AR019197A1 - COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS. - Google Patents

COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS.

Info

Publication number
AR019197A1
AR019197A1 ARP990103193A ARP990103193A AR019197A1 AR 019197 A1 AR019197 A1 AR 019197A1 AR P990103193 A ARP990103193 A AR P990103193A AR P990103193 A ARP990103193 A AR P990103193A AR 019197 A1 AR019197 A1 AR 019197A1
Authority
AR
Argentina
Prior art keywords
preparation
piperidine
alkyl
antihistaminics
intermediaries
Prior art date
Application number
ARP990103193A
Other languages
English (en)
Original Assignee
Aventis Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22328222&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR019197(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Holdings Inc filed Critical Aventis Holdings Inc
Publication of AR019197A1 publication Critical patent/AR019197A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/91—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados de piperidina de formula (I) y a un procedimiento para la preparacion de los mismos, donde: R1 es H o alquilo C1-6 y el resto alquiloC1-6 es lineal o ramificado; R2 es -COOH o -COO alquilo y el resto alquilo tiene C1-6 y es lineal o ramificado; o estereoisomeros o salesde adicion de ácido farmacéuticamente aceptables de los mismos utiles para el tratamiento de trastornos alérgicos. Dichos derivados sepreparan de acuerdo con el esquema 8II9, donde X es independientemente Cl, Br, o I, R1y R2 son alquilo C1-6 lineal o ramificado; R3 es H o alquiloC1-6 lineal o ramificado, esquemas (III).
ARP990103193A 1998-07-02 1999-06-30 COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS. AR019197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10954298A 1998-07-02 1998-07-02

Publications (1)

Publication Number Publication Date
AR019197A1 true AR019197A1 (es) 2001-12-26

Family

ID=22328222

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103193A AR019197A1 (es) 1998-07-02 1999-06-30 COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS.

Country Status (21)

Country Link
EP (1) EP1091938B1 (es)
JP (1) JP2002519411A (es)
KR (2) KR100707904B1 (es)
CN (3) CN100522921C (es)
AR (1) AR019197A1 (es)
AT (1) ATE485271T1 (es)
AU (1) AU769284B2 (es)
BR (1) BR9911794A (es)
CA (1) CA2336380C (es)
DE (1) DE69942876D1 (es)
DK (1) DK1091938T3 (es)
ES (1) ES2354968T3 (es)
HK (3) HK1034065A1 (es)
HU (1) HUP0104159A3 (es)
IL (6) IL140649A0 (es)
NO (1) NO319534B1 (es)
NZ (2) NZ508477A (es)
PT (1) PT1091938E (es)
TW (1) TW533197B (es)
WO (1) WO2000001671A2 (es)
ZA (1) ZA200007034B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005532356A (ja) 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
CN101585767B (zh) * 2009-06-06 2012-02-15 浙江大学宁波理工学院 一种合成2—[4—(4—氯丁酰基)苯基]—2—甲基丙酸酯的方法
CN101585764B (zh) * 2009-06-06 2012-02-15 浙江大学宁波理工学院 合成2—［4—(4—氯丁酰基)苯基］—2—甲基丙酸的方法
CN101585768B (zh) * 2009-06-06 2012-01-04 浙江大学宁波理工学院 合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸酯的方法
CN101585763B (zh) * 2009-06-06 2012-01-04 浙江大学宁波理工学院 一种合成2-[4-(4-氯丁酰基)苯基]-2-甲基丙酸的方法
EP2289867A3 (en) * 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof
JP6192554B2 (ja) * 2014-02-03 2017-09-06 三菱電機株式会社 真空断熱材の製造方法
CN112661693A (zh) * 2021-01-27 2021-04-16 西北农林科技大学 一种非索非那定的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839431A (en) * 1970-07-13 1974-10-01 Squibb & Sons Inc Cyclopropylmethylphenylacetic acids and derivatives
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
NZ251132A (en) * 1992-04-10 1996-12-20 Merrell Dow Pharma 4-diphenylmethyl piperidine derivatives and their preparation
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
WO1995000482A1 (en) * 1993-06-24 1995-01-05 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
EP2261208A1 (en) * 1993-06-25 2010-12-15 Aventisub II Inc. Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
WO1996035667A1 (en) * 1995-05-08 1996-11-14 Hoescht Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators

Also Published As

Publication number Publication date
ATE485271T1 (de) 2010-11-15
IL171063A (en) 2007-09-20
CN1807394A (zh) 2006-07-26
DE69942876D1 (de) 2010-12-02
IL171479A (en) 2007-10-31
CN101311165B (zh) 2011-05-18
IL171061A (en) 2007-09-20
NO20006694L (no) 2001-03-01
KR20060035816A (ko) 2006-04-26
WO2000001671A2 (en) 2000-01-13
CN101311165A (zh) 2008-11-26
NZ528839A (en) 2005-03-24
ZA200007034B (en) 2002-04-08
IL171062A (en) 2007-09-20
KR100707904B1 (ko) 2007-04-16
JP2002519411A (ja) 2002-07-02
CA2336380C (en) 2007-04-10
HUP0104159A3 (en) 2002-04-29
IL140649A0 (en) 2002-02-10
PT1091938E (pt) 2010-12-20
NZ508477A (en) 2003-12-19
TW533197B (en) 2003-05-21
AU769284B2 (en) 2004-01-22
CA2336380A1 (en) 2000-01-13
IL140649A (en) 2006-08-01
HK1125382A1 (en) 2009-08-07
HK1034065A1 (en) 2001-10-12
KR20010053324A (ko) 2001-06-25
NO319534B1 (no) 2005-08-29
HK1091806A1 (en) 2007-01-26
HUP0104159A2 (hu) 2002-03-28
ES2354968T3 (es) 2011-03-21
CN1308611A (zh) 2001-08-15
BR9911794A (pt) 2001-03-27
CN100522921C (zh) 2009-08-05
WO2000001671A3 (en) 2000-04-06
AU4574699A (en) 2000-01-24
NO20006694D0 (no) 2000-12-29
DK1091938T3 (da) 2011-02-07
CN1246312C (zh) 2006-03-22
EP1091938B1 (en) 2010-10-20
EP1091938A2 (en) 2001-04-18
KR100682447B1 (ko) 2007-02-16

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