AR052314A1 - TIENOPIRIDINONE COMPOUNDS AS 5-HT4 RECEIVER AGONISTS - Google Patents

TIENOPIRIDINONE COMPOUNDS AS 5-HT4 RECEIVER AGONISTS

Info

Publication number
AR052314A1
AR052314A1 ARP050104240A ARP050104240A AR052314A1 AR 052314 A1 AR052314 A1 AR 052314A1 AR P050104240 A ARP050104240 A AR P050104240A AR P050104240 A ARP050104240 A AR P050104240A AR 052314 A1 AR052314 A1 AR 052314A1
Authority
AR
Argentina
Prior art keywords
isopropyl
disease
agonists
ethyl
compounds
Prior art date
Application number
ARP050104240A
Other languages
Spanish (es)
Inventor
Dale S Dhanoa
Oren Becker
Silvia Noiman
Dongli Chen
Sharon Shacham
Boaz Inbal
Laurence Wu
Mercedes Lobera
Pradyumna Mohanty
Yael Marantz
Original Assignee
Predix Pharmaceutical Holdings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35594017&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR052314(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Predix Pharmaceutical Holdings filed Critical Predix Pharmaceutical Holdings
Publication of AR052314A1 publication Critical patent/AR052314A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Se refiere a agonistas y agonistas parciales del receptor 5-HT4. Se describen compuestos de tienopiridinona, y la síntesis y utilizacion de los mismos para tratar enfermedades mediadas directa o indirectamente por los receptores 5-HT4. Dichas condiciones incluyen a la enfermedad de Alzheimer, trastornos cognoscitivos, síndrome de colon irritable, enfermedad de Parkinson, nauseas, émesis, vomitos, pro-quinesia, enfermedad de reflujo gastroesofágico y dispepsia no ulcerosa. También se incluyen los métodos para la preparacion y nuevos intermediarios y sales farmacéuticas de los mismos. Reivindicacion 1: Un compuesto que tiene la formula (1), caracterizado porque: R1 es etilo o isopropilo; y R2 es un grupo alquilo opcionalmente sustituido seleccionado del grupo que consiste en etilo, n-propilo, isopropilo, n-isopropilo, n-butilo, isotubilo, secbutilo, pentilo, metilciclopropilo, isopropanol, feniletilo; y las sales y/o ésteres farmacéuticamente aceptables el mismo.It refers to agonists and partial agonists of the 5-HT4 receptor. Thienopyridinone compounds are described, and the synthesis and use thereof to treat diseases directly or indirectly mediated by 5-HT4 receptors. Such conditions include Alzheimer's disease, cognitive disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease and non-ulcer dyspepsia. Methods for the preparation and new intermediates and pharmaceutical salts thereof are also included. Claim 1: A compound having the formula (1), characterized in that: R1 is ethyl or isopropyl; and R2 is an optionally substituted alkyl group selected from the group consisting of ethyl, n-propyl, isopropyl, n-isopropyl, n-butyl, isotubyl, secbutyl, pentyl, methylcyclopropyl, isopropanol, phenylethyl; and pharmaceutically acceptable salts and / or esters thereof.

ARP050104240A 2004-10-07 2005-10-07 TIENOPIRIDINONE COMPOUNDS AS 5-HT4 RECEIVER AGONISTS AR052314A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/960,769 US7407966B2 (en) 2004-10-07 2004-10-07 Thienopyridinone compounds and methods of treatment

Publications (1)

Publication Number Publication Date
AR052314A1 true AR052314A1 (en) 2007-03-14

Family

ID=35594017

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104240A AR052314A1 (en) 2004-10-07 2005-10-07 TIENOPIRIDINONE COMPOUNDS AS 5-HT4 RECEIVER AGONISTS

Country Status (18)

Country Link
US (1) US7407966B2 (en)
EP (1) EP1802631A2 (en)
JP (1) JP2008515907A (en)
KR (1) KR20070106682A (en)
CN (1) CN101061123A (en)
AR (1) AR052314A1 (en)
AU (1) AU2005294329A1 (en)
BR (1) BRPI0516130A (en)
CA (1) CA2583353A1 (en)
IL (1) IL182436A0 (en)
MA (1) MA29211B1 (en)
MX (1) MX2007004230A (en)
NO (1) NO20072348L (en)
NZ (1) NZ554927A (en)
RU (1) RU2007116950A (en)
TW (1) TW200621245A (en)
WO (1) WO2006041985A2 (en)
ZA (1) ZA200703596B (en)

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Also Published As

Publication number Publication date
WO2006041985A2 (en) 2006-04-20
AU2005294329A1 (en) 2006-04-20
IL182436A0 (en) 2007-07-24
NZ554927A (en) 2009-07-31
RU2007116950A (en) 2008-11-20
BRPI0516130A (en) 2008-08-26
ZA200703596B (en) 2008-05-28
EP1802631A2 (en) 2007-07-04
CN101061123A (en) 2007-10-24
KR20070106682A (en) 2007-11-05
MX2007004230A (en) 2007-06-11
JP2008515907A (en) 2008-05-15
US7407966B2 (en) 2008-08-05
TW200621245A (en) 2006-07-01
AU2005294329A2 (en) 2006-04-20
MA29211B1 (en) 2008-02-01
NO20072348L (en) 2007-07-06
US20060079547A1 (en) 2006-04-13
WO2006041985A3 (en) 2006-07-06
CA2583353A1 (en) 2006-04-20

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