AR056087A1 - DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS - Google Patents

DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS

Info

Publication number
AR056087A1
AR056087A1 ARP060104173A ARP060104173A AR056087A1 AR 056087 A1 AR056087 A1 AR 056087A1 AR P060104173 A ARP060104173 A AR P060104173A AR P060104173 A ARP060104173 A AR P060104173A AR 056087 A1 AR056087 A1 AR 056087A1
Authority
AR
Argentina
Prior art keywords
neuroquine
azetidine
derivatives
compound
formula
Prior art date
Application number
ARP060104173A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR056087A1 publication Critical patent/AR056087A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia

Abstract

Composiciones farmacéuticas que los contienen, usos en el tratamiento de desordenes gastrointestinales y métodos de preparacion. Reivindicacion 1: Un compuesto de formula (1) donde Het es como se muestra en el compuesto de formula (2) donde X es C u O; Y es C u O; con la condicion de que o X o Y sea O; R1 y R2 son, de manera independiente, H o alquilo C1-3; y además sus sales aceptables para uso farmacéutico y farmacologico, y enantiomeros del compuesto de formula (1) y sus sales.Pharmaceutical compositions containing them, uses in the treatment of gastrointestinal disorders and methods of preparation. Claim 1: A compound of formula (1) wherein Het is as shown in the compound of formula (2) wherein X is C or O; Y is C or O; with the proviso that either X or Y is O; R1 and R2 are independently H or C1-3 alkyl; and also its acceptable salts for pharmaceutical and pharmacological use, and enantiomers of the compound of formula (1) and its salts.

ARP060104173A 2005-09-29 2006-09-25 DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS AR056087A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0502151 2005-09-29

Publications (1)

Publication Number Publication Date
AR056087A1 true AR056087A1 (en) 2007-09-19

Family

ID=37900051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104173A AR056087A1 (en) 2005-09-29 2006-09-25 DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS

Country Status (4)

Country Link
AR (1) AR056087A1 (en)
TW (1) TW200745133A (en)
UY (1) UY29817A1 (en)
WO (1) WO2007037742A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136325A1 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 2
US8106208B2 (en) * 2006-05-18 2012-01-31 Albireo Ab Benzamide compounds that act as NK receptor antagonists
WO2007136326A2 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab ) t e text as een esta s e y t s ut o ty to rea as o ows: 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 3
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120295942A1 (en) 2010-02-01 2012-11-22 Nicholas James Devereux Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists
AR080056A1 (en) 2010-02-01 2012-03-07 Novartis Ag CICLOHEXIL-AMIDA DERIVATIVES AS ANTAGONISTS OF CRF RECEIVERS
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
GB9601202D0 (en) * 1996-01-22 1996-03-20 Pfizer Ltd Piperidones
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
KR20010083100A (en) * 1998-07-10 2001-08-31 다비드 에 질레스 N-substituted naphthalene carboxamides as neurokinin-receptor antagonists
GB9922519D0 (en) * 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9826941D0 (en) * 1998-12-09 1999-02-03 Zeneca Pharmaceuticals Compounds
AU2003284984B2 (en) * 2002-10-30 2008-10-23 Merck Sharp & Dohme Corp. Gamma-aminoamide modulators of chemokine receptor activity
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds

Also Published As

Publication number Publication date
UY29817A1 (en) 2007-04-30
WO2007037742A1 (en) 2007-04-05
TW200745133A (en) 2007-12-16

Similar Documents

Publication Publication Date Title
AR058807A1 (en) 5- (PHENYLYSOXAZOLETOXI) -TRIAZOL-3-IL PIRIDINES REPLACED, FOR THE TREATMENT OF DISORDERS MEDIATED BY THE RECEIVER MGLUR5
CR9459A (en) BENZODIOXAN AND BENZODIOXOLAN DERIVATIVES AND USES OF THE SAME
SV2005002061A (en) DERIVATIVES OF PIRIDILO AND ITS USE AS ANTAGONISTS OF THE MGLU5 RECEIVER REF. X-16538
UY31127A1 (en) METABOTROPIC RECEIVER OXYADAZOL LIGANDS FOR GLUTAMATE AND ITS USE AS POTENTIALS - 841
UY31254A1 (en) SUBSTITUTED DERIVATIVES OF N4- (5-METHYL-1H-PIRAZOL-3-IL) - 1,3,5-TRIAZINA-2,4-DIAMINE, THEIR ENANTIOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS, PREPARATION PROCESSES AND APPLICATIONS
UY31124A1 (en) DERIVATIVES OF OXIADAZOL AND ITS USE AS POTENTIALS OF THE METABOTROPIC RECEIVER OF GLUTAMATE - 842
CU23464B7 (en) (1,8) NAFTIDIRIN-2-ONAS AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA
UY29177A1 (en) SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES
AR056087A1 (en) DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS
UY28766A1 (en) ADDITIONAL HETEROPOLYCLIC COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE METABOTROPIC GLUTAMATE RECEIVER
ATE429427T1 (en) PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
CO6220949A2 (en) PIRAZOLIC DERIVATIVES AS INHIBITORS OF THE 11 BETA -HSD1
CR10922A (en) DERIVATIVES OF INDOL AS RECEIVING ANTAGONISTS OF S1P1
ATE524466T1 (en) 3-AZABICYCLOÄ3.3.0ÜOCTANE COMPOUNDS
CU20100159A7 (en) COMPOUNDS
ECSP088265A (en) CARBOXAMIDE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC RECEIVER
TW200800962A (en) Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
WO2009065922A3 (en) Organic compounds
ECSP099565A (en) 2-AMINO PYRIMIDINE COMPOUND
ECSP099722A (en) PIRIDO COMPOUNDS [2, 3-D] PIRIMIDINA-7-ONA AS PI3K-ALFA INHIBITORS FOR CANCER TREATMENT
BRPI0519709A2 (en) tetraline and indane derivatives and their use as 5-ht antagonists
ECSP088584A (en) NEW DERIVATIVES OF BENZIMIDAZOL AS INHIBITORS OF VANILLOID RECEIVER 1 (VRL)
ECSP10010105A (en) CGRP ANTAGONISTS
WO2008116185A3 (en) Substituted pyrimidines as adenosine receptor antagonists
AR058319A1 (en) N- (FLUOROPIRAZINIL) PHENYLSULPHONAMIDS AS MODULATORS OF THE CHRIOCHINES CCR4 RECEIVER

Legal Events

Date Code Title Description
FA Abandonment or withdrawal