AR021662A1 - Derivados de la piperazina, proceso para prepararlos. las composiciones farmaceuticas que los contienen y la utilizacion de las mismas como medicamentoso para la preparacion de medicamentos - Google Patents
Derivados de la piperazina, proceso para prepararlos. las composiciones farmaceuticas que los contienen y la utilizacion de las mismas como medicamentoso para la preparacion de medicamentosInfo
- Publication number
- AR021662A1 AR021662A1 ARP990106361A ARP990106361A AR021662A1 AR 021662 A1 AR021662 A1 AR 021662A1 AR P990106361 A ARP990106361 A AR P990106361A AR P990106361 A ARP990106361 A AR P990106361A AR 021662 A1 AR021662 A1 AR 021662A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- tri
- alkoxy
- pyridyl
- substituted
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 18
- -1 nitro, amino Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000003282 alkyl amino group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 abstract 1
- 125000004514 1,2,4-thiadiazolyl group Chemical group 0.000 abstract 1
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se revelan derivados de la piperazina de la siguiente formula (1) y sus sales, en la cual Y es un enlace o un alquileno inferior; R1 es arilo que estásustituido con de 1 a 3 sustituyentes, iguales o diferentes entre sí, seleccionados de entre el grupo consistente en: halogeno, alquilo inferior, alcoxiinferior, mono (o di o tri) halo (inferior) alquilo, nitro, amino, alquilamino inferior, di (inferior) alquilamino, alquil tio inferior, alquil sulfoniloinferior, ciclo (inferior) alquilsulfonilo,aminosulfonilo, alquilamino sulfonilo inferior, di (inferior) alquilamino sulfonilo, pirrolidinilsulfonilo,morfolinil sulfonilo, pirrolil sulfonilo, piridil sulfonilo, pirrolilo y piridilo; R2 es arilo que está sustituido con de 1 a 3 sustituyentes,iguales odiferentes entre sí, seleccionados de entre el grupo consistente en: halogeno, alquilo inferior, mono (o di o tri) halo (inferior) alquilo, mono (o di o tri)halo (inferior) alquilsulfoniloxi, halogeno, alquilen dioxi inferior, alcoxi inferior, alcoxi carbonilo inferior, alcoxi inferior (inferior) alcoxi (inferior)alcoxi, hidroxi, di fenil (inferior) alquil sililoxi, tri (inferior) alquilsililoxi, hidroxi (inferior) alquilo, ciano, amino, [mono (o di o tri) halo(inferior) alquil carbonil] amino, alquilamino inferior, N-(alquilo inferior)-[mono (o di o tri) halo (inferior alquilcarbonil amino, pirrolidinilo ymorfolinilo que pueden estar sustituidos con inferior alcoxi (inferior) alquilo o alquilo inferior; R3 es hidrogeno o alquilo inferior; y R4 es (3-piridil)metilo, (3-piridil) etilo, 3-(3-piridil) propilo, 3-(3-piridil) propenilo, 3-(3-piridil) propinilo, tiazolil (inferior) alquilo, 1,2,4-tiadiazolil (inferior)alquilo o 1,2,4-oxadiazolil (inferior) alquilo, cada uno de los cuales está sustituido con halogeno, amino, alquil amino inferior, o di (inferior) alquilamino;pirazolil metilo que puede estar sustituido con tri fenil (inferior) alquilo o hidroxi (inferior) alquilo; pirazolil (inferior) alquilo que está sustituidoconalquilo inferior; alcoxi inferior (inferior) alquil morfolinil (inferior) alquilo o inferior alcoxi (inferior) alquil morfolinil carbonil-(inferior) alquilo;
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP7706A AUPP770698A0 (en) | 1998-12-14 | 1998-12-14 | Piperazine derivatives |
| AUPQ3568A AUPQ356899A0 (en) | 1999-10-21 | 1999-10-21 | Piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021662A1 true AR021662A1 (es) | 2002-07-31 |
Family
ID=25645943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106361A AR021662A1 (es) | 1998-12-14 | 1999-12-14 | Derivados de la piperazina, proceso para prepararlos. las composiciones farmaceuticas que los contienen y la utilizacion de las mismas como medicamentoso para la preparacion de medicamentos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7166598B2 (es) |
| EP (1) | EP1140924B1 (es) |
| JP (2) | JP3454427B2 (es) |
| KR (1) | KR20010086104A (es) |
| CN (1) | CN1152877C (es) |
| AR (1) | AR021662A1 (es) |
| AT (1) | ATE321042T1 (es) |
| AU (2) | AU768652B2 (es) |
| BR (1) | BR9917047A (es) |
| CA (1) | CA2354875A1 (es) |
| CZ (1) | CZ20012130A3 (es) |
| DE (1) | DE69930543T2 (es) |
| ES (1) | ES2257089T3 (es) |
| HK (1) | HK1043998B (es) |
| HU (1) | HUP0203651A2 (es) |
| IL (1) | IL143577A0 (es) |
| PT (1) | PT1140924E (es) |
| TR (1) | TR200101649T2 (es) |
| TW (1) | TW509688B (es) |
| WO (1) | WO2000035915A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140924B1 (en) * | 1998-12-14 | 2006-03-22 | Astellas Pharma Inc. | Piperazine derivatives |
| GB9923748D0 (en) * | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| TW591025B (en) * | 2000-06-13 | 2004-06-11 | Fujisawa Pharmaceutical Co | Production of the piperazine derivative |
| IT1317049B1 (it) * | 2000-06-23 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
| US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| UA77515C2 (en) | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
| US7776535B2 (en) | 2006-02-06 | 2010-08-17 | Franklin And Marshall College | Site-specific incorporation of fluorinated amino acids into proteins |
| JP5806672B2 (ja) | 2009-10-30 | 2015-11-10 | ドメイン・セラピューティクス | 新規オキシム誘導体及び代謝型グルタミン酸受容体のアロステリック調節因子としての利用 |
| NZ600008A (en) | 2009-12-04 | 2014-10-31 | Sunovion Pharmaceuticals Inc | Multicyclic compounds and methods of use thereof |
| EP2653464B1 (en) | 2012-04-20 | 2017-09-27 | Rohm and Haas Company | Benzylamine hydrophobe |
| WO2015094965A1 (en) * | 2013-12-19 | 2015-06-25 | Archer Daniels Midland Company | Sulfonates of furan-2,5-dimethanol and (tetrahydrofuran-2,5-diyl)dimethanol and derivatives thereof |
| MX2019000980A (es) | 2016-07-29 | 2019-07-04 | Sunovion Pharmaceuticals Inc | Compuestos y composiciones y usos de los mismos. |
| KR20190065246A (ko) | 2016-07-29 | 2019-06-11 | 선오비온 파마슈티컬스 인코포레이티드 | 화합물 및 조성물 및 이들의 용도 |
| JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
| WO2019028165A1 (en) | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | ISOCHROMAN COMPOUNDS AND USES THEREOF |
| EA202091945A1 (ru) | 2018-02-16 | 2021-01-18 | Суновион Фармасьютикалз Инк. | Соли, кристаллические формы и способы их получения |
| US20220041562A1 (en) * | 2018-11-02 | 2022-02-10 | Texas Tech University System | Novel selective kappa opioid receptor antagonists and methods related thereto for treatment of addiction and neuropathic pain |
| MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
| WO2021087268A1 (en) * | 2019-10-30 | 2021-05-06 | Texas Tech University System | Novel selective kappa opioid receptor antagonists and methods related thereto for treatment of addiction and neuropathic pain |
| EP4135690A1 (en) | 2020-04-14 | 2023-02-22 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
