AR021363A1 - Derivados de 6-azauracilo inhibidores de la il-5 - Google Patents
Derivados de 6-azauracilo inhibidores de la il-5Info
- Publication number
- AR021363A1 AR021363A1 ARP990105942A ARP990105942A AR021363A1 AR 021363 A1 AR021363 A1 AR 021363A1 AR P990105942 A ARP990105942 A AR P990105942A AR P990105942 A ARP990105942 A AR P990105942A AR 021363 A1 AR021363 A1 AR 021363A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het3
- aryl
- het1
- nr7r8
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a los compuestos de la formula (1), los N-oxidos, las sales de adicion farmacéuticamente aceptables y ls formasestereoquímicamente isoméricas de los mismos, en los cuales p es 0 a 3; q es de 0 a 5; -A-B- representa -(CH2)r-;-(CH2)t-O-,-(CH2)t-S(=O)u- o (CH2)t-NR3-; r es2 a 4; t es 1 a 3; u es 0 a 2; X1 representa O, S, NR3 o un enlace directo; R1 y R4 son alquilo C1-6 halo, polihaloalquilo C1-6, hidroxi, mercapto, alquiloxiC1-6, alquiltio C1-6, alquilcarboniloxiC1-6, arilo, ciano, nitro, Het3, R6, NR7R8, o alquilo C1-4 sustituido con Het3, R6 o NR7R8; R2representa arilo, Het1,cicloalquilo C3-7, ciano, alquilo C1-6, -C(=Q)-X2-R15 o alquilo C1-6 sustituido con uno o dos sustituyentes seleccionados entre hidroxi, ciano, amino, mono - odi(alquilC1-6)amino, alquiloxi C1-6 alquilsulfoniloxi C1-6, alquiloxicarbonilo C1-6, cicloalquilo C3-7, arilo, ariloxi, ariltio, Het1, Het1 oxi,Het1tio y -C(=Q)-X2-R15, R3 representa hidrogeno o alquilo C1-4, R15 representatambién halo o Het1, donde X2 es NR5, R15 también es hidroxi; donde X2 esC(=O)-NH-NH o NH-NH-C(=O),R15 es reemplazado por R11, R5 representa hidrogeno, alquilo C1-6, alquiloxi C1-6 o arilalquilo C1-6; Q es O, S o NR3; X2 es O, S,NR5, C(=O)-NH-NH, NH-NH-C(=O) o un enlace directo; R6 es un derivado sulfonilo o sulfinilo, R7 y R8 son independientemente hidrogeno, alquilo C1-4optativamente sustituido, arilo, una porcion con contenido de carbonilo, cicloalquilo C3-7, -Y-alcanodiiloC1-4-C(=O)-O-R14, Het3 y R6; R11 es hidroxi,mercapto, ciano, nitro, halo, trihalometilo, alquiloxi C1-4, formilo, trihaloalquilsulfoniloxi C1-4, R6, NR7R8, C(=O)NR7R8, alcanodiiloC1-4- C(=O)-O-R14,C(=O)-O-R14, Y-alcanodiiloC14-C(=O)-O-R14, arilo, ariloxi, arilcarbonilo, cicloalquilo C3-7, cicloalquiloxi C3-7, ftalimida-2-ilo, Het3, Het4, yC(=O)Het3, arilo es fenilo optativamente sustituido, Het1, Het2, Het3 y Het4 son heterociclos optativamente sustituidos; a procesos para su preparacion y a lascomposiciones que los contienen. También se relaciona con su uso como medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203930 | 1998-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021363A1 true AR021363A1 (es) | 2002-07-17 |
Family
ID=8234366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105942A AR021363A1 (es) | 1998-11-23 | 1999-11-22 | Derivados de 6-azauracilo inhibidores de la il-5 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6469001B1 (es) |
| EP (1) | EP1133482B1 (es) |
| JP (1) | JP2002530391A (es) |
| AR (1) | AR021363A1 (es) |
| AT (1) | ATE289596T1 (es) |
| AU (1) | AU767444B2 (es) |
| CA (1) | CA2352275C (es) |
| DE (1) | DE69923861T2 (es) |
| ES (1) | ES2238863T3 (es) |
| TR (1) | TR200101422T2 (es) |
| TW (1) | TW527348B (es) |
| WO (1) | WO2000031054A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10159391B2 (en) * | 2016-01-08 | 2018-12-25 | Omachron Intellectual Property Inc. | Surface cleaning apparatus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69717380T2 (de) | 1996-08-30 | 2003-03-20 | Takeda Schering Plough Animal | 1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel |
| ID24224A (id) | 1997-07-10 | 2000-07-13 | Janssen Pharmaceutica Nv | Turunan-turunan 6-azaurasil sebagai inhibitor il-5 |
-
1999
- 1999-11-22 TR TR2001/01422T patent/TR200101422T2/xx unknown
- 1999-11-22 AR ARP990105942A patent/AR021363A1/es unknown
- 1999-11-22 AT AT99961006T patent/ATE289596T1/de not_active IP Right Cessation
- 1999-11-22 AU AU17773/00A patent/AU767444B2/en not_active Ceased
- 1999-11-22 DE DE69923861T patent/DE69923861T2/de not_active Expired - Fee Related
- 1999-11-22 CA CA002352275A patent/CA2352275C/en not_active Expired - Fee Related
- 1999-11-22 EP EP99961006A patent/EP1133482B1/en not_active Expired - Lifetime
- 1999-11-22 US US09/856,625 patent/US6469001B1/en not_active Expired - Fee Related
- 1999-11-22 WO PCT/EP1999/009155 patent/WO2000031054A1/en active IP Right Grant
- 1999-11-22 JP JP2000583882A patent/JP2002530391A/ja not_active Withdrawn
- 1999-11-22 ES ES99961006T patent/ES2238863T3/es not_active Expired - Lifetime
- 1999-11-23 TW TW088120638A patent/TW527348B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| AU767444B2 (en) | 2003-11-13 |
| DE69923861T2 (de) | 2006-01-12 |
| ATE289596T1 (de) | 2005-03-15 |
| US6469001B1 (en) | 2002-10-22 |
| CA2352275C (en) | 2008-11-18 |
| DE69923861D1 (de) | 2005-03-31 |
| JP2002530391A (ja) | 2002-09-17 |
| AU1777300A (en) | 2000-06-13 |
| TR200101422T2 (tr) | 2001-10-22 |
| TW527348B (en) | 2003-04-11 |
| EP1133482B1 (en) | 2005-02-23 |
| WO2000031054A1 (en) | 2000-06-02 |
| ES2238863T3 (es) | 2005-09-01 |
| CA2352275A1 (en) | 2000-06-02 |
| EP1133482A1 (en) | 2001-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20212251A1 (es) | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar | |
| CO6270320A2 (es) | Derivados de piperidina utiles como antagonistas del receptor orexina | |
| AR061737A1 (es) | Compuestos derivados de pirimidina, un peoceso para su preparacion y composiciones farmaceuticas que los contienen | |
| AR056317A1 (es) | Compuestos de oxindol y composicion farmaceutica | |
| PE20220931A1 (es) | Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina | |
| AR066571A1 (es) | Compuestos de ariloazol-2-il cianoetilamino metodo de fabricacion y metodo de utilizacion | |
| AR043508A1 (es) | 1-amino 1-h-imidazoquinolinas y su uso como inmunomoduladores | |
| PE20030062A1 (es) | Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas | |
| AR050540A1 (es) | Derivados de adamantilamida triciclica como inhibidores de deshidrogenasa 11- beta hidroxiesteroide | |
| AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
| AR049899A1 (es) | Derivados de pirazincarboxanilida sustituidos o sus sales, sus intermediarios, agentes agrohorticolas y metodos para usarlos | |
| AR035523A1 (es) | Uso de compuestos de aminoacetonitrilo para combatir animales daninos endoparasitarios en animales utiles y domesticos de sangre caliente | |
| PE20040411A1 (es) | Compuestos de aril cetona pirrolo triazina | |
| AR040031A1 (es) | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen | |
| DK1696919T3 (da) | 3-cycloalkylaminopyrrolidin-derivater som modulatorer af chemokinreceptorer | |
| PE20030007A1 (es) | Inhibidores de aldosa reductasa del grupo de las piridazinonas | |
| AR066144A1 (es) | Derivados de aril pirrolidinas utiles como insecticidas y/o acaricidas y composiciones insecticidas que los contienen. | |
| ECSP12006640A (es) | Inhibidores heterocíclicos de aspartil proteasa | |
| ECSP10010473A (es) | Nuevos derivados de carbazol, inhibidores de hsp90, composiciones que los contienen y utilización | |
| AR056943A1 (es) | DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS | |
| AR077486A2 (es) | Compuesto derivado de isotiazol sustituido composicion fungicida insecticida acaricida molusquicida o nematicida quelo comprende y metodo para combatir y controlar hongos insectos acaros nematodos o moluscos usando dicho compuesto o dicha composicion | |
| CO5570702A2 (es) | N-sulfonilo-4-metileneamino-3-hidroxilo-2-piridonas como agente antimicrobiano | |
| AR065583A1 (es) | Compuestos macrociclicos y composicion farmaceutica | |
| AR069813A1 (es) | Derivados de 2- amino-pirimidina, una composicion farmaceutica, un metodo de preparacion del compuesto y uso del mismo para preparar un medicamento | |
| CO5050264A1 (es) | Derivados de 6-azauracilo como inhibidores il-5 procedimientos para su preparacion y composiciones farmaceuticas que comprenden dichos derivados |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |