AR032778A1 - Benzimidazoles sustituidos, y su utilizacion para la preparacion de medicamento - Google Patents
Benzimidazoles sustituidos, y su utilizacion para la preparacion de medicamentoInfo
- Publication number
- AR032778A1 AR032778A1 ARP010105612A ARP010105612A AR032778A1 AR 032778 A1 AR032778 A1 AR 032778A1 AR P010105612 A ARP010105612 A AR P010105612A AR P010105612 A ARP010105612 A AR P010105612A AR 032778 A1 AR032778 A1 AR 032778A1
- Authority
- AR
- Argentina
- Prior art keywords
- represent
- alkyl
- substituted
- unsubstituted
- fluorine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Benzimidazoles sustituidos que comprenden la formula (1), en la cual: R1 y R5, independientemente entre sí, representan F, Cl, Br, I, CN, alquilo C1-4, no sustituido o sustituido total o parcialmente por fluor; o R1 y R5 representan cicloalquilo C3-7, no sustituido o sustituido total o parcialmente por fluor; o R1 y R5 representan OH, O-alquilo C1-4, no sustituido o sustituido total o parcialmente por fluor; o R1 y R5 representan OCOR10, NR11R12, COR13, COOH, COOR14, CONR11R12, -(O)n-SOmR15; n vale 0 o 1; m vale 0, 1 o 2; o R1 y R5 representan O-fenilo, que está sin sustituir o está sustituido por de 1 a 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, alquilo C1-4, OH, O-alquilo C1-4, NR16R17, CN o C1-4-alquil sulfonilo, que está sin sustituir o está fluorado parcial o totalmente; R16 y R17, representan H o alquilo C1-4, estando los grupos alquilo no sustituidos o fluorados total o parcialmente; R10 representa H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; R11 y R12, independientemente entre sí, representan H, alquilo C1-4 que pueden estar fluorados total o parcialmente y un grupo CH2 puede estar sustituido por O o NR18; o, R11 y R12, conjuntamente representan un anillo de 5, 6 o 7 miembros; o, R1 y R12 representan COR19 o SO2R20; R18, R19 y R20, independientemente entre sí, representan H o alquilo C1-4, sin sustituir o sustituidos total o parcialmente por fluor; R13 y R14 representan alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; R15 representa alquilo u O-alquilo C1-4, estando los grupos alquilo sin sustituir o fluorado total o parcialmente; o: R15 representa OH u NR21R22; R21 y R22 independientemente entre sí representan H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor, pudiendo un grupo CH2 arbitrario estar sustituido por NR23; R23 representa H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; o R21 y R22 forman conjuntamente un anillo de 5, 6 o 7 miembros; pero R1 y R5 no pueden ser simultáneamente Cl o CH3; R2, R3 y R4 representan H, o una de los radicales R2, R3 o R4 puede ser F; R6, R7, R8 y R9, independientemente entre sí representan H, F, Cl, Br, I, CN, alquilo u O-alquilo C1-4 sin sustituir o sustituido total o parcialmente por fluor; o, R6, R7, R8 y R9, representan cicloalquilo C3-7, sin sustituir o parcialmente por fluor; o R6, R7, R8 y R9 representan OH, OCOR24 o NR25R26; R24 representa H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; R25 y R26, independientemente entre sí representan H o C1-4, sin sustituir o sustituido total o parcialmente por fluor; o, R25 y R26 representan H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; o, R25 y R26 representan COR27; o R25 y R26 conjuntamente con el átomo de nitrogeno al cual están unidos, representan un anillo de 5, 6 o 7 miembros, en el cual un grupo CH2 arbitrario puede estar reemplazado por O o por NR18; R27 representa H o alquilo C1-4, sin sustituir o sustituido total o parcialmente por fluor; como también sus sales farmacéuticamente aceptables o trifluoracetatos para la utilizacion de sustancias de la formula (1) para la preparacion de un medicamento para el tratamiento de las enfermedades que pueden ser influidas por intermedio de la inhibicion del intercambiador Na+/H+, y también se refiere a un medicamento que las contiene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10060292A DE10060292A1 (de) | 2000-12-05 | 2000-12-05 | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032778A1 true AR032778A1 (es) | 2003-11-26 |
Family
ID=7665784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105612A AR032778A1 (es) | 2000-12-05 | 2001-12-03 | Benzimidazoles sustituidos, y su utilizacion para la preparacion de medicamento |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6686384B2 (es) |
| EP (1) | EP1341770B1 (es) |
| JP (1) | JP4323803B2 (es) |
| KR (1) | KR20030070045A (es) |
| CN (1) | CN1478081A (es) |
| AR (1) | AR032778A1 (es) |
| AT (1) | ATE329906T1 (es) |
| AU (1) | AU2002219135A1 (es) |
| BR (1) | BR0115936A (es) |
| CA (1) | CA2430412A1 (es) |
| CZ (1) | CZ20031538A3 (es) |
| DE (2) | DE10060292A1 (es) |
| EE (1) | EE200300193A (es) |
| HR (1) | HRP20030449A2 (es) |
| HU (1) | HUP0400967A3 (es) |
| IL (1) | IL156161A0 (es) |
| MX (1) | MXPA03004932A (es) |
| NO (1) | NO20032490L (es) |
| NZ (1) | NZ526250A (es) |
| PL (1) | PL366305A1 (es) |
| RU (1) | RU2272031C2 (es) |
| SK (1) | SK6822003A3 (es) |
| WO (1) | WO2002046169A1 (es) |
| ZA (1) | ZA200303932B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60025604T2 (de) * | 1999-06-22 | 2006-07-27 | Neurosearch A/S | Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen |
| US20030187045A1 (en) * | 2001-12-21 | 2003-10-02 | Uwe Heinelt | Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic |
| DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
| US20050054705A1 (en) * | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
| DE10304374A1 (de) * | 2003-02-04 | 2004-08-05 | Aventis Pharma Deutschland Gmbh | Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10304294A1 (de) * | 2003-02-04 | 2004-08-12 | Aventis Pharma Deutschland Gmbh | N-Substituierte(Benzoimidazol-2-yl)-phenyl, Verfahren zu ihrer Herstellung , ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10341240A1 (de) * | 2003-09-08 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB0401334D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| WO2006078907A1 (en) * | 2005-01-20 | 2006-07-27 | Amgen Inc. | 2-substituted benzimidazole derivatives as vanilloid receptor ligands and their use in treatments |
| TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| MX2007015689A (es) * | 2005-06-21 | 2008-02-21 | Neurosearch As | Nuevos derivados de 2-(fenilamino)bencimidazol y su uso como moduladores de los canales de potasio activados por calcio de pequena conductancia. |
| PE20070427A1 (es) * | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
| WO2008051533A2 (en) * | 2006-10-25 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Benzimidazole compounds |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
| US8604217B2 (en) | 2009-11-12 | 2013-12-10 | Selvita S.A. | Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| EP2499117B1 (en) * | 2009-11-12 | 2015-10-21 | Selvita S.A. | A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| CN102060780B (zh) | 2010-12-27 | 2014-11-05 | 雅本化学股份有限公司 | 2-(n-取代)-氨基苯并咪唑衍生物的制备方法 |
| CN103435554A (zh) * | 2013-09-06 | 2013-12-11 | 中国药科大学 | 2-苯氨基苯并咪唑类化合物及其用途 |
| EP3105210B1 (en) * | 2014-02-11 | 2019-01-30 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| CN105061324B (zh) * | 2015-08-14 | 2017-09-12 | 广西师范大学 | 一种2‑芳基‑1,3‑二氢苯并咪唑衍生物及其合成方法和应用 |
| CN109331014B (zh) * | 2018-10-29 | 2021-06-04 | 南方医科大学南方医院 | 一种苯并咪唑衍生物在制备治疗心衰药物中的用途 |
| CN112675169A (zh) * | 2020-12-23 | 2021-04-20 | 南京景瑞康分子医药科技有限公司 | Itm-1b4在制备预防和/或***药物中的应用 |
| WO2024028893A1 (en) * | 2022-08-01 | 2024-02-08 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Substituted benzimidazoles for treating viral diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1171904A (en) | 1965-10-21 | 1969-11-26 | Unilever Ltd | Anilinobenzimidazoles having Antibacterial Properties |
| DE4328869A1 (de) | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19548812A1 (de) | 1995-12-27 | 1997-07-03 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation |
| ATE303365T1 (de) * | 1995-12-28 | 2005-09-15 | Fujisawa Pharmaceutical Co | Benzimidazolderivate |
| WO1998008818A1 (en) | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
-
2000
- 2000-12-05 DE DE10060292A patent/DE10060292A1/de not_active Ceased
-
2001
- 2001-11-22 CA CA002430412A patent/CA2430412A1/en not_active Abandoned
- 2001-11-22 CN CNA018200443A patent/CN1478081A/zh active Pending
- 2001-11-22 MX MXPA03004932A patent/MXPA03004932A/es unknown
- 2001-11-22 HU HU0400967A patent/HUP0400967A3/hu unknown
- 2001-11-22 AT AT01999563T patent/ATE329906T1/de not_active IP Right Cessation
- 2001-11-22 EE EEP200300193A patent/EE200300193A/xx unknown
- 2001-11-22 CZ CZ20031538A patent/CZ20031538A3/cs unknown
- 2001-11-22 JP JP2002547908A patent/JP4323803B2/ja not_active Expired - Fee Related
- 2001-11-22 KR KR10-2003-7007467A patent/KR20030070045A/ko not_active Application Discontinuation
- 2001-11-22 PL PL01366305A patent/PL366305A1/xx not_active Application Discontinuation
- 2001-11-22 SK SK682-2003A patent/SK6822003A3/sk unknown
- 2001-11-22 NZ NZ526250A patent/NZ526250A/en unknown
- 2001-11-22 RU RU2003120069/04A patent/RU2272031C2/ru not_active IP Right Cessation
- 2001-11-22 DE DE50110181T patent/DE50110181D1/de not_active Expired - Lifetime
- 2001-11-22 BR BR0115936-4A patent/BR0115936A/pt not_active IP Right Cessation
- 2001-11-22 WO PCT/EP2001/013586 patent/WO2002046169A1/de not_active Application Discontinuation
- 2001-11-22 IL IL15616101A patent/IL156161A0/xx unknown
- 2001-11-22 AU AU2002219135A patent/AU2002219135A1/en not_active Abandoned
- 2001-11-22 EP EP01999563A patent/EP1341770B1/de not_active Expired - Lifetime
- 2001-12-03 AR ARP010105612A patent/AR032778A1/es unknown
- 2001-12-04 US US10/000,028 patent/US6686384B2/en not_active Expired - Fee Related
-
2003
- 2003-05-20 US US10/441,124 patent/US6958357B2/en not_active Expired - Fee Related
- 2003-05-21 ZA ZA200303932A patent/ZA200303932B/en unknown
- 2003-06-02 NO NO20032490A patent/NO20032490L/no unknown
- 2003-06-04 HR HR20030449A patent/HRP20030449A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20030191170A1 (en) | 2003-10-09 |
| CN1478081A (zh) | 2004-02-25 |
| ATE329906T1 (de) | 2006-07-15 |
| ZA200303932B (en) | 2004-04-15 |
| IL156161A0 (en) | 2003-12-23 |
| KR20030070045A (ko) | 2003-08-27 |
| MXPA03004932A (es) | 2003-09-10 |
| NZ526250A (en) | 2004-11-26 |
| HUP0400967A2 (hu) | 2004-08-30 |
| JP4323803B2 (ja) | 2009-09-02 |
| US6958357B2 (en) | 2005-10-25 |
| EP1341770B1 (de) | 2006-06-14 |
| BR0115936A (pt) | 2003-10-28 |
| DE50110181D1 (de) | 2006-07-27 |
| US20020132842A1 (en) | 2002-09-19 |
| AU2002219135A1 (en) | 2002-06-18 |
| RU2272031C2 (ru) | 2006-03-20 |
| WO2002046169A1 (de) | 2002-06-13 |
| EE200300193A (et) | 2003-08-15 |
| SK6822003A3 (en) | 2003-11-04 |
| US6686384B2 (en) | 2004-02-03 |
| NO20032490D0 (no) | 2003-06-02 |
| HRP20030449A2 (en) | 2005-04-30 |
| CZ20031538A3 (cs) | 2003-09-17 |
| DE10060292A1 (de) | 2002-06-20 |
| PL366305A1 (en) | 2005-01-24 |
| CA2430412A1 (en) | 2002-06-13 |
| HUP0400967A3 (en) | 2004-10-28 |
| NO20032490L (no) | 2003-07-22 |
| EP1341770A1 (de) | 2003-09-10 |
| JP2004517086A (ja) | 2004-06-10 |
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