AR026839A1 - Compuestos quimicos - Google Patents

Compuestos quimicos

Info

Publication number
AR026839A1
AR026839A1 ARP010100144A ARP010100144A AR026839A1 AR 026839 A1 AR026839 A1 AR 026839A1 AR P010100144 A ARP010100144 A AR P010100144A AR P010100144 A ARP010100144 A AR P010100144A AR 026839 A1 AR026839 A1 AR 026839A1
Authority
AR
Argentina
Prior art keywords
halo
hydrogen
compound
group
methoxy
Prior art date
Application number
ARP010100144A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR026839A1 publication Critical patent/AR026839A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Un compuesto de la formula (1), donde R1 es hidrogeno, halo o metoxilo; R2 es hidrogeno, halo, metilo, etilo o metoxilo; R3 es un grupo halo o un grupotriflorometilo; R4 es un grupo halo o un grupo triflorometilo; R5 es hidrogeno o halo; R6 es hidrog eno o halo; teniendo en cuenta que cuando R5 y R6 son amboshidrogeno, y uno de R3 o R4 es cloro o floro, entonces el otro no es cloro o floro; o una sal o una prodroga del mismo aceptable para el uso farmacéutico.Estos compuestos presentan una activi dad util en el tratamiento de enfermedades inflamatorias, específicamente para antagonizar un efecto mediado por la MCP-1en un animal de sangre caliente, tal como un ser humano. Un proceso para la preparacion de dicho compuesto activo cuya formula se dá más arriba. Unacomposicion farmacéutica que comprende a dicho compuesto y el uso del compuesto para la fabricacion de un medicamento.
ARP010100144A 2000-01-13 2001-01-12 Compuestos quimicos AR026839A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0000626.2A GB0000626D0 (en) 2000-01-13 2000-01-13 Chemical compounds

Publications (1)

Publication Number Publication Date
AR026839A1 true AR026839A1 (es) 2003-02-26

Family

ID=9883551

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100144A AR026839A1 (es) 2000-01-13 2001-01-12 Compuestos quimicos

Country Status (25)

Country Link
US (1) US20030144339A1 (es)
EP (1) EP1252142A1 (es)
JP (1) JP2003519683A (es)
KR (1) KR20020064375A (es)
CN (1) CN1395565A (es)
AR (1) AR026839A1 (es)
AU (1) AU780992B2 (es)
BG (1) BG106894A (es)
BR (1) BR0107404A (es)
CA (1) CA2393592A1 (es)
CO (1) CO5271703A1 (es)
EE (1) EE200200394A (es)
GB (1) GB0000626D0 (es)
HK (1) HK1049486A1 (es)
HU (1) HUP0300694A3 (es)
IL (1) IL150272A0 (es)
IS (1) IS6429A (es)
MX (1) MXPA02006611A (es)
NO (1) NO20023380L (es)
NZ (1) NZ519312A (es)
PL (1) PL356031A1 (es)
RU (1) RU2002121636A (es)
SK (1) SK10072002A3 (es)
WO (1) WO2001051466A1 (es)
ZA (1) ZA200204354B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
AU2003215549A1 (en) 2003-02-03 2004-08-30 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
DE602005020342D1 (de) * 2004-09-13 2010-05-12 Kureha Corp Thermal aufschäumende mikrokugel, deren herstellung, verwendung, sie enthaltende zusammensetzung sowie erzeugnis
WO2007065820A1 (en) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7507736B2 (en) 2007-02-07 2009-03-24 Hoffmann-La Roche Inc. Indol-2-yl-piperazin-1-yl-methanone derivatives
EP2134685B1 (en) * 2007-04-16 2015-09-02 AbbVie Inc. 7-nonsubstituted indole derivatives as mcl-1 inhibitors
WO2023224981A1 (en) * 2022-05-17 2023-11-23 Inipharm, Inc. Hsd17b13 inhibitors and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529724A (en) * 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
DE3907388A1 (de) * 1989-03-08 1990-09-13 Kali Chemie Pharma Gmbh Verfahren zur herstellung von indolcarbonsaeurederivaten
US5272145A (en) * 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5081145A (en) * 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5273980A (en) * 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5852046A (en) * 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5686481A (en) * 1993-12-21 1997-11-11 Smithkline Beecham Corporation Endothelin receptor antagonists
US5482960A (en) * 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5684032A (en) * 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
EP1021181A4 (en) * 1996-03-28 2002-06-26 Smithkline Beecham Corp INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS
US6184235B1 (en) * 1996-08-14 2001-02-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as MCP-1 antagonists
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716656D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803226D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
GB0000626D0 (en) 2000-03-01
HK1049486A1 (zh) 2003-05-16
IS6429A (is) 2002-06-19
WO2001051466A1 (en) 2001-07-19
EE200200394A (et) 2003-12-15
MXPA02006611A (es) 2002-09-30
BG106894A (bg) 2003-04-30
BR0107404A (pt) 2002-10-08
HUP0300694A3 (en) 2005-08-29
AU2532401A (en) 2001-07-24
ZA200204354B (en) 2003-09-01
NO20023380L (no) 2002-09-03
CA2393592A1 (en) 2001-07-19
HUP0300694A2 (hu) 2003-07-28
KR20020064375A (ko) 2002-08-07
EP1252142A1 (en) 2002-10-30
NZ519312A (en) 2004-04-30
JP2003519683A (ja) 2003-06-24
AU780992B2 (en) 2005-04-28
US20030144339A1 (en) 2003-07-31
SK10072002A3 (sk) 2003-06-03
IL150272A0 (en) 2002-12-01
RU2002121636A (ru) 2004-01-10
CO5271703A1 (es) 2003-04-30
NO20023380D0 (no) 2002-07-12
PL356031A1 (en) 2004-06-14
CN1395565A (zh) 2003-02-05

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal