AR057296A1 - Diarilsulfona sulfonamidas y el uso de las mismas - Google Patents
Diarilsulfona sulfonamidas y el uso de las mismasInfo
- Publication number
- AR057296A1 AR057296A1 ARP060101934A ARP060101934A AR057296A1 AR 057296 A1 AR057296 A1 AR 057296A1 AR P060101934 A ARP060101934 A AR P060101934A AR P060101934 A ARP060101934 A AR P060101934A AR 057296 A1 AR057296 A1 AR 057296A1
- Authority
- AR
- Argentina
- Prior art keywords
- arylcarbonyl
- alkyl
- sulfonyl
- heterocycloalkyl
- hydrogen
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 18
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 11
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 4
- 229920001774 Perfluoroether Polymers 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- -1 perfluoroalkylthio Chemical group 0.000 abstract 2
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 abstract 1
- WRZQIFGGSOMBBS-UHFFFAOYSA-N 2-methyl-5-(4-nitrophenyl)sulfonylbenzenesulfonamide Chemical compound C1=C(S(N)(=O)=O)C(C)=CC=C1S(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1 WRZQIFGGSOMBBS-UHFFFAOYSA-N 0.000 abstract 1
- KDSBHZMMSLNMOL-UHFFFAOYSA-N 5-(2,4-dinitrophenyl)sulfonyl-2-methylbenzenesulfonamide Chemical compound C1=C(S(N)(=O)=O)C(C)=CC=C1S(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O KDSBHZMMSLNMOL-UHFFFAOYSA-N 0.000 abstract 1
- KICJMUSCMNZTOO-UHFFFAOYSA-N 5-(4-bromophenyl)sulfonyl-2-methylbenzenesulfonamide Chemical compound C1=C(S(N)(=O)=O)C(C)=CC=C1S(=O)(=O)C1=CC=C(Br)C=C1 KICJMUSCMNZTOO-UHFFFAOYSA-N 0.000 abstract 1
- AAZKZFDJRWTRQH-UHFFFAOYSA-N 5-(4-chlorophenyl)sulfonyl-2-methyl-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)C=2C=CC(Cl)=CC=2)C=C1S(=O)(=O)NCC1=CC=CN=C1 AAZKZFDJRWTRQH-UHFFFAOYSA-N 0.000 abstract 1
- NCTDHZPYRJQSNF-UHFFFAOYSA-N 5-(4-chlorophenyl)sulfonyl-2-methylbenzenesulfonamide Chemical compound C1=C(S(N)(=O)=O)C(C)=CC=C1S(=O)(=O)C1=CC=C(Cl)C=C1 NCTDHZPYRJQSNF-UHFFFAOYSA-N 0.000 abstract 1
- SPCICLYMFFNRMS-UHFFFAOYSA-N 5-(4-chlorophenyl)sulfonyl-n-(furan-2-ylmethyl)-2-methylbenzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)C=2C=CC(Cl)=CC=2)C=C1S(=O)(=O)NCC1=CC=CO1 SPCICLYMFFNRMS-UHFFFAOYSA-N 0.000 abstract 1
- DFZGXJMUNLWERK-UHFFFAOYSA-N 5-(4-chlorophenyl)sulfonyl-n-cyclohexyl-2-methylbenzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)C=2C=CC(Cl)=CC=2)C=C1S(=O)(=O)NC1CCCCC1 DFZGXJMUNLWERK-UHFFFAOYSA-N 0.000 abstract 1
- LIZDBEGZOXTKPD-UHFFFAOYSA-N 5-(benzenesulfonyl)-2-methyl-n-(2-phenylethyl)benzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C=C1S(=O)(=O)NCCC1=CC=CC=C1 LIZDBEGZOXTKPD-UHFFFAOYSA-N 0.000 abstract 1
- IQXUGIPLBLPXIM-UHFFFAOYSA-N 5-(benzenesulfonyl)-2-methylbenzenesulfonamide Chemical compound C1=C(S(N)(=O)=O)C(C)=CC=C1S(=O)(=O)C1=CC=CC=C1 IQXUGIPLBLPXIM-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004367 cycloalkylaryl group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- CAYKGCGNKOAASD-UHFFFAOYSA-N n-benzyl-5-(4-chlorophenyl)sulfonyl-2-methylbenzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)C=2C=CC(Cl)=CC=2)C=C1S(=O)(=O)NCC1=CC=CC=C1 CAYKGCGNKOAASD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente se refiere a modulares de la proteína rizadasecretada relacionada con la proteína-1. Los compuestos y composiciones, conteniendo dichos compuesto puede ser usados para tratar una variedad de desordenes incluyendo la osteoporosis. Reivindicacion 1: Un compuesto de la formula (1), o una sal farmacéuticamente aceptable de estos, caracterizado porque R1 es un grupo de formulas (2) a (10), y cada grupo R1 es sustituido opcionalmente con más de tres grupos R8; Y es O, S, o NR9; R8 es alquilo, arilalquilo, perfluoroalquilo, alquenilo, arilalquenilo, alquinilo, arilalquinilo, cicloalquilo, alquilcicloalquilo, heterocicloalquilo, alquilheterocicloalquilo, arilo, alquilarilo, heteroarilo, alcoxilo, perfluoroalcoxilo, arilalcoxilo, alquilcarbonilo, arilcarbonilo, halogeno, ciano, azido, hidroxilo, carboxilo, alcoxicarbonilo, alquilamino, dialquilamino, alquilaminocarbonilo, dialquilaminocarbonilo, alquilcarbonilamino, alquilcarbonilalquilamino, hidroxialquilamino, nitro, alquilcarboniloximo, alquilsulfonilo, alquilsulfinilo, alquiltio, perfluoroalquiltio, ariltio, alquilcarbinolo terciario, alquilcicloalquilcarbinolo terciario, o arilalquilcarbinolo terciario; R9 es un hidrogeno, alquilo, arilo, arilalquilo, cicloalquilalquilo, heterocicloalquilo, o espirocicloalquilo; X es un oxígeno o un electron par; R2 es un hidrogeno, alquilo, alcoxilo, cicloalquilo, perfluoroalquilo, perfluoroalquilalquilo, perfluoroalcoxilo, dialquilamino, o un halogeno; R4 es un hidrogeno, halogeno, alquilo, cicloalquilo, alcoxilo, perfluoroalquilo, o perfluoroalcoxilo; o R2 y R4, junto con los átomos de carbono a los cuales ellos son unidos, formando un anillo cicloalquilo de 5 a 7 átomos de carbono que es opcionalmente sustituido con 1 a 3 grupos R; cada R es, un hidrogeno, alquilo, arilalquilo, cianoalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, espirocicloalquilo, arilo, arilalquilo, o alcoxialquilo independiente; R5, y R6 son, un hidrogeno, alquilo, arilo, alcoxilo, halogeno, o perfluoroalquilo independiente; R3 y R7 son, cada uno hidrogeno u opcionalmente un grupo alquilo, cicloalquilo, heterocicloalquilo, alquilheterocicloalquilo, heteroarilalquilo, alquilarilo, alquilheteroarilo, alquenilo, alquinilo, cicloalquilarilo fusionado, heterocicloalquilarilo fusionado, cicloalquilcarbonilo, o heterocicloalquilcarbonilo sustituido; o R3 y R7, juntas con el átomo de hidrogeno a los cuales van a ser, formando un anillo heterocicloalquilo de 5 o 6 miembros opcionalmente sustituido con 1 a 5 sustituyentes seleccionados desde alquilo, arilo, heterocicloalquilo, heterocicloalquilalquilo, alquilamino, dialquilamino, alcoxicarbonilo, alquilcarbonilo, alquilaminocarbonilalquilo, y heterocicloalquilcarbonilalquilo; proveyendo que el compuesto no sea: 2-metil-N-(2-feniletil)-5-(fenilsulfonil)-benzenosulfonamida; 2-metil-N-(2-fenilmetil)-5-(fenilsulfonil)-benzenosulfonamida; 5-[(4- clorofenil)sulfonil]-N-ciclohexil-2-metilbenzenosulfonamida; N-benzil-5-[(4-clorofenil)sulfonil]-2-metilbenzenosulfonamida; 