AR038430A2 - Derivados de parahercuamida b - Google Patents

Derivados de parahercuamida b

Info

Publication number
AR038430A2
AR038430A2 ARP030100484A ARP030100484A AR038430A2 AR 038430 A2 AR038430 A2 AR 038430A2 AR P030100484 A ARP030100484 A AR P030100484A AR P030100484 A ARP030100484 A AR P030100484A AR 038430 A2 AR038430 A2 AR 038430A2
Authority
AR
Argentina
Prior art keywords
parahercuamida
derivatives
parahercuamide
oxides
compounds
Prior art date
Application number
ARP030100484A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21695455&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR038430(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR038430A2 publication Critical patent/AR038430A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Abstract

Compuestos de parahercuamida B de la fórmula (1) en donde n1 es 0 a 3, sus N-óxidos y sus sales farmacéuticamente aceptables.
ARP030100484A 1995-07-21 2003-02-13 Derivados de parahercuamida b AR038430A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US132495P 1995-07-21 1995-07-21

Publications (1)

Publication Number Publication Date
AR038430A2 true AR038430A2 (es) 2005-01-12

Family

ID=21695455

Family Applications (10)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100486A AR038432A2 (es) 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina
ARP030100484A AR038430A2 (es) 1995-07-21 2003-02-13 Derivados de parahercuamida b
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Family Applications Before (6)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100486A AR038432A2 (es) 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Country Status (31)

Country Link
US (2) US5703078A (es)
EP (3) EP0871631B1 (es)
JP (2) JP4122447B2 (es)
KR (1) KR100428335B1 (es)
CN (2) CN1125824C (es)
AR (10) AR003466A1 (es)
AT (1) ATE311390T1 (es)
AU (1) AU699644B2 (es)
BR (7) BR9612974B8 (es)
CA (1) CA2225813C (es)
CO (1) CO4750664A1 (es)
CZ (1) CZ296008B6 (es)
DE (1) DE69635524T2 (es)
DK (2) DK0871631T3 (es)
ES (2) ES2439569T3 (es)
FI (2) FI115912B (es)
HK (2) HK1017883A1 (es)
HU (1) HU226296B1 (es)
ID (1) ID30373A (es)
MX (1) MX9800625A (es)
MY (1) MY113806A (es)
NO (1) NO324287B1 (es)
NZ (1) NZ311952A (es)
PL (1) PL185007B1 (es)
PT (1) PT1489082E (es)
RU (1) RU2162090C2 (es)
SI (1) SI0871631T1 (es)
SK (2) SK284833B6 (es)
TW (1) TW334436B (es)
WO (1) WO1997003988A1 (es)
ZA (1) ZA965908B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA976761B (en) * 1996-09-09 1999-01-29 Upjohn Co 25 Methylene and 24,25-epoxy marcfortines and paraherquamides
AU4911097A (en) * 1996-11-15 1998-06-03 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
PE20011289A1 (es) * 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
LT3050874T (lt) 2008-11-14 2019-04-10 Merial Inc. Enantiomeriškai praturtinti arilazol-2-ilo cianetilamino paraziticidiniai junginiai
AU2009316899B2 (en) 2008-11-19 2015-08-20 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection
AR074482A1 (es) 2008-12-04 2011-01-19 Merial Ltd Derivados dimericos de avermectina y milbemicina
EP2314292A1 (en) 2009-10-20 2011-04-27 Novartis AG Endoparasiticidal compositions
NZ600252A (en) 2009-12-04 2014-03-28 Merial Ltd Pesticidal bis-organosulfur compounds
WO2011075592A1 (en) 2009-12-17 2011-06-23 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
PL2513104T3 (pl) 2009-12-17 2016-08-31 Merial Inc Przeciwpasożytnicze związki dihydroazolu i zawierające je kompozycje
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
NZ610547A (en) 2010-11-16 2015-07-31 Merial Ltd Novel monensin derivatives for the treatment and prevention of protozoal infections
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
BR112013033568B1 (pt) 2011-06-27 2020-11-24 Merial, Inc Compostos eter amidopiridil e composiqoes, e seu uso contra parasitas
DK3172964T3 (da) 2011-09-12 2020-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasitiske sammensætninger indeholdende et isoxazolinaktivstof, fremgangsmåde og anvendelser deraf
US20130079394A1 (en) 2011-09-23 2013-03-28 Cnrs (Centre National Recherche Scientifique) Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
AU2012340351B2 (en) 2011-11-17 2017-06-15 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof
BR122020002199B1 (pt) 2011-12-02 2021-01-19 Merial, Inc. formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
MD20170009A2 (ro) 2012-02-06 2017-07-31 Merial Limited Compoziţii veterinare antiparazitare orale cu conţinut de agenţi activi cu acţiune sistemică, metode şi aplicări ale acestora
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
SG10201704665QA (en) 2012-04-20 2017-07-28 Merial Inc Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof
JP5737255B2 (ja) * 2012-09-27 2015-06-17 ダイキン工業株式会社 チオノカルボン酸エステルの製造方法
SG11201503959VA (en) 2012-11-20 2015-06-29 Merial Inc Anthelmintic compounds and compositions and method of using thereof
EP3063144B1 (en) 2013-11-01 2021-09-08 Boehringer Ingelheim Animal Health USA Inc. Antiparasitic and pesticidal isoxazoline compounds
US10857121B2 (en) 2014-04-17 2020-12-08 Merial Inc. Use of malononitrile compounds for protecting animals from parasites
JP6616786B2 (ja) 2014-05-19 2019-12-04 メリアル インコーポレイテッド 駆虫性化合物
NZ728102A (en) 2014-06-19 2018-04-27 Merial Inc Parasiticidal compositions comprising indole derivatives, methods and uses thereof
AU2015339096B2 (en) 2014-10-31 2018-08-02 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal composition comprising fipronil
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG10202103403SA (en) 2015-05-20 2021-05-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic depsipeptide compounds
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
JP2019535655A (ja) 2016-10-14 2019-12-12 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
HUE061497T2 (hu) 2017-08-14 2023-07-28 Boehringer Ingelheim Animal Health Usa Inc Peszticid és paraziticid hatású pirazol-izoxazolin vegyületek
WO2019157241A1 (en) 2018-02-08 2019-08-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
CN112996788A (zh) 2018-07-09 2021-06-18 勃林格殷格翰动物保健美国公司 驱蠕虫的杂环化合物
WO2020112374A1 (en) 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
EP3930684A1 (en) 2019-03-01 2022-01-05 Boehringer Ingelheim Animal Health USA Inc. Injectable clorsulon compositions, methods and uses thereof
JP2022526901A (ja) 2019-03-19 2022-05-27 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
PE20231205A1 (es) 2020-05-29 2023-08-17 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos como anthelminticos
CN111748503B (zh) * 2020-08-04 2021-12-14 华中农业大学 一种深海独岛枝芽胞杆菌培养基和剂型
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
US20230312207A1 (en) 2022-02-17 2023-10-05 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075307A (en) * 1987-07-28 1991-12-24 Merck & Co., Inc. Paraherquamide and dihydroparaherquamide as antihelminthic agents
US4873247A (en) * 1987-11-27 1989-10-10 Goegelman Robert T Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
US4978656A (en) * 1988-08-12 1990-12-18 Merck & Co., Inc. Synthetic derivatives of paraherquamide
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents
NZ233043A (en) * 1989-03-30 1992-09-25 Merck & Co Inc Anthelmintic heterocyclic compounds prepared by action of cunninghamella blakesleeana on (dihydro)paraherquamide
IE904606A1 (en) * 1989-12-21 1991-07-03 Beecham Group Plc Novel products
GB9014194D0 (en) * 1990-06-26 1990-08-15 Pfizer Ltd Antiparasitic agents
WO1992022555A1 (en) * 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
TW410227B (en) * 1993-06-16 2000-11-01 Upjohn Co 14-substituted marcfortines and derivatives useful as antiparasitic agents

Also Published As

Publication number Publication date
JPH11509550A (ja) 1999-08-24
RU2162090C2 (ru) 2001-01-20
AR003466A1 (es) 1998-08-05
BR9612972B8 (pt) 2014-10-29
CZ296008B6 (cs) 2005-12-14
ATE311390T1 (de) 2005-12-15
SK5498A3 (en) 1998-08-05
JP2008007516A (ja) 2008-01-17
NO980255D0 (no) 1998-01-20
AR038434A2 (es) 2005-01-12
BR9612973B8 (pt) 2014-10-29
AR038431A2 (es) 2005-01-12
CN1495183A (zh) 2004-05-12
US5703078A (en) 1997-12-30
ID30373A (id) 1997-01-23
AR052907A1 (es) 2007-04-11
SI0871631T1 (sl) 2006-04-30
EP0871631A1 (en) 1998-10-21
CN1125824C (zh) 2003-10-29
KR100428335B1 (ko) 2004-06-16
AU6337396A (en) 1997-02-18
WO1997003988A1 (en) 1997-02-06
CO4750664A1 (es) 1999-03-31
EP1489082A1 (en) 2004-12-22
TW334436B (en) 1998-06-21
HU226296B1 (hu) 2008-08-28
FI980112A (fi) 1998-01-20
AU699644B2 (en) 1998-12-10
AR038428A2 (es) 2005-01-12
BR9609812B8 (pt) 2014-10-29
CN1277830C (zh) 2006-10-04
DK0871631T3 (da) 2006-03-13
SK285248B6 (sk) 2006-09-07
FI980112A0 (fi) 1998-01-20
HK1017883A1 (en) 1999-12-03
HUP9802221A3 (en) 2000-05-29
CA2225813C (en) 2008-02-26
ZA965908B (en) 1997-01-12
AR038433A2 (es) 2005-01-12
FI20050238A (fi) 2005-03-04
NZ311952A (en) 1999-03-29
PL185007B1 (pl) 2003-01-31
EP0871631B1 (en) 2005-11-30
ES2439569T3 (es) 2014-01-23
BR9612975B8 (pt) 2014-10-29
DK1489082T3 (da) 2013-12-09
PT1489082E (pt) 2013-12-23
EP1400523A3 (en) 2004-04-07
FI115912B (fi) 2005-08-15
AR038429A2 (es) 2005-01-12
EP1489082B1 (en) 2013-11-20
SK284833B6 (sk) 2005-12-01
CZ11098A3 (cs) 1998-06-17
HUP9802221A2 (hu) 1999-02-01
NO980255L (no) 1998-03-20
BR9612963B8 (pt) 2014-10-29
MY113806A (en) 2002-05-31
PL324574A1 (en) 1998-06-08
AR038427A2 (es) 2005-01-12
CA2225813A1 (en) 1997-02-06
BR9609812A (pt) 1999-03-02
BR9612944B8 (pt) 2014-10-29
AR038432A2 (es) 2005-01-12
DE69635524T2 (de) 2006-07-06
BR9612974B8 (pt) 2014-10-29
EP1400523A2 (en) 2004-03-24
FI118471B (fi) 2007-11-30
CN1191537A (zh) 1998-08-26
ES2249783T3 (es) 2006-04-01
NO324287B1 (no) 2007-09-17
DE69635524D1 (de) 2006-01-05
MX9800625A (es) 1998-04-30
JP4122447B2 (ja) 2008-07-23
HK1061242A1 (en) 2004-09-10
US5750695A (en) 1998-05-12

Similar Documents

Publication Publication Date Title
AR038430A2 (es) Derivados de parahercuamida b
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
FI914928A0 (fi) Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
HN1997000149A (es) Derivados de 6 fenilpiridil 2 amina
ES2191208T3 (es) Oxiimino-pregnano-carbolactonas.
DK0923554T3 (da) N-Benzylpiperidin- og tetrahydropyridinderivater
DE69527072T2 (de) Endothelin antagoniste
UY24625A1 (es) Derivados de la 4-hidroxi-piperidina
TR199701654T1 (xx) 4-Fenilaminotiyazol t�revleri.
DK0747393T3 (da) Dobbeltvirkende inhibitorer indeholdende en thiazolobenzazepinstruktur
ATE214698T1 (de) Neue carbamazepin hapten analoge
ES2151977T3 (es) Inhibidores de accion doble que contienen 1,2-diazepina.
TW334430B (en) Preparation process for benzoyl derivatives and its intermediates
DK0589322T3 (da) 5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler.
NO975869D0 (no) Forbedret syntese av 2,4,6,8,10,12-heksabenzyl-2,4,6,8,10,12-heksaazatetracyklo£5,5,0,05,9,03,11|dodecan
ES2182090T3 (es) Nuevos derivados de pirrol.
DE69600231D1 (de) N-Arylalkylphenylacetamidderivate
FI912963A (fi) Hjaernverksamheten oekande pyrimidinylderivat.
DE3566263D1 (de) Novel cyanoimidazole nucleoside derivatives
DK0457324T3 (da) Heterocycliske NMDA antagonister
NO975582L (no) Fremgangsmåte for syntese av benzo£b|tiofener
ES2093051T3 (es) Purinil- y pirimidil-tetrahidrofuranos.
SE8504409D0 (sv) Novel chemical intermediates
FI934468A (fi) Bensenborsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som sytes mellanprodukter
BR9306924A (pt) Derivados de 1,3-oxazolidina pirdil-substituídos oidetos de 1,2,4-ditioz lio de novos compostos de partida

Legal Events

Date Code Title Description
FG Grant, registration