AR025698A1 - Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
AR025698A1
AR025698A1 ARP000104875A ARP000104875A AR025698A1 AR 025698 A1 AR025698 A1 AR 025698A1 AR P000104875 A ARP000104875 A AR P000104875A AR P000104875 A ARP000104875 A AR P000104875A AR 025698 A1 AR025698 A1 AR 025698A1
Authority
AR
Argentina
Prior art keywords
halogen
alkyl
alkyloxycarbonyl
substituted
alkyloxy
Prior art date
Application number
ARP000104875A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR025698A1 publication Critical patent/AR025698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Derivados de quinolil propil piperidina de formula general 1 en la que R1 es H o de halogeno, o OH, R1 es H, o puede representar halogeno cuando R1 estambién halogeno, y Rs es H, o bien R1 y Rs forman una union y R1 es H, R2 es un radical carboxi,ca rboximetilo o carboxi-2 etilo, y R3 es alquilo (C1-6)sustituido por 1 a 3 sustituyentes elegidos entre OH, halogeno, =O, COOH, alquiloxicarbonilo alquiloxi, alquiltio o entre un radical fenilo, feniltio ofenilalquiltio que pueden ellos mismosllevar 1 a 4 sustituyentes [elegidos entre halogeno, OH, alquilo, alquiloxi, trifluorometilo, trifluorometoxi, COOH,alquiloxicarbonilo, CN, acetamido o NH2] o entre cicloalquilo o cicloalquiltio (3 a 7 eslabones), o entre heterociclilo oheterocicliltio aro mático (5 a 6eslabones) que comprenden 1 a 4 heteroátomos elegidos entre N, O o S y eventualmente ellos mismos sustituidos [por halogeno, OH, alquilo alquiloxi, CF3, OCF3,=O, COOH, alquiloxicarbonilo, CN o NH2], o R3 espropargilo sustituido por feni lo que puede él mismo llevar 1 a 3 sustituyentes [elegidos entre halogneo, OH,alquilo, alquiloxi, CF3, OCF3, COOH, alquiloxicarbonilo, CN o NH2], o sustituido por un radical cicloalquilo que contiene 3 a 7 eslabones osustituido porheterociclilo arom ático (5 a 6 eslabones) que comprende 1 a 4 heteroátomos elegidos entre N, O o S y eventualmente el mismo sustituido [por halogeno, OH,alquilo, alquiloxi, CF3, OCF3, =O, COOH, alquiloxicarbonilo, CN o NH2], o R3representa cinamilo o 4-fenilbuten-3-i lo, o bien R2 es -CH2OH, alquiloxicarbonilo,alquiloxicarbonilmetilo o alquiloxicarbonil-2-etilo y R3 es alquilo (C1-6) sustituido por feniltio que puede el mismo llevar 1 a 3 sustituyentes [elegidosentrehalogeno, OH, alquilo, alquiloxi, CF3, OCF3, C OOH, alquiloxicarbonilo, CN o NH2], por cicloalquiltio (3 a 7 eslabones), o por heterocicliltio aromático(5 a 6 eslabones) que comprende 1 a 4 heteroátomos elegidos entre N, S o O y eventualmente élmismo sustituido [por halogeno, OH, alquilo, alquil oxi, CF3,OCF3, =O, COOH, alquiloxicarbonilo, CN o NH2] o R3 es propargilo sustituido por fenilo que puede el mismo llevar 1 a 3 sustituyentes [elegidos entre halogeno,
ARP000104875A 1995-11-06 2000-09-15 Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen. AR025698A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US728395P 1995-11-06 1995-11-06
US08/730,267 US5756532A (en) 1995-11-06 1996-10-15 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives

Publications (1)

Publication Number Publication Date
AR025698A1 true AR025698A1 (es) 2002-12-11

Family

ID=26676776

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP960105059A AR004284A1 (es) 1995-11-06 1996-11-05 Derivados de aminometil-2,3,8,9-tetrahidro-7h-1,4-dioxino-2,3-e-indol-8-onas y el uso de los mismos para la manufactura de un medicamento
ARP000104875A AR025698A1 (es) 1995-11-06 2000-09-15 Derivados de la quinolil propil piperidina, su preparacion y las composiciones farmaceuticas que los contienen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP960105059A AR004284A1 (es) 1995-11-06 1996-11-05 Derivados de aminometil-2,3,8,9-tetrahidro-7h-1,4-dioxino-2,3-e-indol-8-onas y el uso de los mismos para la manufactura de un medicamento

Country Status (21)

Country Link
US (2) US5756532A (es)
EP (3) EP1726592A1 (es)
JP (1) JP4311770B2 (es)
KR (1) KR100566678B1 (es)
CN (1) CN1084748C (es)
AR (2) AR004284A1 (es)
AT (1) ATE349450T1 (es)
AU (1) AU701624B2 (es)
CA (1) CA2189524C (es)
CZ (1) CZ291731B6 (es)
DE (1) DE69636801T2 (es)
DK (1) DK1375503T3 (es)
ES (1) ES2277014T3 (es)
HU (1) HU224841B1 (es)
IL (1) IL119565A (es)
MX (1) MX9605367A (es)
NO (1) NO317054B1 (es)
NZ (1) NZ299693A (es)
PT (1) PT1375503E (es)
RU (1) RU2178416C2 (es)
SK (1) SK282168B6 (es)

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US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
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US6350773B1 (en) * 1999-12-10 2002-02-26 American Home Products Corporation Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US6458802B1 (en) 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
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US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6821981B2 (en) 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
US6906206B2 (en) 2001-04-30 2005-06-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6555560B2 (en) 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
WO2002092602A2 (en) * 2001-05-17 2002-11-21 Wyeth PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-[2,3-f] QUINOLINE
US6541501B2 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
AR035083A1 (es) 2001-07-25 2004-04-14 Wyeth Corp Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US7135479B2 (en) 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
CN100352820C (zh) * 2002-09-12 2007-12-05 惠氏公司 抗抑郁的杂环稠合的苯并二噁烷的氮杂环甲基衍生物
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US20050095292A1 (en) * 2003-10-29 2005-05-05 Wyeth Sustained release pharmaceutical compositions
GT200600078A (es) 2005-02-17 2007-04-12 Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquil condensados
TW200700413A (en) * 2005-03-01 2007-01-01 Wyeth Corp Crystalline and amorphous 4-cyano-n-{(2r)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-n-pyridin-2-yl-benzamide hydrochloride
JP2008536946A (ja) * 2005-04-22 2008-09-11 ワイス うつ病の処置または予防のための新規の治療的組み合わせ
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BRPI1013579A2 (pt) * 2009-03-30 2020-11-03 Transtech Pharma, Inc. derivados de azoantraceno substituídos, composições farmacêuticas e métodos de uso dos mesmos
RU2554885C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Антагонисты пуринорецепторов на основе новых производных пиридоксина
RU2554883C1 (ru) * 2014-05-27 2015-06-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) Федеральный Университет" (ФГАОУ ВПО КФУ) Применение производных ацеталей пиридоксина в качестве антагонистов пуринорецепторов

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Also Published As

Publication number Publication date
RU2178416C2 (ru) 2002-01-20
MX9605367A (es) 1997-10-31
HUP9603057A3 (en) 1998-12-28
NO964686L (no) 1997-05-07
NZ299693A (en) 1997-09-22
US5756532A (en) 1998-05-26
NO317054B1 (no) 2004-08-02
JPH09249671A (ja) 1997-09-22
CN1155546A (zh) 1997-07-30
KR970027068A (ko) 1997-06-24
EP1375503B1 (en) 2006-12-27
EP1375503A1 (en) 2004-01-02
PT1375503E (pt) 2007-03-30
ATE349450T1 (de) 2007-01-15
HUP9603057A2 (en) 1997-05-28
CZ291731B6 (cs) 2003-05-14
SK141496A3 (en) 1997-08-06
IL119565A (en) 2002-11-10
DE69636801D1 (de) 2007-02-08
EP0771800A2 (en) 1997-05-07
CA2189524A1 (en) 1997-05-07
DK1375503T3 (da) 2007-01-22
CA2189524C (en) 2007-05-01
US5962465A (en) 1999-10-05
IL119565A0 (en) 1997-03-18
CN1084748C (zh) 2002-05-15
KR100566678B1 (ko) 2006-11-30
AU701624B2 (en) 1999-02-04
AR004284A1 (es) 1998-11-04
AU7055396A (en) 1997-05-15
HU9603057D0 (en) 1996-12-30
SK282168B6 (sk) 2001-11-06
EP0771800A3 (en) 1998-01-28
JP4311770B2 (ja) 2009-08-12
HU224841B1 (en) 2006-03-28
CZ324196A3 (en) 1997-12-17
EP1726592A1 (en) 2006-11-29
ES2277014T3 (es) 2007-07-01
DE69636801T2 (de) 2007-04-26
NO964686D0 (no) 1996-11-05

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