AR056847A1 - Método para purificar la fsh o mutaciones de la fsh - Google Patents

Método para purificar la fsh o mutaciones de la fsh

Info

Publication number
AR056847A1
AR056847A1 ARP060105420A ARP060105420A AR056847A1 AR 056847 A1 AR056847 A1 AR 056847A1 AR P060105420 A ARP060105420 A AR P060105420A AR P060105420 A ARP060105420 A AR P060105420A AR 056847 A1 AR056847 A1 AR 056847A1
Authority
AR
Argentina
Prior art keywords
fsh
mutations
purifying
chromatography
anion exchange
Prior art date
Application number
ARP060105420A
Other languages
English (en)
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of AR056847A1 publication Critical patent/AR056847A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se relaciona con un método para purificar glicoproteínas, preferentemente la FSH o las mutaciones de la FSH, incluyendo los pasos de someter un líquido que contenga dicha la FSH o la mutacion de la FSH a: (1) cromatografía de afinidad de tenido; (2) cromatografía de intercambio anion débil; (3) cromatografía de interaccion hidrofobica; y (4) cromatografía de intercambio anion fuerte; los cuales pueden efectuarse en cualquier orden.
ARP060105420A 2005-12-09 2006-12-07 Método para purificar la fsh o mutaciones de la fsh AR056847A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111917 2005-12-09
EP05111915 2005-12-09
US83575406P 2006-08-04 2006-08-04

Publications (1)

Publication Number Publication Date
AR056847A1 true AR056847A1 (es) 2007-10-24

Family

ID=37671008

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105420A AR056847A1 (es) 2005-12-09 2006-12-07 Método para purificar la fsh o mutaciones de la fsh

Country Status (8)

Country Link
US (1) US8604175B2 (es)
EP (1) EP1960419B1 (es)
JP (1) JP5199112B2 (es)
AR (1) AR056847A1 (es)
AU (1) AU2006323925B2 (es)
CA (1) CA2625978A1 (es)
IL (1) IL191619A0 (es)
WO (1) WO2007065918A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1917276T3 (pl) 2005-08-26 2018-08-31 Ares Trading S.A. Sposób wytwarzania glikozylowanego interferonu beta
US7956034B2 (en) * 2006-01-17 2011-06-07 Merck Serono Sa FSH glycosylation variant D3N
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
WO2009053358A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins
US20100256337A1 (en) * 2007-10-22 2010-10-07 Merck Serono Sa Method for purifying an fc-containing protein
JP2009273427A (ja) * 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CN101347613B (zh) * 2008-09-17 2011-10-26 上海天伟生物制药有限公司 几乎不含亚基的糖蛋白的组合物及其制备方法
NZ595661A (en) * 2009-04-01 2013-07-26 Method for purifying recombinant follicle stimulating hormone (fsh)
DE102009032179A1 (de) * 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
US20130331554A1 (en) * 2010-11-15 2013-12-12 Biogen Idec Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
BR112015028737B1 (pt) * 2013-05-16 2022-05-10 Universidade De São Paulo - Usp Métodos para a produção e/ou purificação de hormônios
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
PL3110839T3 (pl) * 2014-02-24 2018-12-31 Altergon S.A. Proces ekstrakcji umożliwiający uzyskanie hcg o wysokiej aktywności biologicznej
MY183011A (en) * 2014-04-18 2021-02-05 Cadila Healthcare Ltd Novel purification process of gonadotropin
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803943B (en) 1979-07-31 1981-06-24 Hoffmann La Roche Homogeneous fibroblast interferon and method for manufacture thereof
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
EP0475779A1 (en) 1990-09-14 1992-03-18 Vittal Mallya Scientific Research Foundation Process for the separation of proteins, polypeptides or metals using immobilized, optionally modified, phosvitin
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
CA2147623C (en) 1992-10-23 2005-05-03 Glenn R. Larsen Novel p-selectin ligand protein
AU720337B2 (en) 1995-02-17 2000-05-25 Stichting Dienst Landbouwkundig Onderzoek Production of biologically active recombinant bovine follicle stimulating hormone (REC bFSH) in the baculovirus expression system
AUPN801296A0 (en) 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
EP2243827B2 (en) 1996-08-30 2017-11-22 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
CZ300296B6 (cs) 1996-11-15 2009-04-15 Genentech, Inc. Zpusob izolace rekombinantního lidského neurotrofinu, neurotrofinový prostredek a zpusob cištení neurotrofinu
US5883073A (en) * 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
CA2369262A1 (en) * 1999-04-13 2000-10-19 Sudha Nagarajan Pulmonary administration of dry powder formulations for treating infertility
AU779005B2 (en) 1999-04-16 2004-12-23 Instituto Massone S.A. Highly purified gonadotropin compositions and process for preparing them
US7431921B2 (en) * 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
WO2001058493A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
BRPI0108553B8 (pt) * 2000-02-22 2021-05-25 Applied Res Systems Ars Holding N V processo para a purificação de hormônio luteinizante (lh) recombinante humano
WO2001079480A1 (en) * 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
US20030017550A1 (en) * 2001-01-22 2003-01-23 Pang Danny Zhong Der DNA sequences encoding fusion proteins comprising IFN-beta and TM-alpha1
AU784808B2 (en) 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
WO2003005986A1 (en) 2001-07-11 2003-01-23 Unilever Plc Hair treatment compositions
US7226903B2 (en) * 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
AU2002368265B2 (en) 2001-10-22 2007-06-07 Merck Serono Sa Mutant glycoproteins
EP1997829A1 (en) * 2001-12-21 2008-12-03 Human Genome Sciences, Inc. Albumin fusion proteins
KR20050021502A (ko) 2002-07-17 2005-03-07 바이오겐 아이덱 엠에이 인코포레이티드 인터페론-β를 이용한 신부전증의 치료법
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
DE602004023757D1 (de) * 2003-12-22 2009-12-03 Ares Trading Sa Methode zur reinigung von fsh
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily
US7294484B2 (en) * 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
JP4933439B2 (ja) * 2004-11-09 2012-05-16 アレス トレーディング ソシエテ アノニム Ｆｓｈの精製方法
DE602005009856D1 (de) * 2004-11-09 2008-10-30 Ares Trading Sa Verfahren zur reinigung von fsh
PL1917276T3 (pl) * 2005-08-26 2018-08-31 Ares Trading S.A. Sposób wytwarzania glikozylowanego interferonu beta
US7956034B2 (en) 2006-01-17 2011-06-07 Merck Serono Sa FSH glycosylation variant D3N

