AR009651A1 - SOLUBILIZING / STABILIZING COMPOSITION ANHYDRABLE, EMULSIONABLE OR MICROEMULSIONABLE IN WATER, FOR THE SOLUBILIZATION OF N-SULFONIL INDOLINE HYDROPHOBIC DERIVATIVES, MICROEMULSULABLE, CAUSABLE, AND EMULSIBLE PHARMACEUTICAL COMPOSITION - Google Patents
SOLUBILIZING / STABILIZING COMPOSITION ANHYDRABLE, EMULSIONABLE OR MICROEMULSIONABLE IN WATER, FOR THE SOLUBILIZATION OF N-SULFONIL INDOLINE HYDROPHOBIC DERIVATIVES, MICROEMULSULABLE, CAUSABLE, AND EMULSIBLE PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- AR009651A1 AR009651A1 ARP970105696A ARP970105696A AR009651A1 AR 009651 A1 AR009651 A1 AR 009651A1 AR P970105696 A ARP970105696 A AR P970105696A AR P970105696 A ARP970105696 A AR P970105696A AR 009651 A1 AR009651 A1 AR 009651A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- solubilizing
- indoline
- stabilizing
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Composicion solubilizante/estabilizante anhidra, emulsionable o microemulsionable en agua, para la solubilizacion de los derivados hidrofobosde N-sulfonil indolina de formula (I), que comprende uno o varios e constituyentes elegidos entre compuestos anfífilos, agentes tensioactivoshidrofobos no ionicos y compuestos hidrofilos no ionicos dotados a la vez de propiedades anfífilas y tensioactivas, entendiéndose que dicha composicioncomprende al menos o bien una mezcla deun compuesto anfífilo y un agente tensioactivo hidrofilo no ionico, o bien al menos un compuesto hidrofilo noionico dotado a la vez de propiedades tensioactivas y anfífilas. Composicion farmacéutica microemulsionable o emulsionable en medioo acuoso, que comprende:el derivado hidrofobo de N-sulfonil indolina, la composicion solubilizante/ estabilizante, eventualmente un excipiente o vehículo farmacéutico apropiado.Cápsula blanda farmacéutica, que contiene la composicion farmacéutica, en forma líquida, para administracion oral. Cápsula farmacéutica, que contiene lacomposicion farmacéutica, en forma semisolida, para administracion oral. La composicion solubilizante/estabilizante capaz de solubilizar los derivadoshidrofobos deN-sulfonil indolina puede ser utilizada válidamente con miras a introducir esos principios activos en composiciones farmacéuticas.Anhydrous, emulsifiable or microemulsifiable anhydrous solubilizing / stabilizing composition for the solubilization of the hydrophobic derivatives of N-sulfonyl indoline of formula (I), which comprises one or more constituents chosen from amphiphilic compounds, non-ionic hydrophobic surfactants and non-ionic hydrophilic compounds both endowed with amphiphilic and surfactant properties, it being understood that said composition comprises at least either a mixture of an amphiphilic compound and a hydrophilic nonionic surfactant, or at least one hydrophilic nonionic compound endowed with both surfactant and amphiphilic properties. Microemulsifiable or emulsifiable pharmaceutical composition in aqueous medium, comprising: the hydrophobic derivative of N-sulfonyl indoline, the stabilizing / stabilizing composition, possibly an appropriate pharmaceutical carrier or excipient, containing the pharmaceutical composition, in liquid form, for oral administration. Pharmaceutical capsule, containing the pharmaceutical composition, in semi-solid form, for oral administration. The solubilizing / stabilizing composition capable of solubilizing the hydrophobic derivatives of N-sulfonyl indoline can be validly used with a view to introducing these active ingredients into pharmaceutical compositions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614957A FR2756736B1 (en) | 1996-12-05 | 1996-12-05 | PHARMACEUTICAL COMPOSITIONS CONTAINING N-SULFONYL INDOLINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009651A1 true AR009651A1 (en) | 2000-04-26 |
Family
ID=9498376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105696A AR009651A1 (en) | 1996-12-05 | 1997-12-04 | SOLUBILIZING / STABILIZING COMPOSITION ANHYDRABLE, EMULSIONABLE OR MICROEMULSIONABLE IN WATER, FOR THE SOLUBILIZATION OF N-SULFONIL INDOLINE HYDROPHOBIC DERIVATIVES, MICROEMULSULABLE, CAUSABLE, AND EMULSIBLE PHARMACEUTICAL COMPOSITION |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0941090A1 (en) |
| JP (1) | JP2000507618A (en) |
| KR (1) | KR20000069308A (en) |
| CN (1) | CN1239887A (en) |
| AR (1) | AR009651A1 (en) |
| AU (1) | AU716575B2 (en) |
| BR (1) | BR9712406A (en) |
| CA (1) | CA2273990A1 (en) |
| CO (1) | CO4910129A1 (en) |
| DZ (1) | DZ2362A1 (en) |
| EE (1) | EE9900206A (en) |
| FR (1) | FR2756736B1 (en) |
| HU (1) | HUP0001386A3 (en) |
| ID (1) | ID23373A (en) |
| IL (1) | IL129936A0 (en) |
| IS (1) | IS5062A (en) |
| MY (1) | MY132819A (en) |
| NO (1) | NO992724D0 (en) |
| NZ (1) | NZ335750A (en) |
| RU (1) | RU2174394C2 (en) |
| SK (1) | SK75599A3 (en) |
| TR (1) | TR199901702T2 (en) |
