AR012437A1 - 4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDURE - Google Patents
4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDUREInfo
- Publication number
- AR012437A1 AR012437A1 ARP980101734A ARP980101734A AR012437A1 AR 012437 A1 AR012437 A1 AR 012437A1 AR P980101734 A ARP980101734 A AR P980101734A AR P980101734 A ARP980101734 A AR P980101734A AR 012437 A1 AR012437 A1 AR 012437A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- manufacture
- preparation
- compounds
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de 4-aminopirido [2,3D]pirimidina 5,6,7-trisustituido o una sal o amida farmacéuticamente aceptable del mismo que tiene la formula (I),donde R1 y R2 son independienteente H, alquilo inferior, arilalquilo o acilo, pueden tomarseconj untamente con el átomo de nitrogeno al cual está unidos paraformar un anillo de 5 a 7 miembros que contiene opcionalmente 1,3 heteroátomos adicionales seleccionados de N, O o S; R3, R4 y R5 están independientementeseleccionados de alquiloinferior, alquenilo inferior, alquinilo inferior, cicloalquilo inferior, arilo, arilalquilo, heteroarilo o un grupo heterocíclicoindica que está presente opcionalmente un doble enlace; el uso de los mismos para la manufactura de unmedicamento util par a inhibir adenosina quinasa, unacomposicion farmacéutica que comprende una cantidad terapéuticamente eficaz de dichos compuestos en combinacion con un portador farmacéuticamente aceptable,eluso de los mismos para lamanufactura de un medicamento ut il para tratar isquemia cerebral, epilepsia, dolor, nocipercepcion, inflamacion y sepsis en unmamífero que necesita dicho tratamiento, procedimiento para su preparacion , compuestos intermediarios yprocedimiento para su preparacion,A 5,6,7-trisubstituted 4-aminopyrido [2,3D] pyrimidine compound or a pharmaceutically acceptable salt or amide thereof having formula (I), wherein R1 and R2 are independently H, lower alkyl, arylalkyl or acyl , can be taken in conjunction with the nitrogen atom to which they are attached to form a 5-7 membered ring optionally containing 1.3 additional heteroatoms selected from N, O, or S; R3, R4 and R5 are independently selected from lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, arylalkyl, heteroaryl or a heterocyclic group indicating that a double bond is optionally present; the use of the same for the manufacture of a useful medicine to inhibit adenosine kinase, a pharmaceutical composition comprising a therapeutically effective amount of said compounds in combination with a pharmaceutically acceptable carrier, the use of the same for the manufacture of a useful medicine to treat ischemia brain, epilepsy, pain, nociperception, inflammation and sepsis in a mammal that needs such treatment, procedure for its preparation, intermediate compounds and procedure for its preparation,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84348497A | 1997-04-16 | 1997-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012437A1 true AR012437A1 (en) | 2000-10-18 |
Family
ID=25290123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101734A AR012437A1 (en) | 1997-04-16 | 1998-04-15 | 4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDURE |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0975633A1 (en) |
| JP (1) | JP2001520654A (en) |
| KR (1) | KR20010006462A (en) |
| CN (1) | CN1252069A (en) |
| AR (1) | AR012437A1 (en) |
| AU (1) | AU741033B2 (en) |
| BG (1) | BG103853A (en) |
| BR (1) | BR9809056A (en) |
| CA (1) | CA2286592A1 (en) |
| CO (1) | CO4940470A1 (en) |
| HU (1) | HUP0001443A3 (en) |
| IL (1) | IL131617A0 (en) |
| NO (1) | NO995035L (en) |
| NZ (1) | NZ337125A (en) |
| PL (1) | PL336265A1 (en) |
| SK (1) | SK140099A3 (en) |
| TR (1) | TR199902550T2 (en) |
| WO (1) | WO1998046604A1 (en) |
| ZA (1) | ZA983175B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| BRPI0207172B8 (en) | 2001-02-12 | 2021-05-25 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, their composition and use, as well as their intermediate |
| CN107744520A (en) * | 2017-10-25 | 2018-03-02 | 南京多宝生物科技有限公司 | Pyrimidines are preparing the application in promoting small bowel peristalsis medicine |
| CN112209924B (en) * | 2019-07-09 | 2022-04-05 | 中国科学院天津工业生物技术研究所 | Selective adenosine A1Receptor antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-04-13 EP EP98918091A patent/EP0975633A1/en not_active Withdrawn
- 1998-04-13 IL IL13161798A patent/IL131617A0/en unknown
- 1998-04-13 CA CA002286592A patent/CA2286592A1/en not_active Abandoned
- 1998-04-13 CN CN98804117A patent/CN1252069A/en active Pending
- 1998-04-13 SK SK1400-99A patent/SK140099A3/en unknown
- 1998-04-13 TR TR1999/02550T patent/TR199902550T2/en unknown
- 1998-04-13 PL PL98336265A patent/PL336265A1/en unknown
- 1998-04-13 WO PCT/US1998/007201 patent/WO1998046604A1/en not_active Application Discontinuation
- 1998-04-13 JP JP54408398A patent/JP2001520654A/en active Pending
- 1998-04-13 HU HU0001443A patent/HUP0001443A3/en unknown
- 1998-04-13 AU AU71080/98A patent/AU741033B2/en not_active Ceased
- 1998-04-13 NZ NZ337125A patent/NZ337125A/en unknown
- 1998-04-13 KR KR1019997009552A patent/KR20010006462A/en not_active Application Discontinuation
- 1998-04-13 BR BR9809056-9A patent/BR9809056A/en not_active IP Right Cessation
- 1998-04-15 ZA ZA983175A patent/ZA983175B/en unknown
- 1998-04-15 AR ARP980101734A patent/AR012437A1/en unknown
- 1998-04-16 CO CO98020978A patent/CO4940470A1/en unknown
-
1999
- 1999-10-15 NO NO995035A patent/NO995035L/en not_active Application Discontinuation
- 1999-11-03 BG BG103853A patent/BG103853A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4940470A1 (en) | 2000-07-24 |
| TR199902550T2 (en) | 2000-04-21 |
| KR20010006462A (en) | 2001-01-26 |
| PL336265A1 (en) | 2000-06-19 |
| BR9809056A (en) | 2000-08-01 |
| NZ337125A (en) | 2001-06-29 |
| WO1998046604A1 (en) | 1998-10-22 |
| HUP0001443A3 (en) | 2001-01-29 |
| EP0975633A1 (en) | 2000-02-02 |
| ZA983175B (en) | 1998-10-21 |
| AU7108098A (en) | 1998-11-11 |
| SK140099A3 (en) | 2000-05-16 |
| CA2286592A1 (en) | 1998-10-22 |
| BG103853A (en) | 2000-06-30 |
| JP2001520654A (en) | 2001-10-30 |
| HUP0001443A2 (en) | 2000-10-28 |
| NO995035L (en) | 1999-12-15 |
| IL131617A0 (en) | 2001-01-28 |
| AU741033B2 (en) | 2001-11-22 |
| CN1252069A (en) | 2000-05-03 |
| NO995035D0 (en) | 1999-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT100631A (en) | BICYCLE FIBRINOGENIC ANTAGONISTS, ITS USE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
| HUT58200A (en) | Process for producing pharmaceutical composition containing adamanthane derivatives for preventing and treating brain ischemia | |
| CA2098076A1 (en) | Imidate prodrugs of pharmaceutically useful anticonvulsant sulfamates | |
| RU2004130488A (en) | Pyrimidine derivatives | |
| UY25225A1 (en) | PLEUROMUTILINE DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | |
| AR012436A1 (en) | 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR LAMANUFACTURE OF MEDICINES, A PROCEDURE FOR THEIR PREPARATION. | |
| OA09454A (en) | New peptide derivatives, their preparation process and pharmaceutical compositions which contain them. | |
| ES2046193T3 (en) | A PROCEDURE FOR THE PREPARATION OF AN IMIDAZOLIDINONE COMPOUND. | |
| AR012437A1 (en) | 4-AMINOPYRID [2,3-D] PIRIMIDINE 5, 6, 7-TRISUSTITUED COMPOUNDS, THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR SUPREPARATION, PHARMACEUTICAL COMPOSITION FOR THEM, PREPARATION AND PROCEDURE | |
| AR040233A1 (en) | XANTINA FOSFODIESTERASA V INHIBITING POLYMORPHES | |
| EA200100597A2 (en) | New 1,1- and 1,2-disubstituted cyclopropane compounds, a process for their preparation and pharmaceutical compositions containing them | |
| AR012435A1 (en) | COMPOUND OF 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 6,7-DISSTITUTED; THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT, INTERMEDIATE COMPOUNDS AND PROCEDURE FOR ITS PREPARATION. | |
| DE69122858T2 (en) | THERAPEUTIC BENZAZEPINE COMPOUNDS | |
| MX9300423A (en) | HETERO CYCLIC DERIVATIVES. | |
| RU96102846A (en) | IZOHINOLIN DERIVATIVES AS THERAPEUTIC TOOLS | |
| NZ222045A (en) | From diamides up to tetrapeptides for use as anticanvulsants | |
| KR930023338A (en) | Depo formulation | |
| ES477257A1 (en) | Isoquinoline derivatives, their preparation and pharmaceutical compositions containing these compounds. | |
| RU2021107688A (en) | TRICYCLIC COMPOUNDS AFFECTING CRBN PROTEINS | |
| UY28119A1 (en) | NEW DERIVATIVES CONTAINING PHOSPHORUS | |
| KR970706258A (en) | (4a-ARYLDECAHYDROISOQUINOLIN COMPOUND AND MEDICINAL USE OF THE SAME) | |
| AR030196A1 (en) | COMPOUND CONTAINING CARBOCICLIC SIDE CHAIN, PHARMACEUTICAL COMPOSITION CONTAINING IT AND USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| GB1455617A (en) | Pyran derivatives | |
| TH13800A (en) | New peptide derivatives | |
| MX9307778A (en) | QUINAZOLINE DERIVATIVES. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |