AR050251A1 - Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto - Google Patents

Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto

Info

Publication number
AR050251A1
AR050251A1 ARP050102198A ARP050102198A AR050251A1 AR 050251 A1 AR050251 A1 AR 050251A1 AR P050102198 A ARP050102198 A AR P050102198A AR P050102198 A ARP050102198 A AR P050102198A AR 050251 A1 AR050251 A1 AR 050251A1
Authority
AR
Argentina
Prior art keywords
alkyl
carbonyl
amino
heterocyclyl
halogen
Prior art date
Application number
ARP050102198A
Other languages
English (en)
Original Assignee
Speedel Experimenta Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Experimenta Ag filed Critical Speedel Experimenta Ag
Publication of AR050251A1 publication Critical patent/AR050251A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Estos compuestos pueden utilizarse para preparar medicamentos, en particular como inhibidores de sintasa de aldosterona. Pueden ser empleados para la prevencion a retardo del avance del estado de hipocalcemia, hipertension, insuficiencia cardíaca congestiva, insuficiencia renal aguda, restinitis y ateroesclerosis, entre otras. Reivindicacion1: Compuestos de la formula general 1 en la cual X es C; Y es C, si Z es C, es también N; Z es C o un enlace; R es hidrogeno, alquilo C1-8, alcoxi C1- 8-alquiloC0-4, halogeno o trifluormetilo; R1 es heterociclilo no saturado-alquilo C0-4, radical que está sin substituir o substituido con 1-4 alquilo C1-8-sulfonilo, halogeno, ciano, oxo, trialquil C1-4-sililo, trifluormetoxilo, trifluormetilo, alquil C0-8-carbonil-amino, alquilo C0-8-carbonil-alquil C1-8-amino, carbamoílo, mono- o di-alquil C1-8-aminocarbonilo, carboxi-alquilo C0-4, alcoxilo C1-8, alcoxi C1-8-carbonilo, heterociclilo o arilo, en donde heterociclilo o arilo están sin substituir o substituidos con 1-4 alquilo C1_8, alquil C1-8-sulfonilo, halogeno, cioano, oxo, trialquil C1-4-sililo, trifluormetoxilo, trifluormetilo, alquil C0-8.carbonil-amino, alquil C0-8-carbonil-amino, alquil C0-8-carbonil-alquil C1-8-amino, carbamoílo, mono- o di-alquil C1-8-aminocarbonilo, caboxi-alquilo C0-4, alcoxilo C1-8-carbonilo; R2 a) es hidrogeno; o b) es alquilo C1-8, cicloalquilo C3-8, halogeno, carboxi-alquilo C1-4, alcoxi C1-4-carbonil-alquilo C1-4, alquil C0-4-carbonilo, aril-alquilo C0-4 o heterociclilo no saturado-alquilo C0-4, radicales que están sin substituir o substituidos con 1-4 alquilo C1-8, alquil C0-8-carbonilo, alquil C1-8 -sulfonilo, halogeno, ciano, oxo, trialquil C1-4-sililo, trifluormetoxilo, trifluormetilo, alquil C0-8-carbonil-amino, alquil C0-8-carbonil-alquil C1-8-amino, cabamoílo, mono- o di-alquil C1-8-aminocarbonilo, carboxi-alquilo C0-4, alcoxilo C1-8, alcoxi C1-8-carbonilo, heterociclilo, arilo, en donde heterociclilo o arilo están sin substituir o substituidos con 1-4 alquilo C1-8, alquil C0-8-carbonilo, alquilo C1-8-sulfonilo, halogeno, ciano, oxo, trialquil C1-4-sililo, trifluormetoxilo, trifluormetilo, alquil C0-8-carbonil-amino, alquil C0-8-carbonil-alquil C1-8- amino, carbamoílo, mono- o di-alquil C1-8-aminocarbonilo, carboxi-alquilo C0-4, alcoxilo C1-8 o alcoxi C1-8-carbonilo; n es un numero 0, 1 o 2; y las sales de los mismos, preferentemente las sales faramcéuticamente utiles de los mismos, y su sal, pro droga o compuesto en el cual uno o másátomos están reemplazados por sus isotopos no radioactivos estables, en particular, sal farmacéuticamente util; en los caules si Z es un enlace y R2 es hidrogeno, R1 no es carbazol, benzoimidoazolilo, benzotriazolilo, priridilo, pirimidinilo, pirazinilo o piridazinilo, o si Z es un enlace, R2 es hidrogeno y R1 es un radical heterocíclico que contiene S no saturado, monocíclico, estando estos radicales substituidos con alquil C0-8-carbonilo, ciano, arilo o heterociclilo.
ARP050102198A 2004-05-28 2005-05-27 Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto AR050251A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH9162004 2004-05-28
CH11572004 2004-07-09

Publications (1)

Publication Number Publication Date
AR050251A1 true AR050251A1 (es) 2006-10-11

Family

ID=34993240

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102198A AR050251A1 (es) 2004-05-28 2005-05-27 Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto

Country Status (11)

Country Link
US (1) US20080076794A1 (es)
EP (1) EP1748986B1 (es)
JP (1) JP2008500999A (es)
AR (1) AR050251A1 (es)
AT (1) ATE490241T1 (es)
BR (1) BRPI0510412A (es)
CA (1) CA2568164A1 (es)
DE (1) DE602005025110D1 (es)
IL (1) IL179409A0 (es)
TW (1) TW200608978A (es)
WO (1) WO2005118541A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8680079B2 (en) * 2004-05-28 2014-03-25 Novartis Ag Tetrahydro-imidazo [1,5-A] pyridyin derivatives as aldosterone synthase inhibitors
TW200716105A (en) * 2005-05-31 2007-05-01 Speedel Experimenta Ag Imidazole compounds
AR056888A1 (es) * 2005-12-09 2007-10-31 Speedel Experimenta Ag Derivados de heterociclil imidazol
EP1842543A1 (en) 2006-04-05 2007-10-10 Speedel Pharma AG Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist
TW200808813A (en) * 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
TW200808812A (en) * 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
EP1886695A1 (en) * 2006-06-27 2008-02-13 Speedel Experimenta AG Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
MX2011012627A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
EP2594557B1 (en) 2009-05-28 2016-08-10 Novartis AG Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
TWI627167B (zh) 2011-07-08 2018-06-21 諾華公司 用於高三酸甘油酯個體治療動脈粥狀硬化之方法
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CN105073762B (zh) 2013-02-14 2017-03-08 诺华股份有限公司 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物
EP3024845A1 (en) 2013-07-25 2016-06-01 Novartis AG Cyclic polypeptides for the treatment of heart failure
UY35671A (es) 2013-07-25 2015-02-27 Novartis Ag Bioconjugados de polipéptidos de apelina sintética
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
EP3887363A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
CN113166204A (zh) 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物
AR127698A1 (es) 2021-11-23 2024-02-21 Novartis Ag Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno

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US4859691A (en) * 1987-07-08 1989-08-22 Ciba-Geigy Corporation Certain 1,2-benzisoxazole derivatives
GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
US5057521A (en) * 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
DK0401707T3 (da) * 1989-06-05 1994-10-17 Daiichi Seiyaku Co Heterocyclisk forbindelse, et farmaceutisk lægemiddel og fremgangsmåde til fremstilling af disse
JP3170273B2 (ja) * 1989-06-05 2001-05-28 第一製薬株式会社 縮合トリアジン誘導体及びその中間体
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
DE69330557T2 (de) * 1992-01-27 2002-06-20 Janssen Pharmaceutica Nv Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren
JPH0971586A (ja) * 1995-09-07 1997-03-18 Yamanouchi Pharmaceut Co Ltd 新規な二環性縮合イミダゾール誘導体
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US20030083342A1 (en) * 2002-08-27 2003-05-01 Steele Ronald Edward Combination of organic compounds

Also Published As

Publication number Publication date
ATE490241T1 (de) 2010-12-15
CA2568164A1 (en) 2005-12-15
EP1748986B1 (en) 2010-12-01
WO2005118541A2 (en) 2005-12-15
TW200608978A (en) 2006-03-16
IL179409A0 (en) 2007-05-15
EP1748986A2 (en) 2007-02-07
DE602005025110D1 (de) 2011-01-13
US20080076794A1 (en) 2008-03-27
BRPI0510412A (pt) 2007-10-23
WO2005118541A3 (en) 2006-02-02
JP2008500999A (ja) 2008-01-17

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