AR021695A1 - 4,5-pirazinoxindoles, composicion farmaceutica y uso - Google Patents
4,5-pirazinoxindoles, composicion farmaceutica y usoInfo
- Publication number
- AR021695A1 AR021695A1 ARP990106420A ARP990106420A AR021695A1 AR 021695 A1 AR021695 A1 AR 021695A1 AR P990106420 A ARP990106420 A AR P990106420A AR P990106420 A ARP990106420 A AR P990106420A AR 021695 A1 AR021695 A1 AR 021695A1
- Authority
- AR
- Argentina
- Prior art keywords
- pirazinoxindoles
- pharmaceutical composition
- protein kinases
- pyrazinoxindoles
- modulate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Los 4,5-pirazinoxindoles de formula (1), donde R1, R2, R3 y X son tal como figuran en la memoria, inhiben o modulan las proteinoquinasas, enparticular la proteinoquinasas JNK, y son de utilidad como agentes antiinflamatorios, en particular en el tratamiento de la artritis reumatoide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11265398P | 1998-12-17 | 1998-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR021695A1 true AR021695A1 (es) | 2002-07-31 |
Family
ID=22345140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990106420A AR021695A1 (es) | 1998-12-17 | 1999-12-15 | 4,5-pirazinoxindoles, composicion farmaceutica y uso |
Country Status (17)
Country | Link |
---|---|
US (1) | US6221867B1 (es) |
EP (1) | EP1149105B1 (es) |
JP (1) | JP2002532503A (es) |
KR (1) | KR20010108024A (es) |
CN (1) | CN1158283C (es) |
AR (1) | AR021695A1 (es) |
AT (1) | ATE387448T1 (es) |
AU (1) | AU767138B2 (es) |
BR (1) | BR9916324A (es) |
CA (1) | CA2354402A1 (es) |
DE (1) | DE69938258T2 (es) |
ES (1) | ES2301255T3 (es) |
PE (1) | PE20001385A1 (es) |
TR (1) | TR200101756T2 (es) |
UY (1) | UY25854A1 (es) |
WO (1) | WO2000035921A1 (es) |
ZA (1) | ZA200104505B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0016454D0 (en) | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Thienopyrrolidinones |
GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
ATE449763T1 (de) | 2001-04-16 | 2009-12-15 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
AR035971A1 (es) | 2001-05-16 | 2004-07-28 | Cephalon Inc | Metodos para el tratamiento y la prevencion del dolor |
ES2318041T3 (es) | 2001-07-23 | 2009-05-01 | Laboratoires Serono Sa | Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales. |
WO2003072550A1 (fr) * | 2002-02-28 | 2003-09-04 | Eisai Co., Ltd. | Nouveaux composes indazole a anneaux fusionnes |
CN100368411C (zh) | 2002-03-28 | 2008-02-13 | 卫材R&D管理有限公司 | 作为c-Jun N-末端激酶抑制剂用于治疗神经变性疾病的7-氮杂吲哚类化合物 |
DE60331219D1 (de) | 2002-03-28 | 2010-03-25 | Eisai R&D Man Co Ltd | Azaindole als hemmstoffe von c-jun n-terminalen kinasen |
IL164209A0 (en) | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
EP1527070B1 (en) | 2002-06-14 | 2013-01-09 | Merck Serono SA | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
MXPA05011777A (es) * | 2003-05-08 | 2006-01-26 | Wyeth Corp | Proteina cinasa c zeta como un farmaco blanco para la artritis y otras enfermadades inflamatorias. |
WO2004101565A2 (en) | 2003-05-16 | 2004-11-25 | Eisai Co., Ltd. | Jnk inhibitors |
WO2005040116A2 (en) | 2003-10-24 | 2005-05-06 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
US20060094753A1 (en) | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
WO2007040208A1 (ja) | 2005-10-03 | 2007-04-12 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
CA2633980A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556672A (en) | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
DE3531678A1 (de) | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DK0429685T3 (da) | 1989-07-25 | 1997-12-15 | Taiho Pharmaceutical Co Ltd | Oxoindolderivat |
WO1991009598A1 (en) | 1990-01-05 | 1991-07-11 | Pfizer Inc. | Azaoxindole derivatives |
GB9004483D0 (en) | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
GB9115160D0 (en) | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
US5322950A (en) | 1991-12-05 | 1994-06-21 | Warner-Lambert Company | Imidazole with angiotensin II antagonist properties |
FR2694004B1 (fr) | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
GB9313638D0 (en) | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
GB9326136D0 (en) | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
GB9423997D0 (en) | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
GB9501567D0 (en) | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
WO1997011692A2 (en) | 1995-09-11 | 1997-04-03 | Osteoarthritis Sciences, Inc. | Protein tyrosine kinase inhibitors for treating osteoarthritis |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
ATE247470T1 (de) | 1996-01-11 | 2003-09-15 | Smithkline Beecham Corp | Neue substituierte imidazolverbindungen |
KR100281867B1 (ko) | 1996-01-17 | 2001-02-15 | 고바야시 유키오 | 3-(비스-치환페닐메틸렌)옥신돌유도체 |
DE69722858T2 (de) * | 1996-01-17 | 2004-05-13 | Taiho Pharmaceutical Co. Ltd. | Intimale verdickungsinhibitoren |
GB9610964D0 (en) | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
GB9611797D0 (en) | 1996-06-06 | 1996-08-07 | Pharmacia Spa | Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors |
CA2264220A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
WO1998024432A2 (en) | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
EP0984930B1 (en) | 1997-05-07 | 2005-04-06 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
EP1066257A2 (en) | 1998-03-26 | 2001-01-10 | Sugen, Inc. | Heterocylic classes of compounds for the modulating tyrosine protein kinase |
AU5468499A (en) | 1998-08-04 | 2000-02-28 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
-
1999
- 1999-12-11 CN CNB998145971A patent/CN1158283C/zh not_active Expired - Fee Related
- 1999-12-11 CA CA002354402A patent/CA2354402A1/en not_active Abandoned
- 1999-12-11 ES ES99963496T patent/ES2301255T3/es not_active Expired - Lifetime
- 1999-12-11 WO PCT/EP1999/009806 patent/WO2000035921A1/en active IP Right Grant
- 1999-12-11 KR KR1020017007570A patent/KR20010108024A/ko not_active Application Discontinuation
- 1999-12-11 TR TR2001/01756T patent/TR200101756T2/xx unknown
- 1999-12-11 AT AT99963496T patent/ATE387448T1/de not_active IP Right Cessation
- 1999-12-11 DE DE69938258T patent/DE69938258T2/de not_active Expired - Fee Related
- 1999-12-11 EP EP99963496A patent/EP1149105B1/en not_active Expired - Lifetime
- 1999-12-11 JP JP2000588180A patent/JP2002532503A/ja active Pending
- 1999-12-11 BR BR9916324-1A patent/BR9916324A/pt not_active IP Right Cessation
- 1999-12-11 AU AU19773/00A patent/AU767138B2/en not_active Ceased
- 1999-12-15 AR ARP990106420A patent/AR021695A1/es unknown
- 1999-12-15 US US09/464,534 patent/US6221867B1/en not_active Expired - Fee Related
- 1999-12-16 PE PE1999001276A patent/PE20001385A1/es not_active Application Discontinuation
- 1999-12-16 UY UY25854A patent/UY25854A1/es not_active Application Discontinuation
-
2001
- 2001-05-31 ZA ZA200104505A patent/ZA200104505B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69938258D1 (de) | 2008-04-10 |
US6221867B1 (en) | 2001-04-24 |
ZA200104505B (en) | 2002-10-04 |
CA2354402A1 (en) | 2000-06-22 |
ATE387448T1 (de) | 2008-03-15 |
DE69938258T2 (de) | 2009-02-26 |
PE20001385A1 (es) | 2000-12-14 |
JP2002532503A (ja) | 2002-10-02 |
AU767138B2 (en) | 2003-10-30 |
CN1330653A (zh) | 2002-01-09 |
UY25854A1 (es) | 2001-07-31 |
CN1158283C (zh) | 2004-07-21 |
WO2000035921A1 (en) | 2000-06-22 |
EP1149105A1 (en) | 2001-10-31 |
KR20010108024A (ko) | 2001-12-07 |
BR9916324A (pt) | 2001-10-02 |
TR200101756T2 (tr) | 2001-10-22 |
ES2301255T3 (es) | 2008-06-16 |
EP1149105B1 (en) | 2008-02-27 |
AU1977300A (en) | 2000-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |