AR060957A1 - Derivados de tiazolo-pirimidina / piridina-urea - Google Patents
Derivados de tiazolo-pirimidina / piridina-ureaInfo
- Publication number
- AR060957A1 AR060957A1 ARP070102114A ARP070102114A AR060957A1 AR 060957 A1 AR060957 A1 AR 060957A1 AR P070102114 A ARP070102114 A AR P070102114A AR P070102114 A ARP070102114 A AR P070102114A AR 060957 A1 AR060957 A1 AR 060957A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aroyl
- arylsulfonyl
- aryl
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la presente son antagonistas activos del receptor de adenosina A2B y son utiles para el tratamiento de la diabetes, la retinopatía diabética, el asma y la diarrea. Reivindicacion 1: Un compuesto de la formula (1) en la que X es C o N, R1 es alcoxi C1-4, R2 es hidrogeno, hidroxi, alcoxi C1-2 o alquiltio C1-2, R3 es hidrogeno o alquilo C1-3, R4 es alquilo C1-4 sustituido con arilo, aroílo, ariloxi, arilsulfonilo, aralquilamino, o aroílamino, o R3 y R4 junto con el nitrogeno de urea al que están unidos forman un anillo heterocíclico de 5 o 6 eslabones de la formula (2) en la que R3 y R4 son ambos CH2 o uno es CH2 y el otro es un metileno monosustituido con un alquilo inferior, Ya es un segmento alquilo saturado o parcialmente insaturado de 2 a 3 carbonos del anillo que tiene un sustituyente aromático elegido entre el grupo formado por arilo, aralquilo, aralquiloxi, aroílo, ariloxi, arilsulfonilo, aralquilamino, ariloxialquilo, ariloxialquilamino y aroilamino, e Ya puede tener además 0, 1 o 2 sustituyentes no aromáticos elegidos entre hidroxi, amino, alquilamino inferior, alcanoilamino inferior, oxo, ciano, carboxi, hidroxialquilamino, carbamoílo y (alquilo inferior)carbamoílo, o R3 y R4 junto con el nitrogeno de urea al que están unidos forman un anillo heterocíclico de 5 o 6 eslabones de la formula (3) en la que R3 y R4 son ambos CH2 o uno es CH2 y el otro es un metileno monosustituido con un alquilo inferior, Yh es un segmento heteroalquilo saturado de 2 o 3 átomos del anillo, uno de los cuales es un heteroátomo e Yh está sustituido con un grupo aromático, que en el caso de un átomo de carbono del anillo se elige entre el grupo formado por arilo, aralquilo, aroílo, ariloxi, arilsulfonilo, aralquilamino, ariloxialquilo, ariloxialquilamino y aroilamino o, en el caso de nitrogeno, se elige entre el grupo formado por arilo, aralquilo, aroílo, arilhidroximetilalquilo, arilcarboximetilalquilo, arilalcoximetilalquilo, arilsulfonilo, ariloxialquilo, arilaminoalquilo y aroilaminoalquilo, o R3 y R4 junto con el nitrogeno de urea al que están unidos forman un piperidinilo o pirrolidinilo, que está benzo-fusionado con un fenilo sin sustituir o mono-, di- o tri-sustituido, o R3 y R4 junto con el nitrogeno de urea al que están unidos forman un piperidinilo, que está espiro-fusionado con un anillo heterocíclico saturado de 5 o 6 eslabones que contiene 1 o 2 heteroátomos, dicho anillo heterocíclico está unido o benzo-fusionado con un fenilo sin sustituir o mono-, di- o tri-sustituido y dicho anillo heterocíclico puede tener además 0, 1 o 2 sustituyentes no aromáticos elegidos entre alquilo inferior, acilo y alquilsulfonilo inferior, o R3 y R4 junto con el nitrogeno de urea al que están unidos forman un 2,5-diaza- [2.2.1]-bicicloheptano sustituido en posicion 5 o un 2,5-diaza-[3.3.0]-biciclooctano sustituido en posicion 5, dicho sustituyente de la posicion 5 se elige entre el grupo formado por arilo, aralquilo, aroílo, arilsulfonilo, ariloxialquilo y arilhidroximetilalquilo, arilcarboximetilalquilo, arilalcoximetilalquilo, o las sales o ésteres farmacéuticamente aceptables del mismo. Reivindicacion 47: El uso de antagonistas del receptor de A2B segun una cualquiera de las reivindicaciones 1- 44 para la fabricacion de medicamentos destinados al tratamiento terapéutico y/o profiláctico de la diabetes de tipo 2, la retinopatía diabética, el asma, las enfermedades broncoespásticas y alérgicas, los trastornos inflamatorios del tracto gastrointestinal y la diarrea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80148106P | 2006-05-18 | 2006-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060957A1 true AR060957A1 (es) | 2008-07-23 |
