AR055111A1 - BENZOATE SALT OF 4- (5-METILOXAZOLO (4,5-METHYLXAZOLO (4,5- B] PIRIDIN -2-IL) -1,4- DIABICICLO (3.2.2) NONANO - Google Patents
BENZOATE SALT OF 4- (5-METILOXAZOLO (4,5-METHYLXAZOLO (4,5- B] PIRIDIN -2-IL) -1,4- DIABICICLO (3.2.2) NONANOInfo
- Publication number
- AR055111A1 AR055111A1 ARP060103433A ARP060103433A AR055111A1 AR 055111 A1 AR055111 A1 AR 055111A1 AR P060103433 A ARP060103433 A AR P060103433A AR P060103433 A ARP060103433 A AR P060103433A AR 055111 A1 AR055111 A1 AR 055111A1
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- benzoate salt
- alzheimer
- disease
- metiloxazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente proporciona una sal benzoato de formula (1), la formula también es conocida como 4-(5-metiloxazolo[4,5-b]piridin-2-il)-1,4- diazabiciclo[3.2.2]nonano. La sal benzoato es util en el tratamiento de esquizofrenia y enfermedad de Alzheimer. Es particularmente util en el tratamiento de déficit cognitivos asociados a esquizofrenia, síntomas de déficit cognitivo y de atencion de la enfermedad de Alzheimer y neurodegeneracion asociada a la enfermedad de Alzheimer. Reivindicacion 2: La sal segun la reivindicacion 1, en la que la sal tiene picos de difraccion de rayos X en polvo característicos medidos con radiacion de cobre de 2-theta+-0,1° de 10,6, 12,9, 13,8,17,6 y 19,3.The present provides a benzoate salt of formula (1), the formula is also known as 4- (5-methyloxazolo [4,5-b] pyridin-2-yl) -1,4-diazabicyclo [3.2.2] nonane. The benzoate salt is useful in the treatment of schizophrenia and Alzheimer's disease. It is particularly useful in the treatment of cognitive deficits associated with schizophrenia, symptoms of cognitive deficit and attention to Alzheimer's disease and neurodegeneration associated with Alzheimer's disease. Claim 2: The salt according to claim 1, wherein the salt has characteristic powder X-ray diffraction peaks measured with 2-theta copper radiation + -0.1 ° of 10.6, 12.9, 13, 8.17.6 and 19.3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70660105P | 2005-08-08 | 2005-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055111A1 true AR055111A1 (en) | 2007-08-08 |
Family
ID=37398316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103433A AR055111A1 (en) | 2005-08-08 | 2006-08-07 | BENZOATE SALT OF 4- (5-METILOXAZOLO (4,5-METHYLXAZOLO (4,5- B] PIRIDIN -2-IL) -1,4- DIABICICLO (3.2.2) NONANO |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR055111A1 (en) |
| DO (1) | DOP2006000185A (en) |
| NL (1) | NL1032286C2 (en) |
| TW (1) | TW200738734A (en) |
| UY (1) | UY29731A1 (en) |
| WO (1) | WO2007017750A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009113950A1 (en) * | 2008-03-10 | 2009-09-17 | Astrazeneca Ab | Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| US20180193283A1 (en) | 2016-12-20 | 2018-07-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| CN107188900B (en) * | 2017-05-27 | 2019-09-06 | 北京师范大学 | The ligand compound of alpha 7 nicotinic acetylcholine receptors and its application |
| EP3644973B1 (en) | 2017-06-26 | 2021-03-24 | LTS LOHMANN Therapie-Systeme AG | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
| JP2021529737A (en) | 2018-06-20 | 2021-11-04 | エルテーエス ローマン テラピー−ジステーメ アーゲー | Percutaneous treatment system containing asenapine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020086871A1 (en) * | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
| JP2007516275A (en) * | 2003-12-23 | 2007-06-21 | ファイザー・プロダクツ・インク | Therapeutic combinations for cognitive enhancement and psychotic disorders |
-
2006
- 2006-08-07 AR ARP060103433A patent/AR055111A1/en unknown
- 2006-08-07 TW TW095128888A patent/TW200738734A/en unknown
- 2006-08-07 WO PCT/IB2006/002219 patent/WO2007017750A1/en active Application Filing
- 2006-08-08 NL NL1032286A patent/NL1032286C2/en not_active IP Right Cessation
- 2006-08-08 UY UY29731A patent/UY29731A1/en not_active Application Discontinuation
- 2006-08-08 DO DO2006000185A patent/DOP2006000185A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL1032286C2 (en) | 2007-08-07 |
| DOP2006000185A (en) | 2007-03-31 |
| TW200738734A (en) | 2007-10-16 |
| WO2007017750A1 (en) | 2007-02-15 |
| UY29731A1 (en) | 2007-03-30 |
| NL1032286A1 (en) | 2007-02-09 |
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Legal Events
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| FB | Suspension of granting procedure |