5-[(4-clorofenil)sulfonil]-N-(2-furilmetil)-2-metilbenzenosulfonamida; 5-[(4-clorofenil)sulfonil]-2-metilbenzenosulfonamida; 2-metil-5-(fenilsulfonil)-benzenosulfonamida; 5-[(4-bromofenil)sulfonil]-2-metilbenzenosulfonamida; 2-metil-5-[(4-nitrofenil)sulfonil]-benzenosulfonamida; 5-[(2,4-dinitrofenil)sulfonil]-2-metil-benzenosulfonamida; o 5-[(4-clorofenil)sulfonil]-2- metil-N-(3-piridinilmetil)-benzenosulfonamida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68108005P | 2005-05-13 | 2005-05-13 | |
| US11/432,788 US20060276464A1 (en) | 2005-05-13 | 2006-05-10 | Diarylsulfone sulfonamides and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057296A1 true AR057296A1 (es) | 2007-11-28 |
Family
ID=37103195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101934A AR057296A1 (es) | 2005-05-13 | 2006-05-12 | Diarilsulfona sulfonamidas y el uso de las mismas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060276464A1 (es) |
| EP (1) | EP1879859A2 (es) |
| JP (1) | JP2008540579A (es) |
| KR (1) | KR20080012361A (es) |
| AR (1) | AR057296A1 (es) |
| AU (1) | AU2006247334A1 (es) |
| BR (1) | BRPI0610009A2 (es) |
| CA (1) | CA2607326A1 (es) |
| CR (1) | CR9507A (es) |
| GT (1) | GT200600199A (es) |
| IL (1) | IL187269A0 (es) |
| NO (1) | NO20075781L (es) |
| PE (1) | PE20061451A1 (es) |
| RU (1) | RU2007141346A (es) |
| SV (1) | SV2007002526A (es) |
| TW (1) | TW200719897A (es) |
| WO (1) | WO2006124875A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2405770C2 (ru) | 2005-09-27 | 2010-12-10 | Сионоги Энд Ко., Лтд. | Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2 |
| WO2008061006A1 (en) * | 2006-11-10 | 2008-05-22 | Wyeth | Substituted indan-2-yl, tetrahydronaphthalen-2-yl, or dihydr0-2h-chr0men-3-yl arylsulfonamides and methods of their use |
| PE20080932A1 (es) * | 2006-11-10 | 2008-07-13 | Wyeth Corp | Piperidinil 4-arilsulfonamidas n-sustituidas como moduladores de la proteina 1 secretada relacionada con frizzled (sfrp-1) |
| WO2008060999A1 (en) * | 2006-11-10 | 2008-05-22 | Wyeth | Piperidinyl arylsulfone derivatives as modulators of secreted frizzled related protein-1 |
| EP1964834A1 (en) * | 2007-03-01 | 2008-09-03 | Bayer Schering Pharma Aktiengesellschaft | Sulphonyltryptophanols |
| US20080255117A1 (en) * | 2007-03-01 | 2008-10-16 | Lars Wortmann | Sulfonyltryptophanols |
| EP1985612A1 (en) * | 2007-04-26 | 2008-10-29 | Bayer Schering Pharma Aktiengesellschaft | Arymethylen substituted N-Acyl-gamma-aminoalcohols |
| WO2009012241A1 (en) * | 2007-07-13 | 2009-01-22 | Icagen, Inc. | Sodium channel inhibitors |
| WO2009064938A1 (en) * | 2007-11-16 | 2009-05-22 | Abbott Laboratories | Method of treating arthritis |
| GB0723794D0 (en) | 2007-12-05 | 2008-01-16 | Lectus Therapeutics Ltd | Potassium ion channel modulators and uses thereof |
| KR101362639B1 (ko) * | 2010-09-16 | 2014-02-13 | 연세대학교 산학협력단 | 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화합물의 용도 |
| EP2471363A1 (de) | 2010-12-30 | 2012-07-04 | Bayer CropScience AG | Verwendung von Aryl-, Heteroaryl- und Benzylsulfonamidocarbonsäuren, -carbonsäureestern, -carbonsäureamiden und -carbonitrilen oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen |
| EP3051946B1 (de) | 2013-10-04 | 2017-11-29 | Bayer CropScience Aktiengesellschaft | Verwendung substituierter dihydrooxindolylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| FR3038324B1 (fr) | 2015-06-30 | 2020-10-30 | Lab Francais Du Fractionnement | Procede de cryoconservation de cellules a visee therapeutique |
| WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| WO2019025153A1 (de) | 2017-07-31 | 2019-02-07 | Bayer Cropscience Aktiengesellschaft | Verwendung von substituierten n-sulfonyl-n'-aryldiaminoalkanen und n-sulfonyl-n'-heteroaryldiaminoalkanen oder deren salzen zur steigerung der stresstoleranz in pflanzen |
| AU2018359224B2 (en) | 2017-10-30 | 2023-10-05 | Neuropore Therapies, Inc. | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof |
| KR102217147B1 (ko) | 2019-06-11 | 2021-02-18 | (주)부흥산업사 | 피페리디닐디페닐술포닐술폰아미드의 제조방법 |
| CN112898178A (zh) * | 2021-01-25 | 2021-06-04 | 蚌埠产品质量监督检验研究院 | 一种N-Boc-反式-1,4-环己二胺的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6593M (es) * | 1965-10-23 | 1969-01-06 | ||
| US4912131A (en) * | 1987-06-18 | 1990-03-27 | Merck Frosst Canada, Inc. | 4,7-diacyloxybenzofuran derivatives |
| DE19920790A1 (de) * | 1999-05-06 | 2000-11-09 | Bayer Ag | Bis-Sulfonamide mit anti-HCMV-Wirkung |
| US20080166356A9 (en) * | 1999-09-13 | 2008-07-10 | Peter Bodine | Pharmaceutical compositions and methods of using secreted frizzled related protein |
| CA2440559C (en) * | 2001-03-13 | 2010-09-21 | Schering Corporation | Novel non-imidazole compounds |
| AR044927A1 (es) * | 2003-06-25 | 2005-10-12 | Elan Pharm Inc | Metodos y composiciones para tratar la artritis reumatoidea |
-
2006
- 2006-05-10 US US11/432,788 patent/US20060276464A1/en not_active Abandoned
- 2006-05-12 EP EP06770422A patent/EP1879859A2/en not_active Withdrawn
- 2006-05-12 JP JP2008511473A patent/JP2008540579A/ja not_active Withdrawn
- 2006-05-12 BR BRPI0610009-0A patent/BRPI0610009A2/pt not_active Application Discontinuation
- 2006-05-12 AU AU2006247334A patent/AU2006247334A1/en not_active Abandoned
- 2006-05-12 AR ARP060101934A patent/AR057296A1/es unknown
- 2006-05-12 PE PE2006000507A patent/PE20061451A1/es not_active Application Discontinuation
- 2006-05-12 TW TW095116813A patent/TW200719897A/zh unknown
- 2006-05-12 CA CA002607326A patent/CA2607326A1/en not_active Abandoned
- 2006-05-12 SV SV2006002526A patent/SV2007002526A/es not_active Application Discontinuation
- 2006-05-12 GT GT200600199A patent/GT200600199A/es unknown
- 2006-05-12 WO PCT/US2006/018886 patent/WO2006124875A2/en active Application Filing
- 2006-05-12 RU RU2007141346/04A patent/RU2007141346A/ru not_active Application Discontinuation
- 2006-05-12 KR KR1020077029176A patent/KR20080012361A/ko not_active Application Discontinuation
-
2007
- 2007-11-08 IL IL187269A patent/IL187269A0/en unknown
- 2007-11-09 CR CR9507A patent/CR9507A/es not_active Application Discontinuation
- 2007-11-12 NO NO20075781A patent/NO20075781L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20061451A1 (es) | 2007-01-22 |
| GT200600199A (es) | 2007-02-23 |
| US20060276464A1 (en) | 2006-12-07 |
| JP2008540579A (ja) | 2008-11-20 |
| WO2006124875A2 (en) | 2006-11-23 |
| CR9507A (es) | 2008-01-10 |
| IL187269A0 (en) | 2008-02-09 |
| CA2607326A1 (en) | 2006-11-23 |
| EP1879859A2 (en) | 2008-01-23 |
| NO20075781L (no) | 2008-02-05 |
| RU2007141346A (ru) | 2009-06-20 |
| TW200719897A (en) | 2007-06-01 |
| WO2006124875A3 (en) | 2007-01-18 |
| BRPI0610009A2 (pt) | 2010-05-18 |
| SV2007002526A (es) | 2007-12-12 |
| KR20080012361A (ko) | 2008-02-11 |
| AU2006247334A1 (en) | 2006-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR057296A1 (es) | Diarilsulfona sulfonamidas y el uso de las mismas | |
| RU2386622C2 (ru) | Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы | |
| PE20040600A1 (es) | Derivados de triazol como antagonistas del receptor de taquicinina | |
| PE20050525A1 (es) | Derivados de pirazol sustituido y compuestos relacionados como antagonistas del receptor de bradiquinina b1 | |
| AR082888A1 (es) | Compuestos de piridina para la inhibicion de nampt | |
| AR046445A1 (es) | Derivados de piridazin-3(2h)-ona | |
| PE20060361A1 (es) | Compuestos heterociclicos como inhibidores de la cinesina mitotica | |
| PE20030200A1 (es) | Bencimidazol como inhibidores de las map quinasas | |
| AR054024A1 (es) | Derivados de piridina -3- carboxamida como agonistas inversos de cb1 | |
| PE20030269A1 (es) | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas | |
| PE20011047A1 (es) | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas | |
| CO5700754A2 (es) | Derivados de piperazina y su uso en el tratamiento de enfermedades neurologicas y psiquiatricas | |
| AR056861A1 (es) | Compuestos triciclicos fusionados como inhibidores de la necrosis tumoral. composiciones farmaceuticas y procesos de obtencion | |
| PE20060483A1 (es) | Compuestos heterociclicos como antagonistas de nk1 | |
| AR040076A1 (es) | Derivados de piridazin-3(2h)-ona | |
| PE20030062A1 (es) | Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas | |
| AR072545A1 (es) | Fenilpirazinonas como inhibidores de la btk, composicion farmaceutica que las contiene y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades autoinmunes e inflamatorias. | |
| AR077440A1 (es) | Bencenosulfonamidas como bloqueadores de canales de calcio y composiciones farmaceuticas | |
| RU2011101774A (ru) | Новые замещенные пиридин-2-оны и пиридазин-3-оны | |
| AR043860A1 (es) | Compuesto de anillo heteroaromatico de 5 miembros y su uso farmaceutico | |
| AR037418A1 (es) | Derivados de benzotiazol | |
| PE20060374A1 (es) | Inhibidores de cinasa heterociclicos fusionados | |
| AR051995A1 (es) | Derivados de tieno-piridina como intensificadores alostericos de gaba -b | |
| AR037901A1 (es) | Beta-amino-alfa-cianoacrilatos | |
| PE20070212A1 (es) | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |