AR025569A1 - Pirazol [4,3-d] pirimidinas - Google Patents

Pirazol [4,3-d] pirimidinas

Info

Publication number
AR025569A1
AR025569A1 ARP000104648A ARP000104648A AR025569A1 AR 025569 A1 AR025569 A1 AR 025569A1 AR P000104648 A ARP000104648 A AR P000104648A AR P000104648 A ARP000104648 A AR P000104648A AR 025569 A1 AR025569 A1 AR 025569A1
Authority
AR
Argentina
Prior art keywords
pyrimidins
pirazol
treatment
pyrimidines
pyrazole
Prior art date
Application number
ARP000104648A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR025569A1 publication Critical patent/AR025569A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pirazol [4,3-d] pirimidinas de la formula (1) y sus sales fisiologicamente inofensivas, donde R1, R2, R3, R4 y X tiene el significado enunciado en lareivindicacion 1, que inhiben la fosfodiesterasa V y pueden ser usados para el tratamiento deenferme dades del sistema cardiocirculatorio y para el tratamientoy/o la terapia de disfunciones eréctiles.
ARP000104648A 1999-09-06 2000-09-06 Pirazol [4,3-d] pirimidinas AR025569A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19942474A DE19942474A1 (de) 1999-09-06 1999-09-06 Pyrazolo[4,3-d]pyrimidine

Publications (1)

Publication Number Publication Date
AR025569A1 true AR025569A1 (es) 2002-12-04

Family

ID=7920966

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104648A AR025569A1 (es) 1999-09-06 2000-09-06 Pirazol [4,3-d] pirimidinas

Country Status (23)

Country Link
US (1) US6777419B1 (es)
EP (1) EP1210349B1 (es)
JP (1) JP4975921B2 (es)
KR (1) KR20020025253A (es)
CN (1) CN1145627C (es)
AR (1) AR025569A1 (es)
AT (1) ATE231866T1 (es)
AU (1) AU773878B2 (es)
BR (1) BR0013781A (es)
CA (1) CA2384037C (es)
CZ (1) CZ294587B6 (es)
DE (2) DE19942474A1 (es)
DK (1) DK1210349T3 (es)
ES (1) ES2189766T3 (es)
HU (1) HUP0202624A3 (es)
MX (1) MXPA02002383A (es)
NO (1) NO20021083D0 (es)
PL (1) PL353366A1 (es)
PT (1) PT1210349E (es)
RU (1) RU2249594C2 (es)
SK (1) SK3132002A3 (es)
WO (1) WO2001018004A2 (es)
ZA (1) ZA200202653B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
WO2002049651A1 (de) * 2000-12-19 2002-06-27 Merck Patent Gmbh Pharmazeutische formulierung enthaltend pyrazolo[4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate
DE10103647A1 (de) 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
DE10148883A1 (de) 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
RS20050810A (en) 2003-04-29 2007-08-03 Pfizer Inc., 5,7-diaminopyrazolo(4,3-d)pyrimidines useful in the treatment of hypertension
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
DK1742950T3 (da) * 2004-04-07 2009-03-16 Pfizer Ltd Pyrazolo-[4,3-D]-pyrimidiner
CA2608018C (en) 2005-05-12 2010-07-13 Pfizer Inc. Anhydrous crystalline forms of n-[1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
PE20140928A1 (es) * 2011-04-21 2014-08-24 Origenis Gmbh Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
RU2020118913A (ru) * 2017-12-14 2022-01-14 Х. Лундбекк А/С (H. Lundbeck A/S) Виды комбинированного лечения, предусматривающего введение 1h-пиразолo[4,3-b]пиридинов
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JP7194738B2 (ja) 2017-12-20 2022-12-22 ハー・ルンドベック・アクチエゼルスカベット ＰＤＥ１阻害剤としてのピラゾロ［３，４－ｂ］ピリジン及びイミダゾ［１，５－ｂ］ピリダジン

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
IL132276A0 (en) * 1997-04-25 2001-03-19 Pfizer Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates

Also Published As

Publication number Publication date
JP4975921B2 (ja) 2012-07-11
SK3132002A3 (en) 2002-07-02
CZ294587B6 (cs) 2005-02-16
PT1210349E (pt) 2003-06-30
DK1210349T3 (da) 2003-05-19
NO20021083L (no) 2002-03-05
MXPA02002383A (es) 2002-09-02
CN1145627C (zh) 2004-04-14
CA2384037C (en) 2009-10-13
HUP0202624A2 (hu) 2002-12-28
KR20020025253A (ko) 2002-04-03
PL353366A1 (en) 2003-11-17
ZA200202653B (en) 2003-09-23
BR0013781A (pt) 2002-05-14
US6777419B1 (en) 2004-08-17
ES2189766T3 (es) 2003-07-16
AU7279300A (en) 2001-04-10
HUP0202624A3 (en) 2004-11-29
EP1210349B1 (de) 2003-01-29
CN1377357A (zh) 2002-10-30
JP2003508534A (ja) 2003-03-04
EP1210349A2 (de) 2002-06-05
CA2384037A1 (en) 2001-03-15
DE19942474A1 (de) 2001-03-15
CZ2002736A3 (cs) 2002-05-15
DE50001191D1 (de) 2003-03-06
NO20021083D0 (no) 2002-03-05
WO2001018004A3 (de) 2001-08-09
WO2001018004A2 (de) 2001-03-15
ATE231866T1 (de) 2003-02-15
AU773878B2 (en) 2004-06-10
RU2249594C2 (ru) 2005-04-10

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