AR055367A1 - Piperazinas biciclicas como antagonistas de receptores de glutamato metabotropicos - Google Patents
Piperazinas biciclicas como antagonistas de receptores de glutamato metabotropicosInfo
- Publication number
- AR055367A1 AR055367A1 ARP060103441A ARP060103441A AR055367A1 AR 055367 A1 AR055367 A1 AR 055367A1 AR P060103441 A ARP060103441 A AR P060103441A AR P060103441 A ARP060103441 A AR P060103441A AR 055367 A1 AR055367 A1 AR 055367A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- 6alkyl
- co2r2
- so2r2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Composiciones farmacéuticas y usos para el tratamiento médico de trastornos mediados por mGluR5. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) en donde: Ar1 es un grupo arilo o heteroarilo opcionalmente sustituido, en donde los sustituyentes se seleccionan del grupo formado por F, Cl, Br, I, OH, nitro, alquilo C1-6, alquilhalo C1-6, Oalquilo C1-6, Oalquilhalo C1-6, alquenilo C2-6, alquinilo C2-6, CN, CO2R2, SR2, S(O)R2, SO2R2, arilo, heteroarilo, cicloalquilo y heterocicloalquilo, en donde cualquier grupo cíclico puede ser adicionalmente sustituido con al menos un sustituyente seleccionado del grupo formado por F, Cl, Br, I, OH, nitro, alquilo C1-6, alquilhalo C1-6, Oalquilo C1-6, Oalquilhalo C1-6, alquenilo C2-6, alquinilo C2-6, CN, CO2R2, SR2, S(O)R2 y SO2R2; A se selecciona del grupo formado por Ar1, CO2R2, CONR2R3, S(O)R2 y SO2R2; R1, en cada caso, se selecciona en forma independiente del grupo formado por F, Cl, Br, I, OH, CN, nitro, alquilo C1-6, Oalquilo C1-6, alquilhalo C1-6, Oalquilhalo C1-6, (CO)R2, O(CO)R2, O(CO)OR2, CO2R2, -CONR2R3, alquileno C1-6OR2, Oalquileno C2-6OR2 y alquilenociano C1-6; R2 y R3 se seleccionan en forma independiente del grupo formado por H, alquilo C1-6, alquilhalo C1-6, alquenilo C2-6, alquinilo C2-6 y cicloalquilo; Hy es un anillo heterocíclico de 5 miembros que contiene dos, tres o cuatro heteroátomos seleccionados en forma independiente el grupo formado por N, O y S, en donde el anillo está opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo formado por F, Cl, Br, I, OH, nitro, alquilo C1-6, alquilhalo C1-6, Oalquilo C1-6, Oalquilhalo C1-6, CN, CO2R2, NR2R3, SR2, S(O)R2 y SO2R2; m es un entero seleccionado del grupo formado por 0, 1, 2, 3 y 4; y n es un entero seleccionado del grupo formado por 1, 2 y 3; o una sal aceptable para uso farmacéutico, hidrato, solvato, isoforma, tautomero, isomero optico, o combinacion de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70794505P | 2005-08-15 | 2005-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055367A1 true AR055367A1 (es) | 2007-08-22 |
Family
ID=37451264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103441A AR055367A1 (es) | 2005-08-15 | 2006-08-08 | Piperazinas biciclicas como antagonistas de receptores de glutamato metabotropicos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20070037816A1 (es) |
| EP (1) | EP1919911A1 (es) |
| JP (1) | JP2009504735A (es) |
| KR (1) | KR20080050392A (es) |
| CN (1) | CN101248071A (es) |
| AR (1) | AR055367A1 (es) |
| AU (1) | AU2006280232A1 (es) |
| BR (1) | BRPI0614480A2 (es) |
