UY31254A1 - SUBSTITUTED DERIVATIVES OF N4- (5-METHYL-1H-PIRAZOL-3-IL) - 1,3,5-TRIAZINA-2,4-DIAMINE, THEIR ENANTIOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS, PREPARATION PROCESSES AND APPLICATIONS - Google Patents
SUBSTITUTED DERIVATIVES OF N4- (5-METHYL-1H-PIRAZOL-3-IL) - 1,3,5-TRIAZINA-2,4-DIAMINE, THEIR ENANTIOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS, PREPARATION PROCESSES AND APPLICATIONSInfo
- Publication number
- UY31254A1 UY31254A1 UY31254A UY31254A UY31254A1 UY 31254 A1 UY31254 A1 UY 31254A1 UY 31254 A UY31254 A UY 31254A UY 31254 A UY31254 A UY 31254A UY 31254 A1 UY31254 A1 UY 31254A1
- Authority
- UY
- Uruguay
- Prior art keywords
- triazina
- pirazol
- enantiomers
- diamine
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención se refiere a los compuestos de fórmula (I): Fórmula (I) y sus sales, composiciones farmacéuticas, métodos de uso y métodos para su preparación. Estos compuestos proporcionan un tratamiento para los trastornos mieloproliferativos y el cáncer.The present invention relates to the compounds of formula (I): Formula (I) and its salts, pharmaceutical compositions, methods of use and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95315807P | 2007-07-31 | 2007-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31254A1 true UY31254A1 (en) | 2009-04-30 |
Family
ID=40304964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31254A UY31254A1 (en) | 2007-07-31 | 2008-07-30 | SUBSTITUTED DERIVATIVES OF N4- (5-METHYL-1H-PIRAZOL-3-IL) - 1,3,5-TRIAZINA-2,4-DIAMINE, THEIR ENANTIOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS, PREPARATION PROCESSES AND APPLICATIONS |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR069899A1 (en) |
CL (1) | CL2008002243A1 (en) |
PE (1) | PE20090895A1 (en) |
TW (1) | TW200906818A (en) |
UY (1) | UY31254A1 (en) |
WO (1) | WO2009016410A2 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010223919B2 (en) | 2009-03-13 | 2016-03-31 | Les Laboratoires Servier | Methods and compositions for cell-proliferation-related disorders |
WO2010144338A1 (en) * | 2009-06-08 | 2010-12-16 | Abraxis Bioscience, Llc | Triazine derivatives and their therapeutical applications |
AU2010258964B2 (en) * | 2009-06-09 | 2014-09-11 | Nantbio, Inc. | Benzyl substituted triazine derivatives and their therapeutical applications |
UA107667C2 (en) | 2009-06-29 | 2015-02-10 | Аджиос Фармасьютікалз, Інк. | Medical compounds stimulating activity of pyruvate kinase m2, compositions on their basis and use in the treatment of cancer |
WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
BR112013028422B8 (en) | 2011-05-03 | 2022-01-11 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
CN102827073A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Therapeutically active compositions and application methods thereof |
CN102827170A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Active treatment compositions and use method thereof |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
AR091858A1 (en) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | CISTATIONIN-g-LIASA INHIBITORS (CSE) |
WO2014062511A1 (en) | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
CN105517996B (en) * | 2013-07-11 | 2019-03-26 | 安吉奥斯医药品有限公司 | Therapeutical active compound and its application method |
WO2015006591A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
AU2015229214B2 (en) | 2014-03-14 | 2019-07-11 | Les Laboratoires Servier | Pharmaceutical compositions of therapeutically active compounds |
EP3245190B1 (en) | 2015-01-16 | 2018-12-26 | Bayer CropScience Aktiengesellschaft | Method for preparing 4-cyanopiperidine hydrochloride |
EP4344703A1 (en) | 2015-06-11 | 2024-04-03 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
DK3362066T3 (en) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | COMBINATION THERAPY FOR THE TREATMENT OF MALIGNITIES |
SG11201803088PA (en) | 2015-10-15 | 2018-05-30 | Agios Pharmaceuticals Inc | Combination therapy for treating malignancies |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
US20210246122A1 (en) * | 2018-06-22 | 2021-08-12 | Aduro Biotech, Inc. | Triazine Compounds and Uses Thereof |
CN109020951B (en) * | 2018-08-24 | 2020-06-02 | 大连理工大学 | Naphthalimide derivative containing trisubstituted cyanuric chloride and synthesis method and application thereof |
CN111454214B (en) * | 2020-05-27 | 2023-04-07 | 龙曦宁(上海)医药科技有限公司 | Synthetic method of 2-methoxy-1-pyrimidineethylamine hydrochloride |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001292670A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
BR0116411A (en) * | 2000-12-21 | 2003-11-11 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
EP1485381B8 (en) * | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine as inhibitors of protein kinases |
EP1899323A2 (en) * | 2005-05-16 | 2008-03-19 | AstraZeneca AB | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
BRPI0618011A2 (en) * | 2005-10-28 | 2011-08-16 | Astrazeneca Ab | compound or a pharmaceutically acceptable salt thereof, process for the preparation thereof, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, and methods for producing an antiproliferative effect and a pro-apoptotic effect in an animal warm-blooded to treat disease and to produce a jak inhibiting effect on a warm-blooded animal |
-
2008
- 2008-07-29 TW TW097128670A patent/TW200906818A/en unknown
- 2008-07-30 UY UY31254A patent/UY31254A1/en unknown
- 2008-07-30 CL CL2008002243A patent/CL2008002243A1/en unknown
- 2008-07-31 WO PCT/GB2008/050644 patent/WO2009016410A2/en active Application Filing
- 2008-07-31 PE PE2008001287A patent/PE20090895A1/en not_active Application Discontinuation
- 2008-07-31 AR ARP080103333A patent/AR069899A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PE20090895A1 (en) | 2009-08-08 |
TW200906818A (en) | 2009-02-16 |
CL2008002243A1 (en) | 2009-08-21 |
AR069899A1 (en) | 2010-03-03 |
WO2009016410A3 (en) | 2009-07-02 |
WO2009016410A2 (en) | 2009-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DESI | Application deemed to be withdrawn |
Effective date: 20120613 |