AR015886A1 - Sintesis de intermediarios utiles en la preparacion de compuestos triciclicos bromo-sustituidos - Google Patents
Sintesis de intermediarios utiles en la preparacion de compuestos triciclicos bromo-sustituidosInfo
- Publication number
- AR015886A1 AR015886A1 ARP980102809A ARP980102809A AR015886A1 AR 015886 A1 AR015886 A1 AR 015886A1 AR P980102809 A ARP980102809 A AR P980102809A AR P980102809 A ARP980102809 A AR P980102809A AR 015886 A1 AR015886 A1 AR 015886A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- bromo
- synthesis
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Proceso para preparar un compuesto de la formula (1), que comprende: (a) la reaccion de 2,5-dibromo-3-metilpiridina con una amina de la formula NHR5R6 paraobtener una amida; (b) la reaccion de la amida con un compuesto de la formula (3), enpresencia de una base fuerte para obtener un compuesto de laformula (4); (c) la conversion de un compuesto de la formula (4) al correspondiente compuesto ciano o aldehido; (d) la reaccion del compuesto cianoo aldehido con un derivado piperidina paraobtener u n aldehido o alcohol de la formula (7a) o (7b) respectivamente; (e) la ciclacion de un compuesto de laformula (7a) o (7b); donde R1-R7 son como se definen en la memoria descriptiva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/882,753 US5760232A (en) | 1997-06-16 | 1997-06-16 | Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015886A1 true AR015886A1 (es) | 2001-05-30 |
Family
ID=25381267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980102809A AR015886A1 (es) | 1997-06-16 | 1998-06-12 | Sintesis de intermediarios utiles en la preparacion de compuestos triciclicos bromo-sustituidos |
Country Status (15)
Country | Link |
---|---|
US (1) | US5760232A (es) |
EP (1) | EP0991640B1 (es) |
JP (1) | JP3210023B2 (es) |
AR (1) | AR015886A1 (es) |
AT (1) | ATE214062T1 (es) |
AU (1) | AU8056898A (es) |
CA (1) | CA2293709C (es) |
DE (1) | DE69804100T2 (es) |
DK (1) | DK0991640T3 (es) |
ES (1) | ES2169917T3 (es) |
IN (1) | IN187755B (es) |
MY (1) | MY133531A (es) |
PT (1) | PT991640E (es) |
WO (1) | WO1998057958A1 (es) |
ZA (1) | ZA985207B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998620A (en) * | 1997-03-25 | 1999-12-07 | Schering Corporation | Synthesis of intermediates useful in preparing tricyclic compounds |
ES2340806T3 (es) | 2002-10-03 | 2010-06-09 | Schering Corporation | Alquilacion enantioselectiva de compuestos triciclicos. |
PE20221914A1 (es) | 2011-12-28 | 2022-12-23 | Global Blood Therapeutics Inc | Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido |
EP2797597B1 (en) | 2011-12-28 | 2020-02-26 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
KR101971385B1 (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AU2014237330A1 (en) | 2013-03-15 | 2015-09-17 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
AU2015214182B2 (en) | 2014-02-07 | 2020-04-30 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
CN112341433A (zh) * | 2020-11-16 | 2021-02-09 | 成都大学 | 一种氯雷他定的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
JP2875393B2 (ja) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | G−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
SK86198A3 (en) * | 1995-12-22 | 1999-02-11 | Schering Corp | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-06-16 US US08/882,753 patent/US5760232A/en not_active Expired - Lifetime
-
1998
- 1998-06-12 MY MYPI98002633A patent/MY133531A/en unknown
- 1998-06-12 AR ARP980102809A patent/AR015886A1/es unknown
- 1998-06-15 WO PCT/US1998/011403 patent/WO1998057958A1/en active IP Right Grant
- 1998-06-15 DK DK98928873T patent/DK0991640T3/da active
- 1998-06-15 EP EP98928873A patent/EP0991640B1/en not_active Expired - Lifetime
- 1998-06-15 ZA ZA985207A patent/ZA985207B/xx unknown
- 1998-06-15 DE DE69804100T patent/DE69804100T2/de not_active Expired - Lifetime
- 1998-06-15 JP JP50447999A patent/JP3210023B2/ja not_active Expired - Fee Related
- 1998-06-15 AT AT98928873T patent/ATE214062T1/de not_active IP Right Cessation
- 1998-06-15 AU AU80568/98A patent/AU8056898A/en not_active Abandoned
- 1998-06-15 ES ES98928873T patent/ES2169917T3/es not_active Expired - Lifetime
- 1998-06-15 IN IN1294MA1998 patent/IN187755B/en unknown
- 1998-06-15 PT PT98928873T patent/PT991640E/pt unknown
- 1998-06-15 CA CA002293709A patent/CA2293709C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA985207B (en) | 1999-04-07 |
PT991640E (pt) | 2002-07-31 |
MY133531A (en) | 2007-11-30 |
JP3210023B2 (ja) | 2001-09-17 |
CA2293709A1 (en) | 1998-12-23 |
EP0991640B1 (en) | 2002-03-06 |
DK0991640T3 (da) | 2002-05-27 |
ATE214062T1 (de) | 2002-03-15 |
US5760232A (en) | 1998-06-02 |
JP2000513032A (ja) | 2000-10-03 |
IN187755B (es) | 2002-06-15 |
ES2169917T3 (es) | 2002-07-16 |
AU8056898A (en) | 1999-01-04 |
CA2293709C (en) | 2004-02-10 |
WO1998057958A1 (en) | 1998-12-23 |
DE69804100D1 (de) | 2002-04-11 |
DE69804100T2 (de) | 2002-10-31 |
EP0991640A1 (en) | 2000-04-12 |
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