/DK2024347T3/da active
- 2007-04-30 ES ES07724733T patent/ES2391203T3/es active Active
- 2007-04-30 BR BRPI0711448-6A patent/BRPI0711448A2/pt not_active IP Right Cessation
- 2007-04-30 KR KR1020087027644A patent/KR20090006846A/ko not_active Application Discontinuation
- 2007-04-30 RU RU2008148838/04A patent/RU2434003C2/ru not_active IP Right Cessation
- 2007-05-09 AR ARP070102008A patent/AR060990A1/es not_active Application Discontinuation
- 2007-05-09 TW TW096116362A patent/TW200812987A/zh unknown
- 2007-05-10 UY UY30338A patent/UY30338A1/es not_active Application Discontinuation
-
2008
- 2008-10-06 ZA ZA200808490A patent/ZA200808490B/xx unknown
- 2008-10-30 CO CO08116211A patent/CO6241107A2/es not_active Application Discontinuation
- 2008-11-05 MA MA31362A patent/MA30402B1/fr unknown
- 2008-11-09 IL IL195179A patent/IL195179A0/en unknown
- 2008-11-10 US US12/267,896 patent/US20090149519A1/en not_active Abandoned
- 2008-12-04 NO NO20085068A patent/NO20085068L/no not_active Application Discontinuation
-
2009
- 2009-10-28 HK HK09110016.0A patent/HK1131978A1/xx not_active IP Right Cessation
-
2012
- 2012-10-12 CY CY20121100941T patent/CY1113177T1/el unknown
- 2012-10-15 HR HRP20120829TT patent/HRP20120829T1/hr unknown
-
2013
- 2013-07-10 US US13/938,627 patent/US8748465B2/en not_active Expired - Fee Related
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