| CA (1) | CA2616308A1 (es) |
| IL (1) | IL188808A0 (es) |
| MX (1) | MX2008001607A (es) |
| NO (1) | NO20080671L (es) |
| TW (1) | TW200800204A (es) |
| UY (1) | UY29734A1 (es) |
| WO (1) | WO2007021574A1 (es) |
| ZA (1) | ZA200801034B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010114971A1 (en) * | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| FR2974365B1 (fr) * | 2011-04-20 | 2017-08-25 | Centre Nat De La Rech Scient (C N R S) | 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques |
| CN108440571B (zh) * | 2012-10-22 | 2022-11-04 | 希望之城 | Etp衍生物 |
| MX2019001680A (es) | 2016-08-10 | 2019-06-06 | Bayer Cropscience Ag | 2-heterociclilimidazolilcarboxamidas sustituidas como pesticidas. |
| CA3036852A1 (en) | 2016-09-15 | 2018-03-22 | City Of Hope | Dithio etp derivatives |
| CN114907258B (zh) * | 2021-02-09 | 2023-04-11 | 中国科学院化学研究所 | 一种钯与氮杂环卡宾协同催化制备炔丙基酮类化合物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1691944A (zh) * | 2002-08-09 | 2005-11-02 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体－5调节剂的噁二唑 |
| WO2004092135A2 (en) * | 2003-04-15 | 2004-10-28 | Astrazeneca | Substituted benzosulphonamide as potentiators of glutamate receptors |
| WO2005077373A2 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
-
2006
- 2006-08-03 TW TW095128478A patent/TW200800204A/zh unknown
- 2006-08-04 MX MX2008001607A patent/MX2008001607A/es not_active Application Discontinuation
- 2006-08-04 BR BRPI0614480A patent/BRPI0614480A2/pt not_active IP Right Cessation
- 2006-08-04 AU AU2006280232A patent/AU2006280232A1/en not_active Abandoned
- 2006-08-04 US US11/498,770 patent/US20070037816A1/en not_active Abandoned
- 2006-08-04 CN CNA2006800281780A patent/CN101248071A/zh active Pending
- 2006-08-04 CA CA002616308A patent/CA2616308A1/en not_active Abandoned
- 2006-08-04 EP EP06789372A patent/EP1919911A1/en not_active Withdrawn
- 2006-08-04 US US11/997,541 patent/US20080312240A1/en not_active Abandoned
- 2006-08-04 KR KR1020087003195A patent/KR20080050392A/ko not_active Application Discontinuation
- 2006-08-04 WO PCT/US2006/030393 patent/WO2007021574A1/en active Application Filing
- 2006-08-04 JP JP2008526974A patent/JP2009504735A/ja active Pending
- 2006-08-08 UY UY29734A patent/UY29734A1/es not_active Application Discontinuation
- 2006-08-08 AR ARP060103441A patent/AR055367A1/es unknown
-
2008
- 2008-01-16 IL IL188808A patent/IL188808A0/en unknown
- 2008-01-31 ZA ZA200801034A patent/ZA200801034B/xx unknown
- 2008-02-05 NO NO20080671A patent/NO20080671L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007021574A1 (en) | 2007-02-22 |
| EP1919911A1 (en) | 2008-05-14 |
| MX2008001607A (es) | 2008-04-14 |
| BRPI0614480A2 (pt) | 2017-06-06 |
| US20070037816A1 (en) | 2007-02-15 |
| JP2009504735A (ja) | 2009-02-05 |
| IL188808A0 (en) | 2008-08-07 |
| UY29734A1 (es) | 2007-02-28 |
| CN101248071A (zh) | 2008-08-20 |
| AU2006280232A1 (en) | 2007-02-22 |
| US20080312240A1 (en) | 2008-12-18 |
| CA2616308A1 (en) | 2007-02-22 |
| NO20080671L (no) | 2008-03-04 |
| ZA200801034B (en) | 2008-12-31 |
| KR20080050392A (ko) | 2008-06-05 |
| TW200800204A (en) | 2008-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |