AR053148A1 - COMBINATIONS UNDERSTANDING ALFA-2- DELTA LIGANDS - Google Patents

COMBINATIONS UNDERSTANDING ALFA-2- DELTA LIGANDS

Info

Publication number
AR053148A1
AR053148A1 ARP060100746A AR053148A1 AR 053148 A1 AR053148 A1 AR 053148A1 AR P060100746 A ARP060100746 A AR P060100746A AR 053148 A1 AR053148 A1 AR 053148A1
Authority
AR
Argentina
Prior art keywords
quinazolin
spiro
dihydro
cyclohexane
chloro
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0504209A external-priority patent/GB0504209D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AR053148A1 publication Critical patent/AR053148A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente se refiere a una combinacion de un inhibidor de PDE7 y un ligando alfa-2-delta, y a sales farmacéuticamente aceptables de los mismos, a composiciones farmacéuticas de los mismos y a su uso en tratamiento del dolor, particularmente dolor inflamatorio, neuropático, visceral y nociceptivo. Reivindicacion 2: Una combinacion de acuerdo con la reivindicacion 1, en la que el inhibidor de PDE7 se selecciona entre: 5'-carboxipropoxi-8'-cloro-espiro[ciclohexano-1-4'-(3',4'- dihidro)quinazolin]-2'(1'H)-ona; ácido cis-3-[(8'-cloro-2'-oxo-2',3'-dihidro-1'H-espiro[ciclohexano-1,4'-quinazolin]-5'-il)oxi]ciclobutanocarboxílico, y ácido trans-3-[(8'-cloro-2'-oxo-2',3'-dihidro-1'H-espiro[ciclohexano-1,4'-quinazolin]-5'- il)oxi]ciclobutanocarboxílico; o una sal o solvato farmacéuticamente aceptable del mismo.This refers to a combination of a PDE7 inhibitor and an alpha-2-delta ligand, and pharmaceutically acceptable salts thereof, to pharmaceutical compositions thereof and their use in the treatment of pain, particularly inflammatory, neuropathic, visceral pain. and nociceptive. Claim 2: A combination according to claim 1, wherein the PDE7 inhibitor is selected from: 5'-carboxypropoxy-8'-chloro-spiro [cyclohexane-1-4 '- (3', 4'-dihydro ) quinazolin] -2 '(1'H) -one; cis-3 - [(8'-chloro-2'-oxo-2 ', 3'-dihydro-1'H-spiro [cyclohexane-1,4'-quinazolin] -5'-yl) oxy] cyclobutanecarboxylic acid, and trans-3 - [(8'-chloro-2'-oxo-2 ', 3'-dihydro-1'H-spiro [cyclohexane-1,4'-quinazolin] -5'-yl) oxy] cyclobutanecarboxylic acid ; or a pharmaceutically acceptable salt or solvate thereof.

ARP060100746 2005-03-01 2006-02-28 COMBINATIONS UNDERSTANDING ALFA-2- DELTA LIGANDS AR053148A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0504209A GB0504209D0 (en) 2005-03-01 2005-03-01 New use of PDE7 inhibitors
US74185405P 2005-12-02 2005-12-02

Publications (1)

Publication Number Publication Date
AR053148A1 true AR053148A1 (en) 2007-04-25

Family

ID=37047905

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100746 AR053148A1 (en) 2005-03-01 2006-02-28 COMBINATIONS UNDERSTANDING ALFA-2- DELTA LIGANDS

Country Status (3)

Country Link
JP (1) JP2006241158A (en)
AR (1) AR053148A1 (en)
TW (1) TW200642687A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2007004161A0 (en) * 2005-04-28 2007-10-31 Pfizer Ltd Amino acid derivatives

Also Published As

Publication number Publication date
TW200642687A (en) 2006-12-16
JP2006241158A (en) 2006-09-14

Similar Documents

Publication Publication Date Title
ES2524320T3 (en) Composition for the prevention or treatment of disease associated with thrombus or embolus
PE20110586A1 (en) SPIRO-OXINDOLIC COMPOUNDS WITH ACTIVITY ON SODIUM CHANNELS
AR056047A1 (en) DERIVATIVES OF BENCIL - BENZENE REPLACED WITH GLUCOPIRANOSIL, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR THEIR PREPARATION.
UY30190A1 (en) IMPROVED PROFESSIONALS OF ANALOGS OF CC-1065
AR062792A1 (en) AZETIDINONE DERIVATIVES AND METHODS OF USE OF THESE
SV2009002832A (en) 1H IMIDAZOPIRIDINS REPLACED WITH HYDROXY AND PROCEDURES
AR051997A1 (en) TRICYCLIC HETEROCICLES, ITS OBTAINING AND USE OF THE SAME C OMO PHARMACEUTICAL AGENTS
AR061238A1 (en) HEPATITIS C PROTEASE INHIBITORS MACROCICLIC OXYLMYL COMPOUNDS
AR044116A1 (en) COMPOUNDS DERIVED FROM 5,7 DIAMINO PIRAZOLO [4,3-D] PYRIMIDINES, INTERMEDIARIES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE FOR THE MANUFACTURE OF MEDICATIONS
AR052322A1 (en) N-BENZOIL-ESTAUROSPORINE COMPOUNDS, PROCESSES FOR PREPARATION AND PHARMACEUTICAL COMPOSITION
CR11789A (en) ORAL FORMULATIONS OF CITIDINE ANALOGS AND METHODS FOR THE USE OF THE SAME
DOP2006000084A (en) SULFOXIMINO-MACROCICLIC COMPOUNDS AND THEIR SALTS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH COMPOUNDS, PREPARATION METHODS AND USES OF THE SAME
AR034389A1 (en) CRYSTALLINE TIOTROPIO BROMIDE MONOHIDRATE, PROCEDURE FOR PREPARATION, ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT, A MEDICINAL PRODUCT CONTAINING THEM, THE CRYSTAL HYDRAPTS OF THE TIOTROPIO BROMIDE AND A PROCEDURE FOR PREPARATION OF THESE HYDRATIOS
GT200000168A (en) PHARMACEUTICALLY ACTIVE COMPOUNDS.
CL2008002107A1 (en) Polymorphic forms of 2- {2-chloro-5 - {[(2s) -3- (5-chloro-1'h, 3h-spiro [1-benzofuran-2,4'-piperidin] -1'-yl acid ) -2-hydroxypropyl] oxy} -4 - [(methylamino] carbonyl] phenoxy} -2-methylpropanoic; preparation process; pharmaceutical composition; pharmaceutical device; and use in the treatment of respiratory diseases.
AR075050A1 (en) DICIANOPIRIDINS ALQUILAMINO-SUBSTITUTES
AR074966A1 (en) AMINO-HETEROCICLIC COMPOUNDS
AR056556A1 (en) IMIDAZO (1,2-A) PIRIDINE WITH CELLULAR ANTIPROLIFERATION ACTIVITY
UY30437A1 (en) QUINOXALINIL MACROCECLIC INHIBITORS OF SERINE PROTEASE VIRUS OF HEPATITIS C
AR070517A1 (en) INHIBITING PIPERIDINS OF 11 BETA-HYDROXIESTEROID DEHYDROGENASE 1
AR048401A1 (en) HCV SERINE-PROTEASA NS3 INHIBITORS
GT200600135A (en) ORTHROMBY CRYSTAL FORM OF ASENAPINE MALEATE AND ITS USE IN THE TREATMENT OF MENTAL DISORDERS
RU2009120988A (en) APPLICATION OF 3-ALPHA-ANDROSTENEDIOL, OPTIONAL IN COMBINATION WITH PHOSPHODESTERASE 5 INHIBITOR, IN THE TREATMENT OF SEXUAL DYSFUNCTION
DOP2006000243A (en) PIRAZINE DERIVATIVES
AR063942A1 (en) HEPATITIS C VIRUS PROTEASA INHIBITING OXYMYL COMPOUNDS

Legal Events

Date Code Title Description
FB Suspension of granting procedure