AR049349A1 - Metodo para la preparacion de acidos hidroxamicos - Google Patents

Metodo para la preparacion de acidos hidroxamicos

Info

Publication number
AR049349A1
AR049349A1 ARP050102314A ARP050102314A AR049349A1 AR 049349 A1 AR049349 A1 AR 049349A1 AR P050102314 A ARP050102314 A AR P050102314A AR P050102314 A ARP050102314 A AR P050102314A AR 049349 A1 AR049349 A1 AR 049349A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
preparation
independently selected
hydroxamic acids
Prior art date
Application number
ARP050102314A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR049349A1 publication Critical patent/AR049349A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Reivindicacion 1: Un proceso para la preparacion de un compuesto de la formula (1): que comprende la reaccion de un éster silílico del ácido (3S)-2,3-dimetil-tetrahidro-2H-1,4-tiazin-3-carboxílico, con un compuesto de la formula (2) en la cual: J es seleccionado del grupo contituido por Cl, Br, F, 1,2,4-triazolilo, benzotriazolilo e imidazolilo, cada uno de R1 y R2 es independientemente seleccionado del grupo constituido por H, alquilo C1-6 o -CCH; cada uno de R3 y R4 es independientemente seleccionado del grupo constituido por H y alquilo C1-6; R5 es seleccionado del grupo constituido por H, -C(O)-alquilo C1-6, -C(O)-cicloalquilo C3-6, -C(O)-arilo, -C(O)-heteroarilo, -C(O)O-alquilo C1-6, -C(O)O-arilo y SiR6R7R8, y cada uno de R6, R7 y R8 es independientemente seleccionado del grupo constituido por alquilo C1-6 y fenilo.
ARP050102314A 2004-06-08 2005-06-07 Metodo para la preparacion de acidos hidroxamicos AR049349A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57778404P 2004-06-08 2004-06-08

Publications (1)

Publication Number Publication Date
AR049349A1 true AR049349A1 (es) 2006-07-19

Family

ID=35106941

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050102315A AR049073A1 (es) 2004-06-08 2005-06-07 Polimorfos cristalinos de (3s)-n-hidroxi-4-({4-[(4-hidroxi-2-butinil)oxi]fenil}sulfonil)-2,2-dimetil-3-tiomorfolina carboxamida
ARP050102314A AR049349A1 (es) 2004-06-08 2005-06-07 Metodo para la preparacion de acidos hidroxamicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP050102315A AR049073A1 (es) 2004-06-08 2005-06-07 Polimorfos cristalinos de (3s)-n-hidroxi-4-({4-[(4-hidroxi-2-butinil)oxi]fenil}sulfonil)-2,2-dimetil-3-tiomorfolina carboxamida

Country Status (6)

Country Link
US (2) US7435732B2 (es)
AR (2) AR049073A1 (es)
GT (1) GT200500139A (es)
PA (2) PA8636301A1 (es)
TW (2) TW200612959A (es)
WO (2) WO2005123706A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1682537E (pt) 2003-11-05 2012-06-20 Sarcode Bioscience Inc Moduladores de adesão celular
GT200500139A (es) * 2004-06-08 2005-07-25 Metodo para la preparacion de acidos hidroxamicos
HUE031979T2 (en) 2005-05-17 2017-08-28 Sarcode Bioscience Inc Preparations and methods for treating eye disorders
FR2898497B1 (fr) * 2006-03-20 2008-05-16 Galderma Res & Dev Utilisation de l'apratastat ou du (s)-n-hydroxy-4-(4-but-2- ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carbo xamide dans le traitement de pathologies inflammatoires cutanees
US7631568B2 (en) * 2007-08-28 2009-12-15 Quest Technologies Particulate monitor
CA3105972A1 (en) 2007-10-19 2009-04-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2011057176A1 (en) * 2009-11-06 2011-05-12 Forest Laboratories Holding Limited Novel crystalline forms of (1s,2r)-2-(amino methyl)-n,n-diethyl-1-phenyl cyclopropane carboxamide
KR102157608B1 (ko) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2195034T3 (es) 1995-12-08 2003-12-01 Agouron Pharma Inhibidor de metaloproteinasas, composicion farmaceutica que contiene este inhibidor y su utilizacion farmaceutica, y procedimientos que sirven para su preparacion.
ID22809A (id) * 1997-02-11 1999-12-09 Pfizer Turunan-turunan asam arilsulfonil hidroksamat
US6225311B1 (en) * 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6387901B1 (en) * 1999-07-06 2002-05-14 Pfizer Inc Alkyne containing metalloproteinase inhibitors
CA2357110A1 (en) * 2001-04-11 2002-10-11 American Cyanamid Company Method for the treatment of polycystic kidney disease
CA2464727A1 (en) 2001-11-01 2003-05-08 Wyeth Holdings Corporation Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors
GT200500139A (es) * 2004-06-08 2005-07-25 Metodo para la preparacion de acidos hidroxamicos

Also Published As

Publication number Publication date
US7435732B2 (en) 2008-10-14
PA8636301A1 (es) 2006-03-24
WO2005123706A1 (en) 2005-12-29
GT200500139A (es) 2005-07-25
TW200610523A (en) 2006-04-01
US20050272928A1 (en) 2005-12-08
US20050272929A1 (en) 2005-12-08
WO2005123706A9 (en) 2006-04-27
TW200612959A (en) 2006-05-01
AR049073A1 (es) 2006-06-21
PA8636101A1 (es) 2006-03-24
WO2005123705A1 (en) 2005-12-29
US7179911B2 (en) 2007-02-20

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