Family
ID=38308768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102114A AR060957A1 (es) | 2006-05-18 | 2007-05-16 | Derivados de tiazolo-pirimidina / piridina-urea |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7947692B2 (es) |
| EP (1) | EP2027132B1 (es) |
| JP (1) | JP5026511B2 (es) |
| KR (1) | KR101077295B1 (es) |
| CN (1) | CN101448844B (es) |
| AR (1) | AR060957A1 (es) |
| AT (1) | ATE481409T1 (es) |
| AU (1) | AU2007253485B2 (es) |
| BR (1) | BRPI0712516A2 (es) |
| CA (1) | CA2651769C (es) |
| CL (1) | CL2007001380A1 (es) |
| DE (1) | DE602007009221D1 (es) |
| ES (1) | ES2350013T3 (es) |
| IL (1) | IL195006A0 (es) |
| MX (1) | MX2008014690A (es) |
| TW (1) | TW200813073A (es) |
| WO (1) | WO2007134958A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2937341B1 (en) | 2004-12-30 | 2017-07-05 | Janssen Pharmaceutica N.V. | 4-(benzyl)-piperazine-1-carboxylic acid phenylamide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions |
| CN101686979A (zh) * | 2007-05-25 | 2010-03-31 | 詹森药业有限公司 | 脂肪酸酰胺水解酶的杂芳基取代的脲调节剂 |
| EP2178534A4 (en) * | 2007-07-17 | 2011-03-30 | Merck Sharp & Dohme | SOLUBLE EPOXY HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND PROCESSING METHODS |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8288397B2 (en) * | 2007-12-17 | 2012-10-16 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
| EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| ES2665277T3 (es) | 2009-03-13 | 2018-04-25 | Katholieke Universiteit Leuven K.U. Leuven R&D | Análogos de purina y su uso como agentes inmunosupresores |
| WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| US8901111B2 (en) | 2009-06-05 | 2014-12-02 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
| MX2012001064A (es) * | 2009-07-24 | 2012-07-17 | Univ Vanderbilt | Inhibidores de la fosfolipasa d selectivos de isoforma. |
| JPWO2011078369A1 (ja) * | 2009-12-25 | 2013-05-09 | 持田製薬株式会社 | 新規アリールウレア誘導体 |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| TW201238950A (en) | 2010-11-15 | 2012-10-01 | Abbott Lab | NAMPT and rock inhibitors |
| WO2012067963A1 (en) * | 2010-11-15 | 2012-05-24 | Abbott Laboratories | Nampt inhibitors |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
| US9453017B2 (en) | 2011-09-30 | 2016-09-27 | Vanderbilt University | Antiviral therapies with phospholipase D inhibitors |
| WO2013129973A1 (ru) * | 2012-03-01 | 2013-09-06 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
| RU2504541C1 (ru) * | 2012-12-26 | 2014-01-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция для местного применения |
| RU2475481C1 (ru) * | 2012-03-01 | 2013-02-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
| EP2968304B1 (en) | 2013-03-14 | 2018-10-10 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| WO2014151959A1 (en) * | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| CN105793267B (zh) * | 2013-10-07 | 2018-02-06 | 拜耳制药股份公司 | 环状噻吩并尿嘧啶甲酰胺类及其用途 |
| DK3137168T3 (da) | 2014-04-30 | 2022-03-21 | Univ Columbia | Substituerede 4-phenylpiperidiner, deres fremstilling og anvendelse |
| KR102296703B1 (ko) | 2017-03-20 | 2021-09-01 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물 |
| SI3661941T1 (sl) * | 2017-08-01 | 2023-04-28 | Merck Patent Gmbh | Tiazolopiridinski derivati kot antagonisti adenozinskih receptorjev |
| US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| BR112021005188A2 (pt) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | tratamento de anemia falciforme com um composto de ativação de piruvato cinase r |
| US20200345725A1 (en) | 2019-01-11 | 2020-11-05 | Omeros Corporation | Methods and Compositions for Treating Cancer |
| WO2022258622A1 (en) * | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
| CN114591327B (zh) * | 2022-03-25 | 2023-02-07 | 河南大学 | 吲哚啉哌啶脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用 |
| WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060481A (en) * | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
| EP1303272B1 (en) * | 2000-06-21 | 2008-02-13 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives for the treatment of alzheimer's disease and parkinson's disease |
| US6713499B2 (en) | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
| EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| BRPI0414266A (pt) * | 2003-09-19 | 2006-11-07 | Hoffmann La Roche | derivados de tiazolopiridina como ligandos receptores da adenosina |
| GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| ES2241496B1 (es) * | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| MX2007001271A (es) * | 2004-08-05 | 2007-03-21 | Hoffmann La Roche | N-acil-2-aminotiazoles sustituidos. |
-
2007
- 2007-05-08 WO PCT/EP2007/054416 patent/WO2007134958A1/en active Application Filing
- 2007-05-08 KR KR1020087028022A patent/KR101077295B1/ko not_active IP Right Cessation
- 2007-05-08 DE DE602007009221T patent/DE602007009221D1/de active Active
- 2007-05-08 CA CA2651769A patent/CA2651769C/en not_active Expired - Fee Related
- 2007-05-08 MX MX2008014690A patent/MX2008014690A/es active IP Right Grant
- 2007-05-08 CN CN2007800180233A patent/CN101448844B/zh not_active Expired - Fee Related
- 2007-05-08 AU AU2007253485A patent/AU2007253485B2/en not_active Ceased
- 2007-05-08 AT AT07728869T patent/ATE481409T1/de active
- 2007-05-08 BR BRPI0712516A patent/BRPI0712516A2/pt not_active IP Right Cessation
- 2007-05-08 JP JP2009510407A patent/JP5026511B2/ja not_active Expired - Fee Related
- 2007-05-08 ES ES07728869T patent/ES2350013T3/es active Active
- 2007-05-08 EP EP07728869A patent/EP2027132B1/en not_active Not-in-force
- 2007-05-11 US US11/801,972 patent/US7947692B2/en not_active Expired - Fee Related
- 2007-05-15 CL CL2007001380A patent/CL2007001380A1/es unknown
- 2007-05-15 TW TW096117228A patent/TW200813073A/zh unknown
- 2007-05-16 AR ARP070102114A patent/AR060957A1/es not_active Application Discontinuation
-
2008
- 2008-10-30 IL IL195006A patent/IL195006A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602007009221D1 (de) | 2010-10-28 |
| MX2008014690A (es) | 2008-11-27 |
| CA2651769C (en) | 2013-12-17 |
| BRPI0712516A2 (pt) | 2016-08-23 |
| WO2007134958A1 (en) | 2007-11-29 |
| CL2007001380A1 (es) | 2008-01-04 |
| AU2007253485B2 (en) | 2010-07-08 |
| EP2027132A1 (en) | 2009-02-25 |
| US20070270433A1 (en) | 2007-11-22 |
| KR20080111141A (ko) | 2008-12-22 |
| AU2007253485A1 (en) | 2007-11-29 |
| TW200813073A (en) | 2008-03-16 |
| ATE481409T1 (de) | 2010-10-15 |
| IL195006A0 (en) | 2009-08-03 |
| JP5026511B2 (ja) | 2012-09-12 |
| ES2350013T3 (es) | 2011-01-14 |
| EP2027132B1 (en) | 2010-09-15 |
| CN101448844A (zh) | 2009-06-03 |
| US7947692B2 (en) | 2011-05-24 |
| CA2651769A1 (en) | 2007-11-29 |
| CN101448844B (zh) | 2012-07-25 |
| KR101077295B1 (ko) | 2011-10-26 |
| JP2009537473A (ja) | 2009-10-29 |
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