AR012435A1 - COMPOUND OF 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 6,7-DISSTITUTED; THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT, INTERMEDIATE COMPOUNDS AND PROCEDURE FOR ITS PREPARATION. - Google Patents
COMPOUND OF 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 6,7-DISSTITUTED; THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT, INTERMEDIATE COMPOUNDS AND PROCEDURE FOR ITS PREPARATION.Info
- Publication number
- AR012435A1 AR012435A1 ARP980101732A ARP980101732A AR012435A1 AR 012435 A1 AR012435 A1 AR 012435A1 AR P980101732 A ARP980101732 A AR P980101732A AR P980101732 A ARP980101732 A AR P980101732A AR 012435 A1 AR012435 A1 AR 012435A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- preparation
- procedure
- aryl
- manufacture
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Un compuesto de 4-aminopirido[2,3-D]piridina 6,7-disustituida y las sales y amidas farmacéuticamente aceptable del mismo que tiene las sigiuente formula Ien la cual: R1 y R2, independientemente entre si, son, hidrogeno, alquilo inferior, aril alquilo o acilo, o pueden ser tomados conjuntamente con el átomode nitrogeno al cual están fijados de manera de formar un anillo de 5 a 7 miembros que opcionalmente contienen un átomo adicional de oxígeno o un átomode nitrogeno; R3 y R4, independientemente entre sí, son seleccionados de entre; alquilo inferior, alquenilo inferior, arilo, aril, alquilo, hetero arilo, o ungrupo hetero cíclico, y las líneas de trazos indican que opcionalmente hay un doble enlace presente inhibir la adenosínquinasa, una composicion farmacéuticaque comprende una cantidad efectiva desde el punto de vista terapéutico de un compuesto de la presente en combinacion con un vehículo farmacéuticamenteaceptable, el uso de dicho compuesto para la manufactura deun medicamento util para tratar la isquemia cerebral, la epilepsia, la noci percepcion, el dolor,la inflamacion y la sepsis en un mamífero que lo necesite, que comprende una cantidad efectiva desde el punto de vista terapéutico, de un compuesto dela presente; procedimientos para la preparacion del compuesto; compuestos intermediarios y procedimientos para su preparacion; el uso del mismo para lamanufactura de un medicamento util.A 6,7-disubstituted 4-aminopyrido [2,3-D] pyridine compound and the pharmaceutically acceptable salts and amides thereof having the following formula I in which: R1 and R2, independently of each other, are, hydrogen, alkyl lower, aryl alkyl or acyl, or can be taken in conjunction with the nitrogen atom to which they are attached so as to form a 5- to 7-membered ring optionally containing an additional oxygen atom or a nitrogen atom; R3 and R4, independently of each other, are selected from; lower alkyl, lower alkenyl, aryl, aryl, alkyl, hetero aryl, or heterocyclic group, and the dashed lines indicate that there is optionally a double bond present inhibiting adenosine kinase, a pharmaceutical composition comprising a therapeutically effective amount of a compound of the present in combination with a pharmaceutically acceptable vehicle, the use of said compound for the manufacture of a medicine useful to treat cerebral ischemia, epilepsy, noci perception, pain, inflammation and sepsis in a mammal that causes it. need, comprising a therapeutically effective amount, of a compound herein; procedures for the preparation of the compound; intermediates and procedures for their preparation; the use of it for the manufacture of a useful medicine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83439397A | 1997-04-16 | 1997-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012435A1 true AR012435A1 (en) | 2000-10-18 |
Family
ID=25266829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101732A AR012435A1 (en) | 1997-04-16 | 1998-04-15 | COMPOUND OF 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 6,7-DISSTITUTED; THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT, INTERMEDIATE COMPOUNDS AND PROCEDURE FOR ITS PREPARATION. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0979230A1 (en) |
| JP (1) | JP2001520649A (en) |
| KR (1) | KR20010006453A (en) |
| CN (1) | CN1259948A (en) |
| AR (1) | AR012435A1 (en) |
| AU (1) | AU744528B2 (en) |
| BG (1) | BG103861A (en) |
| BR (1) | BR9809088A (en) |
| CA (1) | CA2287465A1 (en) |
| CO (1) | CO4940439A1 (en) |
| HU (1) | HUP0001402A3 (en) |
| IL (1) | IL131892A0 (en) |
| NO (1) | NO995033L (en) |
| NZ (1) | NZ337844A (en) |
| PL (1) | PL336262A1 (en) |
| SK (1) | SK142099A3 (en) |
| TR (1) | TR199902456T2 (en) |
| TW (1) | TW458977B (en) |
| WO (1) | WO1998046603A1 (en) |
| ZA (1) | ZA982912B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| HU229604B1 (en) * | 2001-02-12 | 2014-02-28 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them |
| WO2006053250A2 (en) | 2004-11-12 | 2006-05-18 | Trustees Of Tufts College | Lipase inhibitors |
| US20100063032A1 (en) * | 2007-03-28 | 2010-03-11 | Debenham John S | Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators |
| EA201590693A1 (en) * | 2012-10-05 | 2015-08-31 | Ригель Фармасьютикалс, Инк. | INHIBITORS GDF-8 |
| US10016432B2 (en) | 2016-05-27 | 2018-07-10 | Legacy Emanuel Hospital & Health Center | Methanocarba derivatives of pseudoribose that inhibit adenosine kinase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-03-27 TW TW087104674A patent/TW458977B/en not_active IP Right Cessation
- 1998-04-06 ZA ZA982912A patent/ZA982912B/en unknown
- 1998-04-14 CO CO98020309A patent/CO4940439A1/en unknown
- 1998-04-15 AR ARP980101732A patent/AR012435A1/en unknown
- 1998-04-16 NZ NZ337844A patent/NZ337844A/en unknown
- 1998-04-16 EP EP98917950A patent/EP0979230A1/en not_active Withdrawn
- 1998-04-16 TR TR1999/02456T patent/TR199902456T2/en unknown
- 1998-04-16 WO PCT/US1998/004127 patent/WO1998046603A1/en not_active Application Discontinuation
- 1998-04-16 IL IL13189298A patent/IL131892A0/en unknown
- 1998-04-16 JP JP54387898A patent/JP2001520649A/en active Pending
- 1998-04-16 SK SK1420-99A patent/SK142099A3/en unknown
- 1998-04-16 BR BR9809088-7A patent/BR9809088A/en not_active IP Right Cessation
- 1998-04-16 KR KR1019997009543A patent/KR20010006453A/en not_active Application Discontinuation
- 1998-04-16 CN CN98806072A patent/CN1259948A/en active Pending
- 1998-04-16 AU AU70981/98A patent/AU744528B2/en not_active Ceased
- 1998-04-16 HU HU0001402A patent/HUP0001402A3/en unknown
- 1998-04-16 PL PL98336262A patent/PL336262A1/en unknown
- 1998-04-16 CA CA002287465A patent/CA2287465A1/en not_active Abandoned
-
1999
- 1999-10-15 NO NO995033A patent/NO995033L/en not_active Application Discontinuation
- 1999-11-05 BG BG103861A patent/BG103861A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4940439A1 (en) | 2000-07-24 |
| BG103861A (en) | 2000-06-30 |
| NO995033D0 (en) | 1999-10-15 |
| IL131892A0 (en) | 2001-03-19 |
| TR199902456T2 (en) | 2000-07-21 |
| ZA982912B (en) | 1998-10-09 |
| AU744528B2 (en) | 2002-02-28 |
| CA2287465A1 (en) | 1998-10-22 |
| JP2001520649A (en) | 2001-10-30 |
| CN1259948A (en) | 2000-07-12 |
| NO995033L (en) | 1999-12-15 |
| KR20010006453A (en) | 2001-01-26 |
| EP0979230A1 (en) | 2000-02-16 |
| NZ337844A (en) | 2001-11-30 |
| BR9809088A (en) | 2000-08-01 |
| WO1998046603A1 (en) | 1998-10-22 |
| SK142099A3 (en) | 2000-05-16 |
| HUP0001402A3 (en) | 2001-01-29 |
| TW458977B (en) | 2001-10-11 |
| AU7098198A (en) | 1998-11-11 |
| HUP0001402A2 (en) | 2000-10-28 |
| PL336262A1 (en) | 2000-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |