AR029466A1 - Nitrilos de dipeptidos, su proceso de sintesis y su uso para la preparacion de un medicamento en enfermedades en la cual la catepsina k este implicada - Google Patents

Nitrilos de dipeptidos, su proceso de sintesis y su uso para la preparacion de un medicamento en enfermedades en la cual la catepsina k este implicada

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Publication number
AR029466A1
AR029466A1 ARP010100563A ARP010100563A AR029466A1 AR 029466 A1 AR029466 A1 AR 029466A1 AR P010100563 A ARP010100563 A AR P010100563A AR P010100563 A ARP010100563 A AR P010100563A AR 029466 A1 AR029466 A1 AR 029466A1
Authority
AR
Argentina
Prior art keywords
het
formula
preparation
katepsate
nitrils
Prior art date
Application number
ARP010100563A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR029466A1 publication Critical patent/AR029466A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Inhibidores del nitrilo de dipéptido catepsina K de la formula (1) y sales o ésteres farmacéuticamente aceptables de los mismos, en donde R1 y R2 son independientemente H o alquilo inferior de 1 a 7 átomos de carbono, o R1 y R2, junto con el átomo de carbono con el que están unidos forman un anillo cicloalquilo de 3 a 8 átomos de carbono, y Het es un sustituyente heterocíclico que contiene nitrogeno opcionalmente sustituido y Het no es 4-pirrol-1-ilo, utiles por ejemplo, para el tratamiento terapéutico o profiláctico de una enfermedad o condicion médica en donde esté implícita la catepsina K. Adicionalmente, un proceso para la preparacion de un compuesto de la formula (1), o una sal o éster del mismo, el cual comprende acoplar el derivado del ácido benzoico sustituido por Het correspondiente de la formula (3) en donde Het es como se define antes, con cianometilamida del ácido 1-amino-ciclohexan-carboxílico.
ARP010100563A 2000-02-10 2001-02-08 Nitrilos de dipeptidos, su proceso de sintesis y su uso para la preparacion de un medicamento en enfermedades en la cual la catepsina k este implicada AR029466A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0003111.2A GB0003111D0 (en) 2000-02-10 2000-02-10 Organic compounds

Publications (1)

Publication Number Publication Date
AR029466A1 true AR029466A1 (es) 2003-07-02

Family

ID=9885359

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100563A AR029466A1 (es) 2000-02-10 2001-02-08 Nitrilos de dipeptidos, su proceso de sintesis y su uso para la preparacion de un medicamento en enfermedades en la cual la catepsina k este implicada

Country Status (31)

Country Link
US (4) US6642239B2 (es)
EP (1) EP1254124B1 (es)
JP (1) JP3942895B2 (es)
KR (1) KR100544553B1 (es)
CN (2) CN1636980A (es)
AR (1) AR029466A1 (es)
AT (1) ATE402930T1 (es)
AU (1) AU764334B2 (es)
BR (1) BR0108118A (es)
CA (1) CA2396158C (es)
CO (1) CO5261578A1 (es)
CZ (1) CZ20022721A3 (es)
DE (1) DE60135087D1 (es)
ES (1) ES2310177T3 (es)
GB (1) GB0003111D0 (es)
HK (1) HK1050197A1 (es)
HU (1) HUP0300148A3 (es)
IL (1) IL150406A0 (es)
MX (1) MXPA02007768A (es)
MY (1) MY122826A (es)
NO (1) NO20023780L (es)
NZ (1) NZ519940A (es)
PE (1) PE20020220A1 (es)
PL (1) PL200119B1 (es)
PT (1) PT1254124E (es)
RU (2) RU2293732C2 (es)
SK (1) SK11462002A3 (es)
TR (1) TR200201752T2 (es)
TW (1) TWI258473B (es)
WO (1) WO2001058886A1 (es)
ZA (1) ZA200206218B (es)

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Also Published As

Publication number Publication date
US6642239B2 (en) 2003-11-04
PL200119B1 (pl) 2008-12-31
KR20020072310A (ko) 2002-09-14
US20010016207A1 (en) 2001-08-23
NO20023780D0 (no) 2002-08-09
JP3942895B2 (ja) 2007-07-11
CA2396158C (en) 2010-02-02
ES2310177T3 (es) 2009-01-01
CZ20022721A3 (cs) 2002-11-13
AU4642601A (en) 2001-08-20
JP2003522764A (ja) 2003-07-29
ZA200206218B (en) 2003-08-05
SK11462002A3 (sk) 2003-01-09
US20070191392A1 (en) 2007-08-16
TR200201752T2 (tr) 2002-10-21
WO2001058886A1 (en) 2001-08-16
CO5261578A1 (es) 2003-03-31
NO20023780L (no) 2002-08-09
BR0108118A (pt) 2003-02-25
AU764334B2 (en) 2003-08-14
PE20020220A1 (es) 2002-03-25
IL150406A0 (en) 2002-12-01
HUP0300148A3 (en) 2005-04-28
MY122826A (en) 2006-05-31
CN1398260A (zh) 2003-02-19
CA2396158A1 (en) 2001-08-16
CN1183122C (zh) 2005-01-05
GB0003111D0 (en) 2000-03-29
CN1636980A (zh) 2005-07-13
MXPA02007768A (es) 2002-10-11
EP1254124A1 (en) 2002-11-06
PL357901A1 (en) 2004-07-26
US20030203919A1 (en) 2003-10-30
RU2002123350A (ru) 2004-01-10
RU2293732C2 (ru) 2007-02-20
NZ519940A (en) 2004-02-27
PT1254124E (pt) 2008-11-03
US20050267129A1 (en) 2005-12-01
EP1254124B1 (en) 2008-07-30
HUP0300148A2 (en) 2003-05-28
ATE402930T1 (de) 2008-08-15
RU2265601C2 (ru) 2005-12-10
HK1050197A1 (en) 2003-06-13
DE60135087D1 (de) 2008-09-11
TWI258473B (en) 2006-07-21
RU2005108133A (ru) 2006-09-10
KR100544553B1 (ko) 2006-01-24

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