| WO (1) | WO1998024430A1 (en) |
| YU (1) | YU23099A (en) |
| ZA (1) | ZA9710919B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786486B3 (en) * | 1998-11-16 | 2000-12-08 | Sanofi Sa | PROCESS FOR THE PREPARATION OF (2S) -1 - [(2R, 3S) -5-CHLORO-3- (2- CHLOROPHENYL) -1- (3,4-DIMETHOXY BENZENESULFONYL) -3-HYDROXY- 2,3-DIHYDRO- 1H-INDOLE-2-CARBONYL] PYRROLIDINE-2-CARBOXAMIDE, ITS SOLVATES AND / OR HYDRATES |
| DE19913692A1 (en) * | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanically stable pharmaceutical dosage forms containing liquid or semi-solid surface-active substances |
| US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
| WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| FR2805992A1 (en) * | 2000-03-08 | 2001-09-14 | Sanofi Synthelabo | Oral administration of N-sulfonyl-indoline derivative to treat central nervous system, cardiovascular or gastric disorders, using polyethylene glycol, polysorbate and poloxamer as solubilizers for high bioavailability |
| DE10026698A1 (en) | 2000-05-30 | 2001-12-06 | Basf Ag | Self-emulsifying active ingredient formulation and use of this formulation |
| ITMI20011338A1 (en) * | 2001-06-26 | 2002-12-26 | Farmatron Ltd | ORAL PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE OF THE ACTIVE INGREDIENT |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| UA119324C2 (en) * | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Compositions of pharmaceutical actives containing diethylene glycol monoethyl ether or other alkyl derivatives |
| KR102139338B1 (en) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | Cosmetic composition which has improved solubility comprising indole compound |
| KR102139339B1 (en) * | 2013-06-24 | 2020-07-29 | 주식회사 엘지생활건강 | Cosmetic composition which has improved solubility comprising indole compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237814A1 (en) * | 1982-10-12 | 1984-04-12 | Warner-Lambert Co., 07950 Morris Plains, N.J. | WATER-FREE EMULSIONS AND USE THEREOF |
| FR2679903B1 (en) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | DERIVATIVES OF N-SULFONYL INDOLINE CARRYING AN AMIDIC FUNCTION, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
-
1996
- 1996-12-05 FR FR9614957A patent/FR2756736B1/en not_active Expired - Fee Related
-
1997
- 1997-12-03 DZ DZ970212A patent/DZ2362A1/en active
- 1997-12-04 JP JP10525294A patent/JP2000507618A/en active Pending
- 1997-12-04 CN CN97180304A patent/CN1239887A/en active Pending
- 1997-12-04 KR KR1019997004983A patent/KR20000069308A/en not_active Application Discontinuation
- 1997-12-04 ID IDW990445D patent/ID23373A/en unknown
- 1997-12-04 AU AU53262/98A patent/AU716575B2/en not_active Ceased
- 1997-12-04 BR BR9712406-0A patent/BR9712406A/en unknown
- 1997-12-04 WO PCT/FR1997/002210 patent/WO1998024430A1/en not_active Application Discontinuation
- 1997-12-04 ZA ZA9710919A patent/ZA9710919B/en unknown
- 1997-12-04 SK SK755-99A patent/SK75599A3/en unknown
- 1997-12-04 IL IL12993697A patent/IL129936A0/en unknown
- 1997-12-04 MY MYPI97005848A patent/MY132819A/en unknown
- 1997-12-04 EE EEP199900206A patent/EE9900206A/en unknown
- 1997-12-04 CO CO97071118A patent/CO4910129A1/en unknown
- 1997-12-04 TR TR1999/01702T patent/TR199901702T2/en unknown
- 1997-12-04 EP EP97950228A patent/EP0941090A1/en not_active Withdrawn
- 1997-12-04 CA CA002273990A patent/CA2273990A1/en not_active Abandoned
- 1997-12-04 AR ARP970105696A patent/AR009651A1/en unknown
- 1997-12-04 NZ NZ335750A patent/NZ335750A/en unknown
- 1997-12-04 HU HU0001386A patent/HUP0001386A3/en unknown
- 1997-12-04 RU RU99114019/14A patent/RU2174394C2/en active
-
1999
- 1999-05-26 YU YU23099A patent/YU23099A/en unknown
- 1999-06-01 IS IS5062A patent/IS5062A/en unknown
- 1999-06-04 NO NO992724A patent/NO992724D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001386A3 (en) | 2002-03-28 |
| NO992724L (en) | 1999-06-04 |
| DZ2362A1 (en) | 2002-12-28 |
| RU2174394C2 (en) | 2001-10-10 |
| EE9900206A (en) | 1999-12-15 |
| FR2756736B1 (en) | 1999-03-05 |
| FR2756736A1 (en) | 1998-06-12 |
| YU23099A (en) | 1999-11-22 |
| TR199901702T2 (en) | 1999-09-21 |
| CO4910129A1 (en) | 2000-04-24 |
| IL129936A0 (en) | 2000-02-29 |
| HUP0001386A2 (en) | 2001-04-28 |
| WO1998024430A1 (en) | 1998-06-11 |
| EP0941090A1 (en) | 1999-09-15 |
| NZ335750A (en) | 2001-06-29 |
| AU716575B2 (en) | 2000-03-02 |
| IS5062A (en) | 1999-06-01 |
| ZA9710919B (en) | 1999-06-04 |
| AU5326298A (en) | 1998-06-29 |
| CA2273990A1 (en) | 1998-06-11 |
| KR20000069308A (en) | 2000-11-25 |
| CN1239887A (en) | 1999-12-29 |
| NO992724D0 (en) | 1999-06-04 |
| ID23373A (en) | 2000-04-20 |
| SK75599A3 (en) | 2000-08-14 |
| MY132819A (en) | 2007-10-31 |
| BR9712406A (en) | 1999-08-31 |
| JP2000507618A (en) | 2000-06-20 |
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