| US5541054B1 (en) * | 1995-04-20 | 1998-11-17 | Imation Corp | Spectral sensitizing dyes for photothermographic elements |
| BR9610277A (pt) * | 1995-08-31 | 1999-07-06 | Schering Corp | Derivados de piperazino como antagonistas de neurowuinina |
| ATE219064T1 (de) * | 1995-12-18 | 2002-06-15 | Fujisawa Pharmaceutical Co | Piperazinderivative als tachykinin antagonisten |
| AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| AU743723B2 (en) * | 1997-06-17 | 2002-01-31 | Astellas Pharma Inc. | Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists |
| EP1140924B1 (en) * | 1998-12-14 | 2006-03-22 | Astellas Pharma Inc. | Piperazine derivatives |
-
1999
- 1999-12-10 EP EP99959751A patent/EP1140924B1/en not_active Expired - Lifetime
- 1999-12-10 AT AT99959751T patent/ATE321042T1/de not_active IP Right Cessation
- 1999-12-10 CZ CZ20012130A patent/CZ20012130A3/cs unknown
- 1999-12-10 JP JP2000588175A patent/JP3454427B2/ja not_active Expired - Fee Related
- 1999-12-10 CN CNB998161322A patent/CN1152877C/zh not_active Expired - Fee Related
- 1999-12-10 BR BR9917047-7A patent/BR9917047A/pt not_active Application Discontinuation
- 1999-12-10 HU HU0203651A patent/HUP0203651A2/hu unknown
- 1999-12-10 TR TR2001/01649T patent/TR200101649T2/xx unknown
- 1999-12-10 IL IL14357799A patent/IL143577A0/xx unknown
- 1999-12-10 KR KR1020017007333A patent/KR20010086104A/ko active IP Right Grant
- 1999-12-10 DE DE69930543T patent/DE69930543T2/de not_active Expired - Fee Related
- 1999-12-10 AU AU16837/00A patent/AU768652B2/en not_active Ceased
- 1999-12-10 PT PT99959751T patent/PT1140924E/pt unknown
- 1999-12-10 ES ES99959751T patent/ES2257089T3/es not_active Expired - Lifetime
- 1999-12-10 CA CA002354875A patent/CA2354875A1/en not_active Abandoned
- 1999-12-10 WO PCT/JP1999/006943 patent/WO2000035915A1/en not_active Application Discontinuation
- 1999-12-14 TW TW088121878A patent/TW509688B/zh not_active IP Right Cessation
- 1999-12-14 AR ARP990106361A patent/AR021662A1/es unknown
-
2002
- 2002-07-30 HK HK02105609.0A patent/HK1043998B/zh not_active IP Right Cessation
-
2003
- 2003-01-31 JP JP2003023481A patent/JP2003238563A/ja not_active Withdrawn
-
2004
- 2004-03-16 AU AU2004201111A patent/AU2004201111A1/en not_active Abandoned
- 2004-10-20 US US10/968,473 patent/US7166598B2/en not_active Expired - Fee Related
-
2006
- 2006-11-21 US US11/562,149 patent/US20070123532A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU1683700A (en) | 2000-07-03 |
| HUP0203651A2 (en) | 2003-02-28 |
| CN1334812A (zh) | 2002-02-06 |
| EP1140924B1 (en) | 2006-03-22 |
| EP1140924A1 (en) | 2001-10-10 |
| JP3454427B2 (ja) | 2003-10-06 |
| US20070123532A1 (en) | 2007-05-31 |
| DE69930543D1 (de) | 2006-05-11 |
| US7166598B2 (en) | 2007-01-23 |
| CZ20012130A3 (cs) | 2001-10-17 |
| ATE321042T1 (de) | 2006-04-15 |
| BR9917047A (pt) | 2002-07-30 |
| JP2002532499A (ja) | 2002-10-02 |
| WO2000035915A1 (en) | 2000-06-22 |
| DE69930543T2 (de) | 2006-11-09 |
| US20060014948A1 (en) | 2006-01-19 |
| IL143577A0 (en) | 2002-04-21 |
| HK1043998A1 (en) | 2002-10-04 |
| CA2354875A1 (en) | 2000-06-22 |
| JP2003238563A (ja) | 2003-08-27 |
| KR20010086104A (ko) | 2001-09-07 |
| HK1043998B (zh) | 2005-03-18 |
| CN1152877C (zh) | 2004-06-09 |
| AU768652B2 (en) | 2003-12-18 |
| ES2257089T3 (es) | 2006-07-16 |
| AU2004201111A1 (en) | 2004-04-22 |
| TR200101649T2 (tr) | 2001-10-22 |
| TW509688B (en) | 2002-11-11 |
| PT1140924E (pt) | 2006-08-31 |
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