AR022413A1 - Utilizacion de derivados de piridazino(4,5-b)indol-1-acetamida, para la preparacion de medicamentos destinados a las enfermedades del sistema nerviosocentral - Google Patents

Utilizacion de derivados de piridazino(4,5-b)indol-1-acetamida, para la preparacion de medicamentos destinados a las enfermedades del sistema nerviosocentral

Info

Publication number
AR022413A1
AR022413A1 ARP000100305A ARP000100305A AR022413A1 AR 022413 A1 AR022413 A1 AR 022413A1 AR P000100305 A ARP000100305 A AR P000100305A AR P000100305 A ARP000100305 A AR P000100305A AR 022413 A1 AR022413 A1 AR 022413A1
Authority
AR
Argentina
Prior art keywords
preparation
diseases
nervoosocentral
piridazino
indol
Prior art date
Application number
ARP000100305A
Other languages
English (en)
Original Assignee
Dupuis Laurent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupuis Laurent filed Critical Dupuis Laurent
Publication of AR022413A1 publication Critical patent/AR022413A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Utilizacion de un compuesto de formula general (1) en la cual X representa un átomos de halogeno, Y representa uno o varios átomos de grupos elegidos entreel hidrogeno, los halogenos y los grupos metilo, metoxi,nitro e hidroxi, R1 representa un grupo(C1-4)alquilo, R2 y R3 representan cada uno independientementedel otro, un átomo de hidrogeno, un grupo (C1-4)alquilo, o bien R2 y R3 forman, con el átomo de nitrogeno que los lleva, un grupo pirrolidinilo, piperidiniloo morfolinilo para la preparacion de un medicamento destinado a la prevencion y al tratamiento de las neuropatías periféricas y enfermedades degenerativas delsistema nervioso central.
ARP000100305A 1999-01-26 2000-01-25 Utilizacion de derivados de piridazino(4,5-b)indol-1-acetamida, para la preparacion de medicamentos destinados a las enfermedades del sistema nerviosocentral AR022413A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900806A FR2788696B1 (fr) 1999-01-26 1999-01-26 Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central

Publications (1)

Publication Number Publication Date
AR022413A1 true AR022413A1 (es) 2002-09-04

Family

ID=9541212

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100305A AR022413A1 (es) 1999-01-26 2000-01-25 Utilizacion de derivados de piridazino(4,5-b)indol-1-acetamida, para la preparacion de medicamentos destinados a las enfermedades del sistema nerviosocentral

Country Status (32)

Country Link
US (1) US6395729B1 (es)
EP (1) EP1148881B1 (es)
JP (1) JP4688295B2 (es)
KR (1) KR100694752B1 (es)
CN (1) CN100577167C (es)
AR (1) AR022413A1 (es)
AT (1) ATE335487T1 (es)
AU (1) AU764445B2 (es)
BG (1) BG65152B1 (es)
BR (1) BR0007718A (es)
CA (1) CA2360754C (es)
CO (1) CO5160242A1 (es)
CY (1) CY1106257T1 (es)
CZ (1) CZ294283B6 (es)
DE (1) DE60029929T2 (es)
DK (1) DK1148881T3 (es)
EE (1) EE04905B1 (es)
ES (1) ES2269097T3 (es)
FR (1) FR2788696B1 (es)
HK (1) HK1040905B (es)
HU (1) HU228670B1 (es)
IL (2) IL144181A0 (es)
NO (1) NO321997B1 (es)
NZ (1) NZ512981A (es)
PL (1) PL193420B1 (es)
PT (1) PT1148881E (es)
RU (1) RU2243764C2 (es)
SK (1) SK285707B6 (es)
TR (1) TR200102134T2 (es)
TW (1) TW541177B (es)
UA (1) UA70349C2 (es)
WO (1) WO2000044384A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010086073A (ko) * 1998-12-02 2001-09-07 데이비드 존 우드 ｐ53계 단백질의 배좌 안정성을 회복하기 위한 방법 및조성물
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
FR2876715B1 (fr) 2004-10-19 2006-12-15 Profiles Du Ct Sa Embout de protection pour ecran de glissiere de securite routiere
GT200600005A (es) * 2005-01-12 2006-08-16 Un derivado de 2-(aminocarbonilo ciclico)-indolina y una composicion farmaceutica que lo contiene
KR20140002810A (ko) * 2005-05-05 2014-01-08 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
CA2619438A1 (en) * 2005-08-29 2007-03-08 Irwin C. Jacobs Amorphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino(4,5-b) indole-1-acetamide
WO2007027525A1 (en) * 2005-08-29 2007-03-08 Sanofi-Aventis U.S. Llc Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及***
FR2918563B1 (fr) 2007-07-12 2009-12-04 Oreal Composition photoprotectrice fluide aqueuse a base d'un polymere polyamide a terminaison amide tertiaire.
FR2931064B1 (fr) 2008-05-14 2010-08-13 Oreal Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone; procede de photostabilisation du derive de dibenzoylmethane
CA2734448A1 (en) * 2008-08-18 2010-02-25 Sanofi-Aventis U.S. Llc Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide
GB0818738D0 (en) * 2008-10-13 2008-11-19 Ge Healthcare Ltd Imaging neuroflammation
FR2936706B1 (fr) 2008-10-08 2010-12-17 Oreal Composition cosmetique contenant un derive de dibenzoylmethane et un compose dithiolane ; procede de photostabilisation du derive de dibenzoylmethane
EP2181717A1 (en) * 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
WO2011073279A2 (fr) 2009-12-18 2011-06-23 L'oreal Procédé de traitement cosmétique impliquant un composé apte à condenser in situ
FR2960773B1 (fr) 2010-06-03 2015-12-11 Oreal Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether
WO2019113248A1 (en) * 2017-12-07 2019-06-13 The Regents Of The University Of California Anti-upar antibody-drug conjugates and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3121137A1 (de) * 1981-05-27 1982-12-16 Hoechst Ag, 6000 Frankfurt Neue pyridazino(4,5-b)indole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und deren herstellung"
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
US6069267A (en) * 1997-07-29 2000-05-30 E. I. Du Pont De Nemours And Company Selective synthesis of organodiphosphite compounds
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
HU228670B1 (en) 2013-05-28
IL144181A0 (en) 2002-05-23
SK285707B6 (sk) 2007-06-07
IL144181A (en) 2007-06-17
JP2002535370A (ja) 2002-10-22
BR0007718A (pt) 2001-11-13
AU764445B2 (en) 2003-08-21
HUP0201280A2 (en) 2002-08-28
PT1148881E (pt) 2006-12-29
ATE335487T1 (de) 2006-09-15
CA2360754A1 (en) 2000-08-03
CN1344161A (zh) 2002-04-10
UA70349C2 (en) 2004-10-15
WO2000044384A1 (fr) 2000-08-03
CA2360754C (en) 2008-07-08
CO5160242A1 (es) 2002-05-30
TW541177B (en) 2003-07-11
US6395729B1 (en) 2002-05-28
PL193420B1 (pl) 2007-02-28
NZ512981A (en) 2002-10-25
CY1106257T1 (el) 2011-06-08
NO20013645L (no) 2001-09-26
RU2243764C2 (ru) 2005-01-10
EP1148881A1 (fr) 2001-10-31
SK10502001A3 (sk) 2002-01-07
CN100577167C (zh) 2010-01-06
AU3057900A (en) 2000-08-18
CZ20012681A3 (cs) 2001-10-17
PL349364A1 (en) 2002-07-15
KR20010089624A (ko) 2001-10-06
NO321997B1 (no) 2006-07-31
ES2269097T3 (es) 2007-04-01
FR2788696B1 (fr) 2004-03-05
NO20013645D0 (no) 2001-07-24
DE60029929D1 (de) 2006-09-21
DK1148881T3 (da) 2006-12-11
DE60029929T2 (de) 2007-08-30
KR100694752B1 (ko) 2007-03-14
FR2788696A1 (fr) 2000-07-28
HK1040905A1 (en) 2002-06-28
BG105728A (en) 2002-02-28
HUP0201280A3 (en) 2004-12-28
TR200102134T2 (tr) 2003-03-21
CZ294283B6 (cs) 2004-11-10
HK1040905B (zh) 2007-02-23
EP1148881B1 (fr) 2006-08-09
JP4688295B2 (ja) 2011-05-25
EE04905B1 (et) 2007-10-15
EE200100388A (et) 2002-12-16
BG65152B1 (bg) 2007-04-30

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