Also Published As

Publication number Publication date
WO2007065918A3 (en) 2007-08-16
IL191619A0 (en) 2008-12-29
CA2625978A1 (en) 2007-06-14
EP1960419B1 (en) 2016-03-16
EP1960419A2 (en) 2008-08-27
JP2009518361A (ja) 2009-05-07
AU2006323925B2 (en) 2012-08-02
AU2006323925A1 (en) 2007-06-14
WO2007065918A2 (en) 2007-06-14
JP5199112B2 (ja) 2013-05-15
US8604175B2 (en) 2013-12-10
US20090209454A1 (en) 2009-08-20

Similar Documents

Publication Publication Date Title
AR056847A1 (es) Método para purificar la fsh o mutaciones de la fsh
CO6612194A2 (es) Métodos de purificaciñon de adamts 13 y otras proteinas recombinantes y sus composiciones
CL2004000259A1 (es) Anticuerpos neutralizantes especificos para interleuquina 1 b humana (il-1b), polinucleotido, vector y celula que lo expresan, composicion que lo contiene y usos.
BRPI0601896A (pt) composições que contêm microgéis e agentes espessantes
UA99262C2 (uk) СПОСІБ ЗМЕНШЕННЯ КОНЦЕНТРАЦІЇ ВІЛЬНИХ Fc-ЧАСТИН В РІДИНІ, ЩО МІСТИТЬ Fc-ВМІСНИЙ БІЛОК
BRPI0509505A (pt) método e kit útil para branqueamento de uma superfìcie dental
CR9576A (es) METODOS PARA PURIFICAR PROTEINAS QUE CONTIENE LA REGION Fc
CL2011000207A1 (es) Composicion biocida que comprende ciprodinil y flutianil; metodo para controlar enfermedades en plantas utiles o en material de propagacion causadas por fitopatogenos (div. sol. n°2602-06).
CL2007002705A1 (es) Composicion farmaceutica oftalmica autopreservada que comprende 0,04 a 0,9 mm de iones zinc donde la concentracion de aniones tamponantes es menor que 15 mm.
AR030236A1 (es) Moléculas similares a il-17 y usos de las mismas
CR7828A (es) Oxialquilamidas de quinolina, isoquinolina y quinazolina y su uso como fungicidas
BRPI0501326A (pt) Localização de linguagem usando tabelas
BR112018067597A2 (pt) célula progenitora de fígado adulto, população celular, material biológico, composição, método para avaliar a eficácia, o metabolismo, a estabilidade e/ou a toxicidade de um ou mais compostos, uso da célula ou população celular e kit
BR0308211A (pt) Cumarinas úteis como biomarcadores
BR112017010069A2 (pt) redução seletiva de resíduos cisteína em anticorpos para il-17
HUP0302384A2 (hu) Sejtek bioenergia metabolizmusában szerepet játszó biokémiai vegyületeket tartalmazó készítmények és alkalmazásuk
CR9597A (es) Formulaciones de estrogenos conjugados y bazedoxifeno
BR112019003361A2 (pt) métodos e usos de frações de material orgânico dissolvido para ligação a íons metálicos
DE602004012578D1 (de) Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
TW200516497A (en) Method and apparatus for partitioning code in program code conversion
WO2006034264A3 (en) Methods of using sulfur nucleophiles as improved alternatives to sodium bisulfite for methylated dna analysis
AR030554A1 (es) Moleculas similares a receptores il-17 y usos de las mismas
NO20042158L (no) Substituert 4-fenyl-tetrahydroisokinoliner, fremgangsmate for fremstilling derav, anvendelse derav som medikamenter, i tillegg til medikamenter inneholdende samme
WO2006113477A3 (en) Use of phosphonazo iii for the measurement of calcium, magnesium and sodium in analytical samples
BRPI0606239A2 (pt) métodos de análise de um ou mais compostos pesticidas

Legal Events

Date Code Title Description
FA Abandonment or withdrawal