AR047992A1 - Diaminopirimidinas como antagonistas de p2x3 y p2x2/3 - Google Patents

Diaminopirimidinas como antagonistas de p2x3 y p2x2/3

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Publication number
AR047992A1
AR047992A1 ARP050100813A ARP050100813A AR047992A1 AR 047992 A1 AR047992 A1 AR 047992A1 AR P050100813 A ARP050100813 A AR P050100813A AR P050100813 A ARP050100813 A AR P050100813A AR 047992 A1 AR047992 A1 AR 047992A1
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AR
Argentina
Prior art keywords
diaminopirimidins
antagonists
methods
solvate
administering
Prior art date
Application number
ARP050100813A
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English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR047992A1 publication Critical patent/AR047992A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Abstract

Compuestos y métodos para el tratamiento de enfermedades mediadas por un antagonista de receptor P2X3 y/o P2X3, los métodos consisten en administrar a un sujeto que lo necesite una cantidad eficaz de un compuesto de la formula (1), o una sal, solvato o profármaco farmacéuticamente aceptable del mismo, en la que D, X y, R1, R2, R3, R4, R5, R6, R7 y R8 tienen los significados definidos en la presente.
ARP050100813A 2004-03-05 2005-03-03 Diaminopirimidinas como antagonistas de p2x3 y p2x2/3 AR047992A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55049904P 2004-03-05 2004-03-05

Publications (1)

Publication Number Publication Date
AR047992A1 true AR047992A1 (es) 2006-03-15

Family

ID=34961010

Family Applications (1)

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ARP050100813A AR047992A1 (es) 2004-03-05 2005-03-03 Diaminopirimidinas como antagonistas de p2x3 y p2x2/3

Country Status (28)

Country Link
US (10) US7858632B2 (es)
EP (2) EP2343282B1 (es)
JP (4) JP4717876B2 (es)
KR (1) KR100822530B1 (es)
CN (1) CN1930135B (es)
AR (1) AR047992A1 (es)
AU (1) AU2005229331B2 (es)
BR (2) BRPI0508461B8 (es)
CA (1) CA2557372C (es)
CY (1) CY1113450T1 (es)
DK (1) DK1725540T5 (es)
ES (2) ES2548022T3 (es)
FI (1) FIC20240007I1 (es)
HK (1) HK1101074A1 (es)
HR (1) HRP20120901T1 (es)
HU (1) HUS2400005I1 (es)
IL (2) IL177438A (es)
MY (1) MY145465A (es)
NL (1) NL301261I2 (es)
NO (3) NO339497B1 (es)
NZ (1) NZ549069A (es)
PL (1) PL1725540T3 (es)
PT (1) PT1725540E (es)
RU (1) RU2422441C2 (es)
SI (1) SI1725540T1 (es)
TW (1) TWI313604B (es)
WO (1) WO2005095359A1 (es)
ZA (1) ZA200606880B (es)

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