AR026267A1 - Agentes heterociclicos citotoxicos. - Google Patents
Agentes heterociclicos citotoxicos.Info
- Publication number
- AR026267A1 AR026267A1 ARP000105664A ARP000105664A AR026267A1 AR 026267 A1 AR026267 A1 AR 026267A1 AR P000105664 A ARP000105664 A AR P000105664A AR P000105664 A ARP000105664 A AR P000105664A AR 026267 A1 AR026267 A1 AR 026267A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- heterociclic
- cytotoxic
- agents
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Proporciona compuestos de formula 1 donde R1-R8 A-G tiene cualquier de los significados significados definidos en la especificacion, y sus salesfarmacéuticamente aceptables. También proporciona composiciones farmacéuticas que incluyen un compuesto de formula 1, procesos para preparar compuestos deformula 1, intermediarios utiles para preparar compuestos de formula a y métodos terapéuticos para tratar cáncer usando compuestos de formula 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16254099P | 1999-10-29 | 1999-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR026267A1 true AR026267A1 (es) | 2003-02-05 |
Family
ID=22586069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105664A AR026267A1 (es) | 1999-10-29 | 2000-10-27 | Agentes heterociclicos citotoxicos. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1228045A2 (es) |
JP (1) | JP2003513079A (es) |
AR (1) | AR026267A1 (es) |
AU (1) | AU1236401A (es) |
CA (1) | CA2389312A1 (es) |
WO (1) | WO2001032631A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1453507B1 (en) | 2001-11-14 | 2009-03-04 | Rutgers, The State University | Solubilized topoisomerase poison agents |
PT1465625E (pt) * | 2001-11-14 | 2010-03-09 | Univ Rutgers | Venenos de topoisomerase solubilizados |
ATE405568T1 (de) * | 2001-11-14 | 2008-09-15 | Univ Rutgers | Cytotoxische mittel |
EP1453506B1 (en) | 2001-11-14 | 2008-04-02 | Rutgers, The State University | Topoisomerase poison agents |
AU2003265406A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
AU2003265405A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
WO2004014906A2 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
AU2003290818A1 (en) | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
EP1577288B1 (en) | 2002-12-26 | 2014-07-23 | Eisai R&D Management Co., Ltd. | Selective estrogen receptor modulators |
DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
TW201038578A (en) | 2009-01-30 | 2010-11-01 | Univ Rutgers | Methods to treat cancer |
EP2403856B1 (en) | 2009-03-06 | 2012-12-19 | Rutgers, The State University of New Jersey | Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
SI3122426T1 (sl) | 2014-03-28 | 2023-04-28 | Duke University | Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
JP2019515025A (ja) | 2016-04-04 | 2019-06-06 | ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー | トポイソメラーゼ毒 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045272A1 (en) * | 1997-04-07 | 1998-10-15 | Latrobe University | Topoisomerase inhibitors |
-
2000
- 2000-10-26 EP EP00973917A patent/EP1228045A2/en not_active Withdrawn
- 2000-10-26 CA CA002389312A patent/CA2389312A1/en not_active Abandoned
- 2000-10-26 AU AU12364/01A patent/AU1236401A/en not_active Abandoned
- 2000-10-26 WO PCT/US2000/029583 patent/WO2001032631A2/en not_active Application Discontinuation
- 2000-10-26 JP JP2001534782A patent/JP2003513079A/ja not_active Withdrawn
- 2000-10-27 AR ARP000105664A patent/AR026267A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001032631A2 (en) | 2001-05-10 |
AU1236401A (en) | 2001-05-14 |
JP2003513079A (ja) | 2003-04-08 |
EP1228045A2 (en) | 2002-08-07 |
WO2001032631A3 (en) | 2002-02-21 |
CA2389312A1 (en) | 2001-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR026267A1 (es) | Agentes heterociclicos citotoxicos. | |
BG106586A (en) | Pyrazolopyramidines as therapeutic agents | |
PA8575401A1 (es) | Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metrodos para su uso | |
CY1110631T1 (el) | Διαλυτοποιημενα δηλητηρια τοποϊσομερασης | |
BG108268A (en) | Pyrazolopyrimidines as therapeutic agents | |
BG108269A (en) | Pyrazolopyrimidines as therapeutic agents | |
AR007828A1 (es) | Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos | |
CR20140368A (es) | Derivados y composiciones de isoindol 4´-0-sustituidos, composiciones que las comprenden y metodos de uso de los mismos (divisional 11036) | |
MY128765A (en) | Novel benzoimidazole derivatives useful as antiproliferative agents. | |
DE60112974D1 (en) | Carbolinderivate | |
DE60216233D1 (en) | Carbolinderivate | |
SE9903997D0 (sv) | New compounds | |
EE200000472A (et) | Kasvajavastased toimeained | |
ATE297904T1 (de) | Halo-alkoxycarbonylverbindungen | |
UY27685A1 (es) | Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso | |
AR018162A1 (es) | Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica | |
ATE424200T1 (de) | Solubilisierte topoisomerase-gift-mittel | |
AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
EP1109560A4 (en) | COMPOUNDS USEFUL AS AICARFT INHIBITORS | |
AU2002364953A8 (en) | Topoisomerase poison agents | |
ATE266029T1 (de) | Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung | |
MY139228A (en) | Imidazolinylmethyl aralkylsulfonamides | |
MXPA03003971A (es) | Derivados de indol como inhibidores de pde5. | |
PT1017681E (pt) | Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios | |
UY26224A1 (es) | Complejo farmaceutico ley 17164 art. 127 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |