AR014762A1 - PROCEDIMIENTO PARA REDUCIR LA INTERFERENCIA DE COMPONENTES POLISACARIDOS CAPSULARES, DE VACUNAS CONJUGADAS DE HAEMOPHILUS INFLUENZAE B (Hib) EN VACUNASDE COMBINACION, VACUNAS DE COMBINACION OBTENIDAS CON DICHO PROCEDIMIENTO DE VACUNACION CONTRA LA DIFTERIA, TETANO, PERTUSSIS Y HAEMOPHILUS INFLUENZAE - Google Patents

PROCEDIMIENTO PARA REDUCIR LA INTERFERENCIA DE COMPONENTES POLISACARIDOS CAPSULARES, DE VACUNAS CONJUGADAS DE HAEMOPHILUS INFLUENZAE B (Hib) EN VACUNASDE COMBINACION, VACUNAS DE COMBINACION OBTENIDAS CON DICHO PROCEDIMIENTO DE VACUNACION CONTRA LA DIFTERIA, TETANO, PERTUSSIS Y HAEMOPHILUS INFLUENZAE

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Publication number
AR014762A1
AR014762A1 ARP990101271A ARP990101271A AR014762A1 AR 014762 A1 AR014762 A1 AR 014762A1 AR P990101271 A ARP990101271 A AR P990101271A AR P990101271 A ARP990101271 A AR P990101271A AR 014762 A1 AR014762 A1 AR 014762A1
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AR
Argentina
Prior art keywords
vaccines
hib
procedure
interference
combination vaccines
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Application number
ARP990101271A
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English (en)
Original Assignee
Smithkline Beecham Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Smithkline Beecham Biolog filed Critical Smithkline Beecham Biolog
Publication of AR014762A1 publication Critical patent/AR014762A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se trata de un procedimiento general mediante el cual se pueden prepararse vacunas de Hib/DTPa líquida o preparada extemporáneamente, con el fin de evitarla interferencia de Hib al mismo tiempo que se mantiene la absorcion máxima estable de cadaantígeno sobre el adyuvante con una base de aluminio sobre elcual resulta más inmunogena. Mediante este procedimiento, los antígenos de pertussis en vacunas de combinacion de la presente invencion se mantienen en suforma más potente de una manera estable. Específicamente dicho procedimiento permite reducir la interferencia de los componentes polisacáridos capsulares deuna vacuna conjugada de Haemophilus influenzae B (Hib) en vacunas de combinacion que comprende DTPa, caracterizado dicho procedimiento porque comprende: (i)seleccionar uno o más antígeno(s) para adsorberlos sobre un adyuvante de hidroxido de aluminio; (ii) presaturar el adyuvante de hidroxido de aluminiocon los antígenos seleccionados; (iii) seleccionar uno o más antígeno(s) para adsorberlos sobre fosfato de aluminio; (iv) adsorber Hib y dichos antígenosadicionales citados sobre fosfato de aluminio; (v) combinar todos los antígenos en dichas vacunas.
ARP990101271A 1998-03-25 1999-03-23 PROCEDIMIENTO PARA REDUCIR LA INTERFERENCIA DE COMPONENTES POLISACARIDOS CAPSULARES, DE VACUNAS CONJUGADAS DE HAEMOPHILUS INFLUENZAE B (Hib) EN VACUNASDE COMBINACION, VACUNAS DE COMBINACION OBTENIDAS CON DICHO PROCEDIMIENTO DE VACUNACION CONTRA LA DIFTERIA, TETANO, PERTUSSIS Y HAEMOPHILUS INFLUENZAE AR014762A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9806456.1A GB9806456D0 (en) 1998-03-25 1998-03-25 Vaccine composition

Publications (1)

Publication Number Publication Date
AR014762A1 true AR014762A1 (es) 2001-03-28

Family

ID=10829286

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101271A AR014762A1 (es) 1998-03-25 1999-03-23 PROCEDIMIENTO PARA REDUCIR LA INTERFERENCIA DE COMPONENTES POLISACARIDOS CAPSULARES, DE VACUNAS CONJUGADAS DE HAEMOPHILUS INFLUENZAE B (Hib) EN VACUNASDE COMBINACION, VACUNAS DE COMBINACION OBTENIDAS CON DICHO PROCEDIMIENTO DE VACUNACION CONTRA LA DIFTERIA, TETANO, PERTUSSIS Y HAEMOPHILUS INFLUENZAE

Country Status (23)

Country Link
EP (1) EP1066053B8 (es)
JP (1) JP2002507581A (es)
KR (1) KR20010034630A (es)
CN (1) CN1295481A (es)
AR (1) AR014762A1 (es)
AT (1) ATE335509T1 (es)
AU (1) AU735619B2 (es)
BR (1) BR9909037A (es)
CA (1) CA2325436A1 (es)
CO (1) CO4820442A1 (es)
CZ (1) CZ20003536A3 (es)
DE (1) DE69932709T2 (es)
ES (1) ES2270590T3 (es)
GB (1) GB9806456D0 (es)
HU (1) HUP0101323A1 (es)
IL (1) IL137999A0 (es)
MY (1) MY133780A (es)
NO (1) NO20004758L (es)
NZ (1) NZ506604A (es)
PL (1) PL343065A1 (es)
TR (1) TR200002737T2 (es)
WO (1) WO1999048525A1 (es)
ZA (1) ZA200004956B (es)

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DE69935606T9 (de) 1998-10-16 2021-03-11 Glaxosmithkline Biologicals S.A. Adjuvanzsysteme und impfstoffe
EP1004314A1 (fr) * 1998-11-26 2000-05-31 Pasteur Merieux MSD Vaccin T.d. Polio rappel pour une population vaccinée ou sensibilisée
GB0108364D0 (en) 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
PT1296715E (pt) * 2000-06-29 2012-01-19 Smithkline Beecham Biolog Composição vacinal multivalente
KR100385711B1 (ko) * 2000-07-05 2003-05-27 녹십자백신 주식회사 디프테리아, 파상풍 톡소이드와 백일해균 및ｂ형간염표면항원을 포함한 4가 혼합백신 및 그 제조방법
KR100401423B1 (ko) * 2001-01-10 2003-10-17 주식회사 엘지생명과학 혼합 백신의 제조 방법
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
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ES2850973T3 (es) 2010-08-23 2021-09-01 Wyeth Llc Formulaciones estables de antígenos rLP2086 de Neisseria meningitidis
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CN104159603A (zh) * 2012-03-08 2014-11-19 诺华股份有限公司 带有tlr4激动剂的联合疫苗
NZ628449A (en) 2012-03-09 2016-04-29 Pfizer Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
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Also Published As

Publication number Publication date
WO1999048525A1 (en) 1999-09-30
NO20004758D0 (no) 2000-09-22
BR9909037A (pt) 2000-12-05
CZ20003536A3 (cs) 2001-08-15
NZ506604A (en) 2003-02-28
AU3417299A (en) 1999-10-18
TR200002737T2 (tr) 2000-12-21
CN1295481A (zh) 2001-05-16
IL137999A0 (en) 2001-10-31
HUP0101323A1 (hu) 2001-08-28
JP2002507581A (ja) 2002-03-12
ATE335509T1 (de) 2006-09-15
CA2325436A1 (en) 1999-09-30
KR20010034630A (ko) 2001-04-25
EP1066053A1 (en) 2001-01-10
MY133780A (en) 2007-11-30
WO1999048525A8 (en) 1999-11-11
PL343065A1 (en) 2001-07-30
DE69932709D1 (de) 2006-09-21
EP1066053B1 (en) 2006-08-09
EP1066053B8 (en) 2006-12-13
AU735619B2 (en) 2001-07-12
DE69932709T2 (de) 2007-08-16
ES2270590T3 (es) 2007-04-01
CO4820442A1 (es) 1999-07-28
GB9806456D0 (en) 1998-05-27
NO20004758L (no) 2000-11-08
ZA200004956B (en) 2002-02-27

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